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Current Publications Count: 427
Large-scale integration of the plasma proteome with genetics and disease
Nat Genet 53(12): 1712-1721
Mapping the proteo-genomic convergence of human diseases
Science 374(6569): eabj1541
A brain proteomic signature of incipient Alzheimer's disease in young APOE epsilon4 carriers identifies novel drug targets
Sci Adv 7(46): eabi8178.
Plasma protein patterns as comprehensive indicators of health
Nat Med 25(12): 1851-1857.
Undulating changes in human plasma proteome profiles across the lifespan
Nat Med 25(12): 1843-1850
Co-regulatory networks of human serum proteins link genetics to disease
Science 361(6404): 769-773.
Genomic atlas of the human plasma proteome
Nature 558: 73-79.
Improving assessment of drug safety through proteomics: early detection and mechanistic characterization of the unforeseen harmful effects of torcetrapib
Circulation 137(10): 999-1010.
Genetic architecture of the cardiovascular risk proteome
Circulation 137(11): 1158-1172.
Development and validation of a protein-based risk score for cardiovascular outcomes among patients with stable coronary heart disease
JAMA 315(23): 2532-2541.
Using aptamer-based technology to probe the plasma proteome for cardiovascular disease prediction
JAMA 315(23): 2525-2526.
Aptamer-based proteomic profiling reveals novel candidate biomarkers and pathways in cardiovascular disease
Circulation 134(4): 270-285.
Clinically Relevant Circulating Protein Biomarkers for Type 1 Diabetes: Evidence From a Two-Sample Mendelian Randomization Study
Diabetes Care 45(1): 169-177
High-throughput mediation analysis of human proteome and metabolome identifies mediators of post-bariatric surgical diabetes control
Nat Commun 12(1): 6951
Whole Genome Sequence Analysis of the Plasma Proteome in Black Adults Provides Novel Insights into Cardiovascular Disease
Circulation, epub ahead of print
Exercise plasma boosts memory and dampens brain inflammation via clusterin
Nature 600(7889): 494-499
Cross-validation of SARS-CoV-2 responses in kidney organoids and clinical populations
JCI Insight, epub ahead of print
Proteomics and Risk of Atrial Fibrillation in Older Adults (From the Atherosclerosis Risk in Communities [ARIC] Study)
Am J Cardiol 161: 42-50
Synergistic insights into human health from aptamer- and antibody-based proteomic profiling
Nat Commun 12(1): 6822
Identification of blood-based biomarkers for diagnosis and prognosis of Parkinson's disease: A Systematic review of proteomics studies
Ageing Res Rev: 101514
The Use of ‘Omics for Diagnosing and Predicting Progression of Chronic Kidney Disease: A Scoping Review
Front Genet 12: 682929
Proteome-wide associations with short- and long-term weight loss and regain after Roux-en-Y gastric bypass surgery
Obesity (Silver Spring), epub ahead of print
Blood Levels of the SMOC1 Hepatokine Are Not Causally Linked with Type 2 Diabetes: A Bidirectional Mendelian Randomization Study
Nutrients 13(12): 4208
Plasma Proteomics of Renal Function: A Trans-ethnic Meta-analysis and Mendelian Randomization Study
J Am Soc Nephrol. 32(7): 1747-1763
Proteomic Approaches to Defining Remission and the Risk of Relapse in Rheumatoid Arthritis
Front Immunol 12: 729681
Discovery of Novel Proteomic Biomarkers for the Prediction of Kidney Recovery from Dialysis-Dependent AKI Patients
Kidney360 2(11): 1716-1727
Proteomic analysis of serum in workers exposed to diesel engine exhaust
Environ Mol Mutagen, epub ahead of print.
A Combined Proteomics and Mendelian Randomization Approach to Investigate the Effects of Aspirin-Targeted Proteins on Colorectal Cancer
Cancer Epidemiol Biomarkers Prev 30(3): 564-575
Heat Shock-Related Protein Responses and Inflammatory Protein Changes Are Associated with Mild Prolonged Hypoglycemia
Cells 10: 3109
Hypoglycemia-induced changes in complement pathways in type 2 diabetes
Atherosclerosis Plus 46: 35-45
Multi-omic analysis in injured humans: Patterns align with outcomes and treatment responses
Cell Rep Med 2: 100478
Large-scale plasma proteomics can reveal distinct endotypes in chronic obstructive pulmonary disease and severe asthma
Clin Transl Allergy 11(10): e12091
Serum Proteomics Uncovers Biomarkers of Clinical Portal Hypertension in Children With Biliary Atresia
Hepatol Commun, epub ahead of print.
Integrated Multi-Omics for Novel Aging Biomarkers and Antiaging Targets
Biomolecules 12: 39
Cellular and plasma proteomic determinants ofCOVID-19 and non-COVID-19 pulmonary diseases relative to healthy aging.
Nat Aging 1: 535–549.
Predicting the probability of death using proteomics.
Commun Biol 4(1): 758.
Large-scale plasma proteomic analysis
identifies proteins and pathways associated with dementia risk.
Nat Aging 1: 473-489.
Human plasma proteomic profiles indicative of cardiorespiratory fitness.
Nat Metab 3(6): 786-797.
The Plasma Proteome Fingerprint Associated With Circulating Carotenoids And Retinol In Older Adults
J Nutr, epub ahead of print
Group IIA secreted phospholipase A2 is associated with the pathobiology leading to COVID-19 mortality
J Clin Invest, epub ahead of print
Discovery and validation of a novel subgroup and therapeutic target in idiopathic multicentric Castleman disease
Blood Adv 5(17): 3445-3456
Influence of renin-angiotensin-aldosterone system inhibitors on plasma levels of angiotensin-converting enzyme 2
ESC Heart Fail 8(2): 1717-1721
Identification of plasma proteins relating to brain neurodegeneration and vascular pathology in cognitively normal individuals
Alzheimers Dement (Amst) 13(1): e12240.
Proteomic Biomarker Analysis of Serum from Japanese Field Mice (Apodemus Speciosus) Collected within the Fukushima Difficult-to-return Zone
Health Phys 121(6): 564-573
Advances and Utility of the Human Plasma Proteome
J Proteome Res 20(12): 5241-5263
Integrated plasma proteomics and lung transcriptomics reveal novel biomarkers in idiopathic pulmonary fibrosis
Respir Res 22(1): 273
Towards Building a Quantitative Proteomics Toolbox in Precision Medicine: A Mini-Review
Front Physiol 12: 723510.
Vitamin D association with the renin angiotensin system in polycystic ovary syndrome
J Steroid Biochem Mol Biol 214: 105965.
Polygenic Risk Scores for Kidney Function and Their Associations with Circulating Proteome, and Incident Kidney Diseases
J Am Soc Nephrol 32(12): 3161-3173
The proteomic signature of recombinant Growth Hormone in recreational athletes
J Endocrine Soc, epub ahead of print
Distinct Molecular Signatures of Clinical Clusters in People With Type 2 Diabetes: An IMI-RHAPSODY Study
Diabetes 70(11): 2683-2693.
Dysregulated expression levels of APH1B in peripheral blood are associated with brain atrophy and amyloid-beta deposition in Alzheimer's disease
Alzheimers Res Ther 13(1): 183.
Genetically Predicted Glucose-Dependent Insulinotropic Polypeptide (GIP) Levels and Cardiovascular Disease Risk Are Driven by Distinct Causal Variants in the GIPR Region
Diabetes 70(11): 2706-2719.
Ultrasensitive detection of blood biomarkers of Alzheimer's and Parkinson's diseases: a systematic review
Biomark Med 15(17): 1693-1708.
Advances in Aptamer-Based Biomarker Discovery.
Front Cell Dev Biol 9: 659760.
Replication study of plasma proteins relating to Alzheimer's pathology.
Alzheimers Dement, epub ahead of print.
Platelet Protein-Related Abnormalities in Response to Acute Hypoglycemia in Type 2 Diabetes.
Front Endocrinol (Lausanne) 12: 651009.
Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19.
Nat Med 27(4): 668-676.
Broadly effective metabolic and immune recovery with C5 inhibition in CHAPLE disease."
Nat Immunol 22(2): 128-139.
Association of endopeptidases, involved in SARS-CoV-2 infection, with microbial aggravation in sputum of severe asthma.
Allergy 76(6): 1917-1921.
Age-associated difference in circulating ACE2, the gateway for SARS-COV-2, in humans: results from the InCHIANTI study.
Geroscience 43(2): 619-627.
A proteome-wide genetic investigation identifies several SARS-CoV-2-exploited host targets of clinical relevance.
Elife 10: e69719.
Longitudinal proteomic analysis of severe COVID-19 reveals survival-associated signatures, tissue-specific cell death, and cell-cell interactions.
Cell Rep Med 2(5): 100287.
Multi-omics highlights ABO plasma protein as a causal risk factor for COVID-19.
Hum Genet 140(6): 969-979
BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection.
Cell 184(8): 2167-2182 e2122
Soluble Neuropilin-1 Response to Hypoglycemia in Type 2 Diabetes: Increased Risk or Protection in SARS-CoV-2 Infection?
Front Endocrinol (Lausanne) 12: 665134
Type 2 Diabetes Coagulopathy Proteins May Conflict With Biomarkers Reflective of COVID-19 Severity.
Front Endocrinol (Lausanne) 12: 658304
Letter to the Editor: Pro-fibrotic M2 macrophage markers may increase the risk for COVID19 in type 2 diabetes with obesity.
Metabolism 112: 154374
Vitamin D Association With Macrophage-Derived Cytokines in Polycystic Ovary Syndrome: An Enhanced Risk of COVID-19 Infection?
Front Endocrinol (Lausanne) 12: 638621
Using ‘big data’ to disentangle aging and COVID-19."
Aging 1: 496–497.
The COVIDome Explorer researcher portal.
Cell Rep 36(7): 109527.
A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity.
Nat Med 27(4): 659-667.
Early Interleukin-22 and Neutrophil Proteins Are Correlated to Future Lung Damage in Children with Cystic Fibrosis." "
Front Pediatr 9: 640184.
Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children." "
Immunity 54(5): 1083-1095 e1087.
Plasma protein expression profiles, cardiovascular disease, and religious struggles among South Asians in the MASALA study
Sci Rep. 2021 Jan 13;11(1):961
Protein signatures of centenarians and their offspring suggest centenarians age slower than other humans
Aging Cell. 2021 Jan 29:e13290
Identification and Validation of Nutrient State-Dependent Serum Protein Mediators of Human CD4(+) T Cell Responsiveness.
Nutrients 13(5).
Effect of longevity genetic variants on the molecular aging rate.
Geroscience 43(3): 1237-1251.
Novel Murine Biomarkers of Radiation Exposure Using An Aptamer-Based Proteomic Technology.
Front Pharmacol 12: 633131.
The CRTAC1 protein in plasma associates with osteoarthritis and predicts progression to joint replacements: a large-scale proteomics scan in Iceland.
Arthritis Rheumatol, epub ahead of print.
Plasma Proteomic Profile Predicts Survival in Heart Failure with Reduced Ejection Fraction.
Circ Genom Precis Med 14(3): e003140.
Multi-Omic Profiling in Black and White Populations Reveals Novel Candidate Pathways in Left Ventricular Hypertrophy and Incident Heart Failure Specific to Black Adults.
Circ Genom Precis Med 14(3): e003191.
Proteomic signatures of inflammatory skin diseases: a focus on atopic dermatitis.
Expert Rev Proteomics: 1-17.
Metabolic syndrome and the plasma proteome: from association to causation.
Cardiovasc Diabetol 20(1): 111.
Serum Proteomics and Plasma Fibulin-3 in Differentiation of Mesothelioma from Asbestos-Exposed Controls and Patients with Other Pleural Diseases.
J Thorac Oncol 16(10): 1705-1717.
Identification and Evaluation of Serum Protein Biomarkers Which Differentiate Psoriatic from Rheumatoid Arthritis.
Arthritis Rheumatol, epub ahead of print.
Proteome-Wide Analysis using SOMAscan Identifies and Validates Chitinase-3-Like Protein 1 as a Risk and Disease Marker of Delirium Among Older Adults Undergoing Major Elective Surgery
J Gerontol A Biol Sci Med Sci. 2021 Feb 4:glaa326
Identification of Plasma Proteome Signatures Associated With Surgery Using SOMAscan
Ann Surg 273(4): 732-742.
Proteomic Signatures of Lifestyle Risk Factors for Cardiovascular Disease: A Cross‐Sectional Analysis of the Plasma Proteome in the Framingham Heart Study
J Am Heart Assoc. 2021 Jan 5;10(1)
Association of a Serum Protein Signature With Rheumatoid Arthritis Development
Arthritis Rheumatol. 73(1): 78-88.
Inhibition of the Complement Alternative Pathway by Chemically Modified DNA Aptamers That Bind with Picomolar Affinity to Factor B
J Immunol 206(4): 861-873.
Genetics meets proteomics: perspectives for large population-based studies
Nat Rev Genet 22(1): 19-37.
Circulating markers of NADH-reductive stress correlate with mitochondrial disease severity
J Clin Invest 131(2): e136055
Evaluating the effects of cardiometabolic exposures on circulating proteins which may contribute to severe SARS-CoV-2.
EBioMedicine 64: 103228.
A replication-competent adenovirus-vectored influenza vaccine induces durable systemic and mucosal immunity
J Clin Invest 131(5)
Revealing the role of the human blood plasma proteome in obesity using genetic drivers
Nat Commun 12(1): 1279
Plasma Proteomic Profiling in Hypertrophic Cardiomyopathy Patients before and after Surgical Myectomy Reveals Post-Procedural Reduction in Systemic Inflammation
Int J Mol Sci 22(5): 2474
Quantitative Proteomic Analysis of Diabetes Mellitus in Heart Failure With Preserved Ejection Fraction
JACC Basic Transl Sci 6(2): 89-99.
Proteomics in aging research: A roadmap to clinical, translational research
Aging Cell: e13325.
Blood biomarker discovery for autism spectrum disorder: A proteomic analysis
PLoS One 16(2): e0246581.
Biomarker-focused multi-drug combination therapy and repurposing trial in mdx mice
PLoS One 16(2): e0246507
In-Depth Analysis of the Plasma Proteome in ME/CFS Exposes Disrupted Ephrin-Eph and Immune System Signaling
Proteomes 9(1): 6
A meta-analysis uncovers the first sequence variant conferring risk of Bell's palsy
Sci Rep 11(1): 4188
Plasma proteins, cognitive decline, and 20-year risk of dementia in the Whitehall II and Atherosclerosis Risk in Communities studies.
Alzheimers Dement., epub ahead of print
Cognitive stimulation in the workplace, plasma proteins, and risk of dementia: three analyses of population cohort studies.
BMJ 374: n1804.
Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders.
Nat Neurosci. 24: 1302–1312
An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging.
Nat Aging 1, 598–615.
Effects of adiposity on the human plasma proteome: observational and Mendelian randomisation estimates.
Int J Obes (Lond) 45: 2221-2229.
New candidate blood biomarkers potentially associated with white matter hyperintensities progression.
Sci Rep 11(1): 14324.
DNA Damage, n-3 Long-Chain PUFA Levels and Proteomic Profile in Brazilian Children and Adolescents.
Nutrients 2021, 13, 2483.
Comparison of proteomic methods in evaluating biomarker-AKI associations in cardiac surgery patients.
Transl Res 238: 49-62.
Pediatric and adult dilated cardiomyopathy are distinguished by distinct biomarker profiles.
Pediatr Res., epub ahead of print.
Smoking induces sex-specific changes in the small airway proteome.
Respir Res 22(1): 234.
Validation of Chemokine Biomarkers in Duchenne Muscular Dystrophy.
Life (Basel) 11(8): 827.
Serum Proteomics of Older Patients Undergoing Major Cardiac Surgery: Identification of Biomarkers Associated with Postoperative Delirium.
Front Aging Neurosci 13: 699763.
Slow Off-Rate Modified Aptamer (SOMAmer) Proteomic Analysis of Patient-Derived Malignant Glioma Identifies Distinct Cellular Proteomes.
Int J Mol Sci 22(17).
Evolving a RIG-I antagonist: a modified DNA aptamer mimics viral RNA.
J Mol Biol. 433(21): 167227.
Serum levels of ACE2 are higher in patients with obesity and diabetes.
Obes Sci Pract 7(2): 239-243.
Functional Network Profiles in ARSACS Disclosed by Aptamer-Based Proteomic Technology
Front Neurol 11: 603774.
An Approach to Biomarker Discovery of Cannabis Use Utilizing Proteomic, Metabolomic, and Lipidomic Analyses.
Cannabis Cannabinoid Res, epub ahead of print.
Atopic Dermatitis Endotypes Based on Allergen Sensitization, Reactivity to Staphylococcus aureus Antigens, and Underlying Systemic Inflammation
J Allergy Clin Immunol Pract. 8(1): 236-247.e3.
Joint fluid proteome after anterior cruciate ligament rupture reflects an acute posttraumatic inflammatory and chondrodegenerative state
Cartilage 11(3) 329
Vascular Disease and Thrombosis in SARS-CoV-2-Infected Rhesus Macaques
Cell. 2020, 183, 1354–1366
Genetic architecture of host proteins involved in SARS-CoV-2 infection
Nat Commun. 2020; 11: 6397
Platelet-derived growth factor BB: A potential diagnostic blood biomarker for differentiating bipolar disorder from major depressive disorder
J Psychiatr Res. 2020 Dec 21;134:48-56.
Activity of ibrutinib plus R-CHOP in diffuse large B-cell lymphoma: Response, pharmacodynamic, and biomarker analyses of a phase Ib study
Cancer Treatment Res Commun 25: 100235
Identification of Potential Serum Protein Biomarkers and Pathways for Pancreatic Cancer Cachexia Using an Aptamer-Based Discovery Platform
Cancers (Basel). 2020 Dec 15;12(12):E3787
A Plasma Proteomic Signature of Skeletal Muscle Mitochondrial Function
Int J Mol Sci. 2020 Dec 15;21(24):E9540
Coronary Artery Disease and Type 2 Diabetes: A Proteomic Study
Diabetes Care. 2020 Apr;43(4):843-851
Novel Insights Into the Effects of Interleukin 6 Antagonism in Non-ST-Segment-Elevation Myocardial Infarction Employing the SOMAscan Proteomics Platform
J Am Heart Assoc. 2020 Jun 16;9(12):e015628
Colchicine's effects on metabolic and inflammatory molecules in adults with obesity and metabolic syndrome: results from a pilot randomized controlled trial
Int J Obes (Lond). 2020 Aug;44(8):1793-1799
Comparison of Proteomic Assessment Methods in Multiple Cohort Studies
Proteomics. 2020 Jun;20(12):e1900278
Reduced Apolipoprotein M and Adverse Outcomes Across the Spectrum of Human Heart Failure
Circulation. 2020 May 5;141(18):1463-1476
Highly multiplexed proteomic assessment of human bone marrow in acute myeloid leukemia
Blood Adv. 2020 Jan 28;4(2):367-379
Plasma proteomic profile of frailty
Aging Cell. 2020 Sep;19(9):e13193
Serum protein biomarkers for juvenile dermatomyositis: a pilot study
BMC Rheumatol. 2020 Oct 1;4:52
Proteomic biomarkers of sleep apnea
Sleep. 2020 Nov 12;43(11):zsaa086
Early angiogenic proteins associated with high risk for bronchopulmonary dysplasia and pulmonary hypertension in preterm infants
Am J Physiol Lung Cell Mol Physiol. 2020 Apr 1;318(4):L644-L654
Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis
Sci Transl Med. 2020 Dec 2;12(572):eaba4448
Autophagy Modulators Profoundly Alter the Astrocyte Cellular Proteome
Cells. 2020 Mar 26;9(4):805
Impact of Kidney Function on the Blood Proteome and on Protein Cardiovascular Risk Biomarkers in Patients With Stable Coronary Heart Disease
J Am Heart Assoc. 2020 Aug 4;9(15):e016463
Proteomic Signatures of Heart Failure in Relation to Left Ventricular Ejection Fraction
J Am Coll Cardiol. 2020 Oct 27;76(17):1982-1994
"Proteomic and Metabolomic Correlates of Healthy Dietary Patterns: The Framingham Heart Study"" Nutrients"
Nutrients. 2020 May 19;12(5):1476
Plasma proteomic profile of age, health span, and all-cause mortality in older adults
Aging Cell. 2020 Nov;19(11):e13250
Renin-Angiotensin System overactivation in polycystic ovary syndrome, a risk for SARS-CoV-2 infection?
Metabol Open. 2020 Sep;7:100052
ZIKV Infection Induces DNA Damage Response and Alters the Proteome of Gastrointestinal Cells
Viruses. 2020 Jul 17;12(7):771
Plasma proteomic signature of the risk of developing mobility disability: A 9-year follow-up
Aging Cell. 2020 Apr;19(4):e13132
Comparison of Serum Pharmacodynamic Biomarkers in Prednisone-Versus Deflazacort-Treated Duchenne Muscular Dystrophy Boys
J Pers Med. 2020 Oct 12;10(4):164
Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer's Disease Pathology
J Alzheimers Dis. 2020;77(3):1353-1368
Clinical and Proteomic Correlates of Plasma ACE2 (Angiotensin-Converting Enzyme 2) in Human Heart Failure
Hypertension. 2020 Nov;76(5):1526-1536
Protein biomarkers for incident deep venous thrombosis in critically ill adolescents: An exploratory study
Pediatr Blood Cancer. 2020 Apr;67(4):e28159
Aptamer based proteomic pilot study reveals a urine signature indicative of pediatric urinary tract infections
PLoS One. 2020 Jul 6;15(7):e0235328
Increased Levels of Coagulation Factor XI in Plasma Are Related to Alzheimer's Disease Diagnosis
J Alzheimers Dis. 2020;77(1):375-386
Evaluation of a novel blood microsampling device for clinical trial sample collection and protein biomarker analysis
Bioanalysis. 2020 Jul;12(13):919-935
Serum biomarkers associated with baseline clinical severity in young steroid-naïve Duchenne muscular dystrophy boys
Hum Mol Genet. 2020 Aug 29;29(15):2481-2495
Zika virus dysregulates human Sertoli cell proteins involved in spermatogenesis with little effect on tight junctions
PLoS Negl Trop Dis. 2020 Jun 8;14(6):e0008335
Proteomic profiling of HTLV-1 carriers and ATL patients reveals sTNFR2 as a novel diagnostic biomarker for acute ATL
Blood Adv. 2020 Mar 24;4(6):1062-1071
Metabolic profiling shows pre-existing mitochondrial dysfunction contributes to muscle loss in a model of ICU-acquired weakness
J Cachexia Sarcopenia Muscle. 2020 Oct;11(5):1321-1335
Mechanisms of Sodium-Glucose Cotransporter 2 Inhibition: Insights From Large-Scale Proteomics
Diabetes Care. 2020 Sep;43(9):2183-2189
Targeting myostatin/activin A protects against skeletal muscle and bone loss during spaceflight
Proc Natl Acad Sci U S A. 2020 Sep 22;117(38):23942-23951
Multimodal immune phenotyping of maternal peripheral blood in normal human pregnancy
JCI Insight. 2020 Apr 9;5(7):e134838
Effect of induced hypoglycemia on inflammation and oxidative stress in type 2 diabetes and control subjects
Sci Rep. 2020 Mar 16;10(1):4750
Plasma Biomarkers of Reticular Pseudodrusen and the Risk of Progression to Advanced Age-Related Macular Degeneration
Transl Vis Sci Technol. 2020 Sep 11;9(10):12
Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits.
Nat Commun 11(1): 15.
Modified nucleotides may have enhanced early RNA catalysis.
Proc Natl Acad Sci U S A 117(15): 8236-8242.
The Evolution of the Cardiovascular Biomarker Study.
Circulation 142(15): 1422-1424.
Integrative phenotyping of glycemic responders upon clinical weight loss using multi-omics.
Sci Rep 10(1): 9236.
Comprehensive aptamer-based screening identifies a spectrum of urinary biomarkers of lupus nephritis across ethnicities.
Nat Commun 11(1): 2197.
Causal association between mTOR-dependent EIF-4E and EIF-4A circulating protein levels and type 2 diabetes: a Mendelian randomization study.
Sci Rep 10(1): 15737.
Using the circulating proteome to assess type I interferon activity in systemic lupus erythematosus.
Sci Rep 10(1): 4462.
Serum Protein Changes in Pediatric Sepsis Patients Identified With an Aptamer-Based Multiplexed Proteomic Approach.
Crit Care Med 48(1): e48-e57.
Placenta accreta spectrum: biomarker discovery using plasma proteomics.
Am J Obstet Gynecol 223(3): 433 e431-433 e414.
A fully joint Bayesian quantitative trait locus mapping of human protein abundance in plasma.
PLoS Comput Biol 16(6): e1007882.
Type I IFN response associated with mTOR activation in the TAFRO subtype of idiopathic multicentric Castleman disease.
JCI Insight 5(9)
Intense light as anticoagulant therapy in humans.
PLoS One 15(12): e0244792.
Identification of a unique temporal signature in blood and BAL associated with IPF progression.
Sci Rep 10(1): 12049.
Modified aptamers as reagents to characterize recombinant human erythropoietin products.
Sci Rep 10(1): 18593.
Single-Molecule Super-Resolution Microscopy Reveals Heteromeric Complexes of MET and EGFR upon Ligand Activation.
Int J Mol Sci 21(8)
An expanded repertoire of intensity-dependent exercise-responsive plasma proteins tied to loci of human disease risk.
Sci Rep 10(1): 10831.
Circulating Protein Signatures and Causal Candidates for Type 2 Diabetes.
Diabetes 69(8): 1843-1853.
Aptamers and Antisense Oligonucleotides for Diagnosis and Treatment of Hematological Diseases.
Int J Mol Sci 21(9): 3252.
Proteomics for personalized cardiovascular risk assessment: in pursuit of the Holy Grail.
Eur Heart J 41(41): 4008-4010.
Chemical Modification of Aptamers for Increased Binding Affinity in Diagnostic Applications: Current Status and Future Prospects.
Int J Mol Sci 21(12)
Prioritizing Candidates of Post-Myocardial Infarction Heart Failure Using Plasma Proteomics and Single-Cell Transcriptomics
Circulation 142(15): 1408-1421.
Increased mTOR activation in idiopathic multicentric Castleman disease.
Blood 135(19): 1673-1684.
Elevated Plasma Growth and Differentiation Factor 15 Is Associated With Slower Gait Speed and Lower Physical Performance in Healthy Community-Dwelling Adults.
J Gerontol A Biol Sci Med Sci 75(1): 175-180.
High-Throughput Identification of the Plasma Proteomic Signature of Inflammatory Bowel Disease.
J Crohns Colitis 13(4): 462-471.
Transcatheter aortic valve replacements alter circulating serum factors to mediate myofibroblast deactivation
Science Translational Medicine Volume 11 (509) 2019 eaav3233
Accelerating Biomarker Discovery Through Electronic Health Records, Automated Biobanking, and Proteomics.
J Am Coll Cardiol 73(17): 2195-2205.
Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria.
Nat Commun 10(1): 4130.
Blood proteome profiling using aptamer-based technology for rejection biomarker discovery in transplantation.
Sci Data 6(1): 314.
A signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes.
Nat Med 25(5): 805-813.
Beyond Autoantibodies: Biologic Roles of Human Autoreactive B Cells in Rheumatoid Arthritis Revealed by RNA-Sequencing.
Arthritis Rheumatol 71(4): 529-541.
Comparison of Urine and Plasma Biomarker Concentrations Measured by Aptamer-Based versus Immunoassay Methods in Cardiac Surgery Patients.
J Appl Lab Med 4(3): 331-342.
Identifying and targeting pathogenic PI3K/AKT/mTOR signaling in IL-6-blockade-refractory idiopathic multicentric Castleman disease.
J Clin Invest 129(10): 4451-4463.
Predicting health and life span with the deep plasma proteome.
Nat Med 25(12): 1815-1816.
Balanced event prediction through sampled survival analysis.
Systems Medicine 2(1): 28-38.
Stability of the Human Plasma Proteome to Pre-analytical Variability as Assessed by an Aptamer-Based Approach.
J Proteome Res 18(10): 3661-3670.
Circulating proteomic signature of early death in heart failure patients with reduced ejection fraction.
Sci Rep 9(1): 19202.
Aging Disrupts Muscle Stem Cell Function by Impairing Matricellular WISP1 Secretion from Fibro-Adipogenic Progenitors.
Cell Stem Cell 24(3): 433-446 e437.
Neutrophil activation in systemic capillary leak syndrome (Clarkson disease)
J Cell Mol Med 23(8): 5119-5127
Plasma proteome in multiple sclerosis disease progression
Ann Clin Transl Neurol. 2019 Sep;6(9):1582-1594.
Noninvasive exosomal proteomic biosignatures, including cystatin SN, peroxiredoxin-5, and glycoprotein VI, accurately predict chronic rhinosinusitis with nasal polyps
Int Forum Allergy Rhinol 9(2): 177-186.
Osteitis is associated with dysregulated pro-osteoblastic activity in patients with nasal polyps
Laryngoscope 129(3): E102-E109.
Vero cell proteomic changes induced by Zika virus infection
Proteomics 19(4): e1800309.
Application of an Aptamer-Based Proteomics Assay (SOMAscan™) in Rat Cerebrospinal Fluid
Methods Mol Biol. 2044:221-231.
Guidelines for CSF Processing and Biobanking: Impact on the Identification and Development of Optimal CSF Protein Biomarkers
Methods Mol Biol. 2044:27-50.
Assessing the genetic correlations between blood plasma proteins and osteoporosis: a polygenic risk score analysis
Calcif Tissue Int 104(2): 171-181.
Plasma FGF-19 Levels are Increased in Patients with Post-Bariatric Hypoglycemia
Obes Surg. 2019 Jul;29(7):2092-2099.
Application of Proteomics Profiling for Biomarker Discovery in Hypertrophic Cardiomyopathy
J Cardiovasc Transl Res. 2019 Dec;12(6):569-579.
Cancer protein biomarker discovery based on nucleic acid aptamers
Int J Biol Macromol. 2019 Jul 1;132:190-202.
Exosome swarms eliminate airway pathogens and provide passive epithelial immunoprotection through nitric oxide
J Allergy Clin Immunol 143(4):1525-1535 e1521.
Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay
Alzheimers Dement. 5. pii: S1552-5260(19)35118-0.
A framework for multi-omic prediction of treatment response to biologic therapy for psoriasis
J Invest Dermatol 139(1): 100-107.
Fatigue in Sjögren's syndrome: a search for biomarkers and treatment targets
Front Immunol 10: 312.
Disease-specific and glucocorticoid-responsive serum biomarkers for Duchenne Muscular Dystrophy
Sci Rep. 2019 Aug 21;9(1):12167.
Candidate early predictive plasma protein markers of doxorubicin-induced chronic cardiotoxicity in B6C3F1 mice
Toxicol Appl Pharmacol 363:164-173.
A Novel Proteomics Approach to Identify Serum and Urinary Biomarkers and Pathways that Associate with Lower Urinary Tract Symptoms in Men and Women: Pilot Results of the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) Study
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