The industry-leading SomaScan® assay will help revolutionize your research

 

SomaLogic boasts industry-leading reliability metrics that include sensitivity, specificity, and reproducibility, with coefficients of variation less than 5%.

Most protein assays excel in one or two areas.

The SomaScan assay is the first and only platform that can measure 7,000 proteins from a 55-µL sample. That’s more than double the number of proteins compared to any other platform, covering more biological pathways than any other proteomic assay.

Graphic of hexagons

Reproducible (~5% CV)

Because the SomaScan assay does not rely on polyclonal antibodies, which are variable, SomaScan data achieves…

See more

Graphic with different shapes

Specific(extensively characterized)

While most protein assays rely on a variation of the ELISA sandwich approach, the SomaScan assay relies on kinetics: non-specific…

See more

Graphic of chart with arrows

Dynamic(10-log range)

A tiered dilution approach is used to measure proteins of very high abundance and very low abundance separately, such…

See more

Graphic of magnifying glass

Sensitive(125 fM)

The tiered approach used for SomaScan measurements enables the detection of very rare proteins consistently without…

See more

Graphic of hexagon with “7K” written inside

Largest menu (7,000 analytes)

By far the largest commercial proteomic assay on the market, the SomaScan assay provides over 7,000 unique protein…

See more

Speedometer-like arrow pointed to the extreme right

High throughput(over 1,000 samples/day)

Our workflow is massively multiplexed using a scalable system of robotics. Today, we can assay over 1,000 clinical samples per day.

Learn how the SomaScan® assay works

The SomaScan assay profiles 7,000 different proteins from only 55 µL of plasma/serum.

 

A single platform for discovery, validation, and development

The SomaScan® assay uses Slow Off-Rate Modified Aptamers (called SOMAmer® reagents) to provide 7,000 highly reproducible measurements of circulating proteins from a single sample of plasma, serum, or urine.

Graphic

Unique reagents

SOMAmer® reagents are synthetic, ssDNA sequences with protein-like appendages that tightly bind a specific protein target.

Graphic

Developed by SELEX

Precise requirements for binding and durability are controlled via a directed evolution process called SELEX.

Graphic

For discovery, validation, & development

Unlike antibodies, SOMAmer reagents are eternally consistent, enabling unmatched reproducibility.

SomaScan outperforms antibody and mass spec-based proteomic approaches

We are using all major proteomics approaches including antibody-based and MS-based methods in addition to SomaScan because of their complementarity. SomaScan stands out, however, with the largest coverage of plasma proteome, no sensitivity limitation, excellent reproducibility/precision, and impressive throughput.”

Source: Customer Response to Tech Validate Survey

Key SomaLogic publications

PublicationSeminal SomaScan publication

Introduces the SomaScan assay and demonstrates how chemically modified aptamers can be used to detect and discover biomarkers.

Read open access

PublicationImproving SELEX with modified aptamers

Describes how additional functional groups were used to increase the diversity of aptamers in the SELEX process, expanding to 3,000 targets.

Read open access

PublicationSOMAmer reagent crystal structure

Reports the crystal structure of a SOMAmer reagent binding PDGF-BB. Unlike traditional aptamers, the SOMAmer reagent utilizes hydrophobic interactions and mimics the natural receptor.

Read open access

Contact our sales team to get started

Get in touch