What is the SomaScan Platform?

The SomaScan Platform is a high-plex, high-throughput proteomics technology developed by SomaLogic that revolutionizes how researchers gain insights into protein biology and protein-protein interactions.

As a single solution for discovery, validation, and development, the SomaScan Platform is pioneering proteomics. The platform:

  • Enables thousands of protein measurements (currently 11,000!) simultaneously from a single, 55-µL sample of serum, plasma, and various other sample types.
  • Uses SOMAmer® Reagents, single-stranded DNA aptamers, modified to bind to specific proteins with high specificity and sensitivity
  • Provides a vast data landscape for researchers to explore by providing a comprehensive analysis of proteomic biomarkers
  • Helps you move quickly and efficiently from biomarker discovery to validation with a comprehensive suite of solutions covering a wide range of diseases and therapeutic areas:

How can the SomaScan Platform help you?

  • Unparalleled Depth and Breadth: 11,000 protein measurements (half the genetically encoded human proteome!) from a 55-µL sample. Analyzes far more proteins than traditional methods…uncovering downstream effects of genes, protein-protein interactions, and potential biomarkers previously hidden
  • Improved Breakthroughs: Enables identification of novel proteomic biomarkers and therapeutic targets for drug development
  • Unbiased Data: Unlike antibodies, SOMAmer Reagents provide proven specificity (through primary validation and orthogonal confirmation) and avoid pre-conceived biases, leading to novel discoveries and insights into the proteome.
  • Unequaled Scalability: The high-throughput platform allows for large-scale studies with ease.
  • Unmatched Reproducibility: With low coefficients of variation ~5%, you can be confident in accurate, reproducible data and meaningful assay results.

How does the SomaScan Platform revolutionize protein biology research?

The SomaScan Platform provides the ability to detect the most proteins over a broad dynamic range without sacrificing reproducibility, sensitivity, or specificity. By casting the widest net possible, you’re able to see how protein biology and protein-protein interactions reveal disease origin, as well as potential risk progression. With crucial data, you can make informed decisions about which therapeutic targets could be most effective.

Here are some key reasons why you might choose to use it for your proteomic biomarker analysis:

Reproducible Icon

Reproducible (~5% CV)

The SomaScan platform leads the industry in dependability. As it does not rely on highly variable polyclonal antibodies, we can achieve low median coefficient of variation (CV) of 5%. Additionally, it is

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Specific(extensively characterized)

While most protein assays rely on a variation of the ELISA sandwich approach, the SomaScan Assay relies on kinetics: non-specific…

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Sample Versatility

The versatility of the SomaScan platform across a diverse range of species and sample types is unparalleled. This adaptability…

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A tiered dilution approach is used to measure proteins of very high abundance and very low abundance separately, such that a total range of 10 logs can be measured…

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Largest menu (11,000 analytes)

By far the largest commercial proteomic assay on the market, the SomaScan Assay provides thousands of protein…

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High throughput(over 1,000 samples/day)

Our workflow is highly automized using a scalable system of robotics. Today, we can assay over 1,000 clinical samples per day at our US CLIA Certified service lab.

Key SomaLogic publications

PublicationSeminal SomaScan publication

Introduces the SomaScan Assay and demonstrates how chemically modified aptamers can be used to detect and discover biomarkers.

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PublicationImproving SELEX with modified aptamers

Describes how additional functional groups were used to increase the diversity of aptamers in the SELEX process, expanding to 3,000 targets.

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PublicationSOMAmer Reagent crystal structure

Reports the crystal structure of a SOMAmer Reagent binding PDGF-BB. Unlike traditional aptamers, the SOMAmer Reagent utilizes hydrophobic interactions and mimics the natural receptor.

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See how the SomaScan Assay complements mass spectrometry and genomics

Contact our team of experts for questions or to get started: Get in touch with us.