Proteins signify health.
The ~30,000 proteins that make up the human proteome orchestrate the majority of biological processes. By measuring proteins, we can identify patterns of wellness, fitness, and aging.
Proteins reflect treatment.
Medications and lifestyle changes cause shifts in the proteome. By measuring proteins, we can determine if treatments are working.
Proteins reveal risk.
Adverse reactions to drugs, health complications, and comorbidities are also determined by proteins. By measuring proteins, we can identify good candidates for clinical trials.
Proteins are dynamic.
Unlike the genome, which is relatively fixed over time, proteins provide a snapshot of health in real time.
Proteins are accessible.
Key proteins circulate in blood and other fluids, making them easy to sample.
Proteins are the future.
In the past, we’ve looked to the genome, because measuring proteins was too technically challenging. With our pioneering platform, we can now measure 7,000 proteins across a 10-log fold range of concentrations from a single sample.
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The largest commercial proteomic assay on the market,
providing over 7,000 protein measurements.
The scalability enabled by our aptamer-based approach will
enable the SomaScan Assay to continue to grow.
Because the SomaScan Assay does not rely on polyclonal antibodies, which are variable, SomaScan
data achieves coefficients of variation much lower than industry standards. Additionally, it is the only platform
that can be seamlessly used for the entire biomarker research pipeline from discovery to development consistently over time.
While most protein assays rely on a variation of the ELISA sandwich approach, the SomaScan Assay relies on kinetics: non-specific interactions dissociate faster. Tests have confirmed minimal cross-reactivity with closely related proteins.
A tiered dilution approach is used to measure proteins of very high abundance and very low abundance separately, such that a total range of 10 logs can be measured from just 55 μl of plasma or serum.
The tiered approach used for SomaScan measurements enables the
detection of very rare proteins consistently without sample pre-treatment.