One blood sample, multiple CVD indicators

That’s the power of proteomics.

SomaSignal™ tests indicate heart health from just 55 μL of plasma

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Heart Failure

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Cardiorespiratory Fitness

Identify risk and fitness simultaneously​

  • See risk of MI, stroke/TIA, hospitalization for HF or death attributed to CV causes
  • Determine 4-year risk with and without previous event
  • Predict all-cause death within 6/12 months of HFpEF or HFrEF prognosis
  • Estimate VO2 max without exercise tests

Ideal for clinical trial analysis

  • Reveals drug-mediated improvements in disease severity
  • Does not require specialized equipment
  • Simple blood draw is ideal for longitudinal studies
  • Calibrated according to comparison with the ASCVD Pooled Cohort Equation, cardiorespiratory exercise testing, and obervational studies

Additional resources

SomaSignal tests derive clinically relevant metrics from proteomic signatures

Cardiovascular disease is the leading cause of death in the United States and worldwide

Although risk factors for cardiovascular events have been identified, many patients do not present with classical risk factors. Circulating protein biomarkers provide powerful insights into cardiovascular risk, as many proteins associated with heart disease are released in blood.

The SomaScan proteomic platform has been used extensively to discover and characterize protein signatures of heart health

There are more than 25 publications collating thousands of protein measurements across thousands of patients with heart health. Using millions of data points, machine learning models were developed that can simultaneously measure multiple clinically relevant metrics relating to CVD.

The SomaSignal tests turn massive scale proteomics into clinically significant metrics for heart health

Multiple SomaSignal tests can be run on the same sample, enabling the determination of primary cardiovascular risk, secondary cardiovascular risk, pulmonary fitness, heart failure risk, and more, all from a single 55 µl blood sample. Straightforward and thorough reporting (survival probability, percent risk, risk categories, VO2 max, and qualitative fitness levels) simplifies the analysis process, so that outcomes can quickly be reported for assessment in clinical trials.

Additional SomaSignal tests

The CVD, heart failure, and cardiorespiratory fitness tests make up a subset of 22 SomaSignal tests available for research use. Any or all of the SomaSignal tests are available for a single flat cost.

View full SomaSignal test menu

The statements herein have not been evaluated by the Food and Drug Administration