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Publications

Plasma protein patterns as comprehensive indicators of health
Williams SA, et al.
Nat Med 25(12): 1851-1857.
Clinical Large-scale-proteomics
Undulating changes in human plasma proteome profiles across the lifespan
Lehailler, B et al.
Nat Med 25(12): 1843-1850
Disease Biology
Co-regulatory networks of human serum proteins link genetics to disease
Emilsson, V et al.
Science 361(6404): 769-773.
Aging diseasebiology diagnostics
Genomic atlas of the human plasma proteome
Sun, BB et al.
Nature 558: 73-79.
SomaScan Large-scale-proteomics
Genetic architecture of the cardiovascular risk proteome
Benson, MD et al.
Circulation 137(11): 1158-1172.
Cardiovascular diseasebiology targetidentification diagnostics
Using aptamer-based technology to probe the plasma proteome for cardiovascular disease prediction
Sabatine, MS
JAMA 315(23): 2525-2526.
Cardiovascular targetidentification diagnostics
Aptamer-based proteomic profiling reveals novel candidate biomarkers and pathways in cardiovascular disease
Ngo, D et al.
Circulation 134(4): 270-285.
Cardiovascular diagnostics
Advances in Aptamer-Based Biomarker Discovery.
Huang, J et al.
Front Cell Dev Biol 9: 659760.
SomaScan Reviews
Replication study of plasma proteins relating to Alzheimer's pathology.
Shi, L et al.
Alzheimers Dement, epub ahead of print.
Neurobiology stratification
Platelet Protein-Related Abnormalities in Response to Acute Hypoglycemia in Type 2 Diabetes.
Moin, ASM et al.
Front Endocrinol (Lausanne) 12: 651009.
Metabolic
Broadly effective metabolic and immune recovery with C5 inhibition in CHAPLE disease."
Ozen, A et al.
Nat Immunol 22(2): 128-139.
Rare Immunity mechanismofaction
Early Interleukin-22 and Neutrophil Proteins Are Correlated to Future Lung Damage in Children with Cystic Fibrosis." "
Renwick, J et al.
Front Pediatr 9: 640184.
Rare Pediatric stratification Inflammatory
Identification of Plasma Proteome Signatures Associated With Surgery Using SOMAscan
Fong TG, et al.
Ann Surg 273(4): 732-742.
Aging diseasebiology Inflammatory
Association of a Serum Protein Signature With Rheumatoid Arthritis Development
O'Neil LJ, et al.
Arthritis Rheumatol. 73(1): 78-88.
Inflammatory Immunity
Genetics meets proteomics: perspectives for large population-based studies
Suhre, K et al.
Nat Rev Genet 22(1): 19-37.
Reviews Large-scale-proteomics
Circulating markers of NADH-reductive stress correlate with mitochondrial disease severity
Sharma, R et al.
J Clin Invest 131(2): e136055
Metabolic Rare
Atopic Dermatitis Endotypes Based on Allergen Sensitization, Reactivity to Staphylococcus aureus Antigens, and Underlying Systemic Inflammation
Leonard A, et al.
J Allergy Clin Immunol Pract. 8(1): 236-247.e3.
Inflammatory diseasebiology diagnostics
Vascular Disease and Thrombosis in SARS-CoV-2-Infected Rhesus Macaques
Aid M, et al.
Cell. 2020, 183, 1354–1366
Cardiovascular Inflammatory
Genetic architecture of host proteins involved in SARS-CoV-2 infection
Pietzner M, et al.
Nat Commun. 2020; 11: 6397
Cardiovascular Respiratory diseasebiology targetidentification Infection
A Plasma Proteomic Signature of Skeletal Muscle Mitochondrial Function
Zampino M, et al.
Int J Mol Sci. 2020 Dec 15;21(24):E9540
Aging
Coronary Artery Disease and Type 2 Diabetes: A Proteomic Study
Ferrannini G, et al.
Diabetes Care. 2020 Apr;43(4):843-851
Cardiovascular Metabolic
Comparison of Proteomic Assessment Methods in Multiple Cohort Studies
Raffield LM, et al.
Proteomics. 2020 Jun;20(12):e1900278
Reviews
Reduced Apolipoprotein M and Adverse Outcomes Across the Spectrum of Human Heart Failure
Chirinos JA, et al.
Circulation. 2020 May 5;141(18):1463-1476
Cardiovascular
Highly multiplexed proteomic assessment of human bone marrow in acute myeloid leukemia
Çelik H, et al.
Blood Adv. 2020 Jan 28;4(2):367-379
Oncology
Plasma proteomic profile of frailty
Sathyan S, et al.
Aging Cell. 2020 Sep;19(9):e13193
Aging
Serum protein biomarkers for juvenile dermatomyositis: a pilot study
Tawalbeh SM, et al.
BMC Rheumatol. 2020 Oct 1;4:52
Inflammatory Immunity
Proteomic biomarkers of sleep apnea
Ambati A, et al.
Sleep. 2020 Nov 12;43(11):zsaa086
Respiratory
Early angiogenic proteins associated with high risk for bronchopulmonary dysplasia and pulmonary hypertension in preterm infants
Arjaans S, et al.
Am J Physiol Lung Cell Mol Physiol. 2020 Apr 1;318(4):L644-L654
Respiratory
Autophagy Modulators Profoundly Alter the Astrocyte Cellular Proteome
Sher AA, et al.
Cells. 2020 Mar 26;9(4):805
Neurobiology
Proteomic Signatures of Heart Failure in Relation to Left Ventricular Ejection Fraction
Adamo L, et al.
J Am Coll Cardiol. 2020 Oct 27;76(17):1982-1994
Cardiovascular
"Proteomic and Metabolomic Correlates of Healthy Dietary Patterns: The Framingham Heart Study"" Nutrients"
Walker ME, et al.
Nutrients. 2020 May 19;12(5):1476
Cardiovascular Metabolic
Plasma proteomic profile of age, health span, and all-cause mortality in older adults
Sathyan S, et al.
Aging Cell. 2020 Nov;19(11):e13250
Aging
Renin-Angiotensin System overactivation in polycystic ovary syndrome, a risk for SARS-CoV-2 infection?
Moin ASM, et al.
Metabol Open. 2020 Sep;7:100052
Kidney Reproductive
Comparison of Serum Pharmacodynamic Biomarkers in Prednisone-Versus Deflazacort-Treated Duchenne Muscular Dystrophy Boys
Tawalbeh S, et al.
J Pers Med. 2020 Oct 12;10(4):164
Pediatric Musculoskeletal
Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer's Disease Pathology
Shi L, et al.
J Alzheimers Dis. 2020;77(3):1353-1368
Neurobiology diseasebiology mechanismofaction
Clinical and Proteomic Correlates of Plasma ACE2 (Angiotensin-Converting Enzyme 2) in Human Heart Failure
Chirinos JA, et al.
Hypertension. 2020 Nov;76(5):1526-1536
Cardiovascular
Protein biomarkers for incident deep venous thrombosis in critically ill adolescents: An exploratory study
Tala JA, et al.
Pediatr Blood Cancer. 2020 Apr;67(4):e28159
Cardiovascular Pediatric
Aptamer based proteomic pilot study reveals a urine signature indicative of pediatric urinary tract infections
Dong L, et al.
PLoS One. 2020 Jul 6;15(7):e0235328
Kidney Pediatric Infection
Increased Levels of Coagulation Factor XI in Plasma Are Related to Alzheimer's Disease Diagnosis
Begic E, et al.
J Alzheimers Dis. 2020;77(1):375-386
Neurobiology diagnostics
Serum biomarkers associated with baseline clinical severity in young steroid-naïve Duchenne muscular dystrophy boys
Dang UJ, et al.
Hum Mol Genet. 2020 Aug 29;29(15):2481-2495
Pediatric Musculoskeletal
Zika virus dysregulates human Sertoli cell proteins involved in spermatogenesis with little effect on tight junctions
Rashid MU, et al.
PLoS Negl Trop Dis. 2020 Jun 8;14(6):e0008335
Infection Reproductive
Proteomic profiling of HTLV-1 carriers and ATL patients reveals sTNFR2 as a novel diagnostic biomarker for acute ATL
Guerrero CLH, et al.
Blood Adv. 2020 Mar 24;4(6):1062-1071
Oncology Infection
Metabolic profiling shows pre-existing mitochondrial dysfunction contributes to muscle loss in a model of ICU-acquired weakness
Kemp PR, et al.
J Cachexia Sarcopenia Muscle. 2020 Oct;11(5):1321-1335
Musculoskeletal
Mechanisms of Sodium-Glucose Cotransporter 2 Inhibition: Insights From Large-Scale Proteomics
Ferrannini E, et al.
Diabetes Care. 2020 Sep;43(9):2183-2189
Metabolic diseasebiology targetvalidation
Targeting myostatin/activin A protects against skeletal muscle and bone loss during spaceflight
Lee SJ, et al.
Proc Natl Acad Sci U S A. 2020 Sep 22;117(38):23942-23951
Musculoskeletal
Multimodal immune phenotyping of maternal peripheral blood in normal human pregnancy
Apps R, et al.
JCI Insight. 2020 Apr 9;5(7):e134838
Immunity Reproductive
Effect of induced hypoglycemia on inflammation and oxidative stress in type 2 diabetes and control subjects
Kahal H, et al.
Sci Rep. 2020 Mar 16;10(1):4750
Inflammatory Metabolic diseasebiology
Modified nucleotides may have enhanced early RNA catalysis.
Wolk, SK et al.
Proc Natl Acad Sci U S A 117(15): 8236-8242.
SomaScan
The Evolution of the Cardiovascular Biomarker Study.
Wang, TJ
Circulation 142(15): 1422-1424.
Cardiovascular targetidentification
Placenta accreta spectrum: biomarker discovery using plasma proteomics.
Shainker, SA et al.
Am J Obstet Gynecol 223(3): 433 e431-433 e414.
Reproductive
A fully joint Bayesian quantitative trait locus mapping of human protein abundance in plasma.
Ruffieux, H et al.
PLoS Comput Biol 16(6): e1007882.
SomaScan
Intense light as anticoagulant therapy in humans.
Oyama, Y et al.
PLoS One 15(12): e0244792.
SomaScan Clinical
Identification of a unique temporal signature in blood and BAL associated with IPF progression.
Norman, KC et al.
Sci Rep 10(1): 12049.
Fibrotic stratification
Improved cardiovascular risk prediction using targeted plasma proteomics in primary prevention.
Hoogeveen, RM et al.
Eur Heart J 41(41): 3998-4007.
Cardiovascular
Circulating Protein Signatures and Causal Candidates for Type 2 Diabetes.
Gudmundsdottir, V et al.
Diabetes 69(8): 1843-1853.
Metabolic diseasebiology Large-scale-proteomics
Aptamers and Antisense Oligonucleotides for Diagnosis and Treatment of Hematological Diseases.
Giudice, V et al.
Int J Mol Sci 21(9): 3252.
Reviews Clinical
Proteomics for personalized cardiovascular risk assessment: in pursuit of the Holy Grail.
Ganz, P et al.
Eur Heart J 41(41): 4008-4010.
Cardiovascular
Increased mTOR activation in idiopathic multicentric Castleman disease.
Arenas, DJ et al.
Blood 135(19): 1673-1684.
Rare
Transcatheter aortic valve replacements alter circulating serum factors to mediate myofibroblast deactivation
Aguado BA, et al.
Science Translational Medicine Volume 11 (509) 2019 eaav3233
Cardiovascular
Accelerating Biomarker Discovery Through Electronic Health Records, Automated Biobanking, and Proteomics.
Wells, QS et al.
J Am Coll Cardiol 73(17): 2195-2205.
Cardiovascular
Beyond Autoantibodies: Biologic Roles of Human Autoreactive B Cells in Rheumatoid Arthritis Revealed by RNA-Sequencing.
Mahendra, A et al.
Arthritis Rheumatol 71(4): 529-541.
Immunity diseasebiology
Predicting health and life span with the deep plasma proteome.
Emilsson, V et al.
Nat Med 25(12): 1815-1816.
Aging
Balanced event prediction through sampled survival analysis.
Datta, G et al.
Systems Medicine 2(1): 28-38.
SomaScan
Aging Disrupts Muscle Stem Cell Function by Impairing Matricellular WISP1 Secretion from Fibro-Adipogenic Progenitors.
Lukjanenko, L et al.
Cell Stem Cell 24(3): 433-446 e437.
Aging Musculoskeletal
Plasma proteome in multiple sclerosis disease progression
Malekzadeh A, et al.
Ann Clin Transl Neurol. 2019 Sep;6(9):1582-1594.
Neurobiology diseasebiology diagnostics
Osteitis is associated with dysregulated pro-osteoblastic activity in patients with nasal polyps
Wu, D et al.
Laryngoscope 129(3): E102-E109.
Exosomes diseasebiology Osteoporosis
Vero cell proteomic changes induced by Zika virus infection
Glover, KKM et al.
Proteomics 19(4): e1800309.
Neurobiology diseasebiology Infection
Application of an Aptamer-Based Proteomics Assay (SOMAscan™) in Rat Cerebrospinal Fluid
Simats A, et al.
Methods Mol Biol. 2044:221-231.
Neurobiology diseasebiology
Guidelines for CSF Processing and Biobanking: Impact on the Identification and Development of Optimal CSF Protein Biomarkers
Hok-A-Hin YS, et al.
Methods Mol Biol. 2044:27-50.
Neurobiology diseasebiology SomaScan Large-scale-proteomics
Assessing the genetic correlations between blood plasma proteins and osteoporosis: a polygenic risk score analysis
Liang, X et al.
Calcif Tissue Int 104(2): 171-181.
Osteoporosis diseasebiology targetidentification diagnostics
Plasma FGF-19 Levels are Increased in Patients with Post-Bariatric Hypoglycemia
Mulla CM, et al.
Obes Surg. 2019 Jul;29(7):2092-2099.
Metabolic diseasebiology
Application of Proteomics Profiling for Biomarker Discovery in Hypertrophic Cardiomyopathy
Shimada YJ, et al.
J Cardiovasc Transl Res. 2019 Dec;12(6):569-579.
Cardiovascular diseasebiology diagnostics
Cancer protein biomarker discovery based on nucleic acid aptamers
Xiong H, et al.
Int J Biol Macromol. 2019 Jul 1;132:190-202.
Oncology diseasebiology diagnostics
Exosome swarms eliminate airway pathogens and provide passive epithelial immunoprotection through nitric oxide
Nocera, AL et al.
J Allergy Clin Immunol 143(4):1525-1535 e1521.
Exosomes diseasebiology
Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay
Shi L, et al.
Alzheimers Dement. 5. pii: S1552-5260(19)35118-0.
Aging diseasebiology diagnostics
A framework for multi-omic prediction of treatment response to biologic therapy for psoriasis
Foulkes, AC et al.
J Invest Dermatol 139(1): 100-107.
Immunity diseasebiology stratification diagnostics
Fatigue in Sjögren's syndrome: a search for biomarkers and treatment targets
Bodewes, ILA et al.
Front Immunol 10: 312.
Inflammatory diseasebiology Immunity targetidentification diagnostics
Disease-specific and glucocorticoid-responsive serum biomarkers for Duchenne Muscular Dystrophy
Hathout Y, et al.
Sci Rep. 2019 Aug 21;9(1):12167.
Musculoskeletal diseasebiology diagnostics
Candidate early predictive plasma protein markers of doxorubicin-induced chronic cardiotoxicity in B6C3F1 mice
Desai, VG et al.
Toxicol Appl Pharmacol 363:164-173.
Oncology pkpd stratification
Pulmonary Aptamer Signatures in Children's Interstitial and Diffuse Lung Diseases
Deterding RR, et al.
Am J Respir Crit Care Med. doi: 10.1164.
Respiratory diseasebiology diagnostics Pediatric
Metabolic and proteomic signatures of hypoglycemia in type 2 diabetes
Halama, A et al.
Diabetes Obes Metab. 2018 Dec 7. doi: 10.1111.
Metabolic diseasebiology diagnostics
Influenza a virus-triggered autophagy decreases the pluripotency of human-induced pluripotent stem cells
Zahedi-Amiri A, et al.
Cell Death Dis. 2019 May; 10(5): 337.
Infection diseasebiology Reproductive
A serum protein signature of APOE genotypes in centenarians
Sebastiani P, et al.
Aging Cell. :e13023. doi: 10.1111.
Aging diseasebiology diagnostics
Activin type II receptor signaling in cardiac aging and heart failure
Roh, JD et al.
Sci Transl Med 11(482).
diagnostics Aging diseasebiology
Circulating Biomarkers of Testosterone's Anabolic Effects on Fat-Free Mass
Huang G, et al.
The Journal of Clinical Endocrinology and Metabolism 104(9): 3768-3778. https://doi.org/10.1210/jc.2019-00505.
Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study
Penn-Nicholson A, et al.
PLoS Med. 2019 Apr; 16(4): e1002781.
Infection diseasebiology diagnostics
A combined score of clinical factors and serum proteins can predict time to recurrence in high grade serous ovarian cancer
Mysona, D et al.
Gynecol Oncol 152(3):574-580.
Oncology diseasebiology mechanismofaction diagnostics
Proteomics profiling and risk of new-onset atrial fibrillation: Framingham Heart Study
Ko, D et al.
J Am Heart Assoc 8(6): e010976.
Cardiovascular diseasebiology diagnostics
Proteomic profiles in advanced age-related macular degeneration using an aptamer-based proteomic technology
Lynch, AM et al.
Transl Vis Sci Technol 8(1): 14.
Aging diseasebiology diagnostics Ocular
Human PAH is characterized by a pattern of lipid-related insulin resistance
Hemnes, AR et al.
JCI Insight 4(1).
Respiratory diseasebiology Metabolic mechanismofaction diagnostics
Reproducibility and variability of protein analytes measured using a multiplexed modified aptamer assay
Tin, A et al.
J Appl Lab Med. 2019 Jul;4(1):30-39.
Cardiovascular diagnostics
Characterization of Glycolytic Enzymes and Pyruvate Kinase M2 in Type 1 and 2 Diabetic Nephropathy
Gordin D, et al.
Diabetes Care. 2019 Jul;42(7):1263-1273.
Kidney diseasebiology Metabolic diagnostics
Stress Hyperglycemia in Critically Ill Patients: Insight Into Possible Molecular Pathways
Bar-Or D, e tal.
Front Med (Lausanne). 2019; 6: 54.
Neurobiology diseasebiology Metabolic
Zika virus infection disrupts astrocytic proteins involved in synapse control and axon guidance
Sher et al.
Front Microbiol. 2019 Mar 26;10:596.
Neurobiology diseasebiology Infection
Fine-Mapping of the Human Blood Plasma N-Glycome onto Its Proteome
Suhre K, et al.
Metabolites 9(7), 122. https://doi.org/10.3390/metabo9070122.
Effects of codon optimization on coagulation factor IX translation and structure: Implications for protein and gene therapies
Alexaki A, et al.
Sci Rep. 2019 Oct 29;9(1):15449.
SomaScan Binding Large-scale-proteomics
Targeting Unique Epitopes on Highly Similar Proteins GDF-11 and GDF-8 with Modified DNA Aptamers
Ochsner UA, et al.
Biochemistry. 2019 Nov 19;58(46):4632-4640.
SomaScan Binding
Biomarker discovery in cardiac allograft vasculopathy using targeted aptamer proteomics
Almufleh A, et al.
Clin Transplant. 2019 Dec 9:e13765.
Cardiovascular diseasebiology diagnostics
Apabetalone (RVX-208) reduces vascular inflammation in vitro and in CVD patients by a BET-dependent epigenetic mechanism
Tsujikawa LM, et al.
Clin Epigenetics. 2019; 11: 102.
Cardiovascular mechanismofaction stratification diagnostics
Aptamer Profiling of A549 Cells Infected with Low-Pathogenicity and High-Pathogenicity Influenza Viruses
Coombs KM, et al.
Viruses 2019, 11(11), 1028.
Infection diseasebiology diagnostics
Dual-platform affinity proteomics identifies links between the recurrence of ovarian carcinoma and proteins released into the tumor microenvironment
Finkemagel F, et al.
Theranostics. 2019 Aug 22;9(22):6601-6617.
Oncology diseasebiology stratification diagnostics
Proteomics in gastroparesis: Unique and overlapping protein signatures in diabetic and idiopathic gastroparesis
Grover M, et al.
Am J Physiol Gastrointest Liver Physiol. 2019 Sep 4. doi: 10.1152.
Immunity diseasebiology Metabolic diagnostics SomaScan Binding
Plasma proteomics identifies a 'chemokine storm' in idiopathic multicentric Castleman disease
Pierson, SK et al.
Am J Hematol 93(7): 902-912.
Inflammatory diseasebiology diagnostics Rare
Tracking disease progression non-invasively in Duchenne and Becker muscular dystrophies
Spitali, P et al.
J Cachexia Sarcopenia Muscle 9(4): 715-726.
Pediatric diseasebiology diagnostics Musculoskeletal
Serum proteomic assessment of the progression of fracture healing
Hussein, AI et al.
J Orthop Res 36(4): 1153-1163.
Osteoporosis diagnostics
The impact of the glomerular filtration rate on the human plasma proteome
Christensson, A et al.
Proteomics Clin Appl 12(3): e1700067.
Kidney diseasebiology diagnostics
Novel application of aptamer proteomic analysis in cystic fibrosis bronchoalveolar lavage fluid
DeBoer, EM et al.
Proteomics Clin Appl: e1800085.
Rare diseasebiology diagnostics
Benefit of apabetalone on plasma proteins in renal disease
Wasiak, S et al.
Kidney International Reports 3(3): 711-721.
Kidney diseasebiology mechanismofaction diagnostics
Aptamer-based proteomics identifies mortality-associated serum biomarkers in dialysis-dependent AKI patients
Yu, LR et al.
Kidney Int Rep 3(5): 1202-1213.
Kidney diseasebiology targetidentification diagnostics
"Scanning"" into the future: the promise of SOMAScan technology for kidney disease"
Coca, SG
Kidney Int Rep 3(5): 1020-1022.
Kidney diseasebiology diagnostics
Aptamer-based proteomics of serum and plasma in acquired aplastic anemia
Giudice, V et al.
Exp Hematol 68: 38-50.
Rare diseasebiology diagnostics
Sperm cell purification from mock forensic swabs using SOMAmerTM affinity reagents
Katilius E et al.
Forensic Sci Int Genet 35: 9-13.
SomaScan Binding
Sputum transcriptomics reveal up-regulation of IL-1 receptor family members in severe asthma
Rossios, C et al.
J Allergy Clin Immunol 141(2): 560-570.
Respiratory diseasebiology diagnostics
Plasma from some cancer patients inhibits adenoviral Ad5f35 vector transduction of dendritic cells
Jin, P et al.
Cytotherapy 20(5): 728-739.
Oncology mechanismofaction diagnostics
Non-invasive assessment of non-alcoholic fatty liver disease: Clinical prediction rules and blood-based biomarkers
Vilar-Gomez, E et al.
J Hepatol 68(2): 305-315.
Inflammatory diagnostics Fibrotic Metabolic diseasebiology
Cerebrospinal fluid biomarkers link toxic astrogliosis and microglial activation to multiple sclerosis severity
Masvekar, R et al.
Mult Scler Relat Disord 28: 34-43.
Neurobiology diseasebiology diagnostics
Phase IIa trial in Duchenne muscular dystrophy shows vamorolone is a first-in-class dissociative steroidal anti-inflammatory drug
Conklin, LS et al.
Pharmacol Res 136: 140-150.
Neurobiology diseasebiology pkpd stratification diagnostics
Diet-resistant obesity is characterized by a distinct plasma proteomic signature and impaired muscle fiber metabolism
Thrush, AB et al.
Int J Obes (Lond) 42(3): 353-362.
Metabolic diseasebiology diagnostics Osteoporosis
Stability and reproducibility of proteomic profiles measured with an aptamer-based platform
Kim, CH et al.
Sci Rep 8(1): 8382.
SomaScan Binding Reviews
Increased levels of circulating MMP3 correlate with severe rejection in face transplantation
Kollar, B et al.
Sci Rep 8(1): 14915.
Inflammatory diseasebiology diagnostics
Mistimed food intake and sleep alters 24-hour time-of-day patterns of the human plasma proteome
Depner CM et al.
Proc Natl Acad Sci U S A 115(23): E5390-E5399.
Metabolic diseasebiology
Classification of prostate cancer using a protease activity nanosensor library
Dudani, JS et al.
Proc Natl Acad Sci U S A 115(36): 8954-8959.
Oncology diagnostics
Deep molecular phenotypes link complex disorders and physiological insult to CpG methylation
Zaghlool, SB et al.
Hum Mol Genet 27(6): 1106-1121.
Respiratory diseasebiology Metabolic
Identification of novel systemic sclerosis biomarkers employing aptamer proteomic analysis
Wermuth, PJ et al.
Rheumatology (Oxford) 57(10): 1698-1706.
Immunity diseasebiology diagnostics
Plasma proteomic signature of age in healthy humans
Tanaka, T et al.
Aging Cell 17(5): e12799.
Aging diagnostics
Habitual aerobic exercise and circulating proteomic patterns in healthy adults: relation to indicators of healthspan
Santos-Parker, JR et al.
J Appl Physiol (1985) 125(5): 1646-1659.
Aging diseasebiology diagnostics
"Application of large scale aptamer-based proteomic profiling to ""planned"" myocardial infarctions"
Jacob, J et al.
Circulation 137(12): 1270-1277.
Cardiovascular diseasebiology targetidentification diagnostics
Integrative omics: harnessing the proteome to maximize the potential of the genome
McGarrah, RW et al.
Circulation 137(11): 1173-1175.
Cardiovascular diseasebiology
Harnessing the power of proteomics to assess drug safety and guide clinical trials
Lam, MPY et al.
Circulation 137(10): 1011-1014.
Cardiovascular stratification
Probing the virtual proteome to identify novel disease biomarkers
Mosley, JD et al.
Circulation 138(22): 2469-2481.
Cardiovascular diseasebiology diagnostics
Cerebrospinal fluid protein changes in preeclampsia
Ciampa, E et al.
Hypertension 72(1): 219-226.
Reproductive diseasebiology
Endothelial microparticles and systemic complement activation in patients with chronic kidney disease
Jalal, D et al.
J Am Heart Assoc 7(14): e007818.
Kidney diseasebiology Inflammatory
Early identification of bronchopulmonary dysplasia using novel biomarkers by proteomic screening
Forster, K et al.
Am J Respir Crit Care Med 197(8): 1076-1080.
Respiratory diseasebiology diagnostics
Serum biomarker for diagnostic evaluation of pulmonary arterial hypertension in systemic sclerosis
Rice, LM et al.
Arthritis Res Ther 20(1): 185.
Respiratory diseasebiology diagnostics
The differential plasma proteome of obese and overweight individuals undergoing a nutritional weight loss and maintenance intervention
Oller Moreno, S et al.
Proteomics Clin Appl 12(1).
Metabolic diseasebiology diagnostics
Combined use of protein biomarkers and network analysis unveils deregulated regulatory circuits in Duchenne muscular dystrophy
Parolo, S et al.
PLoS One 13(3): e0194225.
Neurobiology diseasebiology diagnostics
A proteomic signature that reflects pancreatic beta-cell function
Curran, AM et al.
PLoS One 13(8): e0202727.
Metabolic diseasebiology diagnostics
Proteomic analysis of heart failure hospitalization among patients with chronic kidney disease: The Heart and Soul Study
Dubin, RF et al.
PLoS One 13(12): e0208042.
Cardiovascular diseasebiology targetidentification diagnostics Kidney
Proteomics: Clinical and research applications in respiratory diseases.
Norman, KC et al.
Respirology 23(11): 993-1003.
Respiratory Reviews
A proteomic clock of human pregnancy.
Aghaeepour, N et al.
Am J Obstet Gynecol 218(3): 347 e341-347 e314.
Reproductive
Genome-wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease
Yao, C et al.
Nat Commun 9(1): 3268.
Cardiovascular diseasebiology targetidentification diagnostics
Chemotherapy-induced differential cell cycle arrest in B-cell lymphomas affects their sensitivity to Wee1 inhibition
Wang, X et al.
Haematologica 103(3): 466-476.
Oncology diseasebiology mechanismofaction
Clinical validation of a protein biomarker panel for non-small cell lung cancer
Jung, YJ et al.
J Korean Med Sci 33(53): e342.
Oncology diseasebiology diagnostics
Improving probes for super-resolution
Moore, RP et al.
Nat Methods 15(9): 659-660.
SomaScan Binding
Proteomic profiling identifies novel circulating markers associated with bronchiectasis in cystic fibrosis
DeBoer, EM et al.
Proteomics Clin Appl 11(9-10).
Respiratory diseasebiology diagnostics Pediatric
Interleukin 1 receptor-like 1 protein (ST2) is a potential biomarker for cardiomyopathy in Duchenne muscular dystrophy
Anderson, J et al.
Pediatr Cardiol 38(8): 1606-1612.
Cardiovascular diagnostics Pediatric Neurobiology
Protein quantitative trait locus study in obesity during weight-loss identifies a leptin regulator
Carayol, J et al.
Nat Commun 8(1): 2084.
Metabolic diseasebiology diagnostics
A proteome-derived longitudinal pharmacodynamic biomarker for diffuse systemic sclerosis skin
Rice, LM et al.
J Invest Dermatol 137(1): 62-70.
Immunity diseasebiology diagnostics
Sexual dimorphism, age, and fat mass are key phenotypic drivers of proteomic signatures
Curran, AM et al.
J Proteome Res 16(11): 4122-4133.
Aging diseasebiology Metabolic
Trisomy 21 causes changes in the circulating proteome indicative of chronic autoinflammation
Sullivan, KD et al.
Sci Rep 7(1): 14818.
Rare diseasebiology
Assessment of variability in the SOMAscan assay
Candia, J et al.
Sci Rep 7(1):14248.
SomaScan Binding Reviews
Divergent roles for clusterin in lung injury and repair
Habiel, DM et al.
Sci Rep 7(1): 15444.
Respiratory diseasebiology Fibrotic
A pilot characterization of the human chronobiome
Skarke, C et al.
Sci Rep 7(1):17141.
Metabolic diseasebiology
Pharmacokinetic properties of DNA aptamers with base modifications
Gupta, S et al.
Nucleic Acid Ther 27(6): 345-353.
SomaScan Binding
Genome-wide quantitative trait loci mapping of the human cerebrospinal fluid proteome
Sasayama, D et al.
Hum Mol Genet 26(1): 44-51.
Neurobiology diseasebiology diagnostics
Identification of unique proteomic signatures in allergic and non-allergic skin disease
Wang, J et al.
Clin Exp Allergy 47(11): 1456-1467.
Inflammatory diseasebiology diagnostics
An immune clock of human pregnancy
Aghaeepour, N et al.
Sci Immunol 2(15):eaan2946.
Immunity diseasebiology Reproductive
A degradation fragment of type X collagen is a real-time marker for bone growth velocity
Coghlan, RF et al.
Sci Transl Med 9(419): eaan4669.
Osteoporosis diseasebiology diagnostics
Large-scale proteomics identifies MMP-7 as a sentinel of epithelial injury and of biliary atresia
Lertudomphonwanit, C et al.
Sci Transl Med 9(417): eaan8462.
Pediatric diseasebiology targetidentification diagnostics
Proteomic profiles associated with early echocardiogram evidence of pulmonary vascular disease in preterm infants
Wagner, BD et al.
Am J Respir Crit Care Med 197(3): 394-397.
Cardiovascular diseasebiology Pediatric
Antiinflammatory effects of aprepitant coadministration with cART regimen containing ritonavir in HIV-infected adults
Spitsin, S et al.
JCI Insight 2(19) 95893
Immunity diseasebiology Infection mechanismofaction
The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimer's pathology
Westwood, S et al.
Alzheimers Res Ther 9(1): 31.
Aging diseasebiology Metabolic
High-throughput characterization of blood serum proteomics of IBD patients with respect to aging and genetic factors
Di Narzo, AF et al.
PLoS Genet 13(1): e1006565.
Aging diseasebiology Inflammatory
Activation of inflammatory and pro-thrombotic pathways in acute stress cardiomyopathy
Fitzgibbons, TP et al.
Frontiers in Cardiovascular Medicine 4: 49.
Cardiovascular diseasebiology diagnostics
Discovery and validation of a six-marker serum protein signature for the diagnosis of active pulmonary tuberculosis
De Groote, MA et al.
J Clin Microbiol 55(10): 3057-3071.
Infection diagnostics
Attenuated PDGF signaling drives alveolar and microvascular defects in neonatal chronic lung disease
Oak, P et al.
EMBO Mol Med 9(11): 1504-1520.
Respiratory diseasebiology diagnostics
GDF15 is a heart-derived hormone that regulates body growth
Wang, T et al.
EMBO Mol Med 9(8): 1150-1164.
Cardiovascular diseasebiology Pediatric
The prediction of late-onset preeclampsia: Results from a longitudinal proteomics study
Erez, O et al.
PLoS One 12(7): e0181468.
Reproductive diseasebiology diagnostics
Diagnosis and prognosis-review of biomarkers for mesothelioma
Sun, HH et al.
Ann Transl Med 5(11): 244.
Respiratory diseasebiology diagnostics
Molecular-based diagnosis of multiple sclerosis and its progressive stage
Barbour, C et al.
Ann Neurol 82(5): 795-812.
Neurobiology diseasebiology diagnostics
Vitamin B12 deficiency and impaired expression of amnionless during aging
Pannerec, A et al.
J Cachexia Sarcopenia Muscle 9(1): 41-52.
Aging diseasebiology
Connecting genetic risk to disease end points through the human blood plasma proteome
Suhre, K et al.
Nat Commun 8: 14357.
SomaScan Large-scale-proteomics
Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms
Howson, JMM et al.
Nat Genet 49(7): 1113-1119.
Cardiovascular diseasebiology
Plasma proteome analysis in patients with pulmonary arterial hypertension: an observational cohort study
Rhodes, CJ et al.
Lancet Respir Med 5(9): 717-726.
Cardiovascular diseasebiology targetidentification Respiratory Rare
Multiomic disease signatures converge to cytotoxic CD8 T cells in primary Sjogren's syndrome
Tasaki, S et al.
Ann Rheum Dis 76(8): 1458-1466.
Immunity diseasebiology targetidentification
Efficacy of individualised diets in patients with irritable bowel syndrome: a randomised controlled trial
Ali A et al.
BMJ Open Gastro 4(1): e000164.
Inflammatory diseasebiology
Identification of serum protein biomarkers for utrophin based DMD therapy
Guiraud, S et al.
Sci Rep 7: 43697.
Pediatric diseasebiology diagnostics Musculoskeletal
Selection of DNA aptamers with two modified bases
Gawande, BN et al.
Proc Natl Acad Sci U S A 114(11): 2898-2903.
SomaScan Binding
The maternal plasma proteome changes as a function of gestational age in normal pregnancy: a longitudinal study
Romero, R et al.
Am J Obstet Gynecol 217(1):67 e61-67 e21.
Reproductive diseasebiology diagnostics
Proteomic study of hepatocellular carcinoma using a novel modified aptamer-based array (SOMAscan) platform
Qiao, Z et al.
Biochim Biophys Acta 1865(4): 434-443.
Oncology diseasebiology diagnostics
Development of a protein biomarker panel to detect non-small-cell lung cancer in Korea
Jung, YJ et al.
Clin Lung Cancer 18(2): e99-e107.
Oncology diagnostics
The relationship of circulating proteins in early pregnancy with preterm birth
Lynch, AM et al.
Am J Obstet Gynecol 214(4): 517 e511-518.
Reproductive diseasebiology diagnostics
Identification of definitive serum biomarkers associated with disease activity in primary Sjögren's syndrome
Nishikawa, A et al.
Arthritis Res Ther 18(1): 106.
Immunity diseasebiology targetidentification diagnostics
Identification of pathway-specific serum biomarkers of response to glucocorticoid and infliximab treatment in children with inflammatory bowel disease
Heier, CR et al.
Clin Transl Gastroenterol 7(9): e192.
Inflammatory diseasebiology mechanismofaction Pediatric
Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice
Lukjanenko, L et al.
Nat Med 22(8): 897-905.
Aging diseasebiology Musculoskeletal
Serum pharmacodynamic biomarkers for chronic corticosteroid treatment of children
Hathout, Y et al.
Sci Rep 6: 31727.
Inflammatory diseasebiology diagnostics Pediatric
A cross sectional study of two independent cohorts identifies serum biomarkers for facioscapulohumeral muscular dystrophy (FSHD)
Petek, LM et al.
Neuromuscul Disord 26(7): 405-413.
Musculoskeletal diseasebiology diagnostics
Chemically modified interleukin-6 aptamer inhibits development of collagen-induced arthritis in cynomolgus monkeys
Hirota, M et al.
Nucleic Acid Ther 26(1): 10-19.
Immunity diseasebiology targetidentification targetvalidation mechanismofaction Binding
Fit for the eye: aptamers in ocular disorders
Drolet, DW et al.
Nucleic Acid Ther 26(3): 127-146.
Ocular diseasebiology targetidentification mechanismofaction pkpd diagnostics
readat: an R package for reading and working with SomaLogic ADAT files
Cotton, RJ et al.
BMC Bioinformatics 17(1): 201.
Respiratory mucosal proteome quantification in human influenza infections
Marion, T et al.
PLoS One 11(4): e0153674.
Infection diseasebiology
Six-SOMAmer index relating to immune, protease and angiogenic functions predicts progression in IPF
Ashley, SL et al.
PLoS One 11(8): e0159878.
Respiratory diseasebiology diagnostics Fibrotic
Longitudinal protein changes in blood plasma associated with the rate of cognitive decline in Alzheimer's disease
Sattlecker, M et al.
J Alzheimers Dis 49(4): 1105-1114.
Aging diseasebiology targetidentification
An evaluation of an aptamer for use as an affinity reagent with MS: PCSK9 as an example protein
Gupta, V et al.
Bioanalysis 8(15): 1557-1564.
SomaScan Binding
Developing clinically relevant biomarkers in inflammatory arthritis: A multiplatform approach for serum candidate protein discovery
McArdle, A et al.
Proteomics Clin Appl 10(6): 691-698.
Immunity diseasebiology diagnostics
The relationship of novel plasma proteins in the early neonatal period with retinopathy of prematurity
Lynch, AM et al.
Invest Ophthalmol Vis Sci 57(11): 5076-5082.
Pediatric diseasebiology diagnostics
Embracing proteins: structural themes in aptamer-protein complexes
Gelinas, AD et al.
Curr Opin Struct Biol 36: 122-132.
SomaScan Structure Binding
Clinical utility of serum biomarkers in Duchenne muscular dystrophy.
Hathout, Y et al.
Clin Proteomics 13: 9.
Rare Reviews
SELEX: How it happened and where it will go
Gold, L
J Mol Evol 81(5-6): 140-143.
Reviews
Non-helical DNA triplex forms a unique aptamer scaffold for high affinity recognition of nerve growth factor
Jarvis, TC et al.
Structure 23(7): 1293-1304.
SomaScan Structure Binding
Increased cerebrospinal fluid fibrinogen in major depressive disorder
Hattori, K et al.
Sci Rep 5: 11412.
Neurobiology diseasebiology
Large-scale serum protein biomarker discovery in Duchenne muscular dystrophy
Hathout, Y et al.
Proc Natl Acad Sci U S A 112(23): 7153-7158.
Pediatric diseasebiology targetidentification diagnostics Musculoskeletal
Practical synthesis of cytidine-5-carboxamide-modified nucleotide reagents
Rohloff, JC et al.
Nucleosides Nucleotides Nucleic Acids 34(3): 180-198.
SomaScan
Influence of 5-N-carboxamide modifications on the thermodynamic stability of oligonucleotides
Wolk, SK et al.
Nucleic Acids Res 43(19): 9107-9122.
SomaScan Binding
Improved preparation of 2 M triethylammonium bicarbonate
Carlson, M et al.
Green Chem Lett Rev 8(3-4): 37-39.
SomaScan
Proteomic methods for biomarker discovery and validation. Are we there yet?
Hathout, Y (2015)
Expert Rev Proteomics 12(4): 329-331.
Reviews
Circulating proteomic signatures of chronological age
Menni, C et al.
J Gerontol A Biol Sci Med Sci 70(7): 809-816.
Aging diseasebiology diagnostics
A candidate plasma protein classifier to identify Alzheimer's disease.
Zhao, X et al.
J Alzheimers Dis 43(2): 549-563.
Neurobiology
Aptamer-based proteomic signature of intensive phase treatment response in pulmonary tuberculosis
Nahid, P et al.
Tuberculosis (Edinb) 94(3): 187-196.
Infection stratification diagnostics
Crystal structure of interleukin-6 in complex with a modified nucleic acid ligand
Gelinas, AD et al.
J Biol Chem 289(12): 8720-8734.
SomaScan Structure Binding
Proteomics analysis of cancer exosomes using a novel modified aptamer-based array (SOMAscan™) platform
Webber, J et al.
Mol Cell Proteomics 13(4): 1050-1064.
Oncology diagnostics Exosomes
DTC-and-me: patient, provider, proteins and regulators.
Steele, FR et al.
J Pers Med 4(1): 79-87.
SomaScan
Beyond antibodies: new affinity reagents to unlock the proteome.
Lollo, B et al.
Proteomics 14(6): 638-644.
SomaScan Binding
Methylation potential associated with diet, genotype, protein, and metabolite levels in the Delta Obesity Vitamin Study
Monteiro, JP et al.
Genes Nutr 9(3): 403.
Metabolic diseasebiology diagnostics
Genetic associations with micronutrient levels identified in immune and gastrointestinal networks
Morine, MJ et al.
Genes Nutr 9(4): 408.
Metabolic diseasebiology
Nucleic acid ligands with protein-like side chains: Modified aptamers and their use as diagnostic and therapeutic agents
Rohloff, JC et al.
Mol Ther Nucleic Acids 3:e201.
SomaScan Binding Reviews Clinical
Specific capture and detection of Staphylococcus aureus with high-affinity modified aptamers to cell surface components
Baumstummler, A et al.
Lett Appl Microbiol 59(4): 422-431.
Infection diagnostics
Validation of a blood protein signature for non-small cell lung cancer
Mehan, MR et al.
Clin Proteomics 11(1): 32.
Oncology diagnostics
Systematic selection of modified aptamer pairs for diagnostic sandwich assays
Ochsner, UA et al.
Biotechniques 56(3): 125-128, 130, 132-133.
Cardiovascular diagnostics Infection SomaScan Binding
Candidate blood proteome markers of Alzheimer's disease onset and progression: a systematic review and replication study
Kiddle, SJ et al.
J Alzheimers Dis 38(3): 515-531.
Aging diseasebiology stratification diagnostics
Alzheimer's disease biomarker discovery using SOMAscan multiplexed protein technology
Sattlecker, M et al.
Alzheimers Dement 10(6): 724-734.
Aging diseasebiology diagnostics
Detection of Clostridium difficile toxins A, B and binary toxin with slow off-rate modified aptamers
Ochsner, UA et al.
Diagn Microbiol Infect Dis 76(3): 278-285.
Infection diagnostics Binding
Elucidating novel serum biomarkers associated with pulmonary tuberculosis treatment
De Groote, MA et al.
PLoS One 8(4): e61002.
Infection diseasebiology diagnostics
Interaction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondin
Xie, Y et al.
EMBO Rep 14(12): 1120-1126.
Oncology diseasebiology SomaScan
Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy
Loffredo, FS et al.
Cell 153(4): 828-839.
Cardiovascular diseasebiology diagnostics
Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets
Davies, DR et al.
Proc Natl Acad Sci U S A 109(49): 19971-19976.
SomaScan Structure Binding
Aptamers and the RNA world, past and present
Gold, L et al.
Cold Spring Harb Perspect Biol 4(3).
Reviews
Life's simple measures: unlocking the proteome
Brody, E et al.
J Mol Biol 422(5):595-606.
Reviews
Protein signature of lung cancer tissues
Mehan, MR et al.
PLoS One 7(4): e35157.
Oncology diseasebiology targetidentification diagnostics
Age-dependent changes in the cerebrospinal fluid proteome by slow off-rate modified aptamer array
Baird, GS et al.
Am J Pathol 180(2): 446-456.
Aging diseasebiology Neurobiology diagnostics
Rapid histochemistry using slow off-rate modified aptamers with anionic competition
Gupta, S et al.
Appl Immunohistochem Mol Morphol 19(3): 273-278.
SomaScan Binding
Unlocking biomarker discovery: large scale application of aptamer proteomic technology for early detection of lung cancer
Ostroff, RM et al.
PLoS One 5(12): e15003.
Oncology diseasebiology diagnostics
Aptamer-based multiplexed proteomic technology for biomarker discovery
Gold, L et al.
PLoS One 5(12): e15004.
Reviews
High-content affinity-based proteomics: unlocking protein biomarker discovery
Brody, EN et al.
Expert Rev Mol Diagn 10(8): 1013-1022.
Reviews
Expanding the chemistry of DNA for in vitro selection
Vaught, JD et al.
J Am Chem Soc 132(12): 4141-4151.
SomaScan
Proteomics and diagnostics: Let's get specific, again
Zichi, D et al.
Curr Opin Chem Biol 12(1): 78-85.
SomaScan
Interlocking structural motifs mediate molecular discrimination by a theophylline-binding RNA
Zimmermann, GR et al.
Nat Struct Biol 4(8): 644-649.
SomaScan Structure
Let's get specific: the relationship between specificity and affinity
Eaton, BE et al.
Chem Biol 2(10): 633-638.
SomaScan Binding
High-resolution molecular discrimination by RNA
Jenison, RD et al.
Science 263(5152): 1425-1429.
Reviews