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Current Publications Count: 490
A proteomic surrogate for cardiovascular outcomes that is sensitive to multiple mechanisms of change in risk
Sci Transl Med 14(639): eabj9625
Large-scale integration of the plasma proteome with genetics and disease
Nat Genet 53(12): 1712-1721
Mapping the proteo-genomic convergence of human diseases
Science 374(6569): eabj1541
A brain proteomic signature of incipient Alzheimer's disease in young APOE epsilon4 carriers identifies novel drug targets
Sci Adv 7(46): eabi8178.
Plasma protein patterns as comprehensive indicators of health
Nat Med 25(12): 1851-1857.
Undulating changes in human plasma proteome profiles across the lifespan
Nat Med 25(12): 1843-1850
Co-regulatory networks of human serum proteins link genetics to disease
Science 361(6404): 769-773.
Genomic atlas of the human plasma proteome
Nature 558: 73-79.
Improving assessment of drug safety through proteomics: early detection and mechanistic characterization of the unforeseen harmful effects of torcetrapib
Circulation 137(10): 999-1010.
Genetic architecture of the cardiovascular risk proteome
Circulation 137(11): 1158-1172.
Development and validation of a protein-based risk score for cardiovascular outcomes among patients with stable coronary heart disease
JAMA 315(23): 2532-2541.
Using aptamer-based technology to probe the plasma proteome for cardiovascular disease prediction
JAMA 315(23): 2525-2526.
Aptamer-based proteomic profiling reveals novel candidate biomarkers and pathways in cardiovascular disease
Circulation 134(4): 270-285.
Whole Genome Sequence Analysis of the Plasma Proteome in Black Adults Provides Novel Insights into Cardiovascular Disease
Circulation 145(5): 357-370
Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19
Nat Med, epub ahead of print.
ADAMTSL2 protein and a soluble biomarker signature identify at-risk non-alcoholic steatohepatitis and fibrosis in adults with NAFLD
J Hepatol 76(1): 25-33
Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology
Nat Commun 13(1): 634
Serum proteome analysis of systemic JIA and related lung disease identifies distinct inflammatory programs and biomarkers
Arthritis Rheumatol, epub ahead of print
Specialized interferon action in COVID-19
Proc Natl Acad Sci U S A 119(11)
Elucidating mechanisms of genetic cross-disease associations at the PROCR vascular disease locus
Nat Commun 13(1): 1222
A genome-wide meta-analysis identifies 50 genetic
loci associated with carpal tunnel syndrome
Nat Commun 13: 1598
Plasma proteome analyses in individuals of European and African ancestry identify cis-pQTLs and models for proteome-wide association studies
Nat Genet., epub ahead of print.
Translation of aptamers toward clinical diagnosis and commercialization
Biosens Bioelectron 208: 114168
Diagnostic Accuracy of Blood-Based Biomarker Panels: A Systematic Review
Front Aging Neurosci 14: 683689
Plasma growth and differentiation factor 15 predict longitudinal changes in bone parameters in women, but not in men
J Gerontol A Biol Sci Med Sci., epub ahead of print.
Ad26.COV2.S prevents upregulation of SARS-CoV-2 induced pathways of inflammation and thrombosis in hamsters and rhesus macaques
PLoS Pathog 18(4): e1009990
Patterns and Persistence of Perioperative Plasma and Cerebrospinal Fluid Neuroinflammatory Protein Biomarkers After Elective Orthopedic Surgery Using SOMAscan
Anesth Analg, epub ahead of print
Epidermal growth factor receptor signaling in precancerous keratinocytes promotes neighboring head and neck cancer squamous cell carcinoma cancer stem cell-like properties and phosphoinositide 3-kinase inhibitor insensitivity
Mol Carcinog, epub ahead of print.
Effects of ivacaftor on systemic inflammation and the plasma proteome in people with CF and G551D
J Cyst Fibros, epub ahead of print.
Chemical modifications for a next generation of nucleic acid aptamers
Chembiochem, epub ahead of print.
Analytical Considerations of Large-Scale Aptamer-Based Datasets for Translational Applications
Cancers 14(9): 2227
Severe Iatrogenic Hypoglycemia Modulates the Fibroblast Growth Factor Protein Response
Diabetes Obes Metab, epub ahead of print.
Proteomics of Human Biological Fluids for Biomarker Discoveries: Technical Advances and Recent Applications
Expert Rev Proteomics, epub ahead of print.
Identifying causal genes for stroke via integrating the proteome and transcriptome from brain and blood
J Transl Med 20(1): 181
Acceptability and experience of a personalised proteomic risk intervention for type 2 diabetes in primary care: qualitative interview study with patients and healthcare providers
Prim Health Care Res Dev 23: e24.
Limited proteolysis–mass spectrometry reveals aging-associated changes in cerebrospinal fluid protein abundances and structures
Nat Aging, epub ahead of print
Proteomics in thrombosis research
Res Pract Thromb Haemost 6(3): e12706.
Harnessing Big Data to Advance Treatment and Understanding of Pulmonary Hypertension
Circ Res 130(9): 1423-1444
Proteome-Wide Analysis using SOMAscan Identifies and Validates Epidermal Growth Factor as a Disease Marker of Collagenous Gastritis
Gastro Hep Advances, epub ahead of print.
Proteomics of lung tissue reveals differences in inflammation and alveolar-capillary barrier response between atelectasis and aerated regions
Sci Rep 12(1): 7065
The Proteomic Profile of Interstitial Lung Abnormalities
Am J Respir Crit Care Med., epub ahead of print.
Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset
Ann Rheum Dis., epub ahead of print.
Serum Protein Signatures Using Aptamer-Based Proteomics for Minimal Change Disease and Membranous Nephropathy
Kidney Int Rep., epub ahead of print.
Lymphocyte activation gene-3-associated protein networks are associated with HDL-cholesterol and mortality in the Trans-omics for Precision Medicine program
Commun Biol 5(1): 362
Comparison of Aptamer-Based and Antibody-Based Assays for Protein Quantification in Chronic Kidney Disease
Clin J Am Soc Nephrol 17(3): 350-360
Aptamer-based screen of Neuropsychiatric Lupus cerebrospinal fluid reveals potential biomarkers that overlap with the choroid plexus transcriptome
Arthritis Rheumatol., epub ahead of print.
Differential Proteomics of Cardiovascular Risk and Coronary Artery Disease in Humans
Front Cardiovasc Med 8: 790289
Defining the effects of traffic-related air pollution on the human plasma proteome using an aptamer proteomic array: A dose-dependent increase in atherosclerosis-related proteins
Environ Res 209: 112803
Placental proteins with predicted roles in fetal development decrease in premature infants
Pediatr Res., epub ahead of print.
Creatine kinase-(MB) and hepcidin as candidate biomarkers for early diagnosis of pulmonary tuberculosis: a proof-of-concept study in Lambarene, Gabon
Infection, epub ahead of print.
Protein and miRNA profile of circulating extracellular vesicles in patients with primary sclerosing cholangitis
Sci Rep 12: 3027
Diagnostic and Prognostic Protein Biomarkers of β-Cell Function in Type 2 Diabetes and Their Modulation with Glucose Normalization
Metabolites 12(3):196
Proteomics technologies for cancer liquid biopsies
Mol Cancer 21(1): 53
Advances in proteomic profiling of pediatric kidney diseases
Pediatr Nephrol, epub ahead of print.
Proteomic Profiling Identifies Novel Proteins for Genetic Risk of Severe COVID-19: the Atherosclerosis Risk in Communities Study
Hum Mol Genet, epub ahead of print
Connecting Genomics and Proteomics to Identify Protein Biomarkers for Adult and Youth-Onset Type 2 Diabetes: A Two-Sample Mendelian Randomization Study
Diabetes, epub ahead of print.
Proteomic Studies of Psoriasis
Biomedicines 10(3): 619
Proteins and pathways in atrial fibrillation and atrial cardiomyopathy underlying cryptogenic stroke
Int J Cardiol Heart Vasc 39: 100977
Protein prediction for trait mapping in diverse populations
PLoS One 17(2): e0264341
Diabetes, GDF-15 and incident heart failure: the atherosclerosis risk in communities study
Diabetologia 65: 955–963
Using the Plasma Proteome for Risk Stratifying Patients with Pulmonary Arterial Hypertension
Am J Respir Crit Care Med., epub ahead of print.
A genome-wide association study of serum proteins reveals shared loci with common diseases
Nat Commun 13(1): 480
Coding and regulatory variants are associated with serum protein levels and disease
Nat Commun 13(1): 481
Plasma proteins, cognitive decline, and 20-year risk of dementia in the Whitehall II and Atherosclerosis Risk in Communities studies.
Alzheimers Dement 18(4): 612-624
Proteins in the pathway from high red blood cell width distribution to all-cause mortality
EBioMedicine 76: 103816
Effects of colchicine on lipolysis and adipose tissue inflammation in adults with obesity and metabolic syndrome
Obesity (Silver Spring), epub ahead of print
Genetics of Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS) and Role of Sacsin in Neurodegeneration
Int J Mol Sci 23(1): 552
Aptamers: Potential Diagnostic and Therapeutic Agents for Blood Diseases
Molecules 27(2): 383
Recent Developments in Clinical Plasma Proteomics-Applied to Cardiovascular Research
Biomedicines 10(1): 162
Influenza A virus uses PSMA2 for downregulation of NRF2-mediated oxidative stress response
J Virol: jvi0199021
Acute serum protein and cytokine response of single dose of prednisone in adult volunteers
Steroids 178: 108953
The amniotic fluid proteome changes with gestational age in normal pregnancy: a cross-sectional study
Sci Rep 12(1): 601
Comparison of Proteomic Expression Profiles after Radiation Exposure across Four Different Species
Radiat Res, epub ahead of print
Association of Circulating Proteins with Death or Lung Transplant in Patients with Idiopathic Pulmonary Fibrosis in the IPF-PRO Registry Cohort
Lung 200(1): 11-18
Aptamers from random sequence space: Accomplishments, gaps and future considerations
Anal Chim Acta 1196: 339511
Clinically Relevant Circulating Protein Biomarkers for Type 1 Diabetes: Evidence From a Two-Sample Mendelian Randomization Study
Diabetes Care 45(1): 169-177
Identification and Evaluation of Serum Protein Biomarkers Which Differentiate Psoriatic from Rheumatoid Arthritis.
Arthritis Rheumatol 74(1): 81-91
The Plasma Proteome Fingerprint Associated With Circulating Carotenoids And Retinol In Older Adults
J Nutr 152(1): 40-48
Comprehensive aptamer-based screen of 1317 proteins uncovers improved stool protein markers of colorectal cancer
J Gastroenterol 56(7): 659-672
An Approach to Biomarker Discovery of Cannabis Use Utilizing Proteomic, Metabolomic, and Lipidomic Analyses.
Cannabis Cannabinoid Res 7(1): 65-77
Proteome-Wide Analysis using SOMAscan Identifies and Validates Chitinase-3-Like Protein 1 as a Risk and Disease Marker of Delirium Among Older Adults Undergoing Major Elective Surgery
J Gerontol A Biol Sci Med Sci 77(3): 484-493
Identification of blood-based biomarkers for diagnosis and prognosis of Parkinson's disease: A Systematic review of proteomics studies
Ageing Res Rev 73: 101514
High-throughput mediation analysis of human proteome and metabolome identifies mediators of post-bariatric surgical diabetes control
Nat Commun 12(1): 6951
Exercise plasma boosts memory and dampens brain inflammation via clusterin
Nature 600(7889): 494-499
Cross-validation of SARS-CoV-2 responses in kidney organoids and clinical populations
JCI Insight 6(24): e154882
Proteomics and Risk of Atrial Fibrillation in Older Adults (From the Atherosclerosis Risk in Communities [ARIC] Study)
Am J Cardiol 161: 42-50
Synergistic insights into human health from aptamer- and antibody-based proteomic profiling
Nat Commun 12(1): 6822
The Use of ‘Omics for Diagnosing and Predicting Progression of Chronic Kidney Disease: A Scoping Review
Front Genet 12: 682929
Proteome-wide associations with short- and long-term weight loss and regain after Roux-en-Y gastric bypass surgery
Obesity (Silver Spring), epub ahead of print
Blood Levels of the SMOC1 Hepatokine Are Not Causally Linked with Type 2 Diabetes: A Bidirectional Mendelian Randomization Study
Nutrients 13(12): 4208
Plasma Proteomics of Renal Function: A Trans-ethnic Meta-analysis and Mendelian Randomization Study
J Am Soc Nephrol. 32(7): 1747-1763
Proteomic Approaches to Defining Remission and the Risk of Relapse in Rheumatoid Arthritis
Front Immunol 12: 729681
Discovery of Novel Proteomic Biomarkers for the Prediction of Kidney Recovery from Dialysis-Dependent AKI Patients
Kidney360 2(11): 1716-1727
Proteomic analysis of serum in workers exposed to diesel engine exhaust
Environ Mol Mutagen 63(1): 18-28
A Combined Proteomics and Mendelian Randomization Approach to Investigate the Effects of Aspirin-Targeted Proteins on Colorectal Cancer
Cancer Epidemiol Biomarkers Prev 30(3): 564-575
Heat Shock-Related Protein Responses and Inflammatory Protein Changes Are Associated with Mild Prolonged Hypoglycemia
Cells 10: 3109
Hypoglycemia-induced changes in complement pathways in type 2 diabetes
Atherosclerosis Plus 46: 35-45
Multi-omic analysis in injured humans: Patterns align with outcomes and treatment responses
Cell Rep Med 2: 100478
Large-scale plasma proteomics can reveal distinct endotypes in chronic obstructive pulmonary disease and severe asthma
Clin Transl Allergy 11(10): e12091
Serum Proteomics Uncovers Biomarkers of Clinical Portal Hypertension in Children With Biliary Atresia
Hepatol Commun, epub ahead of print.
Integrated Multi-Omics for Novel Aging Biomarkers and Antiaging Targets
Biomolecules 12: 39
Cellular and plasma proteomic determinants of COVID-19 and non-COVID-19 pulmonary diseases relative to healthy aging.
Nat Aging 1: 535–549.
Predicting the probability of death using proteomics.
Commun Biol 4(1): 758.
Large-scale plasma proteomic analysis
identifies proteins and pathways associated with dementia risk.
Nat Aging 1: 473-489.
Human plasma proteomic profiles indicative of cardiorespiratory fitness.
Nat Metab 3(6): 786-797.
Group IIA secreted phospholipase A2 is associated with the pathobiology leading to COVID-19 mortality
J Clin Invest, epub ahead of print
Discovery and validation of a novel subgroup and therapeutic target in idiopathic multicentric Castleman disease
Blood Adv 5(17): 3445-3456
Influence of renin-angiotensin-aldosterone system inhibitors on plasma levels of angiotensin-converting enzyme 2
ESC Heart Fail 8(2): 1717-1721
Identification of plasma proteins relating to brain neurodegeneration and vascular pathology in cognitively normal individuals
Alzheimers Dement (Amst) 13(1): e12240.
Proteomic Biomarker Analysis of Serum from Japanese Field Mice (Apodemus Speciosus) Collected within the Fukushima Difficult-to-return Zone
Health Phys 121(6): 564-573
Advances and Utility of the Human Plasma Proteome
J Proteome Res 20(12): 5241-5263
Integrated plasma proteomics and lung transcriptomics reveal novel biomarkers in idiopathic pulmonary fibrosis
Respir Res 22(1): 273
Towards Building a Quantitative Proteomics Toolbox in Precision Medicine: A Mini-Review
Front Physiol 12: 723510.
Vitamin D association with the renin angiotensin system in polycystic ovary syndrome
J Steroid Biochem Mol Biol 214: 105965.
Polygenic Risk Scores for Kidney Function and Their Associations with Circulating Proteome, and Incident Kidney Diseases
J Am Soc Nephrol 32(12): 3161-3173
The proteomic signature of recombinant Growth Hormone in recreational athletes
J Endocrine Soc, epub ahead of print
Distinct Molecular Signatures of Clinical Clusters in People With Type 2 Diabetes: An IMI-RHAPSODY Study
Diabetes 70(11): 2683-2693.
Dysregulated expression levels of APH1B in peripheral blood are associated with brain atrophy and amyloid-beta deposition in Alzheimer's disease
Alzheimers Res Ther 13(1): 183.
Genetically Predicted Glucose-Dependent Insulinotropic Polypeptide (GIP) Levels and Cardiovascular Disease Risk Are Driven by Distinct Causal Variants in the GIPR Region
Diabetes 70(11): 2706-2719.
Ultrasensitive detection of blood biomarkers of Alzheimer's and Parkinson's diseases: a systematic review
Biomark Med 15(17): 1693-1708.
Advances in Aptamer-Based Biomarker Discovery
Front Cell Dev Biol 9: 659760.
Replication study of plasma proteins relating to Alzheimer's pathology.
Alzheimers Dement 17(9): 1452-1464.
Platelet Protein-Related Abnormalities in Response to Acute Hypoglycemia in Type 2 Diabetes.
Front Endocrinol (Lausanne) 12: 651009.
Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19.
Nat Med 27(4): 668-676.
Broadly effective metabolic and immune recovery with C5 inhibition in CHAPLE disease.
Nat Immunol 22(2): 128-139.
Association of endopeptidases, involved in SARS-CoV-2 infection, with microbial aggravation in sputum of severe asthma.
Allergy 76(6): 1917-1921.
Age-associated difference in circulating ACE2, the gateway for SARS-COV-2, in humans: results from the InCHIANTI study.
Geroscience 43(2): 619-627.
A proteome-wide genetic investigation identifies several SARS-CoV-2-exploited host targets of clinical relevance.
Elife 10: e69719.
Longitudinal proteomic analysis of severe COVID-19 reveals survival-associated signatures, tissue-specific cell death, and cell-cell interactions.
Cell Rep Med 2(5): 100287.
Multi-omics highlights ABO plasma protein as a causal risk factor for COVID-19.
Hum Genet 140(6): 969-979
BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection.
Cell 184(8): 2167-2182 e2122
Soluble Neuropilin-1 Response to Hypoglycemia in Type 2 Diabetes: Increased Risk or Protection in SARS-CoV-2 Infection?
Front Endocrinol (Lausanne) 12: 665134
Type 2 Diabetes Coagulopathy Proteins May Conflict With Biomarkers Reflective of COVID-19 Severity.
Front Endocrinol (Lausanne) 12: 658304
Letter to the Editor: Pro-fibrotic M2 macrophage markers may increase the risk for COVID19 in type 2 diabetes with obesity.
Metabolism 112: 154374
Vitamin D Association With Macrophage-Derived Cytokines in Polycystic Ovary Syndrome: An Enhanced Risk of COVID-19 Infection?
Front Endocrinol (Lausanne) 12: 638621
Using ‘big data’ to disentangle aging and COVID-19.
Aging 1: 496–497.
The COVIDome Explorer researcher portal.
Cell Rep 36(7): 109527.
A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity.
Nat Med 27(4): 659-667.
Early Interleukin-22 and Neutrophil Proteins Are Correlated to Future Lung Damage in Children with Cystic Fibrosis.
Front Pediatr 9: 640184.
Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children.
Immunity 54(5): 1083-1095 e1087.
Plasma protein expression profiles, cardiovascular disease, and religious struggles among South Asians in the MASALA study
Sci Rep 11(1): 961
Protein signatures of centenarians and their offspring suggest centenarians age slower than other humans
Aging Cell. 2021 Jan 29:e13290
Identification and Validation of Nutrient State-Dependent Serum Protein Mediators of Human CD4(+) T Cell Responsiveness.
Nutrients 13(5).
Effect of longevity genetic variants on the molecular aging rate.
Geroscience 43(3): 1237-1251.
Novel Murine Biomarkers of Radiation Exposure Using An Aptamer-Based Proteomic Technology.
Front Pharmacol 12: 633131.
The CRTAC1 protein in plasma associates with osteoarthritis and predicts progression to joint replacements: a large-scale proteomics scan in Iceland.
Arthritis Rheumatol, epub ahead of print.
Plasma Proteomic Profile Predicts Survival in Heart Failure with Reduced Ejection Fraction.
Circ Genom Precis Med 14(3): e003140.
Multi-Omic Profiling in Black and White Populations Reveals Novel Candidate Pathways in Left Ventricular Hypertrophy and Incident Heart Failure Specific to Black Adults.
Circ Genom Precis Med 14(3): e003191.
SOMAscan Proteomics Identifies Serum Biomarkers Associated With Liver Fibrosis in Patients With NASH.
Hepatol Commun 5(5): 760-773.
Proteomic signatures of inflammatory skin diseases: a focus on atopic dermatitis.
Expert Rev Proteomics 18(5): 345-361.
Metabolic syndrome and the plasma proteome: from association to causation.
Cardiovasc Diabetol 20(1): 111.
Serum Proteomics and Plasma Fibulin-3 in Differentiation of Mesothelioma from Asbestos-Exposed Controls and Patients with Other Pleural Diseases.
J Thorac Oncol 16(10): 1705-1717.
Identification of Plasma Proteome Signatures Associated With Surgery Using SOMAscan
Ann Surg 273(4): 732-742.
Proteomic Signatures of Lifestyle Risk Factors for Cardiovascular Disease: A Cross‐Sectional Analysis of the Plasma Proteome in the Framingham Heart Study
J Am Heart Assoc 10(1): e018020
Association of a Serum Protein Signature With Rheumatoid Arthritis Development
Arthritis Rheumatol. 73(1): 78-88.
Inhibition of the Complement Alternative Pathway by Chemically Modified DNA Aptamers That Bind with Picomolar Affinity to Factor B
J Immunol 206(4): 861-873.
Genetics meets proteomics: perspectives for large population-based studies
Nat Rev Genet 22(1): 19-37.
Circulating markers of NADH-reductive stress correlate with mitochondrial disease severity
J Clin Invest 131(2): e136055
Evaluating the effects of cardiometabolic exposures on circulating proteins which may contribute to severe SARS-CoV-2.
EBioMedicine 64: 103228.
A replication-competent adenovirus-vectored influenza vaccine induces durable systemic and mucosal immunity
J Clin Invest 131(5)
Revealing the role of the human blood plasma proteome in obesity using genetic drivers
Nat Commun 12(1): 1279
Plasma Proteomic Profiling in Hypertrophic Cardiomyopathy Patients before and after Surgical Myectomy Reveals Post-Procedural Reduction in Systemic Inflammation
Int J Mol Sci 22(5): 2474
Quantitative Proteomic Analysis of Diabetes Mellitus in Heart Failure With Preserved Ejection Fraction
JACC Basic Transl Sci 6(2): 89-99.
Proteomics in aging research: A roadmap to clinical, translational research
Aging Cell: e13325.
Blood biomarker discovery for autism spectrum disorder: A proteomic analysis
PLoS One 16(2): e0246581.
Biomarker-focused multi-drug combination therapy and repurposing trial in mdx mice
PLoS One 16(2): e0246507
In-Depth Analysis of the Plasma Proteome in ME/CFS Exposes Disrupted Ephrin-Eph and Immune System Signaling
Proteomes 9(1): 6
A meta-analysis uncovers the first sequence variant conferring risk of Bell's palsy
Sci Rep 11(1): 4188
Cognitive stimulation in the workplace, plasma proteins, and risk of dementia: three analyses of population cohort studies.
BMJ 374: n1804.
Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders.
Nat Neurosci 24(9): 1302-1312
An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging.
Nat Aging 1: 598–615.
Effects of adiposity on the human plasma proteome: observational and Mendelian randomisation estimates.
Int J Obes (Lond) 45: 2221-2229.
New candidate blood biomarkers potentially associated with white matter hyperintensities progression.
Sci Rep 11(1): 14324.
DNA Damage, n-3 Long-Chain PUFA Levels and Proteomic Profile in Brazilian Children and Adolescents.
Nutrients 2021, 13, 2483.
Comparison of proteomic methods in evaluating biomarker-AKI associations in cardiac surgery patients.
Transl Res 238: 49-62.
Pediatric and adult dilated cardiomyopathy are distinguished by distinct biomarker profiles.
Pediatr Res., epub ahead of print.
Smoking induces sex-specific changes in the small airway proteome.
Respir Res 22(1): 234.
Validation of Chemokine Biomarkers in Duchenne Muscular Dystrophy.
Life (Basel) 11(8): 827.
Serum Proteomics of Older Patients Undergoing Major Cardiac Surgery: Identification of Biomarkers Associated with Postoperative Delirium.
Front Aging Neurosci 13: 699763.
Slow Off-Rate Modified Aptamer (SOMAmer) Proteomic Analysis of Patient-Derived Malignant Glioma Identifies Distinct Cellular Proteomes.
Int J Mol Sci 22(17).
Evolving a RIG-I antagonist: a modified DNA aptamer mimics viral RNA.
J Mol Biol. 433(21): 167227.
Serum levels of ACE2 are higher in patients with obesity and diabetes.
Obes Sci Pract 7(2): 239-243.
Functional Network Profiles in ARSACS Disclosed by Aptamer-Based Proteomic Technology
Front Neurol 11: 603774.
Atopic Dermatitis Endotypes Based on Allergen Sensitization, Reactivity to Staphylococcus aureus Antigens, and Underlying Systemic Inflammation
J Allergy Clin Immunol Pract. 8(1): 236-247.e3.
Joint fluid proteome after anterior cruciate ligament rupture reflects an acute posttraumatic inflammatory and chondrodegenerative state
Cartilage 11(3): 329
Vascular Disease and Thrombosis in SARS-CoV-2-Infected Rhesus Macaques
Cell 183(5): 1354–1366
Genetic architecture of host proteins involved in SARS-CoV-2 infection
Nat Commun 11(1): 6397
Platelet-derived growth factor BB: A potential diagnostic blood biomarker for differentiating bipolar disorder from major depressive disorder
J Psychiatr Res 134: 48-56.
Activity of ibrutinib plus R-CHOP in diffuse large B-cell lymphoma: Response, pharmacodynamic, and biomarker analyses of a phase Ib study
Cancer Treatment Res Commun 25: 100235
Identification of Potential Serum Protein Biomarkers and Pathways for Pancreatic Cancer Cachexia Using an Aptamer-Based Discovery Platform
Cancers (Basel) 12(12): 3787
A Plasma Proteomic Signature of Skeletal Muscle Mitochondrial Function
Int J Mol Sci 21(24): 9540
Coronary Artery Disease and Type 2 Diabetes: A Proteomic Study
Diabetes Care 43(4): 843-851
Novel Insights Into the Effects of Interleukin 6 Antagonism in Non-ST-Segment-Elevation Myocardial Infarction Employing the SOMAscan Proteomics Platform
J Am Heart Assoc 9(12):e015628
Colchicine's effects on metabolic and inflammatory molecules in adults with obesity and metabolic syndrome: results from a pilot randomized controlled trial
Int J Obes (Lond) 44(8):1793-1799
Comparison of Proteomic Assessment Methods in Multiple Cohort Studies
Proteomics 20(12):e1900278
Reduced Apolipoprotein M and Adverse Outcomes Across the Spectrum of Human Heart Failure
Circulation 141(18):1463-1476
Highly multiplexed proteomic assessment of human bone marrow in acute myeloid leukemia
Blood Adv 4(2):367-379
Plasma proteomic profile of frailty
Aging Cell 19(9):e13193
Serum protein biomarkers for juvenile dermatomyositis: a pilot study
BMC Rheumatol 4:52
Proteomic biomarkers of sleep apnea
Sleep 43(11):zsaa086
Early angiogenic proteins associated with high risk for bronchopulmonary dysplasia and pulmonary hypertension in preterm infants
Am J Physiol Lung Cell Mol Physiol 318(4):L644-L654
Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis
Sci Transl Med 12(572):eaba4448
Impact of Kidney Function on the Blood Proteome and on Protein Cardiovascular Risk Biomarkers in Patients With Stable Coronary Heart Disease
J Am Heart Assoc 9(15):e016463
Proteomic Signatures of Heart Failure in Relation to Left Ventricular Ejection Fraction
J Am Coll Cardiol 76(17):1982-1994
Proteomic and Metabolomic Correlates of Healthy Dietary Patterns: The Framingham Heart Study
Nutrients 12(5):1476
Plasma proteomic profile of age, health span, and all-cause mortality in older adults
Aging Cell 19(11):e13250
Renin-Angiotensin System overactivation in polycystic ovary syndrome, a risk for SARS-CoV-2 infection?
Metabol Open 7:100052
ZIKV Infection Induces DNA Damage Response and Alters the Proteome of Gastrointestinal Cells
Viruses 12(7):771
Plasma proteomic signature of the risk of developing mobility disability: A 9-year follow-up
Aging Cell 19(4):e13132
Comparison of Serum Pharmacodynamic Biomarkers in Prednisone-Versus Deflazacort-Treated Duchenne Muscular Dystrophy Boys
J Pers Med 10(4):164
Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer's Disease Pathology
J Alzheimers Dis 77(3):1353-1368
Clinical and Proteomic Correlates of Plasma ACE2 (Angiotensin-Converting Enzyme 2) in Human Heart Failure
Hypertension 76(5):1526-1536
Protein biomarkers for incident deep venous thrombosis in critically ill adolescents: An exploratory study
Pediatr Blood Cancer 67(4):e28159
Aptamer based proteomic pilot study reveals a urine signature indicative of pediatric urinary tract infections
PLoS One 15(7):e0235328
Increased Levels of Coagulation Factor XI in Plasma Are Related to Alzheimer's Disease Diagnosis
J Alzheimers Dis 77(1):375-386
Evaluation of a novel blood microsampling device for clinical trial sample collection and protein biomarker analysis
Bioanalysis 12(13):919-935
Serum biomarkers associated with baseline clinical severity in young steroid-naïve Duchenne muscular dystrophy boys
Hum Mol Genet 29(15):2481-2495
Zika virus dysregulates human Sertoli cell proteins involved in spermatogenesis with little effect on tight junctions
PLoS Negl Trop Dis 14(6):e0008335
Proteomic profiling of HTLV-1 carriers and ATL patients reveals sTNFR2 as a novel diagnostic biomarker for acute ATL
Blood Adv 4(6):1062-1071
Metabolic profiling shows pre-existing mitochondrial dysfunction contributes to muscle loss in a model of ICU-acquired weakness
J Cachexia Sarcopenia Muscle 11(5):1321-1335
Mechanisms of Sodium-Glucose Cotransporter 2 Inhibition: Insights From Large-Scale Proteomics
Diabetes Care 43(9):2183-2189
Targeting myostatin/activin A protects against skeletal muscle and bone loss during spaceflight
Proc Natl Acad Sci U S A 117(38):23942-23951
Multimodal immune phenotyping of maternal peripheral blood in normal human pregnancy
JCI Insight 5(7):e134838
Effect of induced hypoglycemia on inflammation and oxidative stress in type 2 diabetes and control subjects
Sci Rep 10(1):4750
Plasma Biomarkers of Reticular Pseudodrusen and the Risk of Progression to Advanced Age-Related Macular Degeneration
Transl Vis Sci Technol 9(10):12
Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits.
Nat Commun 11(1): 15.
Modified nucleotides may have enhanced early RNA catalysis.
Proc Natl Acad Sci U S A 117(15): 8236-8242.
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Systematic selection of modified aptamer pairs for diagnostic sandwich assays
Biotechniques 56(3): 125-128, 130, 132-133.
Candidate blood proteome markers of Alzheimer's disease onset and progression: a systematic review and replication study
J Alzheimers Dis 38(3): 515-531.
Alzheimer's disease biomarker discovery using SOMAscan multiplexed protein technology
Alzheimers Dement 10(6): 724-734.
Detection of Clostridium difficile toxins A, B and binary toxin with slow off-rate modified aptamers
Diagn Microbiol Infect Dis 76(3): 278-285.
Elucidating novel serum biomarkers associated with pulmonary tuberculosis treatment
PLoS One 8(4): e61002.
Interaction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondin
EMBO Rep 14(12): 1120-1126.
Measurement of cetuximab and panitumumab-unbound serum EGFR extracellular domain using an assay based on slow off-rate modified aptamer (SOMAmer) reagents
PLoS One 8(8): e71703.
Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy
Cell 153(4): 828-839.
Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets
Proc Natl Acad Sci U S A 109(49): 19971-19976.
Early detection of malignant pleural mesothelioma in asbestos-exposed individuals with a noninvasive proteomics-based surveillance tool
PLoS One 7(10):e46091.
Aptamers and the RNA world, past and present
Cold Spring Harb Perspect Biol 4(3).
Life's simple measures: unlocking the proteome
J Mol Biol 422(5):595-606.
Protein signature of lung cancer tissues
PLoS One 7(4): e35157.
Age-dependent changes in the cerebrospinal fluid proteome by slow off-rate modified aptamer array
Am J Pathol 180(2): 446-456.
Rapid histochemistry using slow off-rate modified aptamers with anionic competition
Appl Immunohistochem Mol Morphol 19(3): 273-278.
Unlocking biomarker discovery: large scale application of aptamer proteomic technology for early detection of lung cancer
PLoS One 5(12): e15003.
Aptamer-based multiplexed proteomic technology for biomarker discovery
PLoS One 5(12): e15004.
From SOMAmer-based biomarker discovery to diagnostic and clinical applications: a SOMAmer-based, streamlined multiplex proteomic assay
PLoS One 6(10): e26332.
High-content affinity-based proteomics: unlocking protein biomarker discovery
Expert Rev Mol Diagn 10(8): 1013-1022.
Expanding the chemistry of DNA for in vitro selection
J Am Chem Soc 132(12): 4141-4151.
Proteomics and diagnostics: Let's get specific, again
Curr Opin Chem Biol 12(1): 78-85.
Interlocking structural motifs mediate molecular discrimination by a theophylline-binding RNA
Nat Struct Biol 4(8): 644-649.
Let's get specific: the relationship between specificity and affinity
Chem Biol 2(10): 633-638.
High-resolution molecular discrimination by RNA
Science 263(5152): 1425-1429.
