The industry-leading SomaScan® Assay will help revolutionize your research

 

SomaLogic boasts industry-leading reliability metrics that include sensitivity, specificity, and reproducibility, with coefficients of variation less than 5%.

Most protein assays excel in one or two areas.

The SomaScan Assay is the first and only platform that can measure 7,000 proteins from a 55-µL sample. That’s more than double the number of proteins compared to any other platform, covering more biological pathways than any other proteomic assay.

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Reproducible (~5% CV)

Because the SomaScan Assay does not rely on polyclonal antibodies, which are variable, SomaScan data achieves…

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Specific(extensively characterized)

While most protein assays rely on a variation of the ELISA sandwich approach, the SomaScan Assay relies on kinetics: non-specific…

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Dynamic(10-log range)

A tiered dilution approach is used to measure proteins of very high abundance and very low abundance separately, such…

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Sensitive(125 fM)

The tiered approach used for SomaScan measurements enables the detection of very rare proteins consistently without…

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Largest menu (7,000 analytes)

By far the largest commercial proteomic assay on the market, the SomaScan Assay provides over 7,000 unique protein…

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High throughput(over 1,000 samples/day)

Our workflow is massively multiplexed using a scalable system of robotics. Today, we can assay over 1,000 clinical samples per day.

Learn how the SomaScan® Assay works

The SomaScan Assay profiles 7,000 different proteins from only 55 µL of plasma/serum.

 

A single platform for discovery, validation, and development

The SomaScan® Assay uses Slow Off-Rate Modified Aptamers (called SOMAmer® reagents) to provide 7,000 highly reproducible measurements of circulating proteins from a single sample of plasma, serum, or urine.

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Unique reagents

SOMAmer® reagents are synthetic, ssDNA sequences with protein-like appendages that tightly bind a specific protein target.

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Developed by SELEX

Precise requirements for binding and durability are controlled via a directed evolution process called SELEX.

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For discovery, validation, & development

Unlike antibodies, SOMAmer reagents are eternally consistent, enabling unmatched reproducibility.

SomaScan outperforms antibody and mass spec-based proteomic approaches

We are using all major proteomics approaches including antibody-based and MS-based methods in addition to SomaScan because of their complementarity. SomaScan stands out, however, with the largest coverage of plasma proteome, no sensitivity limitation, excellent reproducibility/precision, and impressive throughput.”

Source: Customer Response to Tech Validate Survey

Key SomaLogic publications

PublicationSeminal SomaScan publication

Introduces the SomaScan Assay and demonstrates how chemically modified aptamers can be used to detect and discover biomarkers.

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PublicationImproving SELEX with modified aptamers

Describes how additional functional groups were used to increase the diversity of aptamers in the SELEX process, expanding to 3,000 targets.

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PublicationSOMAmer reagent crystal structure

Reports the crystal structure of a SOMAmer reagent binding PDGF-BB. Unlike traditional aptamers, the SOMAmer reagent utilizes hydrophobic interactions and mimics the natural receptor.

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See how the SomaScan Assay complements mass spectrometry

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