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Current Publications Count: 578

A proteomic surrogate for cardiovascular outcomes that is sensitive to multiple mechanisms of change in risk

Williams, SA et al.
Sci Transl Med 14(639): eabj9625
Large-scale proteomics Cardiovascular stratification

Large-scale integration of the plasma proteome with genetics and disease

Ferkingstad, E et al.
Nat Genet 53(12): 1712-1721
Large-scale proteomics Rare

Mapping the proteo-genomic convergence of human diseases

Pietzner, M et al.
Science 374(6569): eabj1541
Large-scale proteomics Disease biology Rare

A brain proteomic signature of incipient Alzheimer’s disease in young APOE epsilon4 carriers identifies novel drug targets

Roberts, JA et al.
Sci Adv 7(46): eabi8178.
Neurobiology Disease biology target identification

Evaluating microbiome-directed fibre snacks in gnotobiotic mice and humans

Delannoy-Bruno, O et al.
Nature 595(7865): 91-95

A Microbiota-Directed Food Intervention for Undernourished Children

Chen, RY et al.
N Engl J Med 384(16): 1517-1528
Pediatric Metabolic

Duodenal Microbiota in Stunted Undernourished Children with Enteropathy

Chen, RY et al.
N Engl J Med 384(16): 1517-1528
Pediatric Metabolic

Plasma protein patterns as comprehensive indicators of health

Williams SA, et al.
Nat Med 25(12): 1851-1857.
Clinical Large-scale proteomics

Undulating changes in human plasma proteome profiles across the lifespan

Lehailler, B et al.
Nat Med 25(12): 1843-1850
Disease Biology

Co-regulatory networks of human serum proteins link genetics to disease

Emilsson, V et al.
Science 361(6404): 769-773.
Aging disease biology diagnostics

Genomic atlas of the human plasma proteome

Sun, BB et al.
Nature 558: 73-79.
SomaScan Large-scale proteomics

Genetic architecture of the cardiovascular risk proteome

Benson, MD et al.
Circulation 137(11): 1158-1172.
Cardiovascular disease biology target identification diagnostics

Using aptamer-based technology to probe the plasma proteome for cardiovascular disease prediction

Sabatine, MS
JAMA 315(23): 2525-2526.
Cardiovascular target identification diagnostics

Aptamer-based proteomic profiling reveals novel candidate biomarkers and pathways in cardiovascular disease

Ngo, D et al.
Circulation 134(4): 270-285.
Cardiovascular diagnostics

Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19

Sacco, K et al.
Nat Med 28(5): 1050-1062
Pediatric Infection Inflammatory

Comment on “A proteomic surrogate for cardiovascular outcomes that is sensitive to multiple mechanisms of change in risk”

Kivimaki, M et al.
Sci Transl Med 14(665): eabq4810
Large-scale proteomics Cardiovascular

Response to comment on “A proteomic surrogate for cardiovascular outcomes that is sensitive to multiple mechanisms of change in risk”

Williams, SA et al.
Sci Transl Med 14(665): eadd1355
Large-scale proteomics Cardiovascular

Assessment of variability in the plasma 7k SomaScan proteomics assay

Candia, J et al.
Sci Rep 12(1): 17147
Large-scale proteomics

Altered methylation pattern in EXOC4 is associated with stroke outcome: an epigenome-wide association study

Cullell, N et al.
Clin Epigenetics 14(1): 124
Large-scale proteomics Cardiovascular

The severity and duration of Hypoglycemia affect platelet-derived protein responses in Caucasians

Moin, ASM et al.
Cardiovasc Diabetol 21(1): 202
Metabolic Cardiovascular

Human Plasma Proteome During Normal Pregnancy

Tarca, AL et al.
J. Proteome Res. 21(11): 2687–2702

Plasma proteome profiling identifies changes associated to AD but not to FTD

Mofrad, RB et al.
Acta Neuropathol Commun 10(1): 148

Testican-2 is Associated with Reduced Risk of Incident ESKD

Wen, D et al.
J Am Soc Nephrol., epub ahead of print.

Multiomics study of nonalcoholic fatty liver disease

Sveinbjornsson, G et al.
Nat Genet., epub ahead of print.
Large-scale proteomics

Thirty novel sequence variants impacting human intracranial volume

Nawaz, MS et al.
Brain Communications, epub ahead of print.

The 2022 Report on the Human Proteome from the HUPO Human Proteome Project

Omenn, GS et al.
J Proteome Res., epub ahead of print.
Large-scale proteomics

Components of the Complement Cascade Differ in Polycystic Ovary Syndrome

Butler, AE et al.
Int J Mol Sci 23(20): 12232

ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19.”

Pietzner, M et al.
Nat Commun 13: 4484
Large-scale proteomics Infection

Is an MRI-derived anatomical measure of dementia risk also a measure of brain aging?

Casanova, R et al.
Geroscience, epub ahead of print
Aging Neurobiology

Circulating Proteins Influencing Psychiatric Disease: A Mendelian Randomization Study

Lu, T et al.
Biol Psychiatry, epub ahead of print.

Associations between circulating proteins and risk of breast cancer by intrinsic subtypes: a Mendelian randomisation analysis

Shu 127(8): 1507-1514
Br J Cancer., epub ahead of print.
Large-scale proteomics Oncology

Proteomic Biomarkers of Kleine-Levin Syndrome

Hedou, J et al.
Sleep 45(9)

Genome-wide screening identifies DNA methylation sites that regulate the blood proteome

Nikpay, M et al.
Epigenomics 14(13): 837–848
Large-scale proteomics

Prospects for the application of aptamer based assay platforms in pathogen detection

Banu, K et al.
Biocybern Biomed Eng. 42(3): 934-949

High dimensional immune profiling of smoldering multiple myeloma distinguishes distinct tumor microenvironments

Fernandez, N et al.
Clin Lymphoma Myeloma Leuk, epub ahead of print.
Oncology stratification

Specialized interferon action in COVID-19

Galbraith, MD et al.
Proc Natl Acad Sci U S A 119(11)
Infection Immunity

Elucidating mechanisms of genetic cross-disease associations at the PROCR vascular disease locus

Stacey, D et al.
Nat Commun 13(1): 1222
Cardiovascular Disease biology
A genome-wide meta-analysis identifies 50 genetic
loci associated with carpal tunnel syndrome

Skuladottir, AT et al.
Nat Commun 13: 1598
Large-scale proteomics

Mining the Plasma Proteome for Insights into the Molecular Pathology of Pulmonary Arterial Hypertension

Harbaum, L et al.
Am J Respir Crit Care Med 205(12): 1449-1460
Large-scale-proteomics Rare Cardiovascular

Effects of age, amyloid, sex, and APOE epsilon4 on the CSF proteome in normal cognition

Wesenhagen, KEJ et al.
Alzheimers Dement (Amst) 14(1): e12286.
Aging Neurobiology

Cystatin SN is a Potent Upstream Initiator of Epithelial Derived Type 2 Inflammation in Chronic Rhinosinusitis

Nocera, AL et al.
J Allergy Clin Immunol., epub ahead of print.
Inflammatory Exosomes

Whole-exome sequencing identifies rare genetic variants associated with human plasma metabolites

Bomba, L et al.
Am J Hum Genet. 109(6): 1038-1054
Large-scale proteomics

Clinical applications of plasma proteomics and peptidomics: Towards precision medicine

He, B et al.
Proteomics Clin Appl, epub ahead of print.

Validation of disease-specific biomarkers for the early detection of bronchopulmonary dysplasia

Kindt, ASD et al.
Pediatr Res., epub ahead of print.
Pediatric Respiratory stratification diagnostics

Genetic architecture of band neutrophil fraction in Iceland

Oskarsson, GR et al.
Commun Biol 5(1): 525
Large-scale proteomics

CCL17 acts as a novel therapeutic target in pathological cardiac hypertrophy and heart failure

Zhang, Y et al.
J Exp Med 219(8): e20200418
Cardiovascular Aging

Translation of aptamers toward clinical diagnosis and commercialization

Liu, S et al.
Biosens Bioelectron 208: 114168
Review Diagnostics

Diagnostic Accuracy of Blood-Based Biomarker Panels: A Systematic Review

Hardy-Sosa, A et al.
Front Aging Neurosci 14: 683689
Review Neurobiology

Effects of ivacaftor on systemic inflammation and the plasma proteome in people with CF and G551D

Hoppe, JE et al.
J Cyst Fibros, epub ahead of print.
Inflammatory Respiratory

Chemical modifications for a next generation of nucleic acid aptamers

Chan, KY et al.
Chembiochem, epub ahead of print.

Severe Iatrogenic Hypoglycemia Modulates the Fibroblast Growth Factor Protein Response

Nandakumar, M et al.
Diabetes Obes Metab 24(8): 1483-1497

Identifying causal genes for stroke via integrating the proteome and transcriptome from brain and blood

Wu, BS et al.
J Transl Med 20(1): 181
Cardiovascular Large-scale proteomics

Proteomics in thrombosis research

Edfors, F et al.
Res Pract Thromb Haemost 6(3): e12706.

Harnessing Big Data to Advance Treatment and Understanding of Pulmonary Hypertension

Rhodes, CJ et al.
Circ Res 130(9): 1423-1444
Review Cardiovascular Respiratory

The Proteomic Profile of Interstitial Lung Abnormalities

Axelsson, GT et al.
Am J Respir Crit Care Med 206(3): 337-346
Respiratory Large-scale proteomics

Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset

Saevarsdottir, S et al.
Ann Rheum Dis., epub ahead of print.
Inflammatory Large-scale proteomics

Serum Protein Signatures Using Aptamer-Based Proteomics for Minimal Change Disease and Membranous Nephropathy

Muruve, DA et al.
Kidney Int Rep 7(7): 1539-1556
Kidney stratification

Differential Proteomics of Cardiovascular Risk and Coronary Artery Disease in Humans

Ferrannini, E et al.
Front Cardiovasc Med 8: 790289

Placental proteins with predicted roles in fetal development decrease in premature infants

Schreiner, C et al.
Pediatr Res., epub ahead of print.
Pediatric Reproductive

Proteomics technologies for cancer liquid biopsies

Ding, Z et al.
Mol Cancer 21(1): 53
Review Oncology

Advances in proteomic profiling of pediatric kidney diseases

Cummins, TD et al.
Pediatr Nephrol 37(10): 2255-2265
Review Kidney Pediatric

Proteomic Profiling Identifies Novel Proteins for Genetic Risk of Severe COVID-19: the Atherosclerosis Risk in Communities Study

Steffen, BT et al.
Hum Mol Genet 31(14): 2452-2461
Infection Respiratory Large-scale proteomics

Proteomic Studies of Psoriasis

Sobolev, VV et al.
Biomedicines 10(3): 619
Review Immunity Inflammatory

Proteins and pathways in atrial fibrillation and atrial cardiomyopathy underlying cryptogenic stroke

Pala, E et al.
Int J Cardiol Heart Vasc 39: 100977

Protein prediction for trait mapping in diverse populations

Schubert, R et al.
PLoS One 17(2): e0264341
Large-scale proteomics

Diabetes, GDF-15 and incident heart failure: the atherosclerosis risk in communities study

Echouffo-Tcheugui, JB et al.
Diabetologia 65: 955–963
Metabolic Cardiovascular

Using the Plasma Proteome for Risk Stratifying Patients with Pulmonary Arterial Hypertension

Rhodes, CJ et al.
Am J Respir Crit Care Med 205(9): 1102-1111
Respiratory Rare Stratification

A genome-wide association study of serum proteins reveals shared loci with common diseases

Gudjonsson, A et al.
Nat Commun 13(1): 480
Large-scale proteomics

Coding and regulatory variants are associated with serum protein levels and disease

Emilsson, V et al.
Nat Commun 13(1): 481
Large-scale proteomics

Aptamers: Potential Diagnostic and Therapeutic Agents for Blood Diseases

Aljohani, MM et al.
Molecules 27(2): 383

Recent Developments in Clinical Plasma Proteomics-Applied to Cardiovascular Research

Palstrom, NB et al.
Biomedicines 10(1): 162
Review Cardiovascular

Identification and Evaluation of Serum Protein Biomarkers Which Differentiate Psoriatic from Rheumatoid Arthritis.

Mc Ardle, A et al.
Arthritis Rheumatol 74(1): 81-91
Inflammatory diagnostics

Plasma P-selectin is an early marker of thromboembolism in COVID-19

Fenyves, BG et al.
Am J Hematol 96(12): E468-E471
Cardiovascular Infection

Exercise plasma boosts memory and dampens brain inflammation via clusterin

De Miguel, Z et al.
Nature 600(7889): 494-499

Cross-validation of SARS-CoV-2 responses in kidney organoids and clinical populations

Helms, L et al.
JCI Insight 6(24): e154882
Infection Kidney

Synergistic insights into human health from aptamer- and antibody-based proteomic profiling

Pietzner, M et .
Nat Commun 12(1): 6822
Large-scale proteomics

Plasma Proteomics of Renal Function: A Trans-ethnic Meta-analysis and Mendelian Randomization Study

Matias-Garcia, P et al.
J Am Soc Nephrol. 32(7): 1747-1763

Proteomic analysis of serum in workers exposed to diesel engine exhaust

Rahman, ML et al.
Environ Mol Mutagen 63(1): 18-28

A Combined Proteomics and Mendelian Randomization Approach to Investigate the Effects of Aspirin-Targeted Proteins on Colorectal Cancer

Nounu, A et al.
Cancer Epidemiol Biomarkers Prev 30(3): 564-575
Oncology mechanism of action

Hypoglycemia-induced changes in complement pathways in type 2 diabetes

Moin, ASM et al.
Atherosclerosis Plus 46: 35-45

Predicting the probability of death using proteomics.

Eiriksdottir, T et al.
Commun Biol 4(1): 758.
Aging Large-scale proteomics
Large-scale plasma proteomic analysis
identifies proteins and pathways associated with dementia risk.

Walker, KA et al.
Nat Aging 1: 473-489.
Aging Large-scale proteomics

Human plasma proteomic profiles indicative of cardiorespiratory fitness.

Robbins, JM et al.
Nat Metab 3(6): 786-797.
Cardiovascular Respiratory

Influence of renin-angiotensin-aldosterone system inhibitors on plasma levels of angiotensin-converting enzyme 2

Zimmermann, T et al.
ESC Heart Fail 8(2): 1717-1721
Cardiovascular Infection

Advances and Utility of the Human Plasma Proteome

Deutsch, EW et al.
J Proteome Res 20(12): 5241-5263

Vitamin D association with the renin angiotensin system in polycystic ovary syndrome

Butler, AE et al.
J Steroid Biochem Mol Biol 214: 105965.

The proteomic signature of recombinant Growth Hormone in recreational athletes

Esefeld, M et al.
J Endocrine Soc, epub ahead of print

Advances in Aptamer-Based Biomarker Discovery

Huang, J et al.
Front Cell Dev Biol 9: 659760.
SomaScan Review

Replication study of plasma proteins relating to Alzheimer’s pathology.

Shi, L et al.
Alzheimers Dement 17(9): 1452-1464.
Neurobiology stratification

Platelet Protein-Related Abnormalities in Response to Acute Hypoglycemia in Type 2 Diabetes.

Moin, ASM et al.
Front Endocrinol (Lausanne) 12: 651009.

Broadly effective metabolic and immune recovery with C5 inhibition in CHAPLE disease.

Ozen, A et al.
Nat Immunol 22(2): 128-139.
Rare Immunity mechanism of action

Multi-omics highlights ABO plasma protein as a causal risk factor for COVID-19.

Hernandez Cordero, AI et al.
Hum Genet 140(6): 969-979

Type 2 Diabetes Coagulopathy Proteins May Conflict With Biomarkers Reflective of COVID-19 Severity.

Moin, ASM et al.
Front Endocrinol (Lausanne) 12: 658304
Infection Metabolic

Circulating testican-2 is a podocyte-derived marker of kidney health

Ngo, D et al.
Proc Natl Acad Sci U S A 117(40): 25026-25035

Using ‘big data’ to disentangle aging and COVID-19.

Montgomery, RR et al.
Aging 1: 496–497.
Infection Aging

The COVIDome Explorer researcher portal.

Sullivan, KD et al.
Cell Rep 36(7): 109527.

Early Interleukin-22 and Neutrophil Proteins Are Correlated to Future Lung Damage in Children with Cystic Fibrosis.

Renwick, J et al.
Front Pediatr 9: 640184.
Rare Pediatric Stratification Inflammatory

Effect of longevity genetic variants on the molecular aging rate.

Gurinovich, A et al.
Geroscience 43(3): 1237-1251.
Aging Large-scale proteomics

Novel Murine Biomarkers of Radiation Exposure Using An Aptamer-Based Proteomic Technology.

Sproull, M et al.
Front Pharmacol 12: 633131.

The CRTAC1 protein in plasma associates with osteoarthritis and predicts progression to joint replacements: a large-scale proteomics scan in Iceland.

Styrkarsdottir, U et al.
Arthritis Rheumatol 73(11): 2025-2034
Musculoskeletal Large-scale proteomics

Plasma Proteomic Profile Predicts Survival in Heart Failure with Reduced Ejection Fraction.

Gui, H et al.
Circ Genom Precis Med 14(3): e003140.
cardiovascular Stratification Large-scale proteomics

SOMAscan Proteomics Identifies Serum Biomarkers Associated With Liver Fibrosis in Patients With NASH.

Luo, Y et al.
Hepatol Commun 5(5): 760-773.
Metabolic Fibrotic Diagnostics

Proteomic signatures of inflammatory skin diseases: a focus on atopic dermatitis.

Mikhaylov, D et al.
Expert Rev Proteomics 18(5): 345-361.
Review Inflammatory

Metabolic syndrome and the plasma proteome: from association to causation.

Elhadad, MA et al.
Cardiovasc Diabetol 20(1): 111.
Metabolic Cardiovascular

Identification of Plasma Proteome Signatures Associated With Surgery Using SOMAscan

Fong TG, et al.
Ann Surg 273(4): 732-742.
Aging Disease Biology Inflammatory

Association of a Serum Protein Signature With Rheumatoid Arthritis Development

O’Neil LJ, et al.
Arthritis Rheumatol. 73(1): 78-88.
Inflammatory Immunity

Genetics meets proteomics: perspectives for large population-based studies

Suhre, K et al.
Nat Rev Genet 22(1): 19-37.
Review Large-scale proteomics

Circulating markers of NADH-reductive stress correlate with mitochondrial disease severity

Sharma, R et al.
J Clin Invest 131(2): e136055
Metabolic Rare

Revealing the role of the human blood plasma proteome in obesity using genetic drivers

Zaghlool, SB et al.
Nat Commun 12(1): 1279
Metabolic Large-scale proteomics

Quantitative Proteomic Analysis of Diabetes Mellitus in Heart Failure With Preserved Ejection Fraction

Hanff, TC et al.
JACC Basic Transl Sci 6(2): 89-99.
Cardiovascular Metabolic

Proteomics in aging research: A roadmap to clinical, translational research

Moaddel, R et al.
Aging Cell: e13325.
Aging Review

Blood biomarker discovery for autism spectrum disorder: A proteomic analysis

Hewitson, L et al.
PLoS One 16(2): e0246581.
Pediatric Neurobiology

Biomarker-focused multi-drug combination therapy and repurposing trial in mdx mice

Ziemba, M et al.
PLoS One 16(2): e0246507
Rare PK/PD

Pediatric and adult dilated cardiomyopathy are distinguished by distinct biomarker profiles.

Gropler, MRF et al.
Pediatr Res 92(1): 206-215
Pediatric Cardiovascular

Smoking induces sex-specific changes in the small airway proteome.

Kokelj, S et al.
Respir Res 22(1): 234.

Validation of Chemokine Biomarkers in Duchenne Muscular Dystrophy.

Ogundele, M et al.
Life (Basel) 11(8): 827.
Pediatric Musculoskeletal

Evolving a RIG-I antagonist: a modified DNA aptamer mimics viral RNA.

Ren, X et al.
J Mol Biol. 433(21): 167227.

Serum levels of ACE2 are higher in patients with obesity and diabetes.

Emilsson, V et al.
Obes Sci Pract 7(2): 239-243.

Functional Network Profiles in ARSACS Disclosed by Aptamer-Based Proteomic Technology

Morani F, et al.
Front Neurol 11: 603774.
Neurobiology Rare

Atopic Dermatitis Endotypes Based on Allergen Sensitization, Reactivity to Staphylococcus aureus Antigens, and Underlying Systemic Inflammation

Leonard A, et al.
J Allergy Clin Immunol Pract. 8(1): 236-247.e3.
Inflammatory Disease Biology Diagnostics

Vascular Disease and Thrombosis in SARS-CoV-2-Infected Rhesus Macaques

Aid M, et al.
Cell 183(5): 1354–1366
Cardiovascular Inflammatory

Genetic architecture of host proteins involved in SARS-CoV-2 infection

Pietzner M, et al.
Nat Commun 11(1): 6397
Cardiovascular Respiratory Disease Biology Target Identification Infection

A Plasma Proteomic Signature of Skeletal Muscle Mitochondrial Function

Zampino M, et al.
Int J Mol Sci 21(24): 9540

Coronary Artery Disease and Type 2 Diabetes: A Proteomic Study

Ferrannini G, et al.
Diabetes Care 43(4): 843-851
Cardiovascular Metabolic

Comparison of Proteomic Assessment Methods in Multiple Cohort Studies

Raffield LM, et al.
Proteomics 20(12):e1900278

Reduced Apolipoprotein M and Adverse Outcomes Across the Spectrum of Human Heart Failure

Chirinos JA, et al.
Circulation 141(18):1463-1476

Plasma proteomic profile of frailty

Sathyan S, et al.
Aging Cell 19(9):e13193

Serum protein biomarkers for juvenile dermatomyositis: a pilot study

Tawalbeh SM, et al.
BMC Rheumatol 4:52
Inflammatory Immunity Rare

Proteomic biomarkers of sleep apnea

Ambati A, et al.
Sleep 43(11):zsaa086

Autophagy Modulators Profoundly Alter the Astrocyte Cellular Proteome

Sher AA, et al.
Cells 9(4):805

Proteomic Signatures of Heart Failure in Relation to Left Ventricular Ejection Fraction

Adamo L, et al.
J Am Coll Cardiol 76(17):1982-1994

Proteomic and Metabolomic Correlates of Healthy Dietary Patterns: The Framingham Heart Study

Walker ME, et al.
Nutrients 12(5):1476
Cardiovascular Metabolic

Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer’s Disease Pathology

Shi L, et al.
J Alzheimers Dis 77(3):1353-1368
Neurobiology Disease biology Mechanism of action

Protein biomarkers for incident deep venous thrombosis in critically ill adolescents: An exploratory study

Tala JA, et al.
Pediatr Blood Cancer 67(4):e28159
Cardiovascular Pediatric

Increased Levels of Coagulation Factor XI in Plasma Are Related to Alzheimer’s Disease Diagnosis

Begic E, et al.
J Alzheimers Dis 77(1):375-386
Neurobiology Diagnostics

Mechanisms of Sodium-Glucose Cotransporter 2 Inhibition: Insights From Large-Scale Proteomics

Ferrannini E, et al.
Diabetes Care 43(9):2183-2189
Metabolic Disease biology Target validation

Targeting myostatin/activin A protects against skeletal muscle and bone loss during spaceflight

Lee SJ, et al.
Proc Natl Acad Sci U S A 117(38):23942-23951

Multimodal immune phenotyping of maternal peripheral blood in normal human pregnancy

Apps R, et al.
JCI Insight 5(7):e134838
Immunity Reproductive

Effect of induced hypoglycemia on inflammation and oxidative stress in type 2 diabetes and control subjects

Kahal H, et al.
Sci Rep 10(1):4750
Inflammatory Metabolic Disease biology

Modified nucleotides may have enhanced early RNA catalysis.

Wolk, SK et al.
Proc Natl Acad Sci U S A 117(15): 8236-8242.

The Evolution of the Cardiovascular Biomarker Study.

Wang, TJ
Circulation 142(15): 1422-1424.
Cardiovascular Target identification

Placenta accreta spectrum: biomarker discovery using plasma proteomics.

Shainker, SA et al.
Am J Obstet Gynecol 223(3): 433 e431-433 e414.

A fully joint Bayesian quantitative trait locus mapping of human protein abundance in plasma.

Ruffieux, H et al.
PLoS Comput Biol 16(6): e1007882.

Intense light as anticoagulant therapy in humans.

Oyama, Y et al.
PLoS One 15(12): e0244792.
SomaScan Clinical

Identification of a unique temporal signature in blood and BAL associated with IPF progression.

Norman, KC et al.
Sci Rep 10(1): 12049.
Fibrotic Stratification

Circulating Protein Signatures and Causal Candidates for Type 2 Diabetes.

Gudmundsdottir, V et al.
Diabetes 69(8): 1843-1853.
Metabolic Disease Biology Large-scale proteomics

Aptamers and Antisense Oligonucleotides for Diagnosis and Treatment of Hematological Diseases.

Giudice, V et al.
Int J Mol Sci 21(9): 3252.
Review Clinical

Proteomics for personalized cardiovascular risk assessment: in pursuit of the Holy Grail.

Ganz, P et al.
Eur Heart J 41(41): 4008-4010.

Increased mTOR activation in idiopathic multicentric Castleman disease.

Arenas, DJ et al.
Blood 135(19): 1673-1684.

Multiomics modeling of the immunome, transcriptome, microbiome, proteome and metabolome adaptations during human pregnancy

Ghaemi, MS et al.
Bioinformatics 35(1): 95-103
Large-scale proteomics Reproductive

High-Throughput Identification of the Plasma Proteomic Signature of Inflammatory Bowel Disease.

Di Narzo, AF et al.
J Crohns Colitis 13(4): 462-471.

Transcatheter aortic valve replacements alter circulating serum factors to mediate myofibroblast deactivation

Aguado BA, et al.
Science Translational Medicine Volume 11 (509) 2019 eaav3233

Accelerating Biomarker Discovery Through Electronic Health Records, Automated Biobanking, and Proteomics.

Wells, QS et al.
J Am Coll Cardiol 73(17): 2195-2205.

Beyond Autoantibodies: Biologic Roles of Human Autoreactive B Cells in Rheumatoid Arthritis Revealed by RNA-Sequencing.

Mahendra, A et al.
Arthritis Rheumatol 71(4): 529-541.
Immunity Disease biology

Predicting health and life span with the deep plasma proteome.

Emilsson, V et al.
Nat Med 25(12): 1815-1816.

Balanced event prediction through sampled survival analysis.

Datta, G et al.
Systems Medicine 2(1): 28-38.

Aging Disrupts Muscle Stem Cell Function by Impairing Matricellular WISP1 Secretion from Fibro-Adipogenic Progenitors.

Lukjanenko, L et al.
Cell Stem Cell 24(3): 433-446 e437.
Aging Musculoskeletal

Neutrophil activation in systemic capillary leak syndrome (Clarkson disease)

Xie, Z et al.
J Cell Mol Med 23(8): 5119-5127
Rare Disease biology

Plasma proteome in multiple sclerosis disease progression

Malekzadeh A, et al.
Ann Clin Transl Neurol 6(9):1582-1594.
Neurobiology Disease biology Diagnostics Rare

Osteitis is associated with dysregulated pro-osteoblastic activity in patients with nasal polyps

Wu, D et al.
Laryngoscope 129(3): E102-E109.
Exosomes Disease biology Osteoporosis

Vero cell proteomic changes induced by Zika virus infection

Glover, KKM et al.
Proteomics 19(4): e1800309.
Neurobiology Disease biology Infection

Application of an Aptamer-Based Proteomics Assay (SOMAscan™) in Rat Cerebrospinal Fluid

Simats A, et al.
Methods Mol Biol. 2044:221-231.
Neurobiology Disease biology

Guidelines for CSF Processing and Biobanking: Impact on the Identification and Development of Optimal CSF Protein Biomarkers

Hok-A-Hin YS, et al.
Methods Mol Biol. 2044:27-50.
Neurobiology Disease biology SomaScan Large-scale proteomics

Assessing the genetic correlations between blood plasma proteins and osteoporosis: a polygenic risk score analysis

Liang, X et al.
Calcif Tissue Int 104(2): 171-181.
Osteoporosis Disease biology Target identification Diagnostics

Plasma FGF-19 Levels are Increased in Patients with Post-Bariatric Hypoglycemia

Mulla CM, et al.
Obes Surg 29(7):2092-2099.
Metabolic Disease biology

Application of Proteomics Profiling for Biomarker Discovery in Hypertrophic Cardiomyopathy

Shimada YJ, et al.
J Cardiovasc Transl Res 12(6):569-579.
Cardiovascular Disease biology Diagnostics

Cancer protein biomarker discovery based on nucleic acid aptamers

Xiong H, et al.
Int J Biol Macromol 132:190-202.
Oncology Disease biology Diagnostics

Exosome swarms eliminate airway pathogens and provide passive epithelial immunoprotection through nitric oxide

Nocera, AL et al.
J Allergy Clin Immunol 143(4):1525-1535 e1521.
Exosomes Disease biology

Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay

Shi L, et al.
Alzheimers Dement 15(11): 1478-1488.
Aging Disease biology Diagnostics

A framework for multi-omic prediction of treatment response to biologic therapy for psoriasis

Foulkes, AC et al.
J Invest Dermatol 139(1): 100-107.
Immunity Disease biology Stratification Diagnostics

Fatigue in Sjögren’s syndrome: a search for biomarkers and treatment targets

Bodewes, ILA et al.
Front Immunol 10: 312.
Inflammatory Disease biology Immunity Target identification Diagnostics

Disease-specific and glucocorticoid-responsive serum biomarkers for Duchenne Muscular Dystrophy

Hathout Y, et al.
Sci Rep 9(1):12167.
Musculoskeletal Disease biology Diagnostics Rare

Candidate early predictive plasma protein markers of doxorubicin-induced chronic cardiotoxicity in B6C3F1 mice

Desai, VG et al.
Toxicol Appl Pharmacol 363:164-173.
Oncology PK/PD Stratification

Pulmonary Aptamer Signatures in Children’s Interstitial and Diffuse Lung Diseases

Deterding RR, et al.
Am J Respir Crit Care Med. doi: 10.1164.
Respiratory Disease biology Diagnostics Pediatric Rare

Metabolic and proteomic signatures of hypoglycemia in type 2 diabetes

Halama, A et al.
Diabetes Obes Metab. 2018 Dec 7. doi: 10.1111.
Metabolic Disease biology Diagnostics

Influenza a virus-triggered autophagy decreases the pluripotency of human-induced pluripotent stem cells

Zahedi-Amiri A, et al.
Cell Death Dis 10(5): 337.
Infection Disease biology Reproductive

A serum protein signature of APOE genotypes in centenarians

Sebastiani P, et al.
Aging Cell. :e13023. doi: 10.1111.
Aging Disease biology Diagnostics

Activin type II receptor signaling in cardiac aging and heart failure

Roh, JD et al.
Sci Transl Med 11(482).
Diagnostics Aging Disease biology

Circulating Biomarkers of Testosterone’s Anabolic Effects on Fat-Free Mass

Huang G, et al.
J Clin Endocrinol Metab 104(9): 3768-3778.

Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study

Penn-Nicholson A, et al.
PLoS Med 16(4): e1002781.
Infection Disease biology Diagnostics

A combined score of clinical factors and serum proteins can predict time to recurrence in high grade serous ovarian cancer

Mysona, D et al.
Gynecol Oncol 152(3):574-580.
Oncology Disease biology Mechanism of action Diagnostics

Proteomics profiling and risk of new-onset atrial fibrillation: Framingham Heart Study

Ko, D et al.
J Am Heart Assoc 8(6): e010976.
Cardiovascular Disease biology Diagnostics

Proteomic profiles in advanced age-related macular degeneration using an aptamer-based proteomic technology

Lynch, AM et al.
Transl Vis Sci Technol 8(1): 14.
Aging Disease biology Diagnostics Ocular Rare

Human PAH is characterized by a pattern of lipid-related insulin resistance

Hemnes, AR et al.
JCI Insight 4(1).
Respiratory Rare Disease biology Metabolic Mechanism of action Diagnostics

Reproducibility and variability of protein analytes measured using a multiplexed modified aptamer assay

Tin, A et al.
J Appl Lab Med 4(1):30-39.
Cardiovascular Diagnostics

Characterization of Glycolytic Enzymes and Pyruvate Kinase M2 in Type 1 and 2 Diabetic Nephropathy

Gordin D, et al.
Diabetes Care 42(7):1263-1273.
Kidney Disease biology Diagnostics Metabolic

Zika virus infection disrupts astrocytic proteins involved in synapse control and axon guidance

Sher et al.
Front Microbiol 10:596.
Neurobiology Disease biology Infection

Fine-Mapping of the Human Blood Plasma N-Glycome onto Its Proteome

Suhre K, et al.
Metabolites 9(7), 122.

Targeting Unique Epitopes on Highly Similar Proteins GDF-11 and GDF-8 with Modified DNA Aptamers

Ochsner UA, et al.
Biochemistry 58(46):4632-4640.
SomaScan Binding

Biomarker discovery in cardiac allograft vasculopathy using targeted aptamer proteomics

Almufleh A, et al.
Clin Transplant. 2019 Dec 9:e13765.
Cardiovascular Disease biology Diagnostics

Apabetalone (RVX-208) reduces vascular inflammation in vitro and in CVD patients by a BET-dependent epigenetic mechanism

Tsujikawa LM, et al.
Clin Epigenetics 11: 102.
Cardiovascular Mechanism of action Stratification Diagnostics

Aptamer Profiling of A549 Cells Infected with Low-Pathogenicity and High-Pathogenicity Influenza Viruses

Coombs KM, et al.
Viruses 2019, 11(11), 1028.
Infection Disease biology Diagnostics

Dual-platform affinity proteomics identifies links between the recurrence of ovarian carcinoma and proteins released into the tumor microenvironment

Finkemagel F, et al.
Theranostics 9(22):6601-6617.
Oncology Disease biology Diagnostics Stratification

The nucleolus functions as a phase-separated protein quality control compartment

Frottin, F et al.
Science 365(6451): 342-347

Proteomics in gastroparesis: Unique and overlapping protein signatures in diabetic and idiopathic gastroparesis

Grover M, et al.
Am J Physiol Gastrointest Liver Physiol. 2019 Sep 4. doi: 10.1152.
Immunity Disease biology Diagnostics Metabolic SomaScan Binding

Proteomic analysis reveals distinctive protein profiles involved in CD8(+) T cell-mediated murine autoimmune cholangitis

Zhang, W et al.
Cell Mol Immunol 15(8): 756-767.
Immunity Disease biology Rare

Plasma proteomics identifies a ‘chemokine storm’ in idiopathic multicentric Castleman disease

Pierson, SK et al.
Am J Hematol 93(7): 902-912.
Inflammatory Disease biology Diagnostics Rare

Tracking disease progression non-invasively in Duchenne and Becker muscular dystrophies

Spitali, P et al.
J Cachexia Sarcopenia Muscle 9(4): 715-726.
Pediatric Disease biology Diagnostics Musculoskeletal

Serum proteomic assessment of the progression of fracture healing

Hussein, AI et al.
J Orthop Res 36(4): 1153-1163.
Osteoporosis Diagnostics

The impact of the glomerular filtration rate on the human plasma proteome

Christensson, A et al.
Proteomics Clin Appl 12(3): e1700067.
Kidney Disease biology Diagnostics

Novel application of aptamer proteomic analysis in cystic fibrosis bronchoalveolar lavage fluid

DeBoer, EM et al.
Proteomics Clin Appl: e1800085.
Rare Disease biology Diagnostics

Benefit of apabetalone on plasma proteins in renal disease

Wasiak, S et al.
Kidney International Reports 3(3): 711-721.
Kidney Disease biology Diagnostics Mechanism of action

Aptamer-based proteomics identifies mortality-associated serum biomarkers in dialysis-dependent AKI patients

Yu, LR et al.
Kidney Int Rep 3(5): 1202-1213.
Kidney Disease biology Diagnostics Target identification

“Scanning” into the future: the promise of SOMAScan technology for kidney disease

Coca, SG
Kidney Int Rep 3(5): 1020-1022.
Kidney Disease biology Diagnostics

Aptamer-based proteomics of serum and plasma in acquired aplastic anemia

Giudice, V et al.
Exp Hematol 68: 38-50.
Rare Disease biology Diagnostics

Sperm cell purification from mock forensic swabs using SOMAmerTM affinity reagents

Katilius E et al.
Forensic Sci Int Genet 35: 9-13.
SomaScan Binding

Sputum transcriptomics reveal up-regulation of IL-1 receptor family members in severe asthma

Rossios, C et al.
J Allergy Clin Immunol 141(2): 560-570.
Respiratory Disease biology Diagnostics

Plasma from some cancer patients inhibits adenoviral Ad5f35 vector transduction of dendritic cells

Jin, P et al.
Cytotherapy 20(5): 728-739.
Oncology Mechanism of action Diagnostics

Non-invasive assessment of non-alcoholic fatty liver disease: Clinical prediction rules and blood-based biomarkers

Vilar-Gomez, E et al.
J Hepatol 68(2): 305-315.
Inflammatory Disease biology Diagnostics Fibrotic Metabolic

Cerebrospinal fluid biomarkers link toxic astrogliosis and microglial activation to multiple sclerosis severity

Masvekar, R et al.
Mult Scler Relat Disord 28: 34-43.
Neurobiology Disease biology Diagnostics

Phase IIa trial in Duchenne muscular dystrophy shows vamorolone is a first-in-class dissociative steroidal anti-inflammatory drug

Conklin, LS et al.
Pharmacol Res 136: 140-150.
Neurobiology Disease biology Diagnostics PK/PD Stratification

Diet-resistant obesity is characterized by a distinct plasma proteomic signature and impaired muscle fiber metabolism

Thrush, AB et al.
Int J Obes (Lond) 42(3): 353-362.
Metabolic Disease biology Diagnostics Osteoporosis

Stability and reproducibility of proteomic profiles measured with an aptamer-based platform

Kim, CH et al.
Sci Rep 8(1): 8382.
SomaScan Binding Review

Increased levels of circulating MMP3 correlate with severe rejection in face transplantation

Kollar, B et al.
Sci Rep 8(1): 14915.
Inflammatory Disease biology Diagnostics

Mistimed food intake and sleep alters 24-hour time-of-day patterns of the human plasma proteome

Depner CM et al.
Proc Natl Acad Sci U S A 115(23): E5390-E5399.
Metabolic Disease biology

Classification of prostate cancer using a protease activity nanosensor library

Dudani, JS et al.
Proc Natl Acad Sci U S A 115(36): 8954-8959.
Oncology Diagnostics

Deep molecular phenotypes link complex disorders and physiological insult to CpG methylation

Zaghlool, SB et al.
Hum Mol Genet 27(6): 1106-1121.
Respiratory Disease biology Metabolic

Identification of novel systemic sclerosis biomarkers employing aptamer proteomic analysis

Wermuth, PJ et al.
Rheumatology (Oxford) 57(10): 1698-1706.
Immunity Disease biology Diagnostics

Plasma proteomic signature of age in healthy humans

Tanaka, T et al.
Aging Cell 17(5): e12799.
Aging Diagnostics

Habitual aerobic exercise and circulating proteomic patterns in healthy adults: relation to indicators of healthspan

Santos-Parker, JR et al.
J Appl Physiol (1985) 125(5): 1646-1659.
Aging Disease biology Diagnostics

Application of large scale aptamer-based proteomic profiling to “planned” myocardial infarctions

Jacob, J et al.
Circulation 137(12): 1270-1277.
Cardiovascular Disease biology Diagnostics Target identification

Integrative omics: harnessing the proteome to maximize the potential of the genome

McGarrah, RW et al.
Circulation 137(11): 1173-1175.
Cardiovascular Disease biology

Harnessing the power of proteomics to assess drug safety and guide clinical trials

Lam, MPY et al.
Circulation 137(10): 1011-1014.
Cardiovascular Stratification

Probing the virtual proteome to identify novel disease biomarkers

Mosley, JD et al.
Circulation 138(22): 2469-2481.
Cardiovascular Disease biology Diagnostics

Cerebrospinal fluid protein changes in preeclampsia

Ciampa, E et al.
Hypertension 72(1): 219-226.
Reproductive Disease biology

Endothelial microparticles and systemic complement activation in patients with chronic kidney disease

Jalal, D et al.
J Am Heart Assoc 7(14): e007818.
Kidney Disease biology Inflammatory

Early identification of bronchopulmonary dysplasia using novel biomarkers by proteomic screening

Forster, K et al.
Am J Respir Crit Care Med 197(8): 1076-1080.
Respiratory Disease biology Diagnostics

Serum biomarker for diagnostic evaluation of pulmonary arterial hypertension in systemic sclerosis

Rice, LM et al.
Arthritis Res Ther 20(1): 185.
Respiratory Rare Disease biology Diagnostics

The differential plasma proteome of obese and overweight individuals undergoing a nutritional weight loss and maintenance intervention

Oller Moreno, S et al.
Proteomics Clin Appl 12(1).
Metabolic Disease biology Diagnostics

Combined use of protein biomarkers and network analysis unveils deregulated regulatory circuits in Duchenne muscular dystrophy

Parolo, S et al.
PLoS One 13(3): e0194225.
Neurobiology Disease biology Diagnostics Rare

A proteomic signature that reflects pancreatic beta-cell function

Curran, AM et al.
PLoS One 13(8): e0202727.
Metabolic Disease biology Diagnostics

Proteomic analysis of heart failure hospitalization among patients with chronic kidney disease: The Heart and Soul Study

Dubin, RF et al.
PLoS One 13(12): e0208042.
Cardiovascular Disease biology Diagnostics Target identification Kidney

Proteomics: Clinical and research applications in respiratory diseases.

Norman, KC et al.
Respirology 23(11): 993-1003.
Respiratory Review

A proteomic clock of human pregnancy.

Aghaeepour, N et al.
Am J Obstet Gynecol 218(3): 347 e341-347 e314.

Genome-wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease

Yao, C et al.
Nat Commun 9(1): 3268.
Cardiovascular Disease biology Diagnostics Target identification

Chemotherapy-induced differential cell cycle arrest in B-cell lymphomas affects their sensitivity to Wee1 inhibition

Wang, X et al.
Haematologica 103(3): 466-476.
Oncology Disease biology Mechanism of action

Clinical validation of a protein biomarker panel for non-small cell lung cancer

Jung, YJ et al.
J Korean Med Sci 33(53): e342.
Oncology Disease biology Diagnostics

Modified aptamers enable quantitative sub-10-nm cellular DNA-PAINT imaging

Strauss, S et al.
Nat Methods 15(9): 685-688.
SomaScan Binding

Improving probes for super-resolution

Moore, RP et al.
Nat Methods 15(9): 659-660.
SomaScan Binding

Proteomic profiling identifies novel circulating markers associated with bronchiectasis in cystic fibrosis

DeBoer, EM et al.
Proteomics Clin Appl 11(9-10).
Respiratory Disease biology Diagnostics Pediatric

Interleukin 1 receptor-like 1 protein (ST2) is a potential biomarker for cardiomyopathy in Duchenne muscular dystrophy

Anderson, J et al.
Pediatr Cardiol 38(8): 1606-1612.
Cardiovascular Diagnostics Pediatric Neurobiology

Protein quantitative trait locus study in obesity during weight-loss identifies a leptin regulator

Carayol, J et al.
Nat Commun 8(1): 2084.
Metabolic Disease biology Diagnostics

A proteome-derived longitudinal pharmacodynamic biomarker for diffuse systemic sclerosis skin

Rice, LM et al.
J Invest Dermatol 137(1): 62-70.
Immunity Disease biology Diagnostics

Sexual dimorphism, age, and fat mass are key phenotypic drivers of proteomic signatures

Curran, AM et al.
J Proteome Res 16(11): 4122-4133.
Aging Disease biology Metabolic

Trisomy 21 causes changes in the circulating proteome indicative of chronic autoinflammation

Sullivan, KD et al.
Sci Rep 7(1): 14818.
Rare Disease biology

Assessment of variability in the SOMAscan assay

Candia, J et al.
Sci Rep 7(1):14248.
SomaScan Binding Review

Divergent roles for clusterin in lung injury and repair

Habiel, DM et al.
Sci Rep 7(1): 15444.
Respiratory Disease biology Fibrotic

A pilot characterization of the human chronobiome

Skarke, C et al.
Sci Rep 7(1):17141.
Metabolic Disease biology

Pharmacokinetic properties of DNA aptamers with base modifications

Gupta, S et al.
Nucleic Acid Ther 27(6): 345-353.
SomaScan Binding

Genome-wide quantitative trait loci mapping of the human cerebrospinal fluid proteome

Sasayama, D et al.
Hum Mol Genet 26(1): 44-51.
Neurobiology Disease biology Diagnostics

Identification of unique proteomic signatures in allergic and non-allergic skin disease

Wang, J et al.
Clin Exp Allergy 47(11): 1456-1467.
Inflammatory Disease biology Diagnostics

An immune clock of human pregnancy

Aghaeepour, N et al.
Sci Immunol 2(15):eaan2946.
Immunity Disease biology Reproductive

A degradation fragment of type X collagen is a real-time marker for bone growth velocity

Coghlan, RF et al.
Sci Transl Med 9(419): eaan4669.
Osteoporosis Disease biology Diagnostics

Large-scale proteomics identifies MMP-7 as a sentinel of epithelial injury and of biliary atresia

Lertudomphonwanit, C et al.
Sci Transl Med 9(417): eaan8462.
Pediatric Disease biology Diagnostics Target identification Rare

Proteomic profiles associated with early echocardiogram evidence of pulmonary vascular disease in preterm infants

Wagner, BD et al.
Am J Respir Crit Care Med 197(3): 394-397.
Cardiovascular Disease biology Pediatric

Antiinflammatory effects of aprepitant coadministration with cART regimen containing ritonavir in HIV-infected adults

Spitsin, S et al.
JCI Insight 2(19) 95893
Immunity Disease biology Infection Mechanism of action

The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimer’s pathology

Westwood, S et al.
Alzheimers Res Ther 9(1): 31.
Aging Disease biology Metabolic

High-throughput characterization of blood serum proteomics of IBD patients with respect to aging and genetic factors

Di Narzo, AF et al.
PLoS Genet 13(1): e1006565.
Aging Disease biology Inflammatory

Sequential inflammatory processes define human progression from M. tuberculosis infection to tuberculosis disease

Scriba, TJ et al.
PLoS Pathog 13(11): e1006687.
Infection Disease biology

Activation of inflammatory and pro-thrombotic pathways in acute stress cardiomyopathy

Fitzgibbons, TP et al.
Frontiers in Cardiovascular Medicine 4: 49.
Cardiovascular Disease biology Diagnostics

Discovery and validation of a six-marker serum protein signature for the diagnosis of active pulmonary tuberculosis

De Groote, MA et al.
J Clin Microbiol 55(10): 3057-3071.
Infection Diagnostics

Attenuated PDGF signaling drives alveolar and microvascular defects in neonatal chronic lung disease

Oak, P et al.
EMBO Mol Med 9(11): 1504-1520.
Respiratory Disease biology Diagnostics

GDF15 is a heart-derived hormone that regulates body growth

Wang, T et al.
EMBO Mol Med 9(8): 1150-1164.
Cardiovascular Disease biology Pediatric

The prediction of late-onset preeclampsia: Results from a longitudinal proteomics study

Erez, O et al.
PLoS One 12(7): e0181468.
Reproductive Disease biology Diagnostics

Diagnosis and prognosis-review of biomarkers for mesothelioma

Sun, HH et al.
Ann Transl Med 5(11): 244.
Respiratory Disease biology Diagnostics

Molecular-based diagnosis of multiple sclerosis and its progressive stage

Barbour, C et al.
Ann Neurol 82(5): 795-812.
Neurobiology Disease biology Diagnostics

Vitamin B12 deficiency and impaired expression of amnionless during aging

Pannerec, A et al.
J Cachexia Sarcopenia Muscle 9(1): 41-52.
Aging Disease biology

Connecting genetic risk to disease end points through the human blood plasma proteome

Suhre, K et al.
Nat Commun 8: 14357.
SomaScan Large-scale proteomics

Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms

Howson, JMM et al.
Nat Genet 49(7): 1113-1119.
Cardiovascular Disease biology

Plasma proteome analysis in patients with pulmonary arterial hypertension: an observational cohort study

Rhodes, CJ et al.
Lancet Respir Med 5(9): 717-726.
Cardiovascular Disease biology Target identification Respiratory Rare

Aptamer-based proteomic profiling for prognostication in pulmonary arterial hypertension

Giannitsis, E et al.
Lancet Respir Med 5(9): 671-672.
Cardiovascular Disease biology Target identification Respiratory Rare

Multiomic disease signatures converge to cytotoxic CD8 T cells in primary Sjogren’s syndrome

Tasaki, S et al.
Ann Rheum Dis 76(8): 1458-1466.
Immunity Disease biology Target identification

Efficacy of individualised diets in patients with irritable bowel syndrome: a randomised controlled trial

Ali A et al.
BMJ Open Gastro 4(1): e000164.
Inflammatory Disease biology

Identification of serum protein biomarkers for utrophin based DMD therapy

Guiraud, S et al.
Sci Rep 7: 43697.
Pediatric Disease biology Diagnostics Musculoskeletal

Selection of DNA aptamers with two modified bases

Gawande, BN et al.
Proc Natl Acad Sci U S A 114(11): 2898-2903.
SomaScan Binding

The maternal plasma proteome changes as a function of gestational age in normal pregnancy: a longitudinal study

Romero, R et al.
Am J Obstet Gynecol 217(1):67 e61-67 e21.
Reproductive Disease biology Diagnostics

Proteomic study of hepatocellular carcinoma using a novel modified aptamer-based array (SOMAscan) platform

Qiao, Z et al.
Biochim Biophys Acta 1865(4): 434-443.
Oncology Disease biology Diagnostics Rare

Development of a protein biomarker panel to detect non-small-cell lung cancer in Korea

Jung, YJ et al.
Clin Lung Cancer 18(2): e99-e107.
Oncology Diagnostics

The relationship of circulating proteins in early pregnancy with preterm birth

Lynch, AM et al.
Am J Obstet Gynecol 214(4): 517 e511-518.
Reproductive Disease biology Diagnostics

Identification of definitive serum biomarkers associated with disease activity in primary Sjögren’s syndrome

Nishikawa, A et al.
Arthritis Res Ther 18(1): 106.
Immunity Disease biology Diagnostics Target identification

Identification of pathway-specific serum biomarkers of response to glucocorticoid and infliximab treatment in children with inflammatory bowel disease

Heier, CR et al.
Clin Transl Gastroenterol 7(9): e192.
Inflammatory Disease biology Mechanism of action Pediatric

Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice

Lukjanenko, L et al.
Nat Med 22(8): 897-905.
Aging Disease biology Musculoskeletal

Serum pharmacodynamic biomarkers for chronic corticosteroid treatment of children

Hathout, Y et al.
Sci Rep 6: 31727.
Inflammatory Disease biology Diagnostics Pediatric

A cross sectional study of two independent cohorts identifies serum biomarkers for facioscapulohumeral muscular dystrophy (FSHD)

Petek, LM et al.
Neuromuscul Disord 26(7): 405-413.
Musculoskeletal Disease biology Diagnostics

Chemically modified interleukin-6 aptamer inhibits development of collagen-induced arthritis in cynomolgus monkeys

Hirota, M et al.
Nucleic Acid Ther 26(1): 10-19.
Immunity Disease biology Target identification Target validation mechanism of action Binding

Fit for the eye: aptamers in ocular disorders

Drolet, DW et al.
Nucleic Acid Ther 26(3): 127-146.
Ocular Disease biology Diagnostics Target identification Mechanism of action PK/PD

readat: an R package for reading and working with SomaLogic ADAT files

Cotton, RJ et al.
BMC Bioinformatics 17(1): 201.

Respiratory mucosal proteome quantification in human influenza infections

Marion, T et al.
PLoS One 11(4): e0153674.
Infection Disease biology

Six-SOMAmer index relating to immune, protease and angiogenic functions predicts progression in IPF

Ashley, SL et al.
PLoS One 11(8): e0159878.
Respiratory Disease biology Diagnostics Fibrotic

Longitudinal protein changes in blood plasma associated with the rate of cognitive decline in Alzheimer’s disease

Sattlecker, M et al.
J Alzheimers Dis 49(4): 1105-1114.
Aging Disease biology Target identification

An evaluation of an aptamer for use as an affinity reagent with MS: PCSK9 as an example protein

Gupta, V et al.
Bioanalysis 8(15): 1557-1564.
SomaScan Binding

Developing clinically relevant biomarkers in inflammatory arthritis: A multiplatform approach for serum candidate protein discovery

McArdle, A et al.
Proteomics Clin Appl 10(6): 691-698.
Immunity Disease biology Diagnostics

The relationship of novel plasma proteins in the early neonatal period with retinopathy of prematurity

Lynch, AM et al.
Invest Ophthalmol Vis Sci 57(11): 5076-5082.
Pediatric Disease biology Diagnostics

Embracing proteins: structural themes in aptamer-protein complexes

Gelinas, AD et al.
Curr Opin Struct Biol 36: 122-132.
SomaScan Structure Binding

Clinical utility of serum biomarkers in Duchenne muscular dystrophy.

Hathout, Y et al.
Clin Proteomics 13: 9.
Rare Review

SELEX: How it happened and where it will go

Gold, L
J Mol Evol 81(5-6): 140-143.

Non-helical DNA triplex forms a unique aptamer scaffold for high affinity recognition of nerve growth factor

Jarvis, TC et al.
Structure 23(7): 1293-1304.
SomaScan Structure Binding

Increased cerebrospinal fluid fibrinogen in major depressive disorder

Hattori, K et al.
Sci Rep 5: 11412.
Neurobiology Disease biology

Large-scale serum protein biomarker discovery in Duchenne muscular dystrophy

Hathout, Y et al.
Proc Natl Acad Sci U S A 112(23): 7153-7158.
Pediatric Disease biology Diagnostics Target identification Musculoskeletal Rare

Practical synthesis of cytidine-5-carboxamide-modified nucleotide reagents

Rohloff, JC et al.
Nucleosides Nucleotides Nucleic Acids 34(3): 180-198.

Influence of 5-N-carboxamide modifications on the thermodynamic stability of oligonucleotides

Wolk, SK et al.
Nucleic Acids Res 43(19): 9107-9122.
SomaScan Binding

Improved preparation of 2 M triethylammonium bicarbonate

Carlson, M et al.
Green Chem Lett Rev 8(3-4): 37-39.

Proteomic methods for biomarker discovery and validation. Are we there yet?

Hathout, Y (2015)
Expert Rev Proteomics 12(4): 329-331.

Circulating proteomic signatures of chronological age

Menni, C et al.
J Gerontol A Biol Sci Med Sci 70(7): 809-816.
Aging Disease biology Diagnostics

A candidate plasma protein classifier to identify Alzheimer’s disease.

Zhao, X et al.
J Alzheimers Dis 43(2): 549-563.

Aptamer-based proteomic signature of intensive phase treatment response in pulmonary tuberculosis

Nahid, P et al.
Tuberculosis (Edinb) 94(3): 187-196.
Infection Stratification Diagnostics

Crystal structure of interleukin-6 in complex with a modified nucleic acid ligand

Gelinas, AD et al.
J Biol Chem 289(12): 8720-8734.
SomaScan Structure Binding

Proteomics analysis of cancer exosomes using a novel modified aptamer-based array (SOMAscan™) platform

Webber, J et al.
Mol Cell Proteomics 13(4): 1050-1064.
Oncology Diagnostics Exosomes

DTC-and-me: patient, provider, proteins and regulators.

Steele, FR et al.
J Pers Med 4(1): 79-87.

Beyond antibodies: new affinity reagents to unlock the proteome.

Lollo, B et al.
Proteomics 14(6): 638-644.
SomaScan Binding

Methylation potential associated with diet, genotype, protein, and metabolite levels in the Delta Obesity Vitamin Study

Monteiro, JP et al.
Genes Nutr 9(3): 403.
Metabolic Disease biology Diagnostics

Genetic associations with micronutrient levels identified in immune and gastrointestinal networks

Morine, MJ et al.
Genes Nutr 9(4): 408.
Metabolic Disease biology

Nucleic acid ligands with protein-like side chains: Modified aptamers and their use as diagnostic and therapeutic agents

Rohloff, JC et al.
Mol Ther Nucleic Acids 3:e201.
SomaScan Binding Review Clinical

Specific capture and detection of Staphylococcus aureus with high-affinity modified aptamers to cell surface components

Baumstummler, A et al.
Lett Appl Microbiol 59(4): 422-431.
Infection Diagnostics

Validation of a blood protein signature for non-small cell lung cancer

Mehan, MR et al.
Clin Proteomics 11(1): 32.
Oncology Diagnostics

Systematic selection of modified aptamer pairs for diagnostic sandwich assays

Ochsner, UA et al.
Biotechniques 56(3): 125-128, 130, 132-133.
Cardiovascular Diagnostics Infection SomaScan Binding

Candidate blood proteome markers of Alzheimer’s disease onset and progression: a systematic review and replication study

Kiddle, SJ et al.
J Alzheimers Dis 38(3): 515-531.
Aging Disease biology Diagnostics Stratification

Alzheimer’s disease biomarker discovery using SOMAscan multiplexed protein technology

Sattlecker, M et al.
Alzheimers Dement 10(6): 724-734.
Aging Disease biology Diagnostics

Detection of Clostridium difficile toxins A, B and binary toxin with slow off-rate modified aptamers

Ochsner, UA et al.
Diagn Microbiol Infect Dis 76(3): 278-285.
Infection Diagnostics Binding

Elucidating novel serum biomarkers associated with pulmonary tuberculosis treatment

De Groote, MA et al.
PLoS One 8(4): e61002.
Infection Disease biology Diagnostics

Interaction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondin

Xie, Y et al.
EMBO Rep 14(12): 1120-1126.
Oncology Disease biology SomaScan

Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy

Loffredo, FS et al.
Cell 153(4): 828-839.
Cardiovascular Disease biology Diagnostics

Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets

Davies, DR et al.
Proc Natl Acad Sci U S A 109(49): 19971-19976.
SomaScan Structure Binding

Aptamers and the RNA world, past and present

Gold, L et al.
Cold Spring Harb Perspect Biol 4(3).

Life’s simple measures: unlocking the proteome

Brody, E et al.
J Mol Biol 422(5):595-606.

Protein signature of lung cancer tissues

Mehan, MR et al.
PLoS One 7(4): e35157.
Oncology Disease biology Diagnostics Target identification

Age-dependent changes in the cerebrospinal fluid proteome by slow off-rate modified aptamer array

Baird, GS et al.
Am J Pathol 180(2): 446-456.
Aging Disease biology Diagnostics Neurobiology

Rapid histochemistry using slow off-rate modified aptamers with anionic competition

Gupta, S et al.
Appl Immunohistochem Mol Morphol 19(3): 273-278.
SomaScan Binding

Unlocking biomarker discovery: large scale application of aptamer proteomic technology for early detection of lung cancer

Ostroff, RM et al.
PLoS One 5(12): e15003.
Oncology Disease biology Diagnostics

Aptamer-based multiplexed proteomic technology for biomarker discovery

Gold, L et al.
PLoS One 5(12): e15004.

High-content affinity-based proteomics: unlocking protein biomarker discovery

Brody, EN et al.
Expert Rev Mol Diagn 10(8): 1013-1022.

Expanding the chemistry of DNA for in vitro selection

Vaught, JD et al.
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