Enhance your data by adding SomaScan® Assay services to your mass spectrometry analysis
Analyze 7,000 proteins in 55 µL of plasma, and obtain sensitive detection without complex sample preparation
Adding the SomaScan Assay to mass spectrometry allows for deeper molecular insights, rapidly and consistently
Pairing the SomaScan Assay with complementary technologies, such as mass spectrometry, can accelerate target identification and protein expression analysis, as well as help you differentiate causal links or find new uses for already approved therapeutics.
The SomaScan Assay is based on SOMAmer® (Slow Off-Rate Modified Aptamer) protein affinity reagents, which are aptamers that are custom engineered to have enhanced shape complementarity to their targets, as well as slow off rates for longer target binding. A universal polyanionic competitor further enhances specificity to the target protein.
Our current menu offers 7,000 proteins that can be measured simultaneously from a small sample (~55 µL) of plasma, serum, CSF, and multiple other complex sample types (human and non-human). This platform also offers excellent reproducibility with median coefficients of variation (CVs) around 5%.
Published findings show the benefit of using complementary technologies
- In patients with high-grade serous ovarian carcinoma, researchers used the SomaScan Assay and mass spectrometry to discover protein signatures classifying long- or short-term relapse-free survivors (PMID 31588238)
- Researchers used the SomaScan platform and mass spectrometry to help identify the role of molecular mechanisms in different pathophysiological processes in COVID-19, a complex, heterogeneous condition. These insights may help stratify patients in clinical trials and in the clinic for targeted treatment (PMID 33724185)
- In a study combining the SomaScan Assay with mass spectrometry analysis, research identified aspirin-targeted proteins that are potentially associated with the risk of colorectal cancer (PMID 33318029)
Advantages of a complementary approach
Precision proteomics for diagnostics, drug discovery, and health management
Featuring: Nelson Trujillo, MD
Boulder Community Health
“The resulting prediction of individualized and near-term risk enabled Trujillo to advise 45% of his evaluated patients to change therapy.”
Click below to read more about our proprietary Slow Off-rate Modified Aptamer (SOMAmer®) protein affinity reagents. And watch Dr. Trujillo explain how he uses protein profiling to predict, monitor, and prevent escalation of cardiovascular disease in this on-demand webinar.
A proteomic tool to separate clinical signals from a sea of noise
Featuring: Antoine Dufour, PhD
University of Calgary
“As an initial screen, it’s a game-changer
in terms of numbers.”
Download article
Profiling technology unlocks the predictive power of proteomics
Featuring:
Peter Ganz, MD
University of California, San Francisco
Ali Javaheri, MD
Washington University in St. Louis
Yuichi Shimada, MD
Columbia University
“From a single blood sample, one can simultaneously determine the risk of many diseases.”
Benefits of the SomaScan Assay
The SomaScan Assay utilizes small sample volumes and delivers high-quality, actionable data to accelerate your research.
Sensitive detection
(125 fM)
The SomaScan Assay can measure proteins with low limits of detection (10-log range as low as 125 fM).
Reproducible
(~5% median CV)
Obtain consistent and reproducible inter- and intra- assay results for data analysis and comparison.
High throughput
Screen up to 7,000 proteins per sample, and conduct high-throughput analysis of >1,000 samples per day.
The SomaScan portfolio offers multiple ways to complement your mass spectrometry analysis
SomaScan Assay Services
With the ability to profile 7,000 proteins simultaneously in samples such as blood, urine, and cerebrospinal fluid, the SomaScan Assay lets you measure low- and high-abundant proteins with confidence.
SomaScan Panels
Choose your proteins of interest and customize a panel. Or select from one of our carefully curated disease-specific panels, including neuroscience, cardiovascular disease, cytokines and more.
Become an
Authorized Site
Run the SomaScan Assay in your own lab as an Authorized Site. Having the technology onsite enables you to accelerate your workflow, automate your process, and create revenue-generating capabilities.
Learn more with these SomaScan Assay resources
SomaScan Assay 4.1
The SomaScan Platform measures native proteins in complex matrices by transforming available binding sites on individual proteins into a corresponding SOMAmer reagent concentration, which is then quantified by hybridization to microarrays.
Pre-Analytical Variation
Controlling pre-analytical variation is important to avoid misleading analyses that can impact data and cause setbacks in research efforts – costing time, money, and loss of precious samples.
Elements of Specificity
Each SOMAmer reagent is characterized by two elements of specificity: strong affinity for its target protein and a slow dissociation rate. These two specificity attributes derive from the unique chemical composition of each reagent.