Proteomics Consortium

Advancing precision medicine research through worldwide sharing of human proteomic data

Advancing the power of precision medicine and population proteomics research through global collaboration and data sharing

The SomaScan Proteomics Consortium was founded by Russell Bowler, MD, PhD, to enable researchers to increase the power of their studies by leveraging high-plex proteomic profiling with the SomaScan® Assay across diverse populations worldwide, for more powerful biomarker discovery and deeper insights into human biology. Members are committed to sharing data for the purpose of increasing efficiency and efficacy, as well as for fostering discussions about the development and pursuit of new studies and research directions.

SomaLogic is honored to support the consortium as an independent and open exchange of ideas, knowledge, and results, in order to accelerate the study of disease and human biology.

For general inquiries or to join the consortium, please contact Russell Bowler, MD, PhD.

Consortium Principles

  • Advance knowledge of the proteome to improve understanding of disease etiology, diagnosis and prognosis
  • Promote opportunities to collaborate and share results
  • Adopt a distributive analysis model
  • Preserve governance of cohort data with cohort Principal Investigators
  • Support the development of early-career researchers
  • Raise common funds through grants and donations by sharing analyses and preliminary data

Current cohorts used by consortium members in proteomics research using the SomaScan Assay

To learn more about the biobanks and prospective cohort studies listed, please click “View now” next to each.

Data tips and resources

What is an ADAT file?
What is a data repository?
Resources for data repositories
About the NIH requirement to upload data
How to upload SomaScan data to public repositories
Assistance: SomaLogic Technical Support
What is an ADAT file?

Preview image of SomaLogic GitHub repository

The ADAT file format is a Soma Logic-specific, tab-delimited text file designed to store Somascan study data. This format is intended to be flexible and self-explanatory. When sample analysis is completed, SomaLogic normalizes the data to ensure data quality and then creates an ADAT file for delivery of results to the researcher.

If you have questions or need assistance with ADAT files, please email SomaLogic Technical Support here.

What is a data repository?

Image of three logos - NIH, PRIDE, Proteome Xchange

A data repository serves as a structured digital storage facility, often resembling databases or data lakes, where research data and analytical resources are systematically organized and made accessible in accordance with FAIR (Findable, Accessible, Interoperable, and Reusable) standards. Data repositories exist in two primary forms: open access and closed access.

Learn why researchers are increasingly encouraged – or required – to upload data to a repository before publishing their findings.

Resources for data repositories

SomaLogic ADAT file type preview image

Data repositories can exist in two primary forms: open access, which are open to the public, or closed access, restricted to specific users or groups, and they may cater to discipline-specific or broader research datasets. Choosing which type of data repository to upload to depends on several factors. See the table below for details:

Researchers can analyze and visualize all their studies in one convenient view on the SomaLogic Life Sciences Portal. Digital resources, such as DataDelve™ Statistics and the SomaScan Menu, are easily accessed from the portal, too.

The SomaLogic Technical Support team is always available to support researchers and repository owners. Email us with questions.

About the NIH requirement to upload data

NIH (National Institutes of Health) Logo

In addition to research journals, the National Institutes of Health (NIH) has issued a Data Management and Sharing (DMS) policy from 2023 onwards to promote the sharing of scientific data. Besides the multiple benefits to sharing scientific data, the idea is to ultimately facilitate the development of treatments and products that improve human health.
How to upload SomaScan data to public repositories

Image of SomaLogic repository ReadMe file. This explains how to load our ADAT file

SomaScan data are presented in an ADAT format, a SomaLogic-specific, tab-delimited text file that’s small enough to fit on a standard desktop computer. ADAT files can be read easily into any R/Python scripting languages using our ADAT reader function in SomaDataIO (R package) or Canopy (Python package). For uploading to public data repositories, we recommend that SomaScan data owners provide ADAT files formatted as they received them from SomaLogic.

For more information on ADAT format or handling SomaScan data, please email the SomaLogic Technical Support team.

Assistance: SomaLogic Technical Support

The SomaLogic Technical Support team is available throughout the analysis process – from initial questions and sample prep, to bioinformatics analysis and questions and final delivery of data.
Please email our team here.

Deepen your molecular insights with the SomaScan Platform

The SomaScan Platform is a single platform from discovery to development that gives researchers access to half the genetically encoded human proteome (11,000 protein measurements). The technology is powered by SOMAmer® (Slow Off-rate Modified Aptamer) Reagents, which provide researchers with reliability and reproducibility unparalleled in the proteomics industry.

Read more at the links below:

Additional resources to learn more