SomaScan® Proteomics Consortium
Advancing health information together.
Mission
To promote collaboration among cohort studies that use SomaScan profiling to follow participants for a range of outcomes
The Consortium exists to promote collaboration among prospective cohort studies that follow participants for a range of outcomes and perform SomaScan profiling of individuals. We will provide the framework to foster international collaborations among studies sharing common objectives, including a forum for the discussion, development and pursuit of new collaborative studies and research directions. We will facilitate an open exchange of ideas, knowledge, and results in order to accelerate the study of proteomics profiles associated with chronic disease phenotypes.
Additional consortium principles
- Store datasets locally, not in a repository
- Promote result sharing
- Adopt a distributive analysis model
- Support the development of early career researchers
- Advance the knowledge of the proteome to improve our understanding of prediction of disease etiology, diagnosis and prognosis
- Raise common funds through grants and donations by sharing analyses and preliminary data
- Create a harmonized proteomic resource that bridges platforms for more powerful association analyses
Initial consortium cohorts
| Cohort Acronym |
Population | Website | Contact |
|---|---|---|---|
|
COPDGene
|
US older current and former smokers
|
Russell Bowler |
|
|
SPIROMICS
|
US older current and former smokers
|
Russell Bowler |
|
|
FHS
|
US New England population
|
Debby Ngo |
|
|
JHS
|
US Mississippi AA population
|
Debby Ngo |
|
|
MESA
|
US multi-ethnic population
|
Ani Manichaikul |
|
|
LSC
|
US SW community cohort current and former smokers |
No website
|
Yohannes Tesfaigzi |
|
KORA
|
Southern Germany population
|
Claudia Flexeder |
|
|
EXSCEL
|
International patients with Diabetes and high risk of CVD |
Svati Shah |
Dr. Russell P. Bowler
Professor of Medicine - National Jewish Health
Dr. Claudia Flexeder
Postdoc, Statistician - Helmholtz Institute of Epidemiology
Dr. Ani W. Manichaikul
Assistant Professor - University of Virginia
Dr. Debby Ngo
Instructor in Medicine - Beth Israel Deaconess Medical Center
Dr. Svati Shah
Associate Director of Clinical Translation - Duke Molecular Physiology Institute
Dr. Yohannes Tesfaigzi
Professor of Medicine - Brigham and Women’s Hospital
Get in touch
For general inquries, contact Russ Bowler.
[email protected]
Updates
Meeting and research highlights.
September 15 meeting: Daryl Perry of SomaLogic led a discussion on data normalization
“Thanks everyone for a really great discussion on the different types of controls and the importance of each in normalization. The Bioinformatics Team is always happy to talk more about any of the topics we covered.”
In light of the current pandemic, the SomaScan Proteomics Consortium will be initially focused on the exchange of information relevant to COVID-19
“We are performing a genome-wide association study of ACE2 levels measured by SomaScan to identify the genetic variants and pathways that modulate ACE2 levels. Our project combines SOMAscan data from multiple cohorts including the Multi-Ethnic Study of Atherosclerosis (MESA), the Genetic Epidemiology of COPD (COPDGene) study, and the SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS), among others.”