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Publications
Plasma protein patterns as comprehensive indicators of health
Nat Med 25(12): 1851-1857.
Undulating changes in human plasma proteome profiles across the lifespan
Nat Med 25(12): 1843-1850
Co-regulatory networks of human serum proteins link genetics to disease
Science 361(6404): 769-773.
Genomic atlas of the human plasma proteome
Nature 558: 73-79.
Improving assessment of drug safety through proteomics: early detection and mechanistic characterization of the unforeseen harmful effects of torcetrapib
Circulation 137(10): 999-1010.
Genetic architecture of the cardiovascular risk proteome
Circulation 137(11): 1158-1172.
Development and validation of a protein-based risk score for cardiovascular outcomes among patients with stable coronary heart disease
JAMA 315(23): 2532-2541.
Using aptamer-based technology to probe the plasma proteome for cardiovascular disease prediction
JAMA 315(23): 2525-2526.
Aptamer-based proteomic profiling reveals novel candidate biomarkers and pathways in cardiovascular disease
Circulation 134(4): 270-285.
Cellular and plasma proteomic determinants ofCOVID-19 and non-COVID-19 pulmonary diseases relative to healthy aging.
Nat Aging 1: 535–549.
Predicting the probability of death using proteomics.
Commun Biol 4(1): 758.
Large-scale plasma proteomic analysis
identifies proteins and pathways associated with dementia risk.
Nat Aging 1: 473-489.
Human plasma proteomic profiles indicative of cardiorespiratory fitness.
Nat Metab 3(6): 786-797.
Advances in Aptamer-Based Biomarker Discovery.
Front Cell Dev Biol 9: 659760.
Replication study of plasma proteins relating to Alzheimer's pathology.
Alzheimers Dement, epub ahead of print.
Platelet Protein-Related Abnormalities in Response to Acute Hypoglycemia in Type 2 Diabetes.
Front Endocrinol (Lausanne) 12: 651009.
Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19.
Nat Med 27(4): 668-676.
Broadly effective metabolic and immune recovery with C5 inhibition in CHAPLE disease."
Nat Immunol 22(2): 128-139.
Association of endopeptidases, involved in SARS-CoV-2 infection, with microbial aggravation in sputum of severe asthma.
Allergy 76(6): 1917-1921.
Age-associated difference in circulating ACE2, the gateway for SARS-COV-2, in humans: results from the InCHIANTI study.
Geroscience 43(2): 619-627.
A proteome-wide genetic investigation identifies several SARS-CoV-2-exploited host targets of clinical relevance.
Elife 10: e69719.
Longitudinal proteomic analysis of severe COVID-19 reveals survival-associated signatures, tissue-specific cell death, and cell-cell interactions.
Cell Rep Med 2(5): 100287.
Multi-omics highlights ABO plasma protein as a causal risk factor for COVID-19.
Hum Genet 140(6): 969-979
BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection.
Cell 184(8): 2167-2182 e2122
Soluble Neuropilin-1 Response to Hypoglycemia in Type 2 Diabetes: Increased Risk or Protection in SARS-CoV-2 Infection?
Front Endocrinol (Lausanne) 12: 665134
Type 2 Diabetes Coagulopathy Proteins May Conflict With Biomarkers Reflective of COVID-19 Severity.
Front Endocrinol (Lausanne) 12: 658304
Letter to the Editor: Pro-fibrotic M2 macrophage markers may increase the risk for COVID19 in type 2 diabetes with obesity.
Metabolism 112: 154374
Vitamin D Association With Macrophage-Derived Cytokines in Polycystic Ovary Syndrome: An Enhanced Risk of COVID-19 Infection?
Front Endocrinol (Lausanne) 12: 638621
Using ‘big data’ to disentangle aging and COVID-19."
Aging 1: 496–497.
The COVIDome Explorer researcher portal.
Cell Rep 36(7): 109527.
A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity.
Nat Med 27(4): 659-667.
Early Interleukin-22 and Neutrophil Proteins Are Correlated to Future Lung Damage in Children with Cystic Fibrosis." "
Front Pediatr 9: 640184.
Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children." "
Immunity 54(5): 1083-1095 e1087.
Plasma protein expression profiles, cardiovascular disease, and religious struggles among South Asians in the MASALA study
Sci Rep. 2021 Jan 13;11(1):961
Protein signatures of centenarians and their offspring suggest centenarians age slower than other humans
Aging Cell. 2021 Jan 29:e13290
Identification and Validation of Nutrient State-Dependent Serum Protein Mediators of Human CD4(+) T Cell Responsiveness.
Nutrients 13(5).
Effect of longevity genetic variants on the molecular aging rate.
Geroscience 43(3): 1237-1251.
Novel Murine Biomarkers of Radiation Exposure Using An Aptamer-Based Proteomic Technology.
Front Pharmacol 12: 633131.
The CRTAC1 protein in plasma associates with osteoarthritis and predicts progression to joint replacements: a large-scale proteomics scan in Iceland.
Arthritis Rheumatol, epub ahead of print.
Plasma Proteomic Profile Predicts Survival in Heart Failure with Reduced Ejection Fraction.
Circ Genom Precis Med 14(3): e003140.
Multi-Omic Profiling in Black and White Populations Reveals Novel Candidate Pathways in Left Ventricular Hypertrophy and Incident Heart Failure Specific to Black Adults.
Circ Genom Precis Med 14(3): e003191.
Proteomic signatures of inflammatory skin diseases: a focus on atopic dermatitis.
Expert Rev Proteomics: 1-17.
Metabolic syndrome and the plasma proteome: from association to causation.
Cardiovasc Diabetol 20(1): 111.
Serum Proteomics and Plasma Fibulin-3 in Differentiation of Mesothelioma from Asbestos-Exposed Controls and Patients with Other Pleural Diseases.
J Thorac Oncol, epub ahead of print.
Identification and Evaluation of Serum Protein Biomarkers Which Differentiate Psoriatic from Rheumatoid Arthritis.
Arthritis Rheumatol, epub ahead of print.
Proteome-Wide Analysis using SOMAscan Identifies and Validates Chitinase-3-Like Protein 1 as a Risk and Disease Marker of Delirium Among Older Adults Undergoing Major Elective Surgery
J Gerontol A Biol Sci Med Sci. 2021 Feb 4:glaa326
Identification of Plasma Proteome Signatures Associated With Surgery Using SOMAscan
Ann Surg 273(4): 732-742.
Proteomic Signatures of Lifestyle Risk Factors for Cardiovascular Disease: A Cross‐Sectional Analysis of the Plasma Proteome in the Framingham Heart Study
J Am Heart Assoc. 2021 Jan 5;10(1)
Association of a Serum Protein Signature With Rheumatoid Arthritis Development
Arthritis Rheumatol. 73(1): 78-88.
Inhibition of the Complement Alternative Pathway by Chemically Modified DNA Aptamers That Bind with Picomolar Affinity to Factor B
J Immunol 206(4): 861-873.
Genetics meets proteomics: perspectives for large population-based studies
Nat Rev Genet 22(1): 19-37.
Circulating markers of NADH-reductive stress correlate with mitochondrial disease severity
J Clin Invest 131(2): e136055
Evaluating the effects of cardiometabolic exposures on circulating proteins which may contribute to severe SARS-CoV-2.
EBioMedicine 64: 103228.
A replication-competent adenovirus-vectored influenza vaccine induces durable systemic and mucosal immunity
J Clin Invest 131(5)
Revealing the role of the human blood plasma proteome in obesity using genetic drivers
Nat Commun 12(1): 1279
Plasma Proteomic Profiling in Hypertrophic Cardiomyopathy Patients before and after Surgical Myectomy Reveals Post-Procedural Reduction in Systemic Inflammation
Int J Mol Sci 22(5): 2474
Quantitative Proteomic Analysis of Diabetes Mellitus in Heart Failure With Preserved Ejection Fraction
JACC Basic Transl Sci 6(2): 89-99.
Proteomics in aging research: A roadmap to clinical, translational research
Aging Cell: e13325.
Blood biomarker discovery for autism spectrum disorder: A proteomic analysis
PLoS One 16(2): e0246581.
Biomarker-focused multi-drug combination therapy and repurposing trial in mdx mice
PLoS One 16(2): e0246507
In-Depth Analysis of the Plasma Proteome in ME/CFS Exposes Disrupted Ephrin-Eph and Immune System Signaling
Proteomes 9(1)
A meta-analysis uncovers the first sequence variant conferring risk of Bell's palsy
Sci Rep 11(1): 4188
Functional Network Profiles in ARSACS Disclosed by Aptamer-Based Proteomic Technology
Front Neurol 11: 603774.
An Approach to Biomarker Discovery of Cannabis Use Utilizing Proteomic, Metabolomic, and Lipidomic Analyses.
Cannabis Cannabinoid Res, epub ahead of print.
Atopic Dermatitis Endotypes Based on Allergen Sensitization, Reactivity to Staphylococcus aureus Antigens, and Underlying Systemic Inflammation
J Allergy Clin Immunol Pract. 8(1): 236-247.e3.
Joint fluid proteome after anterior cruciate ligament rupture reflects an acute posttraumatic inflammatory and chondrodegenerative state
Cartilage 11(3) 329
Vascular Disease and Thrombosis in SARS-CoV-2-Infected Rhesus Macaques
Cell. 2020, 183, 1354–1366
Genetic architecture of host proteins involved in SARS-CoV-2 infection
Nat Commun. 2020; 11: 6397
Platelet-derived growth factor BB: A potential diagnostic blood biomarker for differentiating bipolar disorder from major depressive disorder
J Psychiatr Res. 2020 Dec 21;134:48-56.
Activity of ibrutinib plus R-CHOP in diffuse large B-cell lymphoma: Response, pharmacodynamic, and biomarker analyses of a phase Ib study
Cancer Treatment Res Commun 25: 100235
Identification of Potential Serum Protein Biomarkers and Pathways for Pancreatic Cancer Cachexia Using an Aptamer-Based Discovery Platform
Cancers (Basel). 2020 Dec 15;12(12):E3787
A Plasma Proteomic Signature of Skeletal Muscle Mitochondrial Function
Int J Mol Sci. 2020 Dec 15;21(24):E9540
Coronary Artery Disease and Type 2 Diabetes: A Proteomic Study
Diabetes Care. 2020 Apr;43(4):843-851
Novel Insights Into the Effects of Interleukin 6 Antagonism in Non-ST-Segment-Elevation Myocardial Infarction Employing the SOMAscan Proteomics Platform
J Am Heart Assoc. 2020 Jun 16;9(12):e015628
Colchicine's effects on metabolic and inflammatory molecules in adults with obesity and metabolic syndrome: results from a pilot randomized controlled trial
Int J Obes (Lond). 2020 Aug;44(8):1793-1799
Comparison of Proteomic Assessment Methods in Multiple Cohort Studies
Proteomics. 2020 Jun;20(12):e1900278
Reduced Apolipoprotein M and Adverse Outcomes Across the Spectrum of Human Heart Failure
Circulation. 2020 May 5;141(18):1463-1476
Highly multiplexed proteomic assessment of human bone marrow in acute myeloid leukemia
Blood Adv. 2020 Jan 28;4(2):367-379
Plasma proteomic profile of frailty
Aging Cell. 2020 Sep;19(9):e13193
Serum protein biomarkers for juvenile dermatomyositis: a pilot study
BMC Rheumatol. 2020 Oct 1;4:52
Proteomic biomarkers of sleep apnea
Sleep. 2020 Nov 12;43(11):zsaa086
Early angiogenic proteins associated with high risk for bronchopulmonary dysplasia and pulmonary hypertension in preterm infants
Am J Physiol Lung Cell Mol Physiol. 2020 Apr 1;318(4):L644-L654
Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis
Sci Transl Med. 2020 Dec 2;12(572):eaba4448
Autophagy Modulators Profoundly Alter the Astrocyte Cellular Proteome
Cells. 2020 Mar 26;9(4):805
Impact of Kidney Function on the Blood Proteome and on Protein Cardiovascular Risk Biomarkers in Patients With Stable Coronary Heart Disease
J Am Heart Assoc. 2020 Aug 4;9(15):e016463
Proteomic Signatures of Heart Failure in Relation to Left Ventricular Ejection Fraction
J Am Coll Cardiol. 2020 Oct 27;76(17):1982-1994
"Proteomic and Metabolomic Correlates of Healthy Dietary Patterns: The Framingham Heart Study"" Nutrients"
Nutrients. 2020 May 19;12(5):1476
Plasma proteomic profile of age, health span, and all-cause mortality in older adults
Aging Cell. 2020 Nov;19(11):e13250
Renin-Angiotensin System overactivation in polycystic ovary syndrome, a risk for SARS-CoV-2 infection?
Metabol Open. 2020 Sep;7:100052
ZIKV Infection Induces DNA Damage Response and Alters the Proteome of Gastrointestinal Cells
Viruses. 2020 Jul 17;12(7):771
Plasma proteomic signature of the risk of developing mobility disability: A 9-year follow-up
Aging Cell. 2020 Apr;19(4):e13132
Comparison of Serum Pharmacodynamic Biomarkers in Prednisone-Versus Deflazacort-Treated Duchenne Muscular Dystrophy Boys
J Pers Med. 2020 Oct 12;10(4):164
Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer's Disease Pathology
J Alzheimers Dis. 2020;77(3):1353-1368
Clinical and Proteomic Correlates of Plasma ACE2 (Angiotensin-Converting Enzyme 2) in Human Heart Failure
Hypertension. 2020 Nov;76(5):1526-1536
Protein biomarkers for incident deep venous thrombosis in critically ill adolescents: An exploratory study
Pediatr Blood Cancer. 2020 Apr;67(4):e28159
Aptamer based proteomic pilot study reveals a urine signature indicative of pediatric urinary tract infections
PLoS One. 2020 Jul 6;15(7):e0235328
Increased Levels of Coagulation Factor XI in Plasma Are Related to Alzheimer's Disease Diagnosis
J Alzheimers Dis. 2020;77(1):375-386
Evaluation of a novel blood microsampling device for clinical trial sample collection and protein biomarker analysis
Bioanalysis. 2020 Jul;12(13):919-935
Serum biomarkers associated with baseline clinical severity in young steroid-naïve Duchenne muscular dystrophy boys
Hum Mol Genet. 2020 Aug 29;29(15):2481-2495
Zika virus dysregulates human Sertoli cell proteins involved in spermatogenesis with little effect on tight junctions
PLoS Negl Trop Dis. 2020 Jun 8;14(6):e0008335
Proteomic profiling of HTLV-1 carriers and ATL patients reveals sTNFR2 as a novel diagnostic biomarker for acute ATL
Blood Adv. 2020 Mar 24;4(6):1062-1071
Metabolic profiling shows pre-existing mitochondrial dysfunction contributes to muscle loss in a model of ICU-acquired weakness
J Cachexia Sarcopenia Muscle. 2020 Oct;11(5):1321-1335
Mechanisms of Sodium-Glucose Cotransporter 2 Inhibition: Insights From Large-Scale Proteomics
Diabetes Care. 2020 Sep;43(9):2183-2189
Targeting myostatin/activin A protects against skeletal muscle and bone loss during spaceflight
Proc Natl Acad Sci U S A. 2020 Sep 22;117(38):23942-23951
Multimodal immune phenotyping of maternal peripheral blood in normal human pregnancy
JCI Insight. 2020 Apr 9;5(7):e134838
Effect of induced hypoglycemia on inflammation and oxidative stress in type 2 diabetes and control subjects
Sci Rep. 2020 Mar 16;10(1):4750
Plasma Biomarkers of Reticular Pseudodrusen and the Risk of Progression to Advanced Age-Related Macular Degeneration
Transl Vis Sci Technol. 2020 Sep 11;9(10):12
Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits.
Nat Commun 11(1): 15.
Modified nucleotides may have enhanced early RNA catalysis.
Proc Natl Acad Sci U S A 117(15): 8236-8242.
The Evolution of the Cardiovascular Biomarker Study.
Circulation 142(15): 1422-1424.
Integrative phenotyping of glycemic responders upon clinical weight loss using multi-omics.
Sci Rep 10(1): 9236.
Comprehensive aptamer-based screening identifies a spectrum of urinary biomarkers of lupus nephritis across ethnicities.
Nat Commun 11(1): 2197.
Causal association between mTOR-dependent EIF-4E and EIF-4A circulating protein levels and type 2 diabetes: a Mendelian randomization study.
Sci Rep 10(1): 15737.
Using the circulating proteome to assess type I interferon activity in systemic lupus erythematosus.
Sci Rep 10(1): 4462.
Serum Protein Changes in Pediatric Sepsis Patients Identified With an Aptamer-Based Multiplexed Proteomic Approach.
Crit Care Med 48(1): e48-e57.
Placenta accreta spectrum: biomarker discovery using plasma proteomics.
Am J Obstet Gynecol 223(3): 433 e431-433 e414.
A fully joint Bayesian quantitative trait locus mapping of human protein abundance in plasma.
PLoS Comput Biol 16(6): e1007882.
Type I IFN response associated with mTOR activation in the TAFRO subtype of idiopathic multicentric Castleman disease.
JCI Insight 5(9)
Intense light as anticoagulant therapy in humans.
PLoS One 15(12): e0244792.
Identification of a unique temporal signature in blood and BAL associated with IPF progression.
Sci Rep 10(1): 12049.
Modified aptamers as reagents to characterize recombinant human erythropoietin products.
Sci Rep 10(1): 18593.
Improved cardiovascular risk prediction using targeted plasma proteomics in primary prevention.
Eur Heart J 41(41): 3998-4007.
Single-Molecule Super-Resolution Microscopy Reveals Heteromeric Complexes of MET and EGFR upon Ligand Activation.
Int J Mol Sci 21(8)
An expanded repertoire of intensity-dependent exercise-responsive plasma proteins tied to loci of human disease risk.
Sci Rep 10(1): 10831.
Circulating Protein Signatures and Causal Candidates for Type 2 Diabetes.
Diabetes 69(8): 1843-1853.
Aptamers and Antisense Oligonucleotides for Diagnosis and Treatment of Hematological Diseases.
Int J Mol Sci 21(9): 3252.
Proteomics for personalized cardiovascular risk assessment: in pursuit of the Holy Grail.
Eur Heart J 41(41): 4008-4010.
Chemical Modification of Aptamers for Increased Binding Affinity in Diagnostic Applications: Current Status and Future Prospects.
Int J Mol Sci 21(12)
Prioritizing Candidates of Post-Myocardial Infarction Heart Failure Using Plasma Proteomics and Single-Cell Transcriptomics
Circulation 142(15): 1408-1421.
Increased mTOR activation in idiopathic multicentric Castleman disease.
Blood 135(19): 1673-1684.
CDH6 and HAGH protein levels in plasma associate with Alzheimer's disease in APOE epsilon4 carriers.
Sci Rep 10(1): 8233.
Elevated Plasma Growth and Differentiation Factor 15 Is Associated With Slower Gait Speed and Lower Physical Performance in Healthy Community-Dwelling Adults.
J Gerontol A Biol Sci Med Sci 75(1): 175-180.
High-Throughput Identification of the Plasma Proteomic Signature of Inflammatory Bowel Disease.
J Crohns Colitis 13(4): 462-471.
Transcatheter aortic valve replacements alter circulating serum factors to mediate myofibroblast deactivation
Science Translational Medicine Volume 11 (509) 2019 eaav3233
Accelerating Biomarker Discovery Through Electronic Health Records, Automated Biobanking, and Proteomics.
J Am Coll Cardiol 73(17): 2195-2205.
Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria.
Nat Commun 10(1): 4130.
Blood proteome profiling using aptamer-based technology for rejection biomarker discovery in transplantation.
Sci Data 6(1): 314.
A signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes.
Nat Med 25(5): 805-813.
Beyond Autoantibodies: Biologic Roles of Human Autoreactive B Cells in Rheumatoid Arthritis Revealed by RNA-Sequencing.
Arthritis Rheumatol 71(4): 529-541.
Comparison of Urine and Plasma Biomarker Concentrations Measured by Aptamer-Based versus Immunoassay Methods in Cardiac Surgery Patients.
J Appl Lab Med 4(3): 331-342.
Identifying and targeting pathogenic PI3K/AKT/mTOR signaling in IL-6-blockade-refractory idiopathic multicentric Castleman disease.
J Clin Invest 129(10): 4451-4463.
Predicting health and life span with the deep plasma proteome.
Nat Med 25(12): 1815-1816.
Balanced event prediction through sampled survival analysis.
Systems Medicine 2(1): 28-38.
Stability of the Human Plasma Proteome to Pre-analytical Variability as Assessed by an Aptamer-Based Approach.
J Proteome Res 18(10): 3661-3670.
Circulating proteomic signature of early death in heart failure patients with reduced ejection fraction.
Sci Rep 9(1): 19202.
Aging Disrupts Muscle Stem Cell Function by Impairing Matricellular WISP1 Secretion from Fibro-Adipogenic Progenitors.
Cell Stem Cell 24(3): 433-446 e437.
Plasma proteome in multiple sclerosis disease progression
Ann Clin Transl Neurol. 2019 Sep;6(9):1582-1594.
Noninvasive exosomal proteomic biosignatures, including cystatin SN, peroxiredoxin-5, and glycoprotein VI, accurately predict chronic rhinosinusitis with nasal polyps
Int Forum Allergy Rhinol 9(2): 177-186.
Osteitis is associated with dysregulated pro-osteoblastic activity in patients with nasal polyps
Laryngoscope 129(3): E102-E109.
Vero cell proteomic changes induced by Zika virus infection
Proteomics 19(4): e1800309.
Application of an Aptamer-Based Proteomics Assay (SOMAscan™) in Rat Cerebrospinal Fluid
Methods Mol Biol. 2044:221-231.
Guidelines for CSF Processing and Biobanking: Impact on the Identification and Development of Optimal CSF Protein Biomarkers
Methods Mol Biol. 2044:27-50.
Assessing the genetic correlations between blood plasma proteins and osteoporosis: a polygenic risk score analysis
Calcif Tissue Int 104(2): 171-181.
Plasma FGF-19 Levels are Increased in Patients with Post-Bariatric Hypoglycemia
Obes Surg. 2019 Jul;29(7):2092-2099.
Application of Proteomics Profiling for Biomarker Discovery in Hypertrophic Cardiomyopathy
J Cardiovasc Transl Res. 2019 Dec;12(6):569-579.
Cancer protein biomarker discovery based on nucleic acid aptamers
Int J Biol Macromol. 2019 Jul 1;132:190-202.
Exosome swarms eliminate airway pathogens and provide passive epithelial immunoprotection through nitric oxide
J Allergy Clin Immunol 143(4):1525-1535 e1521.
Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay
Alzheimers Dement. 5. pii: S1552-5260(19)35118-0.
A framework for multi-omic prediction of treatment response to biologic therapy for psoriasis
J Invest Dermatol 139(1): 100-107.
Fatigue in Sjögren's syndrome: a search for biomarkers and treatment targets
Front Immunol 10: 312.
Disease-specific and glucocorticoid-responsive serum biomarkers for Duchenne Muscular Dystrophy
Sci Rep. 2019 Aug 21;9(1):12167.
Candidate early predictive plasma protein markers of doxorubicin-induced chronic cardiotoxicity in B6C3F1 mice
Toxicol Appl Pharmacol 363:164-173.
A Novel Proteomics Approach to Identify Serum and Urinary Biomarkers and Pathways that Associate with Lower Urinary Tract Symptoms in Men and Women: Pilot Results of the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) Study
Urology. 2019 Jul;129:35-42.
Pulmonary Aptamer Signatures in Children's Interstitial and Diffuse Lung Diseases
Am J Respir Crit Care Med. doi: 10.1164.
Metabolic and proteomic signatures of hypoglycemia in type 2 diabetes
Diabetes Obes Metab. 2018 Dec 7. doi: 10.1111.
Influenza a virus-triggered autophagy decreases the pluripotency of human-induced pluripotent stem cells
Cell Death Dis. 2019 May; 10(5): 337.
The human placental proteome secreted into the maternal and fetal circulations in normal pregnancy based on 4-vessel sampling
FASEB J 33(2):2944-2956.
A serum protein signature of APOE genotypes in centenarians
Aging Cell. :e13023. doi: 10.1111.
Activin type II receptor signaling in cardiac aging and heart failure
Sci Transl Med 11(482).
Circulating Biomarkers of Testosterone's Anabolic Effects on Fat-Free Mass
The Journal of Clinical Endocrinology and Metabolism 104(9): 3768-3778. https://doi.org/10.1210/jc.2019-00505.
Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study
PLoS Med. 2019 Apr; 16(4): e1002781.
A combined score of clinical factors and serum proteins can predict time to recurrence in high grade serous ovarian cancer
Gynecol Oncol 152(3):574-580.
Proteomics profiling and risk of new-onset atrial fibrillation: Framingham Heart Study
J Am Heart Assoc 8(6): e010976.
Proteomic profiles in advanced age-related macular degeneration using an aptamer-based proteomic technology
Transl Vis Sci Technol 8(1): 14.
SOMAscan-based proteomic measurements of plasma brain natriuretic peptide are decreased in mild cognitive impairment and in Alzheimer's dementia patients
PLoS One. 2019 Feb 14;14(2):e0212261.
Reproducibility and variability of protein analytes measured using a multiplexed modified aptamer assay
J Appl Lab Med. 2019 Jul;4(1):30-39.
Characterization of Glycolytic Enzymes and Pyruvate Kinase M2 in Type 1 and 2 Diabetic Nephropathy
Diabetes Care. 2019 Jul;42(7):1263-1273.
Stress Hyperglycemia in Critically Ill Patients: Insight Into Possible Molecular Pathways
Front Med (Lausanne). 2019; 6: 54.
Zika virus infection disrupts astrocytic proteins involved in synapse control and axon guidance
Front Microbiol. 2019 Mar 26;10:596.
Fine-Mapping of the Human Blood Plasma N-Glycome onto Its Proteome
Metabolites 9(7), 122. https://doi.org/10.3390/metabo9070122.
Effects of codon optimization on coagulation factor IX translation and structure: Implications for protein and gene therapies
Sci Rep. 2019 Oct 29;9(1):15449.
Targeting Unique Epitopes on Highly Similar Proteins GDF-11 and GDF-8 with Modified DNA Aptamers
Biochemistry. 2019 Nov 19;58(46):4632-4640.
Biomarker discovery in cardiac allograft vasculopathy using targeted aptamer proteomics
Clin Transplant. 2019 Dec 9:e13765.
Multi-platform Affinity Proteomics Identify Proteins Linked to Metastasis and Immune Suppression in Ovarian Cancer Plasma
Front Oncol. 9: 1150.
Apabetalone (RVX-208) reduces vascular inflammation in vitro and in CVD patients by a BET-dependent epigenetic mechanism
Clin Epigenetics. 2019; 11: 102.
Aptamer Profiling of A549 Cells Infected with Low-Pathogenicity and High-Pathogenicity Influenza Viruses
Viruses 2019, 11(11), 1028.
Dual-platform affinity proteomics identifies links between the recurrence of ovarian carcinoma and proteins released into the tumor microenvironment
Theranostics. 2019 Aug 22;9(22):6601-6617.
Proteomics in gastroparesis: Unique and overlapping protein signatures in diabetic and idiopathic gastroparesis
Am J Physiol Gastrointest Liver Physiol. 2019 Sep 4. doi: 10.1152.
Proteomic analysis reveals distinctive protein profiles involved in CD8(+) T cell-mediated murine autoimmune cholangitis
Cell Mol Immunol 15(8): 756-767.
Plasma proteomics identifies a 'chemokine storm' in idiopathic multicentric Castleman disease
Am J Hematol 93(7): 902-912.
Highly multiplexed proteomic analysis reveals significant tissue and exosomal coagulation pathway derangement in chronic rhinosinusitis with nasal polyps
Int Forum Allergy Rhinol 8(12): 1438-1444.
Tracking disease progression non-invasively in Duchenne and Becker muscular dystrophies
J Cachexia Sarcopenia Muscle 9(4): 715-726.
Serum proteomic assessment of the progression of fracture healing
J Orthop Res 36(4): 1153-1163.
The impact of the glomerular filtration rate on the human plasma proteome
Proteomics Clin Appl 12(3): e1700067.
Novel application of aptamer proteomic analysis in cystic fibrosis bronchoalveolar lavage fluid
Proteomics Clin Appl: e1800085.
Cytokines IL-17, TNF and IFN-gamma alter the expression of antimicrobial peptides and proteins disparately: a targeted proteomics analysis using SOMAscan technology
Vaccines (Basel) 6(3).
Benefit of apabetalone on plasma proteins in renal disease
Kidney International Reports 3(3): 711-721.
Aptamer-based proteomics identifies mortality-associated serum biomarkers in dialysis-dependent AKI patients
Kidney Int Rep 3(5): 1202-1213.
"Scanning"" into the future: the promise of SOMAScan technology for kidney disease"
Kidney Int Rep 3(5): 1020-1022.
Aptamer-based proteomics of serum and plasma in acquired aplastic anemia
Exp Hematol 68: 38-50.
Sperm cell purification from mock forensic swabs using SOMAmerTM affinity reagents
Forensic Sci Int Genet 35: 9-13.
Sputum transcriptomics reveal up-regulation of IL-1 receptor family members in severe asthma
J Allergy Clin Immunol 141(2): 560-570.
Plasma from some cancer patients inhibits adenoviral Ad5f35 vector transduction of dendritic cells
Cytotherapy 20(5): 728-739.
Non-invasive assessment of non-alcoholic fatty liver disease: Clinical prediction rules and blood-based biomarkers
J Hepatol 68(2): 305-315.
Cerebrospinal fluid biomarkers link toxic astrogliosis and microglial activation to multiple sclerosis severity
Mult Scler Relat Disord 28: 34-43.
Phase IIa trial in Duchenne muscular dystrophy shows vamorolone is a first-in-class dissociative steroidal anti-inflammatory drug
Pharmacol Res 136: 140-150.
Serum biomarkers of glucocorticoid response and safety in anti-neutrophil cytoplasmic antibody-associated vasculitis and juvenile dermatomyositis
Steroids 140: 159-166.
Diet-resistant obesity is characterized by a distinct plasma proteomic signature and impaired muscle fiber metabolism
Int J Obes (Lond) 42(3): 353-362.
Characterization of the rat cerebrospinal fluid proteome following acute cerebral ischemia using an aptamer-based proteomic technology
Sci Rep 8(1): 7899.
Stability and reproducibility of proteomic profiles measured with an aptamer-based platform
Sci Rep 8(1): 8382.
Increased levels of circulating MMP3 correlate with severe rejection in face transplantation
Sci Rep 8(1): 14915.
Mistimed food intake and sleep alters 24-hour time-of-day patterns of the human plasma proteome
Proc Natl Acad Sci U S A 115(23): E5390-E5399.
Classification of prostate cancer using a protease activity nanosensor library
Proc Natl Acad Sci U S A 115(36): 8954-8959.
Deep molecular phenotypes link complex disorders and physiological insult to CpG methylation
Hum Mol Genet 27(6): 1106-1121.
Identification of novel systemic sclerosis biomarkers employing aptamer proteomic analysis
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