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Current Publications Count: 550

A proteomic surrogate for cardiovascular outcomes that is sensitive to multiple mechanisms of change in risk

Williams, SA et al.
Sci Transl Med 14(639): eabj9625
Large-scale proteomics Cardiovascular stratification

Large-scale integration of the plasma proteome with genetics and disease

Ferkingstad, E et al.
Nat Genet 53(12): 1712-1721
Large-scale proteomics Rare

Mapping the proteo-genomic convergence of human diseases

Pietzner, M et al.
Science 374(6569): eabj1541
Large-scale proteomics Disease biology Rare

A brain proteomic signature of incipient Alzheimer’s disease in young APOE epsilon4 carriers identifies novel drug targets

Roberts, JA et al.
Sci Adv 7(46): eabi8178.
Neurobiology Disease biology target identification

Evaluating microbiome-directed fibre snacks in gnotobiotic mice and humans

Delannoy-Bruno, O et al.
Nature 595(7865): 91-95
Metabolic

A Microbiota-Directed Food Intervention for Undernourished Children

Chen, RY et al.
N Engl J Med 384(16): 1517-1528
Pediatric Metabolic

Duodenal Microbiota in Stunted Undernourished Children with Enteropathy

Chen, RY et al.
N Engl J Med 384(16): 1517-1528
Pediatric Metabolic

Plasma protein patterns as comprehensive indicators of health

Williams SA, et al.
Nat Med 25(12): 1851-1857.
Clinical Large-scale proteomics

Effects of microbiota-directed foods in gnotobiotic animals and undernourished children

Gehrig, JL et al.
Science 365(6449)
Pediatric Metabolic

Undulating changes in human plasma proteome profiles across the lifespan

Lehailler, B et al.
Nat Med 25(12): 1843-1850
Disease Biology

Co-regulatory networks of human serum proteins link genetics to disease

Emilsson, V et al.
Science 361(6404): 769-773.
Aging disease biology diagnostics

Genomic atlas of the human plasma proteome

Sun, BB et al.
Nature 558: 73-79.
SomaScan Large-scale proteomics

Improving assessment of drug safety through proteomics: early detection and mechanistic characterization of the unforeseen harmful effects of torcetrapib

Williams, SA et al.
Circulation 137(10): 999-1010.
Cardiovascular stratification

Genetic architecture of the cardiovascular risk proteome

Benson, MD et al.
Circulation 137(11): 1158-1172.
Cardiovascular disease biology target identification diagnostics

Development and validation of a protein-based risk score for cardiovascular outcomes among patients with stable coronary heart disease

Ganz, P et al.
JAMA 315(23): 2532-2541.
Cardiovascular diagnostics

Using aptamer-based technology to probe the plasma proteome for cardiovascular disease prediction

Sabatine, MS
JAMA 315(23): 2525-2526.
Cardiovascular target identification diagnostics

Aptamer-based proteomic profiling reveals novel candidate biomarkers and pathways in cardiovascular disease

Ngo, D et al.
Circulation 134(4): 270-285.
Cardiovascular diagnostics

Whole Genome Sequence Analysis of the Plasma Proteome in Black Adults Provides Novel Insights into Cardiovascular Disease

Katz, DH et al.
Circulation 145(5): 357-370
Cardiovascular Disease biology

Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19

Sacco, K et al.
Nat Med 28(5): 1050-1062
Pediatric Infection Inflammatory

ADAMTSL2 protein and a soluble biomarker signature identify at-risk non-alcoholic steatohepatitis and fibrosis in adults with NAFLD

Corey KE et al.
J Hepatol 76(1): 25-33
Metabolic Diagnostics Fibrotic

Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology

Bjornsdottir, G et al.
Nat Commun 13(1): 634
Large-scale proteomics

Plasma Proteomics of COVID-19-Associated Cardiovascular Complications: Implications for Pathophysiology and Therapeutics

Roh, JD et al.
JACC Basic Transl Sci 7(5): 425-441
Cardiovascular Infection

ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19.”

Pietzner, M et al.
Nat Commun 13: 4484
Large-scale proteomics Infection

Serum proteomic profiling of rheumatoid arthritis-interstitial lung disease with a comparison to idiopathic pulmonary fibrosis

Wu, X et al.
Thorax, epub ahead of print.
Inflammatory Respiratory

Neuroblastoma suppressor of tumorigenicity 1 is a circulating protein associated with progression to end-stage kidney disease in diabetes

Kobayashi, H et al.
Sci Transl Med 14(657): eabj2109
Kidney Metabolic

Blood-biomarkers and devices for atrial fibrillation screening: Lessons learned from the AFRICAT (Atrial Fibrillation Research In CATalonia) study

Pala, E et al.
PLoS One 17(8): e0273571
Cardiovascular

Markers of endothelial glycocalyx dysfunction in Clarkson disease

Xie, Z et al.
J Transl Med 20(1): 380
Rare

Neurocognitive trajectory and proteomic signature of inherited risk for Alzheimer’s disease

Paranjpe, MD et al.
PLoS Genet 18(9): e1010294
Neurobiology

Multi-Omic Admission-Based Prognostic Biomarkers Identified by Machine Learning Algorithms Predict Patient Recovery and 30-Day Survival in Trauma Patients

Abdelhamid, SS et al.
Metabolites 12(9): 774
Large-scale proteomics Clinical

Long-term changes in plasma proteomic profiles in premenopausal and postmenopausal Black and White women: the Atherosclerosis Risk in Communities study

Appiah, D et al.
Menopause, epub ahead of print
Reproductive

Is an MRI-derived anatomical measure of dementia risk also a measure of brain aging?

Casanova, R et al.
Geroscience, epub ahead of print
Aging Neurobiology

Proteomic Analysis of Effects of Spironolactone in Heart Failure With Preserved Ejection Fraction

Javaheri, A et al.
Circ Heart Fail., epub ahead of print
Cardiovascular

Circulating Proteins Influencing Psychiatric Disease: A Mendelian Randomization Study

Lu, T et al.
Biol Psychiatry, epub ahead of print.
Neurobiology

Proteomic profiling platforms head to head: Leveraging genetics and clinical traits to compare aptamer- and antibody-based methods

Katz, DH et al.
Sci Adv 8:eabm5164div>
Large-scale proteomics

The associations between plasma soluble Trem1 and neurological diseases: a Mendelian randomization study

Shi, X et al.
J Neuroinflammation 19(1): 218
Neurobiology

Inflammatory Markers in Non-Obese Women with Polycystic Ovary Syndrome Are Not Elevated and Show No Correlation with Vitamin D Metabolites

Moin ASM et al.
Nutrients 14(17):3540.
Reproductive

High Dimensional Multi-omics Reveals Unique Characteristics of Early Plasma Administration in Polytrauma Patients with TBI

Wu, J et al.
Ann Surg 276(4): 673-683
Stratification Clinical

The circulating proteomic signature of alcohol-associated liver disease

Luther, J et al.
JCI Insight 7(14): e159775

Identification of 969 protein quantitative trait loci in an African American population with kidney disease attributed to hypertension

Surapaneni, A et al.
Kidney Int., epub ahead of print.
Large-scale proteomics Kidney

Associations between circulating proteins and risk of breast cancer by intrinsic subtypes: a Mendelian randomisation analysis

Shu, X et al.
Br J Cancer., epub ahead of print.
Large-scale proteomics Oncology

Placenta-derived proteins across gestation in healthy pregnancies-a novel approach to assess placental function?

Degnes, ML et al.
BMC Med 20(1): 227
Reproductive

Circulating proteomic profiles associated with endometriosis in adolescents and young adults

Sasamoto, N et al.
Hum Reprod 37(9): 2042-2053
Reproductive

The nucleolus functions as a phase-separated protein

Frottin, F et al.
Science 365(6451): 342-347
Binding

Proteomics and Population Biology in the Cardiovascular Health Study (CHS): design of a study with mentored access and active data sharing

Austin, TR et al.
Eur J Epidemiol 37(7): 755-765
Large-scale-proteomics

The minimum aptamer publication standards (MAPS guidelines) for de novo aptamer selection

McKeague, M et al.
Aptamers 6: 10-18
Review

The amniotic fluid proteome predicts imminent preterm delivery in asymptomatic women with a short cervix

Gudicha, DW et al.
Sci Rep 12(1): 11781
Reproductive

Proteomic Profiling of Plasma Biomarkers Associated With Return to Sport Following Concussion: Findings From the NCAA and Department of Defense CARE Consortium

Vorn, R et al.
Front Neurol 13: 901238
Neurobiology

Proteomic Biomarkers of the Apnea Hypopnea Index and Obstructive Sleep Apnea: Insights into the Pathophysiology of Presence, Severity, and Treatment Response

Cederberg, KLJ et al.
Int J Mol Sci. 23(14): 7983
Respiratory

Proteomic Biomarkers of Kleine-Levin Syndrome

Hedou, J et al.
Sleep 45(9)
Rare

Genome-wide screening identifies DNA methylation sites that regulate the blood proteome

Nikpay, M et al.
Epigenomics 14(13): 837–848
Large-scale proteomics

Comparative Analysis of Alzheimer’s Disease Cerebrospinal Fluid Biomarkers Measurement by Multiplex SOMAscan Platform and Immunoassay-Based Approach

Timsina, J et al.
J Alzheimers Dis 89(1): 193-207
Neurobiology

Prospects for the application of aptamer based assay platforms in pathogen detection

Banu, K et al.
Biocybern Biomed Eng. 42(3): 934-949
Review

High dimensional immune profiling of smoldering multiple myeloma distinguishes distinct tumor microenvironments

Fernandez, N et al.
Clin Lymphoma Myeloma Leuk, epub ahead of print.
Oncology stratification

Exploring the genetic relationship between deep vein thrombosis and plasma protein: a new research idea

Luo, P et al.
Expert Rev Hematol: 1-7
Large-scale proteomics

Genome- and transcriptome-wide association studies show that pulmonary embolism is associated with bone-forming proteins

Feng, R et al.
Expert Rev Hematol., epub ahead of print.
Large-scale proteomics

Serum proteome analysis of systemic JIA and related lung disease identifies distinct inflammatory programs and biomarkers

Chen, G et al.
Arthritis Rheumatol 74(7): 1271-1283
Rare Pediatric Inflammatory

Specialized interferon action in COVID-19

Galbraith, MD et al.
Proc Natl Acad Sci U S A 119(11)
Infection Immunity

Elucidating mechanisms of genetic cross-disease associations at the PROCR vascular disease locus

Stacey, D et al.
Nat Commun 13(1): 1222
Cardiovascular Disease biology
A genome-wide meta-analysis identifies 50 genetic
loci associated with carpal tunnel syndrome

Skuladottir, AT et al.
Nat Commun 13: 1598
Large-scale proteomics

Plasma proteome analyses in individuals of European and African ancestry identify cis-pQTLs and models for proteome-wide association studies

Zhang, J et al.
Nat Genet 54(5): 593-602
Large-scale proteomics

An approach for evaluating the effects of dietary fiber polysaccharides on the human gut microbiome and plasma proteome

Delannoy-Bruno, O et al.
Proc Natl Acad Sci U S A 119(20): e2123411119
SomaScan

Mining the Plasma Proteome for Insights into the Molecular Pathology of Pulmonary Arterial Hypertension

Harbaum, L et al.
Am J Respir Crit Care Med 205(12): 1449-1460
Large-scale-proteomics Rare Cardiovascular

Effects of age, amyloid, sex, and APOE epsilon4 on the CSF proteome in normal cognition

Wesenhagen, KEJ et al.
Alzheimers Dement (Amst) 14(1): e12286.
Aging Neurobiology

Assay-related differences in SuPAR levels: implications for measurement and data interpretation

Vasbinder, A et al.
J Nephrol., epub ahead of print.
Kidney

Proteomics of Coagulopathy Following Injury Reveals Limitations of Using Laboratory Assessment to Define Trauma-Induced Coagulopathy to Predict Massive Transfusion

Moore, HB et al.
Ann Surg 3(2): e167
Clinical

Results of untargeted analysis using the SOMAscan proteomics platform indicates novel associations of circulating proteins with risk of progression to kidney failure in diabetes

Kobayashi, H et al.
Kidney Int 102(2): 370-381
Kidney

Association between vascular endothelial growth factor-mediated blood-brain barrier dysfunction and stress-induced depression

Matsuno, H et al.
Mol Psychiatry, epub ahead of print.
Neurobiology

Cystatin SN is a Potent Upstream Initiator of Epithelial Derived Type 2 Inflammation in Chronic Rhinosinusitis

Nocera, AL et al.
J Allergy Clin Immunol., epub ahead of print.
Inflammatory Exosomes

Serological Biomarkers of Progression towards Diagnosis of Rheumatoid Arthritis in Active Component Military Personnel

Loza, MJ et al.
Arthritis Rheumatol., epub ahead of print.
Inflammatory

Whole-exome sequencing identifies rare genetic variants associated with human plasma metabolites

Bomba, L et al.
Am J Hum Genet. 109(6): 1038-1054
Large-scale proteomics

Aptamers Targeting Cardiac Biomarkers as an Analytical Tool for the Diagnostics of Cardiovascular Diseases: A Review

Komarova, N et al.
Biomedicines 10(5): 1085
Review Cardiovascular

Proteomic Analysis of Plasma Markers in Patients Maintained on Antipsychotics: Comparison to Patients Off Antipsychotics and Normal Controls

Engelke, R et al.
Front Psychiatry 13: 809071
Neurobiology

Clinical applications of plasma proteomics and peptidomics: Towards precision medicine

He, B et al.
Proteomics Clin Appl, epub ahead of print.
Review

Validation of disease-specific biomarkers for the early detection of bronchopulmonary dysplasia

Kindt, ASD et al.
Pediatr Res., epub ahead of print.
Pediatric Respiratory stratification diagnostics

Stability and reproducibility of proteomic profiles in epidemiological studies: Comparing the Olink and SOMAscan platforms

Haslam, DE et al.
Proteomics 22(13-14): e2100170
Large-scale proteomics

Mendelian randomization analysis of plasma levels of CD209 and MICB proteins and the risk of varicose veins of lower extremities

Shadrina, AS et al.
PLoS One 17(5): e0268725
SomaScan

Genetic architecture of band neutrophil fraction in Iceland

Oskarsson, GR et al.
Commun Biol 5(1): 525
Large-scale proteomics

A novel non-invasive method allowing for discovery of pathologically relevant proteins from small airways

Ostling, J et al.
Clin Proteomics 19(1): 20
Respiratory

A serum protein network early predicts the need for systemic immunomodulatory therapy in non-infectious uveitis

Kuiper JJW et al.
Ophthalmol Sci 2(3): 100175
Ocular stratification

CCL17 acts as a novel therapeutic target in pathological cardiac hypertrophy and heart failure

Zhang, Y et al.
J Exp Med 219(8): e20200418
Cardiovascular Aging

Translation of aptamers toward clinical diagnosis and commercialization

Liu, S et al.
Biosens Bioelectron 208: 114168
Review Diagnostics

Diagnostic Accuracy of Blood-Based Biomarker Panels: A Systematic Review

Hardy-Sosa, A et al.
Front Aging Neurosci 14: 683689
Review Neurobiology

Plasma growth and differentiation factor 15 predict longitudinal changes in bone parameters in women, but not in men

Osawa, Y et al.
J Gerontol A Biol Sci Med Sci., epub ahead of print.
Osteoporosis

Ad26.COV2.S prevents upregulation of SARS-CoV-2 induced pathways of inflammation and thrombosis in hamsters and rhesus macaques

Aid, M et al.
PLoS Pathog 18(4): e1009990
Infection Immunity

Patterns and Persistence of Perioperative Plasma and Cerebrospinal Fluid Neuroinflammatory Protein Biomarkers After Elective Orthopedic Surgery Using SOMAscan

Dillon, ST et al.
Anesth Analg, epub ahead of print
Neurobiology Inflammatory Aging

Epidermal growth factor receptor signaling in precancerous keratinocytes promotes neighboring head and neck cancer squamous cell carcinoma cancer stem cell-like properties and phosphoinositide 3-kinase inhibitor insensitivity

Nguyen, KA et al.
Mol Carcinog 61(7): 664-676
Oncology

Effects of ivacaftor on systemic inflammation and the plasma proteome in people with CF and G551D

Hoppe, JE et al.
J Cyst Fibros, epub ahead of print.
Inflammatory Respiratory

Chemical modifications for a next generation of nucleic acid aptamers

Chan, KY et al.
Chembiochem, epub ahead of print.
Review

Analytical Considerations of Large-Scale Aptamer-Based Datasets for Translational Applications

Jiang, W et al.
Cancers (Basel) 14(9): 2227
SomaScan

Severe Iatrogenic Hypoglycemia Modulates the Fibroblast Growth Factor Protein Response

Nandakumar, M et al.
Diabetes Obes Metab 24(8): 1483-1497
Metabolic

Proteomics of Human Biological Fluids for Biomarker Discoveries: Technical Advances and Recent Applications

Dayon, L et al.
Expert Rev Proteomics, 19(2): 131-151
Review

Identifying causal genes for stroke via integrating the proteome and transcriptome from brain and blood

Wu, BS et al.
J Transl Med 20(1): 181
Cardiovascular Large-scale proteomics

Acceptability and experience of a personalised proteomic risk intervention for type 2 diabetes in primary care: qualitative interview study with patients and healthcare providers

Honey, S et al.
Prim Health Care Res Dev 23: e24.
Clinical

Limited proteolysis–mass spectrometry reveals aging-associated changes in cerebrospinal fluid protein abundances and structures

Shuken, SR et al.
Nat Aging 2: 379-388
Aging Neurobiology targetidentification

Proteomics in thrombosis research

Edfors, F et al.
Res Pract Thromb Haemost 6(3): e12706.
Review

Harnessing Big Data to Advance Treatment and Understanding of Pulmonary Hypertension

Rhodes, CJ et al.
Circ Res 130(9): 1423-1444
Review Cardiovascular Respiratory

Proteome-Wide Analysis using SOMAscan Identifies and Validates Epidermal Growth Factor as a Disease Marker of Collagenous Gastritis

Curci, D et al.
Gastro Hep Advances 1(5):689-702
Rare

Proteomics of lung tissue reveals differences in inflammation and alveolar-capillary barrier response between atelectasis and aerated regions

Rashid, A et al.
Sci Rep 12(1): 7065
Respiratory

The Proteomic Profile of Interstitial Lung Abnormalities

Axelsson, GT et al.
Am J Respir Crit Care Med 206(3): 337-346
Respiratory Large-scale proteomics

Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset

Saevarsdottir, S et al.
Ann Rheum Dis., epub ahead of print.
Inflammatory Large-scale proteomics

Serum Protein Signatures Using Aptamer-Based Proteomics for Minimal Change Disease and Membranous Nephropathy

Muruve, DA et al.
Kidney Int Rep 7(7): 1539-1556
Kidney stratification

Lymphocyte activation gene-3-associated protein networks are associated with HDL-cholesterol and mortality in the Trans-omics for Precision Medicine program

Manichaikul, A et al.
Commun Biol 5(1): 362
Cardiovascular

Comparison of Aptamer-Based and Antibody-Based Assays for Protein Quantification in Chronic Kidney Disease

Lopez-Silva, C et al.
Clin J Am Soc Nephrol 17(3): 350-360
Kidney

Epigenetic scores for the circulating proteome as tools for disease prediction

Gadd, DA et al.
Elife 11
Aging

Aptamer-based screen of Neuropsychiatric Lupus cerebrospinal fluid reveals potential biomarkers that overlap with the choroid plexus transcriptome

Vanarsa, K et al.
Arthritis Rheumatol 74(7): 1223-1234
Neurobiology Inflammatory

Differential Proteomics of Cardiovascular Risk and Coronary Artery Disease in Humans

Ferrannini, E et al.
Front Cardiovasc Med 8: 790289
Cardiovascular

Defining the effects of traffic-related air pollution on the human plasma proteome using an aptamer proteomic array: A dose-dependent increase in atherosclerosis-related proteins

Mookherjee, N et al.
Environ Res 209: 112803
Cardiovascular Respiratory

Placental proteins with predicted roles in fetal development decrease in premature infants

Schreiner, C et al.
Pediatr Res., epub ahead of print.
Pediatric Reproductive

Creatine kinase-(MB) and hepcidin as candidate biomarkers for early diagnosis of pulmonary tuberculosis: a proof-of-concept study in Lambarene, Gabon

Essone, PN et al.
Infection 50(4): 897-905
Respiratory Diagnostics

Protein and miRNA profile of circulating extracellular vesicles in patients with primary sclerosing cholangitis

Povero, D et al.
Sci Rep 12: 3027
Rare Diagnostics

Diagnostic and Prognostic Protein Biomarkers of β-Cell Function in Type 2 Diabetes and Their Modulation with Glucose Normalization

Moin, ASM et al.
Metabolites 12(3):196
Metabolic

Proteomics technologies for cancer liquid biopsies

Ding, Z et al.
Mol Cancer 21(1): 53
Review Oncology

Advances in proteomic profiling of pediatric kidney diseases

Cummins, TD et al.
Pediatr Nephrol 37(10): 2255-2265
Review Kidney Pediatric

Proteomic Profiling Identifies Novel Proteins for Genetic Risk of Severe COVID-19: the Atherosclerosis Risk in Communities Study

Steffen, BT et al.
Hum Mol Genet 31(14): 2452-2461
Infection Respiratory Large-scale proteomics

Connecting Genomics and Proteomics to Identify Protein Biomarkers for Adult and Youth-Onset Type 2 Diabetes: A Two-Sample Mendelian Randomization Study

Ghanbari, F et al.
Diabetes 71(6): 1324-1337
Pediatric Metabolic

Proteomic Studies of Psoriasis

Sobolev, VV et al.
Biomedicines 10(3): 619
Review Immunity Inflammatory

Proteins and pathways in atrial fibrillation and atrial cardiomyopathy underlying cryptogenic stroke

Pala, E et al.
Int J Cardiol Heart Vasc 39: 100977
Cardiovascular

Protein prediction for trait mapping in diverse populations

Schubert, R et al.
PLoS One 17(2): e0264341
Large-scale proteomics

Diabetes, GDF-15 and incident heart failure: the atherosclerosis risk in communities study

Echouffo-Tcheugui, JB et al.
Diabetologia 65: 955–963
Metabolic Cardiovascular

Using the Plasma Proteome for Risk Stratifying Patients with Pulmonary Arterial Hypertension

Rhodes, CJ et al.
Am J Respir Crit Care Med 205(9): 1102-1111
Respiratory Rare Stratification

A genome-wide association study of serum proteins reveals shared loci with common diseases

Gudjonsson, A et al.
Nat Commun 13(1): 480
Large-scale proteomics

Coding and regulatory variants are associated with serum protein levels and disease

Emilsson, V et al.
Nat Commun 13(1): 481
Large-scale proteomics

Plasma proteins, cognitive decline, and 20-year risk of dementia in the Whitehall II and Atherosclerosis Risk in Communities studies.

Lindbohm, JV et al.
Alzheimers Dement 18(4): 612-624
Neurobiology

Proteins in the pathway from high red blood cell width distribution to all-cause mortality

Osawa, Y et al.
EBioMedicine 76: 103816
Aging

Effects of colchicine on lipolysis and adipose tissue inflammation in adults with obesity and metabolic syndrome

Levine, JA et al.
Obesity (Silver Spring) 30(2): 358-368
Metabolic

Genetics of Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS) and Role of Sacsin in Neurodegeneration

Bagaria, J et al.
Int J Mol Sci 23(1): 552
Review Rare Neurobiology

Aptamers: Potential Diagnostic and Therapeutic Agents for Blood Diseases

Aljohani, MM et al.
Molecules 27(2): 383
Review

Recent Developments in Clinical Plasma Proteomics-Applied to Cardiovascular Research

Palstrom, NB et al.
Biomedicines 10(1): 162
Review Cardiovascular

Influenza A virus uses PSMA2 for downregulation of NRF2-mediated oxidative stress response

Rashid, MU et al.
J Virol: jvi0199021
Infection

Acute serum protein and cytokine response of single dose of prednisone in adult volunteers

Roy, R et al.
Steroids 178: 108953
Inflammatory

The amniotic fluid proteome changes with gestational age in normal pregnancy: a cross-sectional study

Bhatti, G et al.
Sci Rep 12(1): 601
Reproductive

Comparison of Proteomic Expression Profiles after Radiation Exposure across Four Different Species

Sproull, M et al.
Radiat Res 197(4): 315-323
SomaScan

Association of Circulating Proteins with Death or Lung Transplant in Patients with Idiopathic Pulmonary Fibrosis in the IPF-PRO Registry Cohort

Todd, JL et al.
Lung 200(1): 11-18
Respiratory Rare Fibrotic Stratification

Aptamers from random sequence space: Accomplishments, gaps and future considerations

Qian, S et al.
Anal Chim Acta 1196: 339511
Review

Clinically Relevant Circulating Protein Biomarkers for Type 1 Diabetes: Evidence From a Two-Sample Mendelian Randomization Study

Yazdanpanah, N et al.
Diabetes Care 45(1): 169-177
Metabolic target identification

Identification and Evaluation of Serum Protein Biomarkers Which Differentiate Psoriatic from Rheumatoid Arthritis.

Mc Ardle, A et al.
Arthritis Rheumatol 74(1): 81-91
Inflammatory diagnostics

The Plasma Proteome Fingerprint Associated With Circulating Carotenoids And Retinol In Older Adults

Yamaguchi, Y et al.
J Nutr 152(1): 40-48
Immunity

Plasma P-selectin is an early marker of thromboembolism in COVID-19

Fenyves, BG et al.
Am J Hematol 96(12): E468-E471
Cardiovascular Infection

Comprehensive aptamer-based screen of 1317 proteins uncovers improved stool protein markers of colorectal cancer

Li, H et al.
J Gastroenterol 56(7): 659-672
Oncology

An Approach to Biomarker Discovery of Cannabis Use Utilizing Proteomic, Metabolomic, and Lipidomic Analyses.

Hinckley, JD et al.
Cannabis Cannabinoid Res 7(1): 65-77
SomaScan

Proteome-Wide Analysis using SOMAscan Identifies and Validates Chitinase-3-Like Protein 1 as a Risk and Disease Marker of Delirium Among Older Adults Undergoing Major Elective Surgery

Vasunilashorn SM, et al.
J Gerontol A Biol Sci Med Sci 77(3): 484-493
Aging

Identification of blood-based biomarkers for diagnosis and prognosis of Parkinson’s disease: A Systematic review of proteomics studies

Chelliah, SS et al.
Ageing Res Rev 73: 101514
Neurobiology Review

High-throughput mediation analysis of human proteome and metabolome identifies mediators of post-bariatric surgical diabetes control

Dreyfuss, JM et al.
Nat Commun 12(1): 6951
Metabolic mechanism of action

Exercise plasma boosts memory and dampens brain inflammation via clusterin

De Miguel, Z et al.
Nature 600(7889): 494-499
Neurobiology

Cross-validation of SARS-CoV-2 responses in kidney organoids and clinical populations

Helms, L et al.
JCI Insight 6(24): e154882
Infection Kidney

Proteomics and Risk of Atrial Fibrillation in Older Adults (From the Atherosclerosis Risk in Communities [ARIC] Study)

Norby, FL et al.
Am J Cardiol 161: 42-50
Cardiovascular target identification

Synergistic insights into human health from aptamer- and antibody-based proteomic profiling

Pietzner, M et .
Nat Commun 12(1): 6822
Large-scale proteomics

The Use of ‘Omics for Diagnosing and Predicting Progression of Chronic Kidney Disease: A Scoping Review

Govender, MA et al.
Front Genet 12: 682929
Review Kidney

Proteome-wide associations with short- and long-term weight loss and regain after Roux-en-Y gastric bypass surgery

Yousri, NA et al.
Obesity (Silver Spring) 30(1): 129-141
Metabolic

Blood Levels of the SMOC1 Hepatokine Are Not Causally Linked with Type 2 Diabetes: A Bidirectional Mendelian Randomization Study

Ghodsian, N et al.
Nutrients 13(12): 4208
Metabolic

Plasma Proteomics of Renal Function: A Trans-ethnic Meta-analysis and Mendelian Randomization Study

Matias-Garcia, P et al.
J Am Soc Nephrol. 32(7): 1747-1763
Kidney

Proteomic Approaches to Defining Remission and the Risk of Relapse in Rheumatoid Arthritis

O’Neil, LJ et al.
Front Immunol 12: 729681
Inflammatory

Discovery of Novel Proteomic Biomarkers for the Prediction of Kidney Recovery from Dialysis-Dependent AKI Patients

Daniels, JR et al.
Kidney360 2(11): 1716-1727
Kidney

Proteomic analysis of serum in workers exposed to diesel engine exhaust

Rahman, ML et al.
Environ Mol Mutagen 63(1): 18-28
Oncology

A Combined Proteomics and Mendelian Randomization Approach to Investigate the Effects of Aspirin-Targeted Proteins on Colorectal Cancer

Nounu, A et al.
Cancer Epidemiol Biomarkers Prev 30(3): 564-575
Oncology mechanism of action

Heat Shock-Related Protein Responses and Inflammatory Protein Changes Are Associated with Mild Prolonged Hypoglycemia

Moin, ASM et al.
Cells 10: 3109
Metabolic

Hypoglycemia-induced changes in complement pathways in type 2 diabetes

Moin, ASM et al.
Atherosclerosis Plus 46: 35-45
Metabolic

Multi-omic analysis in injured humans: Patterns align with outcomes and treatment responses

Wu, J et al.
Cell Rep Med 2: 100478
Stratification Clinical

Large-scale plasma proteomics can reveal distinct endotypes in chronic obstructive pulmonary disease and severe asthma

Suzuki, M et al.
Clin Transl Allergy 11(10): e12091
Respiratory

Serum Proteomics Uncovers Biomarkers of Clinical Portal Hypertension in Children With Biliary Atresia

Osborn, J et al.
Hepatol Commun 6(5): 995-1004
Pediatric

Integrated Multi-Omics for Novel Aging Biomarkers and Antiaging Targets

Wu, L et al.
Biomolecules 12: 39
Review Aging

Cellular and plasma proteomic determinants of COVID-19 and non-COVID-19 pulmonary diseases relative to healthy aging.

Arthur, L et al.
Nat Aging 1: 535–549.
Inflammatory Aging Infection

Predicting the probability of death using proteomics.

Eiriksdottir, T et al.
Commun Biol 4(1): 758.
Aging Large-scale proteomics
Large-scale plasma proteomic analysis
identifies proteins and pathways associated with dementia risk.

Walker, KA et al.
Nat Aging 1: 473-489.
Aging Large-scale proteomics

Human plasma proteomic profiles indicative of cardiorespiratory fitness.

Robbins, JM et al.
Nat Metab 3(6): 786-797.
Cardiovascular Respiratory

Group IIA secreted phospholipase A2 is associated with the pathobiology leading to COVID-19 mortality

Snider, JM et al.
J Clin Invest 131(19): e149236
Infection

Discovery and validation of a novel subgroup and therapeutic target in idiopathic multicentric Castleman disease

Pierson, SK et al.
Blood Adv 5(17): 3445-3456
Rare

Influence of renin-angiotensin-aldosterone system inhibitors on plasma levels of angiotensin-converting enzyme 2

Zimmermann, T et al.
ESC Heart Fail 8(2): 1717-1721
Cardiovascular Infection

Identification of plasma proteins relating to brain neurodegeneration and vascular pathology in cognitively normal individuals

Shi, L et al.
Alzheimers Dement (Amst) 13(1): e12240.
Neurobiology Review

Proteomic Biomarker Analysis of Serum from Japanese Field Mice (Apodemus Speciosus) Collected within the Fukushima Difficult-to-return Zone

Sproull, M et al.
Health Phys 121(6): 564-573
SomaScan

Advances and Utility of the Human Plasma Proteome

Deutsch, EW et al.
J Proteome Res 20(12): 5241-5263
Review

Integrated plasma proteomics and lung transcriptomics reveal novel biomarkers in idiopathic pulmonary fibrosis

Sivakumar, P et al.
Respir Res 22(1): 273
Respiratory Rare Fibrotic

Towards Building a Quantitative Proteomics Toolbox in Precision Medicine: A Mini-Review

Correa Rojo, A et al.
Front Physiol 12: 723510.
Review

Vitamin D association with the renin angiotensin system in polycystic ovary syndrome

Butler, AE et al.
J Steroid Biochem Mol Biol 214: 105965.
Reproductive

Polygenic Risk Scores for Kidney Function and Their Associations with Circulating Proteome, and Incident Kidney Diseases

Yu, Z et al.
J Am Soc Nephrol 32(12): 3161-3173
Kidney

The proteomic signature of recombinant Growth Hormone in recreational athletes

Esefeld, M et al.
J Endocrine Soc, epub ahead of print
SomaScan

Distinct Molecular Signatures of Clinical Clusters in People With Type 2 Diabetes: An IMI-RHAPSODY Study

Slieker, RC et al.
Diabetes 70(11): 2683-2693.
Metabolic

Dysregulated expression levels of APH1B in peripheral blood are associated with brain atrophy and amyloid-beta deposition in Alzheimer’s disease

Park, YH et al.
Alzheimers Res Ther 13(1): 183.
Neurobiology

Genetically Predicted Glucose-Dependent Insulinotropic Polypeptide (GIP) Levels and Cardiovascular Disease Risk Are Driven by Distinct Causal Variants in the GIPR Region

Bowker, N et al.
Diabetes 70(11): 2706-2719.
Cardiovascular Metabolic

Ultrasensitive detection of blood biomarkers of Alzheimer’s and Parkinson’s diseases: a systematic review

Singh, K et al.
Biomark Med 15(17): 1693-1708.
Review Neurobiology

Advances in Aptamer-Based Biomarker Discovery

Huang, J et al.
Front Cell Dev Biol 9: 659760.
SomaScan Review

Replication study of plasma proteins relating to Alzheimer’s pathology.

Shi, L et al.
Alzheimers Dement 17(9): 1452-1464.
Neurobiology stratification

Platelet Protein-Related Abnormalities in Response to Acute Hypoglycemia in Type 2 Diabetes.

Moin, ASM et al.
Front Endocrinol (Lausanne) 12: 651009.
Metabolic

Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19.

Gaziano, L et al.
Nat Med 27(4): 668-676.
Infection

Broadly effective metabolic and immune recovery with C5 inhibition in CHAPLE disease.

Ozen, A et al.
Nat Immunol 22(2): 128-139.
Rare Immunity mechanism of action

Association of endopeptidases, involved in SARS-CoV-2 infection, with microbial aggravation in sputum of severe asthma.

Abdel-Aziz, MI et al.
Allergy 76(6): 1917-1921.
Respiratory Infection

Age-associated difference in circulating ACE2, the gateway for SARS-COV-2, in humans: results from the InCHIANTI study.

AlGhatrif, M et al.
Geroscience 43(2): 619-627.
Infection Aging

A proteome-wide genetic investigation identifies several SARS-CoV-2-exploited host targets of clinical relevance.

Anisul, M et al.
Elife 10: e69719.
Infection

Longitudinal proteomic analysis of severe COVID-19 reveals survival-associated signatures, tissue-specific cell death, and cell-cell interactions.

Filbin, MR et al.
Cell Rep Med 2(5): 100287.
Infection

Seroconversion stages COVID19 into distinct pathophysiological states

Galbraith, MD et al.
Elife 10
Infection

Multi-omics highlights ABO plasma protein as a causal risk factor for COVID-19.

Hernandez Cordero, AI et al.
Hum Genet 140(6): 969-979
Infection

BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection.

Mills, RJ et al.
Cell 184(8): 2167-2182 e2122
Infection

Soluble Neuropilin-1 Response to Hypoglycemia in Type 2 Diabetes: Increased Risk or Protection in SARS-CoV-2 Infection?

Moin, ASM et al.
Front Endocrinol (Lausanne) 12: 665134
Infection Metabolic

Type 2 Diabetes Coagulopathy Proteins May Conflict With Biomarkers Reflective of COVID-19 Severity.

Moin, ASM et al.
Front Endocrinol (Lausanne) 12: 658304
Infection Metabolic

Letter to the Editor: Pro-fibrotic M2 macrophage markers may increase the risk for COVID19 in type 2 diabetes with obesity.

Moin, ASM et al.
Metabolism 112: 154374
Infection Metabolic

Vitamin D Association With Macrophage-Derived Cytokines in Polycystic Ovary Syndrome: An Enhanced Risk of COVID-19 Infection?

Moin, ASM et al.
Front Endocrinol (Lausanne) 12: 638621
Infection

Using ‘big data’ to disentangle aging and COVID-19.

Montgomery, RR et al.
Aging 1: 496–497.
Infection Aging

The COVIDome Explorer researcher portal.

Sullivan, KD et al.
Cell Rep 36(7): 109527.
Infection

A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity.

Zhou, S et al.
Nat Med 27(4): 659-667.
Infection

Early Interleukin-22 and Neutrophil Proteins Are Correlated to Future Lung Damage in Children with Cystic Fibrosis.

Renwick, J et al.
Front Pediatr 9: 640184.
Rare Pediatric Stratification Inflammatory

Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children.

Ramaswamy, A et al.
Immunity 54(5): 1083-1095 e1087.
Infection Pediatric

Plasma protein expression profiles, cardiovascular disease, and religious struggles among South Asians in the MASALA study

Ngo LH, et al.
Sci Rep 11(1): 961
Cardiovascular

Protein signatures of centenarians and their offspring suggest centenarians age slower than other humans

Sebastiani P, et al.
Aging Cell. 2021 Jan 29:e13290
Aging

Identification and Validation of Nutrient State-Dependent Serum Protein Mediators of Human CD4(+) T Cell Responsiveness.

Han, K et al.
Nutrients 13(5).
Inflammatory

Effect of longevity genetic variants on the molecular aging rate.

Gurinovich, A et al.
Geroscience 43(3): 1237-1251.
Aging Large-scale proteomics

Novel Murine Biomarkers of Radiation Exposure Using An Aptamer-Based Proteomic Technology.

Sproull, M et al.
Front Pharmacol 12: 633131.
Diagnostics

The CRTAC1 protein in plasma associates with osteoarthritis and predicts progression to joint replacements: a large-scale proteomics scan in Iceland.

Styrkarsdottir, U et al.
Arthritis Rheumatol 73(11): 2025-2034
Musculoskeletal Large-scale proteomics

Plasma Proteomic Profile Predicts Survival in Heart Failure with Reduced Ejection Fraction.

Gui, H et al.
Circ Genom Precis Med 14(3): e003140.
cardiovascular Stratification Large-scale proteomics

Multi-Omic Profiling in Black and White Populations Reveals Novel Candidate Pathways in Left Ventricular Hypertrophy and Incident Heart Failure Specific to Black Adults.

Katz, DH et al.
Circ Genom Precis Med 14(3): e003191.
Cardiovascular

SOMAscan Proteomics Identifies Serum Biomarkers Associated With Liver Fibrosis in Patients With NASH.

Luo, Y et al.
Hepatol Commun 5(5): 760-773.
Metabolic Fibrotic Diagnostics

Proteomic signatures of inflammatory skin diseases: a focus on atopic dermatitis.

Mikhaylov, D et al.
Expert Rev Proteomics 18(5): 345-361.
Review Inflammatory

Effect of TNFalpha stimulation on expression of kidney risk inflammatory proteins in human umbilical vein endothelial cells cultured in hyperglycemia.

Md Dom, ZI et al.
Sci Rep 11(1): 11133.
Metabolic Kidney Disease biology

Metabolic syndrome and the plasma proteome: from association to causation.

Elhadad, MA et al.
Cardiovasc Diabetol 20(1): 111.
Metabolic Cardiovascular

Serum Proteomics and Plasma Fibulin-3 in Differentiation of Mesothelioma from Asbestos-Exposed Controls and Patients with Other Pleural Diseases.

Tsim, S et al.
J Thorac Oncol 16(10): 1705-1717.
Oncology Diagnostics

Identification of Plasma Proteome Signatures Associated With Surgery Using SOMAscan

Fong TG, et al.
Ann Surg 273(4): 732-742.
Aging Disease Biology Inflammatory

Proteomic Signatures of Lifestyle Risk Factors for Cardiovascular Disease: A Cross‐Sectional Analysis of the Plasma Proteome in the Framingham Heart Study

Corlin L, et al.
J Am Heart Assoc 10(1): e018020
Cardiovascular

Association of a Serum Protein Signature With Rheumatoid Arthritis Development

O’Neil LJ, et al.
Arthritis Rheumatol. 73(1): 78-88.
Inflammatory Immunity

Inhibition of the Complement Alternative Pathway by Chemically Modified DNA Aptamers That Bind with Picomolar Affinity to Factor B

Xu, X et al.
J Immunol 206(4): 861-873.
Inflammatory Binding Structure

Genetics meets proteomics: perspectives for large population-based studies

Suhre, K et al.
Nat Rev Genet 22(1): 19-37.
Review Large-scale proteomics

Circulating markers of NADH-reductive stress correlate with mitochondrial disease severity

Sharma, R et al.
J Clin Invest 131(2): e136055
Metabolic Rare

Evaluating the effects of cardiometabolic exposures on circulating proteins which may contribute to severe SARS-CoV-2.

Richardson, TG et al.
EBioMedicine 64: 103228.
SomaScan

A replication-competent adenovirus-vectored influenza vaccine induces durable systemic and mucosal immunity

Matsuda, K et al.
J Clin Invest 131(5)
Immunity Infection

Revealing the role of the human blood plasma proteome in obesity using genetic drivers

Zaghlool, SB et al.
Nat Commun 12(1): 1279
Metabolic Large-scale proteomics

Plasma Proteomic Profiling in Hypertrophic Cardiomyopathy Patients before and after Surgical Myectomy Reveals Post-Procedural Reduction in Systemic Inflammation

Larson, A et al.
Int J Mol Sci 22(5): 2474
Cardiovascular

Quantitative Proteomic Analysis of Diabetes Mellitus in Heart Failure With Preserved Ejection Fraction

Hanff, TC et al.
JACC Basic Transl Sci 6(2): 89-99.
Cardiovascular Metabolic

Proteomics in aging research: A roadmap to clinical, translational research

Moaddel, R et al.
Aging Cell: e13325.
Aging Review

Blood biomarker discovery for autism spectrum disorder: A proteomic analysis

Hewitson, L et al.
PLoS One 16(2): e0246581.
Pediatric Neurobiology

Biomarker-focused multi-drug combination therapy and repurposing trial in mdx mice

Ziemba, M et al.
PLoS One 16(2): e0246507
Rare PK/PD

In-Depth Analysis of the Plasma Proteome in ME/CFS Exposes Disrupted Ephrin-Eph and Immune System Signaling

Germain, A et al.
Proteomes 9(1): 6
SomaScan Rare

A meta-analysis uncovers the first sequence variant conferring risk of Bell’s palsy

Skuladottir, AT et al.
Sci Rep 11(1): 4188
SomaScan

Cognitive stimulation in the workplace, plasma proteins, and risk of dementia: three analyses of population cohort studies.

Kivimaki, M et al.
BMJ 374: n1804.
Neurobiology

Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders.

Yang, C et al.
Nat Neurosci 24(9): 1302-1312
Neurobiology

An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging.

Sayed, N et al.
Nat Aging 1: 598–615.
Aging Inflammatory

Effects of adiposity on the human plasma proteome: observational and Mendelian randomisation estimates.

Goudswaard, LJ et al.
Int J Obes (Lond) 45: 2221-2229.
Metabolic

New candidate blood biomarkers potentially associated with white matter hyperintensities progression.

Jimenez-Balado, J et al.
Sci Rep 11(1): 14324.
Neurobiology

DNA Damage, n-3 Long-Chain PUFA Levels and Proteomic Profile in Brazilian Children and Adolescents.

Barros, TT et al.
Nutrients 2021, 13, 2483.
Pediatric

Comparison of proteomic methods in evaluating biomarker-AKI associations in cardiac surgery patients.

Liu, RX et al.
Transl Res 238: 49-62.
Kidney Cardiovascular

Pediatric and adult dilated cardiomyopathy are distinguished by distinct biomarker profiles.

Gropler, MRF et al.
Pediatr Res 92(1): 206-215
Pediatric Cardiovascular

Smoking induces sex-specific changes in the small airway proteome.

Kokelj, S et al.
Respir Res 22(1): 234.
Respiratory

Validation of Chemokine Biomarkers in Duchenne Muscular Dystrophy.

Ogundele, M et al.
Life (Basel) 11(8): 827.
Pediatric Musculoskeletal

Serum Proteomics of Older Patients Undergoing Major Cardiac Surgery: Identification of Biomarkers Associated with Postoperative Delirium.

Rhee, J et al.
Front Aging Neurosci 13: 699763.
Aging

Slow Off-Rate Modified Aptamer (SOMAmer) Proteomic Analysis of Patient-Derived Malignant Glioma Identifies Distinct Cellular Proteomes.

Thanasupawat, T et al.
Int J Mol Sci 22(17).
Oncology

Evolving a RIG-I antagonist: a modified DNA aptamer mimics viral RNA.

Ren, X et al.
J Mol Biol. 433(21): 167227.
Structure

Serum levels of ACE2 are higher in patients with obesity and diabetes.

Emilsson, V et al.
Obes Sci Pract 7(2): 239-243.
Infection

Functional Network Profiles in ARSACS Disclosed by Aptamer-Based Proteomic Technology

Morani F, et al.
Front Neurol 11: 603774.
Neurobiology Rare

Atopic Dermatitis Endotypes Based on Allergen Sensitization, Reactivity to Staphylococcus aureus Antigens, and Underlying Systemic Inflammation

Leonard A, et al.
J Allergy Clin Immunol Pract. 8(1): 236-247.e3.
Inflammatory Disease Biology Diagnostics

Joint fluid proteome after anterior cruciate ligament rupture reflects an acute posttraumatic inflammatory and chondrodegenerative state

King, JD et al.
Cartilage 11(3): 329
Inflammatory Disease Biology Diagnostics

Vascular Disease and Thrombosis in SARS-CoV-2-Infected Rhesus Macaques

Aid M, et al.
Cell 183(5): 1354–1366
Cardiovascular Inflammatory

Genetic architecture of host proteins involved in SARS-CoV-2 infection

Pietzner M, et al.
Nat Commun 11(1): 6397
Cardiovascular Respiratory Disease Biology Target Identification Infection

Platelet-derived growth factor BB: A potential diagnostic blood biomarker for differentiating bipolar disorder from major depressive disorder

Idemoto K, et al.
J Psychiatr Res 134: 48-56.
Neurobiology Diagnostics

Activity of ibrutinib plus R-CHOP in diffuse large B-cell lymphoma: Response, pharmacodynamic, and biomarker analyses of a phase Ib study

Schaffer M, et al.
Cancer Treatment Res Commun 25: 100235
Oncology

Identification of Potential Serum Protein Biomarkers and Pathways for Pancreatic Cancer Cachexia Using an Aptamer-Based Discovery Platform

Narasimhan A, et al.
Cancers (Basel) 12(12): 3787
Oncology

A Plasma Proteomic Signature of Skeletal Muscle Mitochondrial Function

Zampino M, et al.
Int J Mol Sci 21(24): 9540
Aging

Coronary Artery Disease and Type 2 Diabetes: A Proteomic Study

Ferrannini G, et al.
Diabetes Care 43(4): 843-851
Cardiovascular Metabolic

Novel Insights Into the Effects of Interleukin 6 Antagonism in Non-ST-Segment-Elevation Myocardial Infarction Employing the SOMAscan Proteomics Platform

George MJ, et al.
J Am Heart Assoc 9(12):e015628
Cardiovascular

Colchicine’s effects on metabolic and inflammatory molecules in adults with obesity and metabolic syndrome: results from a pilot randomized controlled trial

Demidowich AP, et al.
Int J Obes (Lond) 44(8):1793-1799
Inflammatory Metabolic

Comparison of Proteomic Assessment Methods in Multiple Cohort Studies

Raffield LM, et al.
Proteomics 20(12):e1900278
Review

Reduced Apolipoprotein M and Adverse Outcomes Across the Spectrum of Human Heart Failure

Chirinos JA, et al.
Circulation 141(18):1463-1476
Cardiovascular

Highly multiplexed proteomic assessment of human bone marrow in acute myeloid leukemia

Çelik H, et al.
Blood Adv 4(2):367-379
Oncology

Plasma proteomic profile of frailty

Sathyan S, et al.
Aging Cell 19(9):e13193
Aging

Serum protein biomarkers for juvenile dermatomyositis: a pilot study

Tawalbeh SM, et al.
BMC Rheumatol 4:52
Inflammatory Immunity Rare

Proteomic biomarkers of sleep apnea

Ambati A, et al.
Sleep 43(11):zsaa086
Respiratory

Early angiogenic proteins associated with high risk for bronchopulmonary dysplasia and pulmonary hypertension in preterm infants

Arjaans S, et al.
Am J Physiol Lung Cell Mol Physiol 318(4):L644-L654
Respiratory

Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis

Govaere O, et al.
Sci Transl Med 12(572):eaba4448
Metabolic Fibrotic

Autophagy Modulators Profoundly Alter the Astrocyte Cellular Proteome

Sher AA, et al.
Cells 9(4):805
Neurobiology

Impact of Kidney Function on the Blood Proteome and on Protein Cardiovascular Risk Biomarkers in Patients With Stable Coronary Heart Disease

Yang J, et al.
J Am Heart Assoc 9(15):e016463
Kidney

Proteomic Signatures of Heart Failure in Relation to Left Ventricular Ejection Fraction

Adamo L, et al.
J Am Coll Cardiol 76(17):1982-1994
Cardiovascular

Proteomic and Metabolomic Correlates of Healthy Dietary Patterns: The Framingham Heart Study

Walker ME, et al.
Nutrients 12(5):1476
Cardiovascular Metabolic

Plasma proteomic profile of age, health span, and all-cause mortality in older adults

Sathyan S, et al.
Aging Cell 19(11):e13250
Aging

Renin-Angiotensin System overactivation in polycystic ovary syndrome, a risk for SARS-CoV-2 infection?

Moin ASM, et al.
Metabol Open 7:100052
Kidney Reproductive

ZIKV Infection Induces DNA Damage Response and Alters the Proteome of Gastrointestinal Cells

Glover K, et al.
Viruses 12(7):771
Infection

Plasma proteomic signature of the risk of developing mobility disability: A 9-year follow-up

Osawa Y, et al.
Aging Cell 19(4):e13132
Aging

Comparison of Serum Pharmacodynamic Biomarkers in Prednisone-Versus Deflazacort-Treated Duchenne Muscular Dystrophy Boys

Tawalbeh S, et al.
J Pers Med 10(4):164
Pediatric Musculoskeletal

Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer’s Disease Pathology

Shi L, et al.
J Alzheimers Dis 77(3):1353-1368
Neurobiology Disease biology Mechanism of action

Clinical and Proteomic Correlates of Plasma ACE2 (Angiotensin-Converting Enzyme 2) in Human Heart Failure

Chirinos JA, et al.
Hypertension 76(5):1526-1536
Cardiovascular

Protein biomarkers for incident deep venous thrombosis in critically ill adolescents: An exploratory study

Tala JA, et al.
Pediatr Blood Cancer 67(4):e28159
Cardiovascular Pediatric

Aptamer based proteomic pilot study reveals a urine signature indicative of pediatric urinary tract infections

Dong L, et al.
PLoS One 15(7):e0235328
Kidney Pediatric Infection

Increased Levels of Coagulation Factor XI in Plasma Are Related to Alzheimer’s Disease Diagnosis

Begic E, et al.
J Alzheimers Dis 77(1):375-386
Neurobiology Diagnostics

Evaluation of a novel blood microsampling device for clinical trial sample collection and protein biomarker analysis

Xing J, et al.
Bioanalysis 12(13):919-935
SomaScan

Serum biomarkers associated with baseline clinical severity in young steroid-naïve Duchenne muscular dystrophy boys

Dang UJ, et al.
Hum Mol Genet 29(15):2481-2495
Pediatric Musculoskeletal

Zika virus dysregulates human Sertoli cell proteins involved in spermatogenesis with little effect on tight junctions

Rashid MU, et al.
PLoS Negl Trop Dis 14(6):e0008335
Infection Reproductive

Proteomic profiling of HTLV-1 carriers and ATL patients reveals sTNFR2 as a novel diagnostic biomarker for acute ATL

Guerrero CLH, et al.
Blood Adv 4(6):1062-1071
Oncology Infection

Metabolic profiling shows pre-existing mitochondrial dysfunction contributes to muscle loss in a model of ICU-acquired weakness

Kemp PR, et al.
J Cachexia Sarcopenia Muscle 11(5):1321-1335
Musculoskeletal

Mechanisms of Sodium-Glucose Cotransporter 2 Inhibition: Insights From Large-Scale Proteomics

Ferrannini E, et al.
Diabetes Care 43(9):2183-2189
Metabolic Disease biology Target validation

Targeting myostatin/activin A protects against skeletal muscle and bone loss during spaceflight

Lee SJ, et al.
Proc Natl Acad Sci U S A 117(38):23942-23951
Musculoskeletal

Multimodal immune phenotyping of maternal peripheral blood in normal human pregnancy

Apps R, et al.
JCI Insight 5(7):e134838
Immunity Reproductive

Effect of induced hypoglycemia on inflammation and oxidative stress in type 2 diabetes and control subjects

Kahal H, et al.
Sci Rep 10(1):4750
Inflammatory Metabolic Disease biology

Plasma Biomarkers of Reticular Pseudodrusen and the Risk of Progression to Advanced Age-Related Macular Degeneration

Lynch AM, et al.
Transl Vis Sci Technol 9(10):12
Rare

Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits.

Zaghlool, SB et al.
Nat Commun 11(1): 15.
SomaScan

Modified nucleotides may have enhanced early RNA catalysis.

Wolk, SK et al.
Proc Natl Acad Sci U S A 117(15): 8236-8242.
SomaScan

The Evolution of the Cardiovascular Biomarker Study.

Wang, TJ
Circulation 142(15): 1422-1424.
Cardiovascular Target identification

Integrative phenotyping of glycemic responders upon clinical weight loss using multi-omics.

Valsesia, A et al.
Sci Rep 10(1): 9236.
Metabolic

Comprehensive aptamer-based screening identifies a spectrum of urinary biomarkers of lupus nephritis across ethnicities.

Stanley, S et al.
Nat Commun 11(1): 2197.
Kidney Inflammatory

Causal association between mTOR-dependent EIF-4E and EIF-4A circulating protein levels and type 2 diabetes: a Mendelian randomization study.

Soliman, GA et al.
Sci Rep 10(1): 15737.
Metabolic Disease biology Target identification

Using the circulating proteome to assess type I interferon activity in systemic lupus erythematosus.

Smith, MA et al.
Sci Rep 10(1): 4462.
Inflammatory

Serum Protein Changes in Pediatric Sepsis Patients Identified With an Aptamer-Based Multiplexed Proteomic Approach.

Shubin, NJ et al.
Crit Care Med 48(1): e48-e57.
Pediatric

Placenta accreta spectrum: biomarker discovery using plasma proteomics.

Shainker, SA et al.
Am J Obstet Gynecol 223(3): 433 e431-433 e414.
Reproductive

A fully joint Bayesian quantitative trait locus mapping of human protein abundance in plasma.

Ruffieux, H et al.
PLoS Comput Biol 16(6): e1007882.
SomaScan

Type I IFN response associated with mTOR activation in the TAFRO subtype of idiopathic multicentric Castleman disease.

Pai, RL et al.
JCI Insight 5(9)
Inflammatory Disease biology Rare

Intense light as anticoagulant therapy in humans.

Oyama, Y et al.
PLoS One 15(12): e0244792.
SomaScan Clinical

Identification of a unique temporal signature in blood and BAL associated with IPF progression.

Norman, KC et al.
Sci Rep 10(1): 12049.
Fibrotic Stratification

Modified aptamers as reagents to characterize recombinant human erythropoietin products.

Jankowski, W et al.
Sci Rep 10(1): 18593.
Binding

Single-Molecule Super-Resolution Microscopy Reveals Heteromeric Complexes of MET and EGFR upon Ligand Activation.

Harwardt, MIE et al.
Int J Mol Sci 21(8)
Binding

An expanded repertoire of intensity-dependent exercise-responsive plasma proteins tied to loci of human disease risk.

Guseh, JS et al.
Sci Rep 10(1): 10831.
SomaScan

Circulating Protein Signatures and Causal Candidates for Type 2 Diabetes.

Gudmundsdottir, V et al.
Diabetes 69(8): 1843-1853.
Metabolic Disease Biology Large-scale proteomics

Aptamers and Antisense Oligonucleotides for Diagnosis and Treatment of Hematological Diseases.

Giudice, V et al.
Int J Mol Sci 21(9): 3252.
Review Clinical

Proteomics for personalized cardiovascular risk assessment: in pursuit of the Holy Grail.

Ganz, P et al.
Eur Heart J 41(41): 4008-4010.
Cardiovascular

Chemical Modification of Aptamers for Increased Binding Affinity in Diagnostic Applications: Current Status and Future Prospects.

Elskens, JP et al.
Int J Mol Sci 21(12)
Binding Review

Prioritizing Candidates of Post-Myocardial Infarction Heart Failure Using Plasma Proteomics and Single-Cell Transcriptomics

Chan, MY et al.
Circulation 142(15): 1408-1421.
Cardiovascular

Increased mTOR activation in idiopathic multicentric Castleman disease.

Arenas, DJ et al.
Blood 135(19): 1673-1684.
Rare

Elevated Plasma Growth and Differentiation Factor 15 Is Associated With Slower Gait Speed and Lower Physical Performance in Healthy Community-Dwelling Adults.

Semba, RD et al.
J Gerontol A Biol Sci Med Sci 75(1): 175-180.
Aging

Characterization of Parkinson’s disease using blood-based biomarkers: A multicohort proteomic analysis

Posavi, M et al.
PLoS Med 16(10): e1002931
Neurobiology

High-Throughput Identification of the Plasma Proteomic Signature of Inflammatory Bowel Disease.

Di Narzo, AF et al.
J Crohns Colitis 13(4): 462-471.
Inflammatory

Transcatheter aortic valve replacements alter circulating serum factors to mediate myofibroblast deactivation

Aguado BA, et al.
Science Translational Medicine Volume 11 (509) 2019 eaav3233
Cardiovascular

Accelerating Biomarker Discovery Through Electronic Health Records, Automated Biobanking, and Proteomics.

Wells, QS et al.
J Am Coll Cardiol 73(17): 2195-2205.
Cardiovascular

Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria.

Teumer, A et al.
Nat Commun 10(1): 4130.
Kidney

Blood proteome profiling using aptamer-based technology for rejection biomarker discovery in transplantation.

Shubin, AV et al.
Sci Data 6(1): 314.
SomaScan

A signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes.

Niewczas, MA et al.
Nat Med 25(5): 805-813.
Kidney Metabolic

Beyond Autoantibodies: Biologic Roles of Human Autoreactive B Cells in Rheumatoid Arthritis Revealed by RNA-Sequencing.

Mahendra, A et al.
Arthritis Rheumatol 71(4): 529-541.
Immunity Disease biology

Comparison of Urine and Plasma Biomarker Concentrations Measured by Aptamer-Based versus Immunoassay Methods in Cardiac Surgery Patients.

Kukova, LZ et al.
J Appl Lab Med 4(3): 331-342.
SomaScan

Identifying and targeting pathogenic PI3K/AKT/mTOR signaling in IL-6-blockade-refractory idiopathic multicentric Castleman disease.

Fajgenbaum, DC et al.
J Clin Invest 129(10): 4451-4463.
Rare Target identification

Predicting health and life span with the deep plasma proteome.

Emilsson, V et al.
Nat Med 25(12): 1815-1816.
Aging

Balanced event prediction through sampled survival analysis.

Datta, G et al.
Systems Medicine 2(1): 28-38.
SomaScan

Stability of the Human Plasma Proteome to Pre-analytical Variability as Assessed by an Aptamer-Based Approach.

Daniels, JR et al.
J Proteome Res 18(10): 3661-3670.
SomaScan

Circulating proteomic signature of early death in heart failure patients with reduced ejection fraction.

Cuvelliez, M et al.
Sci Rep 9(1): 19202.
Cardiovascular

Aging Disrupts Muscle Stem Cell Function by Impairing Matricellular WISP1 Secretion from Fibro-Adipogenic Progenitors.

Lukjanenko, L et al.
Cell Stem Cell 24(3): 433-446 e437.
Aging Musculoskeletal

Neutrophil activation in systemic capillary leak syndrome (Clarkson disease)

Xie, Z et al.
J Cell Mol Med 23(8): 5119-5127
Rare Disease biology

Plasma proteome in multiple sclerosis disease progression

Malekzadeh A, et al.
Ann Clin Transl Neurol 6(9):1582-1594.
Neurobiology Disease biology Diagnostics Rare

Noninvasive exosomal proteomic biosignatures, including cystatin SN, peroxiredoxin-5, and glycoprotein VI, accurately predict chronic rhinosinusitis with nasal polyps

Mueller, SK et al.
Int Forum Allergy Rhinol 9(2): 177-186.
Exosomes Disease biology Diagnostics

Osteitis is associated with dysregulated pro-osteoblastic activity in patients with nasal polyps

Wu, D et al.
Laryngoscope 129(3): E102-E109.
Exosomes Disease biology Osteoporosis

Vero cell proteomic changes induced by Zika virus infection

Glover, KKM et al.
Proteomics 19(4): e1800309.
Neurobiology Disease biology Infection

Application of an Aptamer-Based Proteomics Assay (SOMAscan™) in Rat Cerebrospinal Fluid

Simats A, et al.
Methods Mol Biol. 2044:221-231.
Neurobiology Disease biology

Guidelines for CSF Processing and Biobanking: Impact on the Identification and Development of Optimal CSF Protein Biomarkers

Hok-A-Hin YS, et al.
Methods Mol Biol. 2044:27-50.
Neurobiology Disease biology SomaScan Large-scale proteomics

Assessing the genetic correlations between blood plasma proteins and osteoporosis: a polygenic risk score analysis

Liang, X et al.
Calcif Tissue Int 104(2): 171-181.
Osteoporosis Disease biology Target identification Diagnostics

Plasma FGF-19 Levels are Increased in Patients with Post-Bariatric Hypoglycemia

Mulla CM, et al.
Obes Surg 29(7):2092-2099.
Metabolic Disease biology

Application of Proteomics Profiling for Biomarker Discovery in Hypertrophic Cardiomyopathy

Shimada YJ, et al.
J Cardiovasc Transl Res 12(6):569-579.
Cardiovascular Disease biology Diagnostics

Cancer protein biomarker discovery based on nucleic acid aptamers

Xiong H, et al.
Int J Biol Macromol 132:190-202.
Oncology Disease biology Diagnostics

Exosome swarms eliminate airway pathogens and provide passive epithelial immunoprotection through nitric oxide

Nocera, AL et al.
J Allergy Clin Immunol 143(4):1525-1535 e1521.
Exosomes Disease biology

Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay

Shi L, et al.
Alzheimers Dement 15(11): 1478-1488.
Aging Disease biology Diagnostics

A framework for multi-omic prediction of treatment response to biologic therapy for psoriasis

Foulkes, AC et al.
J Invest Dermatol 139(1): 100-107.
Immunity Disease biology Stratification Diagnostics

Fatigue in Sjögren’s syndrome: a search for biomarkers and treatment targets

Bodewes, ILA et al.
Front Immunol 10: 312.
Inflammatory Disease biology Immunity Target identification Diagnostics

Disease-specific and glucocorticoid-responsive serum biomarkers for Duchenne Muscular Dystrophy

Hathout Y, et al.
Sci Rep 9(1):12167.
Musculoskeletal Disease biology Diagnostics Rare

Candidate early predictive plasma protein markers of doxorubicin-induced chronic cardiotoxicity in B6C3F1 mice

Desai, VG et al.
Toxicol Appl Pharmacol 363:164-173.
Oncology PK/PD Stratification

A Novel Proteomics Approach to Identify Serum and Urinary Biomarkers and Pathways that Associate with Lower Urinary Tract Symptoms in Men and Women: Pilot Results of the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) Study

Helfand BT, et al.
Urology 129:35-42.
Kidney Disease biology Diagnostics

Pulmonary Aptamer Signatures in Children’s Interstitial and Diffuse Lung Diseases

Deterding RR, et al.
Am J Respir Crit Care Med. doi: 10.1164.
Respiratory Disease biology Diagnostics Pediatric Rare

Metabolic and proteomic signatures of hypoglycemia in type 2 diabetes

Halama, A et al.
Diabetes Obes Metab. 2018 Dec 7. doi: 10.1111.
Metabolic Disease biology Diagnostics

Influenza a virus-triggered autophagy decreases the pluripotency of human-induced pluripotent stem cells

Zahedi-Amiri A, et al.
Cell Death Dis 10(5): 337.
Infection Disease biology Reproductive

The human placental proteome secreted into the maternal and fetal circulations in normal pregnancy based on 4-vessel sampling

Michelsen, TM et al.
FASEB J 33(2):2944-2956.
Reproductive Disease biology

A serum protein signature of APOE genotypes in centenarians

Sebastiani P, et al.
Aging Cell. :e13023. doi: 10.1111.
Aging Disease biology Diagnostics

Activin type II receptor signaling in cardiac aging and heart failure

Roh, JD et al.
Sci Transl Med 11(482).
Diagnostics Aging Disease biology

Circulating Biomarkers of Testosterone’s Anabolic Effects on Fat-Free Mass

Huang G, et al.
J Clin Endocrinol Metab 104(9): 3768-3778.
Musculoskeletal

Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study

Penn-Nicholson A, et al.
PLoS Med 16(4): e1002781.
Infection Disease biology Diagnostics

A combined score of clinical factors and serum proteins can predict time to recurrence in high grade serous ovarian cancer

Mysona, D et al.
Gynecol Oncol 152(3):574-580.
Oncology Disease biology Mechanism of action Diagnostics

Proteomics profiling and risk of new-onset atrial fibrillation: Framingham Heart Study

Ko, D et al.
J Am Heart Assoc 8(6): e010976.
Cardiovascular Disease biology Diagnostics

Proteomic profiles in advanced age-related macular degeneration using an aptamer-based proteomic technology

Lynch, AM et al.
Transl Vis Sci Technol 8(1): 14.
Aging Disease biology Diagnostics Ocular Rare

Human PAH is characterized by a pattern of lipid-related insulin resistance

Hemnes, AR et al.
JCI Insight 4(1).
Respiratory Rare Disease biology Metabolic Mechanism of action Diagnostics

SOMAscan-based proteomic measurements of plasma brain natriuretic peptide are decreased in mild cognitive impairment and in Alzheimer’s dementia patients

Begic E, et al.
PLoS One 14(2):e0212261.
Aging Disease biology Diagnostics

Reproducibility and variability of protein analytes measured using a multiplexed modified aptamer assay

Tin, A et al.
J Appl Lab Med 4(1):30-39.
Cardiovascular Diagnostics

Characterization of Glycolytic Enzymes and Pyruvate Kinase M2 in Type 1 and 2 Diabetic Nephropathy

Gordin D, et al.
Diabetes Care 42(7):1263-1273.
Kidney Disease biology Diagnostics Metabolic

Zika virus infection disrupts astrocytic proteins involved in synapse control and axon guidance

Sher et al.
Front Microbiol 10:596.
Neurobiology Disease biology Infection

Fine-Mapping of the Human Blood Plasma N-Glycome onto Its Proteome

Suhre K, et al.
Metabolites 9(7), 122.
SomaScan

Effects of codon optimization on coagulation factor IX translation and structure: Implications for protein and gene therapies

Alexaki A, et al.
Sci Rep 9(1):15449.
SomaScan Binding Large-scale proteomics

Targeting Unique Epitopes on Highly Similar Proteins GDF-11 and GDF-8 with Modified DNA Aptamers

Ochsner UA, et al.
Biochemistry 58(46):4632-4640.
SomaScan Binding

Biomarker discovery in cardiac allograft vasculopathy using targeted aptamer proteomics

Almufleh A, et al.
Clin Transplant. 2019 Dec 9:e13765.
Cardiovascular Disease biology Diagnostics

Multi-platform Affinity Proteomics Identify Proteins Linked to Metastasis and Immune Suppression in Ovarian Cancer Plasma

Graumann J, et al.
Front Oncol. 9: 1150.
Oncology Disease biology Diagnostics

Apabetalone (RVX-208) reduces vascular inflammation in vitro and in CVD patients by a BET-dependent epigenetic mechanism

Tsujikawa LM, et al.
Clin Epigenetics 11: 102.
Cardiovascular Mechanism of action Stratification Diagnostics

Aptamer Profiling of A549 Cells Infected with Low-Pathogenicity and High-Pathogenicity Influenza Viruses

Coombs KM, et al.
Viruses 2019, 11(11), 1028.
Infection Disease biology Diagnostics

Dual-platform affinity proteomics identifies links between the recurrence of ovarian carcinoma and proteins released into the tumor microenvironment

Finkemagel F, et al.
Theranostics 9(22):6601-6617.
Oncology Disease biology Diagnostics Stratification

Proteomics in gastroparesis: Unique and overlapping protein signatures in diabetic and idiopathic gastroparesis

Grover M, et al.
Am J Physiol Gastrointest Liver Physiol. 2019 Sep 4. doi: 10.1152.
Immunity Disease biology Diagnostics Metabolic SomaScan Binding

Proteomic analysis reveals distinctive protein profiles involved in CD8(+) T cell-mediated murine autoimmune cholangitis

Zhang, W et al.
Cell Mol Immunol 15(8): 756-767.
Immunity Disease biology Rare

Plasma proteomics identifies a ‘chemokine storm’ in idiopathic multicentric Castleman disease

Pierson, SK et al.
Am J Hematol 93(7): 902-912.
Inflammatory Disease biology Diagnostics Rare

Highly multiplexed proteomic analysis reveals significant tissue and exosomal coagulation pathway derangement in chronic rhinosinusitis with nasal polyps

Mueller, SK et al.
Int Forum Allergy Rhinol 8(12): 1438-1444.
Exosomes Disease biology Diagnostics

Tracking disease progression non-invasively in Duchenne and Becker muscular dystrophies

Spitali, P et al.
J Cachexia Sarcopenia Muscle 9(4): 715-726.
Pediatric Disease biology Diagnostics Musculoskeletal

Serum proteomic assessment of the progression of fracture healing

Hussein, AI et al.
J Orthop Res 36(4): 1153-1163.
Osteoporosis Diagnostics

The impact of the glomerular filtration rate on the human plasma proteome

Christensson, A et al.
Proteomics Clin Appl 12(3): e1700067.
Kidney Disease biology Diagnostics

Novel application of aptamer proteomic analysis in cystic fibrosis bronchoalveolar lavage fluid

DeBoer, EM et al.
Proteomics Clin Appl: e1800085.
Rare Disease biology Diagnostics

Cytokines IL-17, TNF and IFN-gamma alter the expression of antimicrobial peptides and proteins disparately: a targeted proteomics analysis using SOMAscan technology

Altieri, A et al.
Vaccines (Basel) 6(3).
Infection Disease biology

Benefit of apabetalone on plasma proteins in renal disease

Wasiak, S et al.
Kidney International Reports 3(3): 711-721.
Kidney Disease biology Diagnostics Mechanism of action

Aptamer-based proteomics identifies mortality-associated serum biomarkers in dialysis-dependent AKI patients

Yu, LR et al.
Kidney Int Rep 3(5): 1202-1213.
Kidney Disease biology Diagnostics Target identification

“Scanning” into the future: the promise of SOMAScan technology for kidney disease

Coca, SG
Kidney Int Rep 3(5): 1020-1022.
Kidney Disease biology Diagnostics

Aptamer-based proteomics of serum and plasma in acquired aplastic anemia

Giudice, V et al.
Exp Hematol 68: 38-50.
Rare Disease biology Diagnostics

Sperm cell purification from mock forensic swabs using SOMAmerTM affinity reagents

Katilius E et al.
Forensic Sci Int Genet 35: 9-13.
SomaScan Binding

Sputum transcriptomics reveal up-regulation of IL-1 receptor family members in severe asthma

Rossios, C et al.
J Allergy Clin Immunol 141(2): 560-570.
Respiratory Disease biology Diagnostics

Plasma from some cancer patients inhibits adenoviral Ad5f35 vector transduction of dendritic cells

Jin, P et al.
Cytotherapy 20(5): 728-739.
Oncology Mechanism of action Diagnostics

Non-invasive assessment of non-alcoholic fatty liver disease: Clinical prediction rules and blood-based biomarkers

Vilar-Gomez, E et al.
J Hepatol 68(2): 305-315.
Inflammatory Disease biology Diagnostics Fibrotic Metabolic

Cerebrospinal fluid biomarkers link toxic astrogliosis and microglial activation to multiple sclerosis severity

Masvekar, R et al.
Mult Scler Relat Disord 28: 34-43.
Neurobiology Disease biology Diagnostics

Phase IIa trial in Duchenne muscular dystrophy shows vamorolone is a first-in-class dissociative steroidal anti-inflammatory drug

Conklin, LS et al.
Pharmacol Res 136: 140-150.
Neurobiology Disease biology Diagnostics PK/PD Stratification

Serum biomarkers of glucocorticoid response and safety in anti-neutrophil cytoplasmic antibody-associated vasculitis and juvenile dermatomyositis

Conklin, LS et al.
Steroids 140: 159-166.
Inflammatory Disease biology Diagnostics Rare

Diet-resistant obesity is characterized by a distinct plasma proteomic signature and impaired muscle fiber metabolism

Thrush, AB et al.
Int J Obes (Lond) 42(3): 353-362.
Metabolic Disease biology Diagnostics Osteoporosis

Characterization of the rat cerebrospinal fluid proteome following acute cerebral ischemia using an aptamer-based proteomic technology

Simats, A et al.
Sci Rep 8(1): 7899.
Neurobiology Disease biology Diagnostics

Stability and reproducibility of proteomic profiles measured with an aptamer-based platform

Kim, CH et al.
Sci Rep 8(1): 8382.
SomaScan Binding Review

Increased levels of circulating MMP3 correlate with severe rejection in face transplantation

Kollar, B et al.
Sci Rep 8(1): 14915.
Inflammatory Disease biology Diagnostics

Mistimed food intake and sleep alters 24-hour time-of-day patterns of the human plasma proteome

Depner CM et al.
Proc Natl Acad Sci U S A 115(23): E5390-E5399.
Metabolic Disease biology

Classification of prostate cancer using a protease activity nanosensor library

Dudani, JS et al.
Proc Natl Acad Sci U S A 115(36): 8954-8959.
Oncology Diagnostics

Deep molecular phenotypes link complex disorders and physiological insult to CpG methylation

Zaghlool, SB et al.
Hum Mol Genet 27(6): 1106-1121.
Respiratory Disease biology Metabolic

Identification of novel systemic sclerosis biomarkers employing aptamer proteomic analysis

Wermuth, PJ et al.
Rheumatology (Oxford) 57(10): 1698-1706.
Immunity Disease biology Diagnostics

Plasma proteomic signature of age in healthy humans

Tanaka, T et al.
Aging Cell 17(5): e12799.
Aging Diagnostics

Habitual aerobic exercise and circulating proteomic patterns in healthy adults: relation to indicators of healthspan

Santos-Parker, JR et al.
J Appl Physiol (1985) 125(5): 1646-1659.
Aging Disease biology Diagnostics

Application of large scale aptamer-based proteomic profiling to “planned” myocardial infarctions

Jacob, J et al.
Circulation 137(12): 1270-1277.
Cardiovascular Disease biology Diagnostics Target identification

Integrative omics: harnessing the proteome to maximize the potential of the genome

McGarrah, RW et al.
Circulation 137(11): 1173-1175.
Cardiovascular Disease biology

Harnessing the power of proteomics to assess drug safety and guide clinical trials

Lam, MPY et al.
Circulation 137(10): 1011-1014.
Cardiovascular Stratification

Probing the virtual proteome to identify novel disease biomarkers

Mosley, JD et al.
Circulation 138(22): 2469-2481.
Cardiovascular Disease biology Diagnostics

Cerebrospinal fluid protein changes in preeclampsia

Ciampa, E et al.
Hypertension 72(1): 219-226.
Reproductive Disease biology

Endothelial microparticles and systemic complement activation in patients with chronic kidney disease

Jalal, D et al.
J Am Heart Assoc 7(14): e007818.
Kidney Disease biology Inflammatory

Early identification of bronchopulmonary dysplasia using novel biomarkers by proteomic screening

Forster, K et al.
Am J Respir Crit Care Med 197(8): 1076-1080.
Respiratory Disease biology Diagnostics

Analysis of circulating angiopoietin-like protein 3 and genetic variants in lipid metabolism and liver health: the DiOGenes study

Hess, AL et al.
Genes Nutr 13: 7.
Metabolic Disease biology Diagnostics

Serum biomarker for diagnostic evaluation of pulmonary arterial hypertension in systemic sclerosis

Rice, LM et al.
Arthritis Res Ther 20(1): 185.
Respiratory Rare Disease biology Diagnostics

Aptamer-based search for correlates of plasma and serum water T2: implications for early metabolic dysregulation and metabolic syndrome

Patel, V et al.
Biomark Res 6: 28.
Metabolic Disease biology Diagnostics

The differential plasma proteome of obese and overweight individuals undergoing a nutritional weight loss and maintenance intervention

Oller Moreno, S et al.
Proteomics Clin Appl 12(1).
Metabolic Disease biology Diagnostics

Combined use of protein biomarkers and network analysis unveils deregulated regulatory circuits in Duchenne muscular dystrophy

Parolo, S et al.
PLoS One 13(3): e0194225.
Neurobiology Disease biology Diagnostics Rare

A proteomic signature that reflects pancreatic beta-cell function

Curran, AM et al.
PLoS One 13(8): e0202727.
Metabolic Disease biology Diagnostics

Proteomic analysis of heart failure hospitalization among patients with chronic kidney disease: The Heart and Soul Study

Dubin, RF et al.
PLoS One 13(12): e0208042.
Cardiovascular Disease biology Diagnostics Target identification Kidney

Validation of a novel modified aptamer-based array proteomic platform in patients with end-stage renal disease

Han, Z et al.
Diagnostics (Basel) 8(4).
Kidney Diagnostics

Adrenomedullin surges are linked to acute episodes of the systemic capillary leak syndrome (Clarkson disease).

Xie, Z et al.
J Leukoc Biol 103(4): 749-759.
Rare

Proteomics: Clinical and research applications in respiratory diseases.

Norman, KC et al.
Respirology 23(11): 993-1003.
Respiratory Review

A proteomic clock of human pregnancy.

Aghaeepour, N et al.
Am J Obstet Gynecol 218(3): 347 e341-347 e314.
Reproductive

Genome-wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease

Yao, C et al.
Nat Commun 9(1): 3268.
Cardiovascular Disease biology Diagnostics Target identification

Chemotherapy-induced differential cell cycle arrest in B-cell lymphomas affects their sensitivity to Wee1 inhibition

Wang, X et al.
Haematologica 103(3): 466-476.
Oncology Disease biology Mechanism of action

Clinical validation of a protein biomarker panel for non-small cell lung cancer

Jung, YJ et al.
J Korean Med Sci 33(53): e342.
Oncology Disease biology Diagnostics

Multi-omics monitoring of drug response in rheumatoid arthritis in pursuit of molecular remission

Tasaki, S et al.
Nat Commun 9(1): 2755.
Immunity Diagnostics

Modified aptamers enable quantitative sub-10-nm cellular DNA-PAINT imaging

Strauss, S et al.
Nat Methods 15(9): 685-688.
SomaScan Binding

Improving probes for super-resolution

Moore, RP et al.
Nat Methods 15(9): 659-660.
SomaScan Binding

Slow Off-Rate Modified Aptamer (SOMAmer) as a Novel Reagent in Immunoassay Development for Accurate Soluble Glypican-3 Quantification in Clinical Samples

Duo J et al.
Anal Chem 90(8): 5162-5170.
Oncology Diagnostics SomaScan Binding

Proteomic profiling identifies novel circulating markers associated with bronchiectasis in cystic fibrosis

DeBoer, EM et al.
Proteomics Clin Appl 11(9-10).
Respiratory Disease biology Diagnostics Pediatric

Interleukin 1 receptor-like 1 protein (ST2) is a potential biomarker for cardiomyopathy in Duchenne muscular dystrophy

Anderson, J et al.
Pediatr Cardiol 38(8): 1606-1612.
Cardiovascular Diagnostics Pediatric Neurobiology

Complementarity of SOMAscan to LC-MS/MS and RNA-seq for quantitative profiling of human embryonic and mesenchymal stem cells

Billing, AM et al.
J Proteomics 150: 86-97.
SomaScan

Structural basis for IL-1α recognition by a modified DNA aptamer that specifically inhibits IL-1α signaling.

Ren, X et al.
Nat Commun 8(1): 810.
Binding SomaScan Structure

Protein quantitative trait locus study in obesity during weight-loss identifies a leptin regulator

Carayol, J et al.
Nat Commun 8(1): 2084.
Metabolic Disease biology Diagnostics

Downregulation of the complement cascade in vitro, in mice and in patients with cardiovascular disease by the BET protein inhibitor apabetalone (RVX-208)

Wasiak, S et al.
J Cardiovasc Transl Res, 10(4): 337-347.
Cardiovascular Mechanism of action

A proteome-derived longitudinal pharmacodynamic biomarker for diffuse systemic sclerosis skin

Rice, LM et al.
J Invest Dermatol 137(1): 62-70.
Immunity Disease biology Diagnostics

Selection of aptamers to Neisseria meningitidis and Streptococcus pneumoniae surface specific proteins and affinity assay using thin film AlN resonators

Escolano, JM et al.
Sensors and Actuators B: Chemical 246: 591-596.
Infection Diagnostics

Development and characterization of an HPV Type-16 specific modified DNA aptamer for the improvement of potency assays

Trausch, JJ et al.
Anal Chem 89(6): 3554-3561.
Infection Diagnostics

The peripheral blood proteome signature of idiopathic pulmonary fibrosis is distinct from normal and is associated with novel immunological processes

O’Dwyer, DN et al.
Sci Rep 7: 46560.
Respiratory Rare Disease biology Diagnostics Fibrotic

Sexual dimorphism, age, and fat mass are key phenotypic drivers of proteomic signatures

Curran, AM et al.
J Proteome Res 16(11): 4122-4133.
Aging Disease biology Metabolic

Identification of novel biomarkers to monitor β-cell function and enable early detection of type 2 diabetes risk

Belongie, KJ et al.
PLoS One 12(8): e0182932.
Metabolic Disease biology

Trisomy 21 causes changes in the circulating proteome indicative of chronic autoinflammation

Sullivan, KD et al.
Sci Rep 7(1): 14818.
Rare Disease biology

Assessment of variability in the SOMAscan assay

Candia, J et al.
Sci Rep 7(1):14248.
SomaScan Binding Review

Divergent roles for clusterin in lung injury and repair

Habiel, DM et al.
Sci Rep 7(1): 15444.
Respiratory Disease biology Fibrotic

A pilot characterization of the human chronobiome

Skarke, C et al.
Sci Rep 7(1):17141.
Metabolic Disease biology

Pharmacokinetic properties of DNA aptamers with base modifications

Gupta, S et al.
Nucleic Acid Ther 27(6): 345-353.
SomaScan Binding

Genome-wide quantitative trait loci mapping of the human cerebrospinal fluid proteome

Sasayama, D et al.
Hum Mol Genet 26(1): 44-51.
Neurobiology Disease biology Diagnostics

Identification of unique proteomic signatures in allergic and non-allergic skin disease

Wang, J et al.
Clin Exp Allergy 47(11): 1456-1467.
Inflammatory Disease biology Diagnostics

An immune clock of human pregnancy

Aghaeepour, N et al.
Sci Immunol 2(15):eaan2946.
Immunity Disease biology Reproductive

A degradation fragment of type X collagen is a real-time marker for bone growth velocity

Coghlan, RF et al.
Sci Transl Med 9(419): eaan4669.
Osteoporosis Disease biology Diagnostics

Large-scale proteomics identifies MMP-7 as a sentinel of epithelial injury and of biliary atresia

Lertudomphonwanit, C et al.
Sci Transl Med 9(417): eaan8462.
Pediatric Disease biology Diagnostics Target identification Rare

Proteomic profiles associated with early echocardiogram evidence of pulmonary vascular disease in preterm infants

Wagner, BD et al.
Am J Respir Crit Care Med 197(3): 394-397.
Cardiovascular Disease biology Pediatric

Antiinflammatory effects of aprepitant coadministration with cART regimen containing ritonavir in HIV-infected adults

Spitsin, S et al.
JCI Insight 2(19) 95893
Immunity Disease biology Infection Mechanism of action

The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimer’s pathology

Westwood, S et al.
Alzheimers Res Ther 9(1): 31.
Aging Disease biology Metabolic

Paracrine signals regulate human liver organoid maturation from induced pluripotent stem cells

Asai, A et al.
Development 144(6): 1056-1064.

High-throughput characterization of blood serum proteomics of IBD patients with respect to aging and genetic factors

Di Narzo, AF et al.
PLoS Genet 13(1): e1006565.
Aging Disease biology Inflammatory

Sequential inflammatory processes define human progression from M. tuberculosis infection to tuberculosis disease

Scriba, TJ et al.
PLoS Pathog 13(11): e1006687.
Infection Disease biology

Activation of inflammatory and pro-thrombotic pathways in acute stress cardiomyopathy

Fitzgibbons, TP et al.
Frontiers in Cardiovascular Medicine 4: 49.
Cardiovascular Disease biology Diagnostics

A moderate increase in dietary zinc reduces DNA strand breaks in leukocytes and alters plasma proteins without changing plasma zinc concentrations

Zyba, SJ et al.
Am J Clin Nutr 105(2): 343-351.
Metabolic Disease biology

Discovery and validation of a six-marker serum protein signature for the diagnosis of active pulmonary tuberculosis

De Groote, MA et al.
J Clin Microbiol 55(10): 3057-3071.
Infection Diagnostics

Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity

Saleheen, D et al.
Nature 544(7649): 235-239.

Attenuated PDGF signaling drives alveolar and microvascular defects in neonatal chronic lung disease

Oak, P et al.
EMBO Mol Med 9(11): 1504-1520.
Respiratory Disease biology Diagnostics

GDF15 is a heart-derived hormone that regulates body growth

Wang, T et al.
EMBO Mol Med 9(8): 1150-1164.
Cardiovascular Disease biology Pediatric

The prediction of late-onset preeclampsia: Results from a longitudinal proteomics study

Erez, O et al.
PLoS One 12(7): e0181468.
Reproductive Disease biology Diagnostics

Diagnosis and prognosis-review of biomarkers for mesothelioma

Sun, HH et al.
Ann Transl Med 5(11): 244.
Respiratory Disease biology Diagnostics

Molecular-based diagnosis of multiple sclerosis and its progressive stage

Barbour, C et al.
Ann Neurol 82(5): 795-812.
Neurobiology Disease biology Diagnostics

Vitamin B12 deficiency and impaired expression of amnionless during aging

Pannerec, A et al.
J Cachexia Sarcopenia Muscle 9(1): 41-52.
Aging Disease biology

Aging and sarcopenia associate with specific interactions between gut microbes, serum biomarkers and host physiology in rats.

Siddharth, J et al.
Aging (Albany NY) 9(7): 1698-1720.
Aging Musculoskeletal

Evaluation of two high-throughput proteomic technologies for plasma biomarker discovery in immunotherapy-treated melanoma patients.

Lim, SY et al.
Biomark Res 5: 32.
Oncology

Highly multiplexed proteomic analysis of quantiferon supernatants to identify biomarkers of latent tuberculosis infection

De Groote, MA et al.
J Clin Microbiol 55(2): 391-402.
Infection Diagnostics

Connecting genetic risk to disease end points through the human blood plasma proteome

Suhre, K et al.
Nat Commun 8: 14357.
SomaScan Large-scale proteomics

Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms

Howson, JMM et al.
Nat Genet 49(7): 1113-1119.
Cardiovascular Disease biology

Plasma proteome analysis in patients with pulmonary arterial hypertension: an observational cohort study

Rhodes, CJ et al.
Lancet Respir Med 5(9): 717-726.
Cardiovascular Disease biology Target identification Respiratory Rare

Aptamer-based proteomic profiling for prognostication in pulmonary arterial hypertension

Giannitsis, E et al.
Lancet Respir Med 5(9): 671-672.
Cardiovascular Disease biology Target identification Respiratory Rare

Multiomic disease signatures converge to cytotoxic CD8 T cells in primary Sjogren’s syndrome

Tasaki, S et al.
Ann Rheum Dis 76(8): 1458-1466.
Immunity Disease biology Target identification

Efficacy of individualised diets in patients with irritable bowel syndrome: a randomised controlled trial

Ali A et al.
BMJ Open Gastro 4(1): e000164.
Inflammatory Disease biology

Identification of serum protein biomarkers for utrophin based DMD therapy

Guiraud, S et al.
Sci Rep 7: 43697.
Pediatric Disease biology Diagnostics Musculoskeletal

Selection of DNA aptamers with two modified bases

Gawande, BN et al.
Proc Natl Acad Sci U S A 114(11): 2898-2903.
SomaScan Binding

The maternal plasma proteome changes as a function of gestational age in normal pregnancy: a longitudinal study

Romero, R et al.
Am J Obstet Gynecol 217(1):67 e61-67 e21.
Reproductive Disease biology Diagnostics

The impact of micronutrient status on health: correlation network analysis to understand the role of micronutrients in metabolic-inflammatory processes regulating homeostasis and phenotypic flexibility

van den Broek, TJ et al.
Genes Nutr 12: 5.
Metabolic Disease biology

Potential of high-affinity, Slow Off-Rate Modified Aptamer (SOMAmer) reagents for Mycobacterium tuberculosis proteins as tools for infection models and diagnostic applications

Russell, T et al.
J Clin Microbiol 55(10): 3072-3088.
Infection Diagnostics

Proteomic study of hepatocellular carcinoma using a novel modified aptamer-based array (SOMAscan) platform

Qiao, Z et al.
Biochim Biophys Acta 1865(4): 434-443.
Oncology Disease biology Diagnostics Rare

Development of a protein biomarker panel to detect non-small-cell lung cancer in Korea

Jung, YJ et al.
Clin Lung Cancer 18(2): e99-e107.
Oncology Diagnostics

A multi-component classifier for nonalcoholic fatty liver disease (NAFLD) based on genomic, proteomic, and phenomic data domains

Wood, GC et al.
Sci Rep 7: 43238.
Metabolic Diagnostics

The relationship of circulating proteins in early pregnancy with preterm birth

Lynch, AM et al.
Am J Obstet Gynecol 214(4): 517 e511-518.
Reproductive Disease biology Diagnostics

Serum proteomic analysis identifies interleukin 16 as a biomarker for clinical response during early treatment of rheumatoid arthritis

Murota, A et al.
Cytokine 78: 87-93.
Immunity Disease biology Diagnostics

Identification of definitive serum biomarkers associated with disease activity in primary Sjögren’s syndrome

Nishikawa, A et al.
Arthritis Res Ther 18(1): 106.
Immunity Disease biology Diagnostics Target identification

Incorporation of Slow Off-Rate Modified Aptamers reagents in single molecule array assays for cytokine detection with ultrahigh sensitivity

Wu, D et al.
Anal Chem 88(17): 8385-8389.
SomaScan Binding

Identification of pathway-specific serum biomarkers of response to glucocorticoid and infliximab treatment in children with inflammatory bowel disease

Heier, CR et al.
Clin Transl Gastroenterol 7(9): e192.
Inflammatory Disease biology Mechanism of action Pediatric

Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice

Lukjanenko, L et al.
Nat Med 22(8): 897-905.
Aging Disease biology Musculoskeletal

Serum pharmacodynamic biomarkers for chronic corticosteroid treatment of children

Hathout, Y et al.
Sci Rep 6: 31727.
Inflammatory Disease biology Diagnostics Pediatric

A cross sectional study of two independent cohorts identifies serum biomarkers for facioscapulohumeral muscular dystrophy (FSHD)

Petek, LM et al.
Neuromuscul Disord 26(7): 405-413.
Musculoskeletal Disease biology Diagnostics

Chemically modified interleukin-6 aptamer inhibits development of collagen-induced arthritis in cynomolgus monkeys

Hirota, M et al.
Nucleic Acid Ther 26(1): 10-19.
Immunity Disease biology Target identification Target validation mechanism of action Binding

Fit for the eye: aptamers in ocular disorders

Drolet, DW et al.
Nucleic Acid Ther 26(3): 127-146.
Ocular Disease biology Diagnostics Target identification Mechanism of action PK/PD

readat: an R package for reading and working with SomaLogic ADAT files

Cotton, RJ et al.
BMC Bioinformatics 17(1): 201.

Diagnostic and Prognostic Biomarkers in the Rational Assessment of Mesothelioma (DIAPHRAGM) study: protocol of a prospective, multicentre, observational study

Tsim, S et al.
BMJ Open 6(11): e013324.
Respiratory Disease biology Diagnostics Stratification

Identifying low-abundance biomarkers: Aptamer-based proteomics potentially enables more sensitive detection in cardiovascular diseases

Gramolini, A et al.
Circulation 134(4): 286-289.
Cardiovascular Diagnostics

Respiratory mucosal proteome quantification in human influenza infections

Marion, T et al.
PLoS One 11(4): e0153674.
Infection Disease biology

Six-SOMAmer index relating to immune, protease and angiogenic functions predicts progression in IPF

Ashley, SL et al.
PLoS One 11(8): e0159878.
Respiratory Disease biology Diagnostics Fibrotic

Longitudinal protein changes in blood plasma associated with the rate of cognitive decline in Alzheimer’s disease

Sattlecker, M et al.
J Alzheimers Dis 49(4): 1105-1114.
Aging Disease biology Target identification

An evaluation of an aptamer for use as an affinity reagent with MS: PCSK9 as an example protein

Gupta, V et al.
Bioanalysis 8(15): 1557-1564.
SomaScan Binding

Developing clinically relevant biomarkers in inflammatory arthritis: A multiplatform approach for serum candidate protein discovery

McArdle, A et al.
Proteomics Clin Appl 10(6): 691-698.
Immunity Disease biology Diagnostics

The relationship of novel plasma proteins in the early neonatal period with retinopathy of prematurity

Lynch, AM et al.
Invest Ophthalmol Vis Sci 57(11): 5076-5082.
Pediatric Disease biology Diagnostics

Embracing proteins: structural themes in aptamer-protein complexes

Gelinas, AD et al.
Curr Opin Struct Biol 36: 122-132.
SomaScan Structure Binding

Proteomics analysis of vesicles isolated from plasma and urine of prostate cancer patients using a multiplex, aptamer-based protein array

Welton, JL et al.
J Extracell Vesicles 5: 31209.
Oncology Diagnostics Exosomes

Clinical utility of serum biomarkers in Duchenne muscular dystrophy.

Hathout, Y et al.
Clin Proteomics 13: 9.
Rare Review

SELEX: How it happened and where it will go

Gold, L
J Mol Evol 81(5-6): 140-143.
Review

Non-helical DNA triplex forms a unique aptamer scaffold for high affinity recognition of nerve growth factor

Jarvis, TC et al.
Structure 23(7): 1293-1304.
SomaScan Structure Binding

Increased cerebrospinal fluid fibrinogen in major depressive disorder

Hattori, K et al.
Sci Rep 5: 11412.
Neurobiology Disease biology

Plasma protein biomarkers of Alzheimer’s disease endophenotypes in asymptomatic older twins: early cognitive decline and regional brain volumes

Kiddle, SJ et al.
Transl Psychiatry 5: e584.
Aging Disease biology Diagnostics Stratification

Large-scale serum protein biomarker discovery in Duchenne muscular dystrophy

Hathout, Y et al.
Proc Natl Acad Sci U S A 112(23): 7153-7158.
Pediatric Disease biology Diagnostics Target identification Musculoskeletal Rare

Practical synthesis of cytidine-5-carboxamide-modified nucleotide reagents

Rohloff, JC et al.
Nucleosides Nucleotides Nucleic Acids 34(3): 180-198.
SomaScan

Influence of 5-N-carboxamide modifications on the thermodynamic stability of oligonucleotides

Wolk, SK et al.
Nucleic Acids Res 43(19): 9107-9122.
SomaScan Binding

Improved preparation of 2 M triethylammonium bicarbonate

Carlson, M et al.
Green Chem Lett Rev 8(3-4): 37-39.
SomaScan

Proteomic methods for biomarker discovery and validation. Are we there yet?

Hathout, Y (2015)
Expert Rev Proteomics 12(4): 329-331.
Review

Rapid Slow Off-Rate Modified Aptamer (SOMAmer)-based detection of C-reactive protein using isotachophoresis and an ionic spacer.

Eid, C et al.
Anal Chem 87(13): 6736-6743.
SomaScan

Association of growth differentiation factor 11/8, putative anti-ageing factor, with cardiovascular outcomes and overall mortality in humans: analysis of the Heart and Soul and HUNT3 cohorts

Olson, KA et al.
Eur Heart J 36(48): 3426-3434.
Cardiovascular Disease biology Diagnostics Aging

Circulating proteomic signatures of chronological age

Menni, C et al.
J Gerontol A Biol Sci Med Sci 70(7): 809-816.
Aging Disease biology Diagnostics

Blood protein markers of neocortical amyloid-beta burden: a candidate study using SOMAscan technology.

Voyle, N et al.
J Alzheimers Dis 46(4): 947-961.
Neurobiology

A candidate plasma protein classifier to identify Alzheimer’s disease.

Zhao, X et al.
J Alzheimers Dis 43(2): 549-563.
Neurobiology

Investigation of novel circulating proteins, germ line single-nucleotide polymorphisms, and molecular tumor markers as potential efficacy biomarkers of first-line sunitinib therapy for advanced renal cell carcinoma

Motzer, RJ et al.
Cancer Chemother Pharmacol 74(4): 739-750.
Oncology Stratification Diagnostics

Aptamer-based proteomic signature of intensive phase treatment response in pulmonary tuberculosis

Nahid, P et al.
Tuberculosis (Edinb) 94(3): 187-196.
Infection Stratification Diagnostics

Chemically modified DNA aptamers bind interleukin-6 with high affinity and inhibit signaling by blocking its interaction with interleukin-6 receptor

Gupta, S et al.
J Biol Chem 289(12): 8706-8719.
SomaScan Structure Clinical Binding

Crystal structure of interleukin-6 in complex with a modified nucleic acid ligand

Gelinas, AD et al.
J Biol Chem 289(12): 8720-8734.
SomaScan Structure Binding

Proteomics analysis of cancer exosomes using a novel modified aptamer-based array (SOMAscan™) platform

Webber, J et al.
Mol Cell Proteomics 13(4): 1050-1064.
Oncology Diagnostics Exosomes

DTC-and-me: patient, provider, proteins and regulators.

Steele, FR et al.
J Pers Med 4(1): 79-87.
SomaScan

Beyond antibodies: new affinity reagents to unlock the proteome.

Lollo, B et al.
Proteomics 14(6): 638-644.
SomaScan Binding

Methylation potential associated with diet, genotype, protein, and metabolite levels in the Delta Obesity Vitamin Study

Monteiro, JP et al.
Genes Nutr 9(3): 403.
Metabolic Disease biology Diagnostics

Genetic associations with micronutrient levels identified in immune and gastrointestinal networks

Morine, MJ et al.
Genes Nutr 9(4): 408.
Metabolic Disease biology

Nucleic acid ligands with protein-like side chains: Modified aptamers and their use as diagnostic and therapeutic agents

Rohloff, JC et al.
Mol Ther Nucleic Acids 3:e201.
SomaScan Binding Review Clinical

Specific capture and detection of Staphylococcus aureus with high-affinity modified aptamers to cell surface components

Baumstummler, A et al.
Lett Appl Microbiol 59(4): 422-431.
Infection Diagnostics

Validation of a blood protein signature for non-small cell lung cancer

Mehan, MR et al.
Clin Proteomics 11(1): 32.
Oncology Diagnostics

Systematic selection of modified aptamer pairs for diagnostic sandwich assays

Ochsner, UA et al.
Biotechniques 56(3): 125-128, 130, 132-133.
Cardiovascular Diagnostics Infection SomaScan Binding

Candidate blood proteome markers of Alzheimer’s disease onset and progression: a systematic review and replication study

Kiddle, SJ et al.
J Alzheimers Dis 38(3): 515-531.
Aging Disease biology Diagnostics Stratification

Alzheimer’s disease biomarker discovery using SOMAscan multiplexed protein technology

Sattlecker, M et al.
Alzheimers Dement 10(6): 724-734.
Aging Disease biology Diagnostics

Detection of Clostridium difficile toxins A, B and binary toxin with slow off-rate modified aptamers

Ochsner, UA et al.
Diagn Microbiol Infect Dis 76(3): 278-285.
Infection Diagnostics Binding

Elucidating novel serum biomarkers associated with pulmonary tuberculosis treatment

De Groote, MA et al.
PLoS One 8(4): e61002.
Infection Disease biology Diagnostics

Interaction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondin

Xie, Y et al.
EMBO Rep 14(12): 1120-1126.
Oncology Disease biology SomaScan

Measurement of cetuximab and panitumumab-unbound serum EGFR extracellular domain using an assay based on slow off-rate modified aptamer (SOMAmer) reagents

Park, NJ et al.
PLoS One 8(8): e71703.

Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy

Loffredo, FS et al.
Cell 153(4): 828-839.
Cardiovascular Disease biology Diagnostics

Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets

Davies, DR et al.
Proc Natl Acad Sci U S A 109(49): 19971-19976.
SomaScan Structure Binding

Early detection of malignant pleural mesothelioma in asbestos-exposed individuals with a noninvasive proteomics-based surveillance tool

Ostroff, RM et al.
PLoS One 7(10):e46091.
Oncology Disease biology Diagnostics Rare

Aptamers and the RNA world, past and present

Gold, L et al.
Cold Spring Harb Perspect Biol 4(3).
Review

Life’s simple measures: unlocking the proteome

Brody, E et al.
J Mol Biol 422(5):595-606.
Review

Protein signature of lung cancer tissues

Mehan, MR et al.
PLoS One 7(4): e35157.
Oncology Disease biology Diagnostics Target identification

Age-dependent changes in the cerebrospinal fluid proteome by slow off-rate modified aptamer array

Baird, GS et al.
Am J Pathol 180(2): 446-456.
Aging Disease biology Diagnostics Neurobiology

Rapid histochemistry using slow off-rate modified aptamers with anionic competition

Gupta, S et al.
Appl Immunohistochem Mol Morphol 19(3): 273-278.
SomaScan Binding

Unlocking biomarker discovery: large scale application of aptamer proteomic technology for early detection of lung cancer

Ostroff, RM et al.
PLoS One 5(12): e15003.
Oncology Disease biology Diagnostics

Aptamer-based multiplexed proteomic technology for biomarker discovery

Gold, L et al.
PLoS One 5(12): e15004.
Review

From SOMAmer-based biomarker discovery to diagnostic and clinical applications: a SOMAmer-based, streamlined multiplex proteomic assay

Kraemer, S et al.
PLoS One 6(10): e26332.
SomaScan Binding

High-content affinity-based proteomics: unlocking protein biomarker discovery

Brody, EN et al.
Expert Rev Mol Diagn 10(8): 1013-1022.
Review

Expanding the chemistry of DNA for in vitro selection

Vaught, JD et al.
J Am Chem Soc 132(12): 4141-4151.
SomaScan

Proteomics and diagnostics: Let’s get specific, again

Zichi, D et al.
Curr Opin Chem Biol 12(1): 78-85.
SomaScan

Interlocking structural motifs mediate molecular discrimination by a theophylline-binding RNA

Zimmermann, GR et al.
Nat Struct Biol 4(8): 644-649.
SomaScan Structure

Let’s get specific: the relationship between specificity and affinity

Eaton, BE et al.
Chem Biol 2(10): 633-638.
SomaScan Binding

High-resolution molecular discrimination by RNA

Jenison, RD et al.
Science 263(5152): 1425-1429.
Review