SomaScan® Proteomics Consortium

Advancing health information together.


To promote collaboration among cohort studies that use SomaScan profiling to follow participants for a range of outcomes

The Consortium exists to promote collaboration among prospective cohort studies that follow participants for a range of outcomes and perform SomaScan profiling of individuals. We will provide the framework to foster international collaborations among studies sharing common objectives, including a forum for the discussion, development and pursuit of new collaborative studies and research directions. We will facilitate an open exchange of ideas, knowledge, and results in order to accelerate the study of proteomics profiles associated with chronic disease phenotypes.

Additional consortium principles

  • Store datasets locally, not in a repository
  • Promote result sharing
  • Adopt a distributive analysis model
  • Support the development of early career researchers
  • Advance the knowledge of the proteome to improve our understanding of prediction of disease etiology, diagnosis and prognosis
  • Raise common funds through grants and donations by sharing analyses and preliminary data
  • Create a harmonized proteomic resource that bridges platforms for more powerful association analyses

Initial consortium cohorts

Population Website Contact
US older current and former smokers

Russell Bowler

[email protected]

US older current and former smokers

Russell Bowler

[email protected]

US New England population

Debby Ngo

[email protected]

US Mississippi AA population

Debby Ngo

[email protected]

US multi-ethnic population

Ani Manichaikul

[email protected]


US SW community cohort

current and former smokers

No website

Yohannes Tesfaigzi

[email protected]

Southern Germany population

Claudia Flexeder

[email protected]


International patients with

Diabetes and high risk of CVD

Svati Shah

[email protected]

Dr. Russell P. Bowler

Professor of Medicine - National Jewish Health

Dr. Claudia Flexeder

Postdoc, Statistician - Helmholtz Institute of Epidemiology

Dr. Ani W. Manichaikul

Assistant Professor - University of Virginia

Dr. Debby Ngo

Instructor in Medicine - Beth Israel Deaconess Medical Center

Dr. Svati Shah

Associate Director of Clinical Translation - Duke Molecular Physiology Institute

Dr. Yohannes Tesfaigzi

Professor of Medicine - Brigham and Women’s Hospital

Get in touch

For general inquries, contact Russ Bowler.
[email protected]


Meeting and research highlights.

September 15 meeting: Daryl Perry of SomaLogic led a discussion on data normalization

“Thanks everyone for a really great discussion on the different types of controls and the importance of each in normalization. The Bioinformatics Team is always happy to talk more about any of the topics we covered.”

In light of the current pandemic, the SomaScan Proteomics Consortium will be initially focused on the exchange of information relevant to COVID-19

“We are performing a genome-wide association study of ACE2 levels measured by SomaScan to identify the genetic variants and pathways that modulate ACE2 levels. Our project combines SOMAscan data from multiple cohorts including the Multi-Ethnic Study of Atherosclerosis (MESA), the Genetic Epidemiology of COPD (COPDGene) study, and the SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS), among others.”