The industry-leading SomaScan® Assay will help revolutionize your research
SomaLogic boasts industry-leading reliability metrics that include sensitivity, specificity, and reproducibility, with coefficients of variation less than 5%.
Most protein assays excel in one or two areas.
The SomaScan Assay is the first and only platform that can measure 7,000 proteins from a 55-µL sample. That’s more than double the number of proteins compared to any other platform, covering more biological pathways than any other proteomic assay.
Reproducible (~5% CV)
Because the SomaScan Assay does not rely on polyclonal antibodies, which are variable, SomaScan data achieves…
Specific(extensively characterized)
While most protein assays rely on a variation of the ELISA sandwich approach, the SomaScan Assay relies on kinetics: non-specific…
Dynamic(10-log range)
A tiered dilution approach is used to measure proteins of very high abundance and very low abundance separately, such…
Sensitive(125 fM)
The tiered approach used for SomaScan measurements enables the detection of very rare proteins consistently without…
Largest menu (7,000 analytes)
By far the largest commercial proteomic assay on the market, the SomaScan Assay provides over 7,000 unique protein…
High throughput(over 1,000 samples/day)
Our workflow is massively multiplexed using a scalable system of robotics. Today, we can assay over 1,000 clinical samples per day.
A single platform for discovery, validation, and development
The SomaScan® Assay uses Slow Off-Rate Modified Aptamers (called SOMAmer® reagents) to provide 7,000 highly reproducible measurements of circulating proteins from a single sample of plasma, serum, or urine.
Unique reagents
SOMAmer® reagents are synthetic, ssDNA sequences with protein-like appendages that tightly bind a specific protein target.
Developed by SELEX
Precise requirements for binding and durability are controlled via a directed evolution process called SELEX.
For discovery, validation, & development
Unlike antibodies, SOMAmer reagents are eternally consistent, enabling unmatched reproducibility.
SomaScan outperforms antibody and mass spec-based proteomic approaches
We are using all major proteomics approaches including antibody-based and MS-based methods in addition to SomaScan because of their complementarity. SomaScan stands out, however, with the largest coverage of plasma proteome, no sensitivity limitation, excellent reproducibility/precision, and impressive throughput.”
Source: Customer Response to Tech Validate Survey
Key SomaLogic publications
PublicationSeminal SomaScan publication
Introduces the SomaScan Assay and demonstrates how chemically modified aptamers can be used to detect and discover biomarkers.
PublicationImproving SELEX with modified aptamers
Describes how additional functional groups were used to increase the diversity of aptamers in the SELEX process, expanding to 3,000 targets.
PublicationSOMAmer reagent crystal structure
Reports the crystal structure of a SOMAmer reagent binding PDGF-BB. Unlike traditional aptamers, the SOMAmer reagent utilizes hydrophobic interactions and mimics the natural receptor.
