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Current Publications Count: 490

A proteomic surrogate for cardiovascular outcomes that is sensitive to multiple mechanisms of change in risk
Williams, SA et al.
Sci Transl Med 14(639): eabj9625
Large-scale proteomics Cardiovascular stratification
Large-scale integration of the plasma proteome with genetics and disease
Ferkingstad, E et al.
Nat Genet 53(12): 1712-1721
Large-scale proteomics Rare
Mapping the proteo-genomic convergence of human diseases
Pietzner, M et al.
Science 374(6569): eabj1541
Large-scale proteomics Disease biology Rare
A brain proteomic signature of incipient Alzheimer's disease in young APOE epsilon4 carriers identifies novel drug targets
Roberts, JA et al.
Sci Adv 7(46): eabi8178.
Neurobiology Disease biology target identification
Plasma protein patterns as comprehensive indicators of health
Williams SA, et al.
Nat Med 25(12): 1851-1857.
Clinical Large-scale proteomics
Undulating changes in human plasma proteome profiles across the lifespan
Lehailler, B et al.
Nat Med 25(12): 1843-1850
Disease Biology
Co-regulatory networks of human serum proteins link genetics to disease
Emilsson, V et al.
Science 361(6404): 769-773.
Aging disease biology diagnostics
Genomic atlas of the human plasma proteome
Sun, BB et al.
Nature 558: 73-79.
SomaScan Large-scale proteomics
Genetic architecture of the cardiovascular risk proteome
Benson, MD et al.
Circulation 137(11): 1158-1172.
Cardiovascular disease biology target identification diagnostics
Using aptamer-based technology to probe the plasma proteome for cardiovascular disease prediction
Sabatine, MS
JAMA 315(23): 2525-2526.
Cardiovascular target identification diagnostics
Aptamer-based proteomic profiling reveals novel candidate biomarkers and pathways in cardiovascular disease
Ngo, D et al.
Circulation 134(4): 270-285.
Cardiovascular diagnostics
Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19
Sacco, K et al.
Nat Med, epub ahead of print.
Pediatric Infection Inflammatory
Serum proteome analysis of systemic JIA and related lung disease identifies distinct inflammatory programs and biomarkers
Chen, G et al.
Arthritis Rheumatol, epub ahead of print
Rare Pediatric Inflammatory
Specialized interferon action in COVID-19
Galbraith, MD et al.
Proc Natl Acad Sci U S A 119(11)
Infection Immunity
Elucidating mechanisms of genetic cross-disease associations at the PROCR vascular disease locus
Stacey, D et al.
Nat Commun 13(1): 1222
Cardiovascular Disease biology
A genome-wide meta-analysis identifies 50 genetic loci associated with carpal tunnel syndrome
Skuladottir, AT et al.
Nat Commun 13: 1598
Large-scale proteomics
Translation of aptamers toward clinical diagnosis and commercialization
Liu, S et al.
Biosens Bioelectron 208: 114168
Review Diagnostics
Diagnostic Accuracy of Blood-Based Biomarker Panels: A Systematic Review
Hardy-Sosa, A et al.
Front Aging Neurosci 14: 683689
Review Neurobiology
Plasma growth and differentiation factor 15 predict longitudinal changes in bone parameters in women, but not in men
Osawa, Y et al.
J Gerontol A Biol Sci Med Sci., epub ahead of print.
Effects of ivacaftor on systemic inflammation and the plasma proteome in people with CF and G551D
Hoppe, JE et al.
J Cyst Fibros, epub ahead of print.
Inflammatory Respiratory
Chemical modifications for a next generation of nucleic acid aptamers
Chan, KY et al.
Chembiochem, epub ahead of print.
Severe Iatrogenic Hypoglycemia Modulates the Fibroblast Growth Factor Protein Response
Nandakumar, M et al.
Diabetes Obes Metab, epub ahead of print.
Identifying causal genes for stroke via integrating the proteome and transcriptome from brain and blood
Wu, BS et al.
J Transl Med 20(1): 181
Cardiovascular Large-scale proteomics
Limited proteolysis–mass spectrometry reveals aging-associated changes in cerebrospinal fluid protein abundances and structures
Shuken, SR et al.
Nat Aging, epub ahead of print
Aging Neurobiology targetidentification
Proteomics in thrombosis research
Edfors, F et al.
Res Pract Thromb Haemost 6(3): e12706.
Harnessing Big Data to Advance Treatment and Understanding of Pulmonary Hypertension
Rhodes, CJ et al.
Circ Res 130(9): 1423-1444
Review Cardiovascular Respiratory
The Proteomic Profile of Interstitial Lung Abnormalities
Axelsson, GT et al.
Am J Respir Crit Care Med., epub ahead of print.
Respiratory Large-scale proteomics
Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset
Saevarsdottir, S et al.
Ann Rheum Dis., epub ahead of print.
Inflammatory Large-scale proteomics
Serum Protein Signatures Using Aptamer-Based Proteomics for Minimal Change Disease and Membranous Nephropathy
Muruve, DA et al.
Kidney Int Rep., epub ahead of print.
Kidney stratification
Differential Proteomics of Cardiovascular Risk and Coronary Artery Disease in Humans
Ferrannini, E et al.
Front Cardiovasc Med 8: 790289
Placental proteins with predicted roles in fetal development decrease in premature infants
Schreiner, C et al.
Pediatr Res., epub ahead of print.
Pediatric Reproductive
Proteomics technologies for cancer liquid biopsies
Ding, Z et al.
Mol Cancer 21(1): 53
Review Oncology
Advances in proteomic profiling of pediatric kidney diseases
Cummins, TD et al.
Pediatr Nephrol, epub ahead of print.
Review Kidney Pediatric
Proteomic Profiling Identifies Novel Proteins for Genetic Risk of Severe COVID-19: the Atherosclerosis Risk in Communities Study
Steffen, BT et al.
Hum Mol Genet, epub ahead of print
Infection Respiratory Large-scale proteomics
Proteomic Studies of Psoriasis
Sobolev, VV et al.
Biomedicines 10(3): 619
Review Immunity Inflammatory
Proteins and pathways in atrial fibrillation and atrial cardiomyopathy underlying cryptogenic stroke
Pala, E et al.
Int J Cardiol Heart Vasc 39: 100977
Protein prediction for trait mapping in diverse populations
Schubert, R et al.
PLoS One 17(2): e0264341
Large-scale proteomics
Diabetes, GDF-15 and incident heart failure: the atherosclerosis risk in communities study
Echouffo-Tcheugui, JB et al.
Diabetologia 65: 955–963
Metabolic Cardiovascular
Using the Plasma Proteome for Risk Stratifying Patients with Pulmonary Arterial Hypertension
Rhodes, CJ et al.
Am J Respir Crit Care Med., epub ahead of print.
Respiratory Rare Stratification
A genome-wide association study of serum proteins reveals shared loci with common diseases
Gudjonsson, A et al.
Nat Commun 13(1): 480
Large-scale proteomics
Coding and regulatory variants are associated with serum protein levels and disease
Emilsson, V et al.
Nat Commun 13(1): 481
Large-scale proteomics
Effects of colchicine on lipolysis and adipose tissue inflammation in adults with obesity and metabolic syndrome
Levine, JA et al.
Obesity (Silver Spring), epub ahead of print
Aptamers: Potential Diagnostic and Therapeutic Agents for Blood Diseases
Aljohani, MM et al.
Molecules 27(2): 383
Recent Developments in Clinical Plasma Proteomics-Applied to Cardiovascular Research
Palstrom, NB et al.
Biomedicines 10(1): 162
Review Cardiovascular
Identification and Evaluation of Serum Protein Biomarkers Which Differentiate Psoriatic from Rheumatoid Arthritis.
Mc Ardle, A et al.
Arthritis Rheumatol 74(1): 81-91
Inflammatory diagnostics
Exercise plasma boosts memory and dampens brain inflammation via clusterin
De Miguel, Z et al.
Nature 600(7889): 494-499
Cross-validation of SARS-CoV-2 responses in kidney organoids and clinical populations
Helms, L et al.
JCI Insight 6(24): e154882
Infection Kidney
Synergistic insights into human health from aptamer- and antibody-based proteomic profiling
Pietzner, M et .
Nat Commun 12(1): 6822
Large-scale proteomics
Plasma Proteomics of Renal Function: A Trans-ethnic Meta-analysis and Mendelian Randomization Study
Matias-Garcia, P et al.
J Am Soc Nephrol. 32(7): 1747-1763
Proteomic analysis of serum in workers exposed to diesel engine exhaust
Rahman, ML et al.
Environ Mol Mutagen 63(1): 18-28
A Combined Proteomics and Mendelian Randomization Approach to Investigate the Effects of Aspirin-Targeted Proteins on Colorectal Cancer
Nounu, A et al.
Cancer Epidemiol Biomarkers Prev 30(3): 564-575
Oncology mechanism of action
Hypoglycemia-induced changes in complement pathways in type 2 diabetes
Moin, ASM et al.
Atherosclerosis Plus 46: 35-45
Predicting the probability of death using proteomics.
Eiriksdottir, T et al.
Commun Biol 4(1): 758.
Aging Large-scale proteomics
Large-scale plasma proteomic analysis identifies proteins and pathways associated with dementia risk.
Walker, KA et al.
Nat Aging 1: 473-489.
Aging Large-scale proteomics
Human plasma proteomic profiles indicative of cardiorespiratory fitness.
Robbins, JM et al.
Nat Metab 3(6): 786-797.
Cardiovascular Respiratory
Influence of renin-angiotensin-aldosterone system inhibitors on plasma levels of angiotensin-converting enzyme 2
Zimmermann, T et al.
ESC Heart Fail 8(2): 1717-1721
Cardiovascular Infection
Advances and Utility of the Human Plasma Proteome
Deutsch, EW et al.
J Proteome Res 20(12): 5241-5263
Vitamin D association with the renin angiotensin system in polycystic ovary syndrome
Butler, AE et al.
J Steroid Biochem Mol Biol 214: 105965.
The proteomic signature of recombinant Growth Hormone in recreational athletes
Esefeld, M et al.
J Endocrine Soc, epub ahead of print
Advances in Aptamer-Based Biomarker Discovery
Huang, J et al.
Front Cell Dev Biol 9: 659760.
SomaScan Review
Replication study of plasma proteins relating to Alzheimer's pathology.
Shi, L et al.
Alzheimers Dement 17(9): 1452-1464.
Neurobiology stratification
Platelet Protein-Related Abnormalities in Response to Acute Hypoglycemia in Type 2 Diabetes.
Moin, ASM et al.
Front Endocrinol (Lausanne) 12: 651009.
Broadly effective metabolic and immune recovery with C5 inhibition in CHAPLE disease.
Ozen, A et al.
Nat Immunol 22(2): 128-139.
Rare Immunity mechanism of action
Multi-omics highlights ABO plasma protein as a causal risk factor for COVID-19.
Hernandez Cordero, AI et al.
Hum Genet 140(6): 969-979
Type 2 Diabetes Coagulopathy Proteins May Conflict With Biomarkers Reflective of COVID-19 Severity.
Moin, ASM et al.
Front Endocrinol (Lausanne) 12: 658304
Infection Metabolic
Using ‘big data’ to disentangle aging and COVID-19.
Montgomery, RR et al.
Aging 1: 496–497.
Infection Aging
The COVIDome Explorer researcher portal.
Sullivan, KD et al.
Cell Rep 36(7): 109527.
Early Interleukin-22 and Neutrophil Proteins Are Correlated to Future Lung Damage in Children with Cystic Fibrosis.
Renwick, J et al.
Front Pediatr 9: 640184.
Rare Pediatric Stratification Inflammatory
Effect of longevity genetic variants on the molecular aging rate.
Gurinovich, A et al.
Geroscience 43(3): 1237-1251.
Aging Large-scale proteomics
Novel Murine Biomarkers of Radiation Exposure Using An Aptamer-Based Proteomic Technology.
Sproull, M et al.
Front Pharmacol 12: 633131.
The CRTAC1 protein in plasma associates with osteoarthritis and predicts progression to joint replacements: a large-scale proteomics scan in Iceland.
Styrkarsdottir, U et al.
Arthritis Rheumatol, epub ahead of print.
Musculoskeletal Large-scale proteomics
Plasma Proteomic Profile Predicts Survival in Heart Failure with Reduced Ejection Fraction.
Gui, H et al.
Circ Genom Precis Med 14(3): e003140.
cardiovascular Stratification Large-scale proteomics
SOMAscan Proteomics Identifies Serum Biomarkers Associated With Liver Fibrosis in Patients With NASH.
Luo, Y et al.
Hepatol Commun 5(5): 760-773.
Metabolic Fibrotic Diagnostics
Proteomic signatures of inflammatory skin diseases: a focus on atopic dermatitis.
Mikhaylov, D et al.
Expert Rev Proteomics 18(5): 345-361.
Review Inflammatory
Metabolic syndrome and the plasma proteome: from association to causation.
Elhadad, MA et al.
Cardiovasc Diabetol 20(1): 111.
Metabolic Cardiovascular
Identification of Plasma Proteome Signatures Associated With Surgery Using SOMAscan
Fong TG, et al.
Ann Surg 273(4): 732-742.
Aging Disease Biology Inflammatory
Association of a Serum Protein Signature With Rheumatoid Arthritis Development
O'Neil LJ, et al.
Arthritis Rheumatol. 73(1): 78-88.
Inflammatory Immunity
Genetics meets proteomics: perspectives for large population-based studies
Suhre, K et al.
Nat Rev Genet 22(1): 19-37.
Review Large-scale proteomics
Circulating markers of NADH-reductive stress correlate with mitochondrial disease severity
Sharma, R et al.
J Clin Invest 131(2): e136055
Metabolic Rare
Revealing the role of the human blood plasma proteome in obesity using genetic drivers
Zaghlool, SB et al.
Nat Commun 12(1): 1279
Metabolic Large-scale proteomics
Quantitative Proteomic Analysis of Diabetes Mellitus in Heart Failure With Preserved Ejection Fraction
Hanff, TC et al.
JACC Basic Transl Sci 6(2): 89-99.
Cardiovascular Metabolic
Proteomics in aging research: A roadmap to clinical, translational research
Moaddel, R et al.
Aging Cell: e13325.
Aging Review
Blood biomarker discovery for autism spectrum disorder: A proteomic analysis
Hewitson, L et al.
PLoS One 16(2): e0246581.
Pediatric Neurobiology
Biomarker-focused multi-drug combination therapy and repurposing trial in mdx mice
Ziemba, M et al.
PLoS One 16(2): e0246507
Rare PK/PD
Pediatric and adult dilated cardiomyopathy are distinguished by distinct biomarker profiles.
Gropler, MRF et al.
Pediatr Res., epub ahead of print.
Pediatric Cardiovascular
Smoking induces sex-specific changes in the small airway proteome.
Kokelj, S et al.
Respir Res 22(1): 234.
Validation of Chemokine Biomarkers in Duchenne Muscular Dystrophy.
Ogundele, M et al.
Life (Basel) 11(8): 827.
Pediatric Musculoskeletal
Evolving a RIG-I antagonist: a modified DNA aptamer mimics viral RNA.
Ren, X et al.
J Mol Biol. 433(21): 167227.
Serum levels of ACE2 are higher in patients with obesity and diabetes.
Emilsson, V et al.
Obes Sci Pract 7(2): 239-243.
Functional Network Profiles in ARSACS Disclosed by Aptamer-Based Proteomic Technology
Morani F, et al.
Front Neurol 11: 603774.
Neurobiology Rare
Atopic Dermatitis Endotypes Based on Allergen Sensitization, Reactivity to Staphylococcus aureus Antigens, and Underlying Systemic Inflammation
Leonard A, et al.
J Allergy Clin Immunol Pract. 8(1): 236-247.e3.
Inflammatory Disease Biology Diagnostics
Vascular Disease and Thrombosis in SARS-CoV-2-Infected Rhesus Macaques
Aid M, et al.
Cell 183(5): 1354–1366
Cardiovascular Inflammatory
Genetic architecture of host proteins involved in SARS-CoV-2 infection
Pietzner M, et al.
Nat Commun 11(1): 6397
Cardiovascular Respiratory Disease Biology Target Identification Infection
A Plasma Proteomic Signature of Skeletal Muscle Mitochondrial Function
Zampino M, et al.
Int J Mol Sci 21(24): 9540
Coronary Artery Disease and Type 2 Diabetes: A Proteomic Study
Ferrannini G, et al.
Diabetes Care 43(4): 843-851
Cardiovascular Metabolic
Comparison of Proteomic Assessment Methods in Multiple Cohort Studies
Raffield LM, et al.
Proteomics 20(12):e1900278
Reduced Apolipoprotein M and Adverse Outcomes Across the Spectrum of Human Heart Failure
Chirinos JA, et al.
Circulation 141(18):1463-1476
Plasma proteomic profile of frailty
Sathyan S, et al.
Aging Cell 19(9):e13193
Serum protein biomarkers for juvenile dermatomyositis: a pilot study
Tawalbeh SM, et al.
BMC Rheumatol 4:52
Inflammatory Immunity Rare
Proteomic biomarkers of sleep apnea
Ambati A, et al.
Sleep 43(11):zsaa086
Autophagy Modulators Profoundly Alter the Astrocyte Cellular Proteome
Sher AA, et al.
Cells 9(4):805
Proteomic Signatures of Heart Failure in Relation to Left Ventricular Ejection Fraction
Adamo L, et al.
J Am Coll Cardiol 76(17):1982-1994
Proteomic and Metabolomic Correlates of Healthy Dietary Patterns: The Framingham Heart Study
Walker ME, et al.
Nutrients 12(5):1476
Cardiovascular Metabolic
Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer's Disease Pathology
Shi L, et al.
J Alzheimers Dis 77(3):1353-1368
Neurobiology Disease biology Mechanism of action
Protein biomarkers for incident deep venous thrombosis in critically ill adolescents: An exploratory study
Tala JA, et al.
Pediatr Blood Cancer 67(4):e28159
Cardiovascular Pediatric
Increased Levels of Coagulation Factor XI in Plasma Are Related to Alzheimer's Disease Diagnosis
Begic E, et al.
J Alzheimers Dis 77(1):375-386
Neurobiology Diagnostics
Mechanisms of Sodium-Glucose Cotransporter 2 Inhibition: Insights From Large-Scale Proteomics
Ferrannini E, et al.
Diabetes Care 43(9):2183-2189
Metabolic Disease biology Target validation
Targeting myostatin/activin A protects against skeletal muscle and bone loss during spaceflight
Lee SJ, et al.
Proc Natl Acad Sci U S A 117(38):23942-23951
Multimodal immune phenotyping of maternal peripheral blood in normal human pregnancy
Apps R, et al.
JCI Insight 5(7):e134838
Immunity Reproductive
Effect of induced hypoglycemia on inflammation and oxidative stress in type 2 diabetes and control subjects
Kahal H, et al.
Sci Rep 10(1):4750
Inflammatory Metabolic Disease biology
Modified nucleotides may have enhanced early RNA catalysis.
Wolk, SK et al.
Proc Natl Acad Sci U S A 117(15): 8236-8242.
The Evolution of the Cardiovascular Biomarker Study.
Wang, TJ
Circulation 142(15): 1422-1424.
Cardiovascular Target identification
Placenta accreta spectrum: biomarker discovery using plasma proteomics.
Shainker, SA et al.
Am J Obstet Gynecol 223(3): 433 e431-433 e414.
A fully joint Bayesian quantitative trait locus mapping of human protein abundance in plasma.
Ruffieux, H et al.
PLoS Comput Biol 16(6): e1007882.
Intense light as anticoagulant therapy in humans.
Oyama, Y et al.
PLoS One 15(12): e0244792.
SomaScan Clinical
Identification of a unique temporal signature in blood and BAL associated with IPF progression.
Norman, KC et al.
Sci Rep 10(1): 12049.
Fibrotic Stratification
Circulating Protein Signatures and Causal Candidates for Type 2 Diabetes.
Gudmundsdottir, V et al.
Diabetes 69(8): 1843-1853.
Metabolic Disease Biology Large-scale proteomics
Aptamers and Antisense Oligonucleotides for Diagnosis and Treatment of Hematological Diseases.
Giudice, V et al.
Int J Mol Sci 21(9): 3252.
Review Clinical
Proteomics for personalized cardiovascular risk assessment: in pursuit of the Holy Grail.
Ganz, P et al.
Eur Heart J 41(41): 4008-4010.
Increased mTOR activation in idiopathic multicentric Castleman disease.
Arenas, DJ et al.
Blood 135(19): 1673-1684.
High-Throughput Identification of the Plasma Proteomic Signature of Inflammatory Bowel Disease.
Di Narzo, AF et al.
J Crohns Colitis 13(4): 462-471.
Transcatheter aortic valve replacements alter circulating serum factors to mediate myofibroblast deactivation
Aguado BA, et al.
Science Translational Medicine Volume 11 (509) 2019 eaav3233
Accelerating Biomarker Discovery Through Electronic Health Records, Automated Biobanking, and Proteomics.
Wells, QS et al.
J Am Coll Cardiol 73(17): 2195-2205.
Beyond Autoantibodies: Biologic Roles of Human Autoreactive B Cells in Rheumatoid Arthritis Revealed by RNA-Sequencing.
Mahendra, A et al.
Arthritis Rheumatol 71(4): 529-541.
Immunity Disease biology
Predicting health and life span with the deep plasma proteome.
Emilsson, V et al.
Nat Med 25(12): 1815-1816.
Balanced event prediction through sampled survival analysis.
Datta, G et al.
Systems Medicine 2(1): 28-38.
Aging Disrupts Muscle Stem Cell Function by Impairing Matricellular WISP1 Secretion from Fibro-Adipogenic Progenitors.
Lukjanenko, L et al.
Cell Stem Cell 24(3): 433-446 e437.
Aging Musculoskeletal
Neutrophil activation in systemic capillary leak syndrome (Clarkson disease)
Xie, Z et al.
J Cell Mol Med 23(8): 5119-5127
Rare Disease biology
Plasma proteome in multiple sclerosis disease progression
Malekzadeh A, et al.
Ann Clin Transl Neurol 6(9):1582-1594.
Neurobiology Disease biology Diagnostics Rare
Osteitis is associated with dysregulated pro-osteoblastic activity in patients with nasal polyps
Wu, D et al.
Laryngoscope 129(3): E102-E109.
Exosomes Disease biology Osteoporosis
Vero cell proteomic changes induced by Zika virus infection
Glover, KKM et al.
Proteomics 19(4): e1800309.
Neurobiology Disease biology Infection
Application of an Aptamer-Based Proteomics Assay (SOMAscan™) in Rat Cerebrospinal Fluid
Simats A, et al.
Methods Mol Biol. 2044:221-231.
Neurobiology Disease biology
Guidelines for CSF Processing and Biobanking: Impact on the Identification and Development of Optimal CSF Protein Biomarkers
Hok-A-Hin YS, et al.
Methods Mol Biol. 2044:27-50.
Neurobiology Disease biology SomaScan Large-scale proteomics
Assessing the genetic correlations between blood plasma proteins and osteoporosis: a polygenic risk score analysis
Liang, X et al.
Calcif Tissue Int 104(2): 171-181.
Osteoporosis Disease biology Target identification Diagnostics
Plasma FGF-19 Levels are Increased in Patients with Post-Bariatric Hypoglycemia
Mulla CM, et al.
Obes Surg 29(7):2092-2099.
Metabolic Disease biology
Application of Proteomics Profiling for Biomarker Discovery in Hypertrophic Cardiomyopathy
Shimada YJ, et al.
J Cardiovasc Transl Res 12(6):569-579.
Cardiovascular Disease biology Diagnostics
Cancer protein biomarker discovery based on nucleic acid aptamers
Xiong H, et al.
Int J Biol Macromol 132:190-202.
Oncology Disease biology Diagnostics
Exosome swarms eliminate airway pathogens and provide passive epithelial immunoprotection through nitric oxide
Nocera, AL et al.
J Allergy Clin Immunol 143(4):1525-1535 e1521.
Exosomes Disease biology
Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay
Shi L, et al.
Alzheimers Dement 15(11): 1478-1488.
Aging Disease biology Diagnostics
A framework for multi-omic prediction of treatment response to biologic therapy for psoriasis
Foulkes, AC et al.
J Invest Dermatol 139(1): 100-107.
Immunity Disease biology Stratification Diagnostics
Fatigue in Sjögren's syndrome: a search for biomarkers and treatment targets
Bodewes, ILA et al.
Front Immunol 10: 312.
Inflammatory Disease biology Immunity Target identification Diagnostics
Disease-specific and glucocorticoid-responsive serum biomarkers for Duchenne Muscular Dystrophy
Hathout Y, et al.
Sci Rep 9(1):12167.
Musculoskeletal Disease biology Diagnostics Rare
Candidate early predictive plasma protein markers of doxorubicin-induced chronic cardiotoxicity in B6C3F1 mice
Desai, VG et al.
Toxicol Appl Pharmacol 363:164-173.
Oncology PK/PD Stratification
Pulmonary Aptamer Signatures in Children's Interstitial and Diffuse Lung Diseases
Deterding RR, et al.
Am J Respir Crit Care Med. doi: 10.1164.
Respiratory Disease biology Diagnostics Pediatric Rare
Metabolic and proteomic signatures of hypoglycemia in type 2 diabetes
Halama, A et al.
Diabetes Obes Metab. 2018 Dec 7. doi: 10.1111.
Metabolic Disease biology Diagnostics
Influenza a virus-triggered autophagy decreases the pluripotency of human-induced pluripotent stem cells
Zahedi-Amiri A, et al.
Cell Death Dis 10(5): 337.
Infection Disease biology Reproductive
A serum protein signature of APOE genotypes in centenarians
Sebastiani P, et al.
Aging Cell. :e13023. doi: 10.1111.
Aging Disease biology Diagnostics
Activin type II receptor signaling in cardiac aging and heart failure
Roh, JD et al.
Sci Transl Med 11(482).
Diagnostics Aging Disease biology
Circulating Biomarkers of Testosterone's Anabolic Effects on Fat-Free Mass
Huang G, et al.
J Clin Endocrinol Metab 104(9): 3768-3778.
Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study
Penn-Nicholson A, et al.
PLoS Med 16(4): e1002781.
Infection Disease biology Diagnostics
A combined score of clinical factors and serum proteins can predict time to recurrence in high grade serous ovarian cancer
Mysona, D et al.
Gynecol Oncol 152(3):574-580.
Oncology Disease biology Mechanism of action Diagnostics
Proteomics profiling and risk of new-onset atrial fibrillation: Framingham Heart Study
Ko, D et al.
J Am Heart Assoc 8(6): e010976.
Cardiovascular Disease biology Diagnostics
Proteomic profiles in advanced age-related macular degeneration using an aptamer-based proteomic technology
Lynch, AM et al.
Transl Vis Sci Technol 8(1): 14.
Aging Disease biology Diagnostics Ocular Rare
Human PAH is characterized by a pattern of lipid-related insulin resistance
Hemnes, AR et al.
JCI Insight 4(1).
Respiratory Rare Disease biology Metabolic Mechanism of action Diagnostics
Reproducibility and variability of protein analytes measured using a multiplexed modified aptamer assay
Tin, A et al.
J Appl Lab Med 4(1):30-39.
Cardiovascular Diagnostics
Characterization of Glycolytic Enzymes and Pyruvate Kinase M2 in Type 1 and 2 Diabetic Nephropathy
Gordin D, et al.
Diabetes Care 42(7):1263-1273.
Kidney Disease biology Diagnostics Metabolic
Zika virus infection disrupts astrocytic proteins involved in synapse control and axon guidance
Sher et al.
Front Microbiol 10:596.
Neurobiology Disease biology Infection
Fine-Mapping of the Human Blood Plasma N-Glycome onto Its Proteome
Suhre K, et al.
Metabolites 9(7), 122.
Targeting Unique Epitopes on Highly Similar Proteins GDF-11 and GDF-8 with Modified DNA Aptamers
Ochsner UA, et al.
Biochemistry 58(46):4632-4640.
SomaScan Binding
Biomarker discovery in cardiac allograft vasculopathy using targeted aptamer proteomics
Almufleh A, et al.
Clin Transplant. 2019 Dec 9:e13765.
Cardiovascular Disease biology Diagnostics
Apabetalone (RVX-208) reduces vascular inflammation in vitro and in CVD patients by a BET-dependent epigenetic mechanism
Tsujikawa LM, et al.
Clin Epigenetics 11: 102.
Cardiovascular Mechanism of action Stratification Diagnostics
Aptamer Profiling of A549 Cells Infected with Low-Pathogenicity and High-Pathogenicity Influenza Viruses
Coombs KM, et al.
Viruses 2019, 11(11), 1028.
Infection Disease biology Diagnostics
Dual-platform affinity proteomics identifies links between the recurrence of ovarian carcinoma and proteins released into the tumor microenvironment
Finkemagel F, et al.
Theranostics 9(22):6601-6617.
Oncology Disease biology Diagnostics Stratification
Proteomics in gastroparesis: Unique and overlapping protein signatures in diabetic and idiopathic gastroparesis
Grover M, et al.
Am J Physiol Gastrointest Liver Physiol. 2019 Sep 4. doi: 10.1152.
Immunity Disease biology Diagnostics Metabolic SomaScan Binding
Proteomic analysis reveals distinctive protein profiles involved in CD8(+) T cell-mediated murine autoimmune cholangitis
Zhang, W et al.
Cell Mol Immunol 15(8): 756-767.
Immunity Disease biology Rare
Plasma proteomics identifies a 'chemokine storm' in idiopathic multicentric Castleman disease
Pierson, SK et al.
Am J Hematol 93(7): 902-912.
Inflammatory Disease biology Diagnostics Rare
Tracking disease progression non-invasively in Duchenne and Becker muscular dystrophies
Spitali, P et al.
J Cachexia Sarcopenia Muscle 9(4): 715-726.
Pediatric Disease biology Diagnostics Musculoskeletal
Serum proteomic assessment of the progression of fracture healing
Hussein, AI et al.
J Orthop Res 36(4): 1153-1163.
Osteoporosis Diagnostics
The impact of the glomerular filtration rate on the human plasma proteome
Christensson, A et al.
Proteomics Clin Appl 12(3): e1700067.
Kidney Disease biology Diagnostics
Novel application of aptamer proteomic analysis in cystic fibrosis bronchoalveolar lavage fluid
DeBoer, EM et al.
Proteomics Clin Appl: e1800085.
Rare Disease biology Diagnostics
Benefit of apabetalone on plasma proteins in renal disease
Wasiak, S et al.
Kidney International Reports 3(3): 711-721.
Kidney Disease biology Diagnostics Mechanism of action
Aptamer-based proteomics identifies mortality-associated serum biomarkers in dialysis-dependent AKI patients
Yu, LR et al.
Kidney Int Rep 3(5): 1202-1213.
Kidney Disease biology Diagnostics Target identification
"Scanning" into the future: the promise of SOMAScan technology for kidney disease
Coca, SG
Kidney Int Rep 3(5): 1020-1022.
Kidney Disease biology Diagnostics
Aptamer-based proteomics of serum and plasma in acquired aplastic anemia
Giudice, V et al.
Exp Hematol 68: 38-50.
Rare Disease biology Diagnostics
Sperm cell purification from mock forensic swabs using SOMAmerTM affinity reagents
Katilius E et al.
Forensic Sci Int Genet 35: 9-13.
SomaScan Binding
Sputum transcriptomics reveal up-regulation of IL-1 receptor family members in severe asthma
Rossios, C et al.
J Allergy Clin Immunol 141(2): 560-570.
Respiratory Disease biology Diagnostics
Plasma from some cancer patients inhibits adenoviral Ad5f35 vector transduction of dendritic cells
Jin, P et al.
Cytotherapy 20(5): 728-739.
Oncology Mechanism of action Diagnostics
Non-invasive assessment of non-alcoholic fatty liver disease: Clinical prediction rules and blood-based biomarkers
Vilar-Gomez, E et al.
J Hepatol 68(2): 305-315.
Inflammatory Disease biology Diagnostics Fibrotic Metabolic
Cerebrospinal fluid biomarkers link toxic astrogliosis and microglial activation to multiple sclerosis severity
Masvekar, R et al.
Mult Scler Relat Disord 28: 34-43.
Neurobiology Disease biology Diagnostics
Phase IIa trial in Duchenne muscular dystrophy shows vamorolone is a first-in-class dissociative steroidal anti-inflammatory drug
Conklin, LS et al.
Pharmacol Res 136: 140-150.
Neurobiology Disease biology Diagnostics PK/PD Stratification
Diet-resistant obesity is characterized by a distinct plasma proteomic signature and impaired muscle fiber metabolism
Thrush, AB et al.
Int J Obes (Lond) 42(3): 353-362.
Metabolic Disease biology Diagnostics Osteoporosis
Stability and reproducibility of proteomic profiles measured with an aptamer-based platform
Kim, CH et al.
Sci Rep 8(1): 8382.
SomaScan Binding Review
Increased levels of circulating MMP3 correlate with severe rejection in face transplantation
Kollar, B et al.
Sci Rep 8(1): 14915.
Inflammatory Disease biology Diagnostics
Mistimed food intake and sleep alters 24-hour time-of-day patterns of the human plasma proteome
Depner CM et al.
Proc Natl Acad Sci U S A 115(23): E5390-E5399.
Metabolic Disease biology
Classification of prostate cancer using a protease activity nanosensor library
Dudani, JS et al.
Proc Natl Acad Sci U S A 115(36): 8954-8959.
Oncology Diagnostics
Deep molecular phenotypes link complex disorders and physiological insult to CpG methylation
Zaghlool, SB et al.
Hum Mol Genet 27(6): 1106-1121.
Respiratory Disease biology Metabolic
Identification of novel systemic sclerosis biomarkers employing aptamer proteomic analysis
Wermuth, PJ et al.
Rheumatology (Oxford) 57(10): 1698-1706.
Immunity Disease biology Diagnostics
Plasma proteomic signature of age in healthy humans
Tanaka, T et al.
Aging Cell 17(5): e12799.
Aging Diagnostics
Habitual aerobic exercise and circulating proteomic patterns in healthy adults: relation to indicators of healthspan
Santos-Parker, JR et al.
J Appl Physiol (1985) 125(5): 1646-1659.
Aging Disease biology Diagnostics
Application of large scale aptamer-based proteomic profiling to "planned" myocardial infarctions
Jacob, J et al.
Circulation 137(12): 1270-1277.
Cardiovascular Disease biology Diagnostics Target identification
Integrative omics: harnessing the proteome to maximize the potential of the genome
McGarrah, RW et al.
Circulation 137(11): 1173-1175.
Cardiovascular Disease biology
Harnessing the power of proteomics to assess drug safety and guide clinical trials
Lam, MPY et al.
Circulation 137(10): 1011-1014.
Cardiovascular Stratification
Probing the virtual proteome to identify novel disease biomarkers
Mosley, JD et al.
Circulation 138(22): 2469-2481.
Cardiovascular Disease biology Diagnostics
Cerebrospinal fluid protein changes in preeclampsia
Ciampa, E et al.
Hypertension 72(1): 219-226.
Reproductive Disease biology
Endothelial microparticles and systemic complement activation in patients with chronic kidney disease
Jalal, D et al.
J Am Heart Assoc 7(14): e007818.
Kidney Disease biology Inflammatory
Early identification of bronchopulmonary dysplasia using novel biomarkers by proteomic screening
Forster, K et al.
Am J Respir Crit Care Med 197(8): 1076-1080.
Respiratory Disease biology Diagnostics
Serum biomarker for diagnostic evaluation of pulmonary arterial hypertension in systemic sclerosis
Rice, LM et al.
Arthritis Res Ther 20(1): 185.
Respiratory Rare Disease biology Diagnostics
The differential plasma proteome of obese and overweight individuals undergoing a nutritional weight loss and maintenance intervention
Oller Moreno, S et al.
Proteomics Clin Appl 12(1).
Metabolic Disease biology Diagnostics
Combined use of protein biomarkers and network analysis unveils deregulated regulatory circuits in Duchenne muscular dystrophy
Parolo, S et al.
PLoS One 13(3): e0194225.
Neurobiology Disease biology Diagnostics Rare
A proteomic signature that reflects pancreatic beta-cell function
Curran, AM et al.
PLoS One 13(8): e0202727.
Metabolic Disease biology Diagnostics
Proteomic analysis of heart failure hospitalization among patients with chronic kidney disease: The Heart and Soul Study
Dubin, RF et al.
PLoS One 13(12): e0208042.
Cardiovascular Disease biology Diagnostics Target identification Kidney
Proteomics: Clinical and research applications in respiratory diseases.
Norman, KC et al.
Respirology 23(11): 993-1003.
Respiratory Review
A proteomic clock of human pregnancy.
Aghaeepour, N et al.
Am J Obstet Gynecol 218(3): 347 e341-347 e314.
Genome-wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease
Yao, C et al.
Nat Commun 9(1): 3268.
Cardiovascular Disease biology Diagnostics Target identification
Chemotherapy-induced differential cell cycle arrest in B-cell lymphomas affects their sensitivity to Wee1 inhibition
Wang, X et al.
Haematologica 103(3): 466-476.
Oncology Disease biology Mechanism of action
Clinical validation of a protein biomarker panel for non-small cell lung cancer
Jung, YJ et al.
J Korean Med Sci 33(53): e342.
Oncology Disease biology Diagnostics
Modified aptamers enable quantitative sub-10-nm cellular DNA-PAINT imaging
Strauss, S et al.
Nat Methods 15(9): 685-688.
SomaScan Binding
Improving probes for super-resolution
Moore, RP et al.
Nat Methods 15(9): 659-660.
SomaScan Binding
Proteomic profiling identifies novel circulating markers associated with bronchiectasis in cystic fibrosis
DeBoer, EM et al.
Proteomics Clin Appl 11(9-10).
Respiratory Disease biology Diagnostics Pediatric
Interleukin 1 receptor-like 1 protein (ST2) is a potential biomarker for cardiomyopathy in Duchenne muscular dystrophy
Anderson, J et al.
Pediatr Cardiol 38(8): 1606-1612.
Cardiovascular Diagnostics Pediatric Neurobiology
Protein quantitative trait locus study in obesity during weight-loss identifies a leptin regulator
Carayol, J et al.
Nat Commun 8(1): 2084.
Metabolic Disease biology Diagnostics
A proteome-derived longitudinal pharmacodynamic biomarker for diffuse systemic sclerosis skin
Rice, LM et al.
J Invest Dermatol 137(1): 62-70.
Immunity Disease biology Diagnostics
Sexual dimorphism, age, and fat mass are key phenotypic drivers of proteomic signatures
Curran, AM et al.
J Proteome Res 16(11): 4122-4133.
Aging Disease biology Metabolic
Trisomy 21 causes changes in the circulating proteome indicative of chronic autoinflammation
Sullivan, KD et al.
Sci Rep 7(1): 14818.
Rare Disease biology
Assessment of variability in the SOMAscan assay
Candia, J et al.
Sci Rep 7(1):14248.
SomaScan Binding Review
Divergent roles for clusterin in lung injury and repair
Habiel, DM et al.
Sci Rep 7(1): 15444.
Respiratory Disease biology Fibrotic
A pilot characterization of the human chronobiome
Skarke, C et al.
Sci Rep 7(1):17141.
Metabolic Disease biology
Pharmacokinetic properties of DNA aptamers with base modifications
Gupta, S et al.
Nucleic Acid Ther 27(6): 345-353.
SomaScan Binding
Genome-wide quantitative trait loci mapping of the human cerebrospinal fluid proteome
Sasayama, D et al.
Hum Mol Genet 26(1): 44-51.
Neurobiology Disease biology Diagnostics
Identification of unique proteomic signatures in allergic and non-allergic skin disease
Wang, J et al.
Clin Exp Allergy 47(11): 1456-1467.
Inflammatory Disease biology Diagnostics
An immune clock of human pregnancy
Aghaeepour, N et al.
Sci Immunol 2(15):eaan2946.
Immunity Disease biology Reproductive
A degradation fragment of type X collagen is a real-time marker for bone growth velocity
Coghlan, RF et al.
Sci Transl Med 9(419): eaan4669.
Osteoporosis Disease biology Diagnostics
Large-scale proteomics identifies MMP-7 as a sentinel of epithelial injury and of biliary atresia
Lertudomphonwanit, C et al.
Sci Transl Med 9(417): eaan8462.
Pediatric Disease biology Diagnostics Target identification Rare
Proteomic profiles associated with early echocardiogram evidence of pulmonary vascular disease in preterm infants
Wagner, BD et al.
Am J Respir Crit Care Med 197(3): 394-397.
Cardiovascular Disease biology Pediatric
Antiinflammatory effects of aprepitant coadministration with cART regimen containing ritonavir in HIV-infected adults
Spitsin, S et al.
JCI Insight 2(19) 95893
Immunity Disease biology Infection Mechanism of action
The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimer's pathology
Westwood, S et al.
Alzheimers Res Ther 9(1): 31.
Aging Disease biology Metabolic
High-throughput characterization of blood serum proteomics of IBD patients with respect to aging and genetic factors
Di Narzo, AF et al.
PLoS Genet 13(1): e1006565.
Aging Disease biology Inflammatory
Sequential inflammatory processes define human progression from M. tuberculosis infection to tuberculosis disease
Scriba, TJ et al.
PLoS Pathog 13(11): e1006687.
Infection Disease biology
Activation of inflammatory and pro-thrombotic pathways in acute stress cardiomyopathy
Fitzgibbons, TP et al.
Frontiers in Cardiovascular Medicine 4: 49.
Cardiovascular Disease biology Diagnostics
Discovery and validation of a six-marker serum protein signature for the diagnosis of active pulmonary tuberculosis
De Groote, MA et al.
J Clin Microbiol 55(10): 3057-3071.
Infection Diagnostics
Attenuated PDGF signaling drives alveolar and microvascular defects in neonatal chronic lung disease
Oak, P et al.
EMBO Mol Med 9(11): 1504-1520.
Respiratory Disease biology Diagnostics
GDF15 is a heart-derived hormone that regulates body growth
Wang, T et al.
EMBO Mol Med 9(8): 1150-1164.
Cardiovascular Disease biology Pediatric
The prediction of late-onset preeclampsia: Results from a longitudinal proteomics study
Erez, O et al.
PLoS One 12(7): e0181468.
Reproductive Disease biology Diagnostics
Diagnosis and prognosis-review of biomarkers for mesothelioma
Sun, HH et al.
Ann Transl Med 5(11): 244.
Respiratory Disease biology Diagnostics
Molecular-based diagnosis of multiple sclerosis and its progressive stage
Barbour, C et al.
Ann Neurol 82(5): 795-812.
Neurobiology Disease biology Diagnostics
Vitamin B12 deficiency and impaired expression of amnionless during aging
Pannerec, A et al.
J Cachexia Sarcopenia Muscle 9(1): 41-52.
Aging Disease biology
Connecting genetic risk to disease end points through the human blood plasma proteome
Suhre, K et al.
Nat Commun 8: 14357.
SomaScan Large-scale proteomics
Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms
Howson, JMM et al.
Nat Genet 49(7): 1113-1119.
Cardiovascular Disease biology
Plasma proteome analysis in patients with pulmonary arterial hypertension: an observational cohort study
Rhodes, CJ et al.
Lancet Respir Med 5(9): 717-726.
Cardiovascular Disease biology Target identification Respiratory Rare
Aptamer-based proteomic profiling for prognostication in pulmonary arterial hypertension
Giannitsis, E et al.
Lancet Respir Med 5(9): 671-672.
Cardiovascular Disease biology Target identification Respiratory Rare
Multiomic disease signatures converge to cytotoxic CD8 T cells in primary Sjogren's syndrome
Tasaki, S et al.
Ann Rheum Dis 76(8): 1458-1466.
Immunity Disease biology Target identification
Efficacy of individualised diets in patients with irritable bowel syndrome: a randomised controlled trial
Ali A et al.
BMJ Open Gastro 4(1): e000164.
Inflammatory Disease biology
Identification of serum protein biomarkers for utrophin based DMD therapy
Guiraud, S et al.
Sci Rep 7: 43697.
Pediatric Disease biology Diagnostics Musculoskeletal
Selection of DNA aptamers with two modified bases
Gawande, BN et al.
Proc Natl Acad Sci U S A 114(11): 2898-2903.
SomaScan Binding
The maternal plasma proteome changes as a function of gestational age in normal pregnancy: a longitudinal study
Romero, R et al.
Am J Obstet Gynecol 217(1):67 e61-67 e21.
Reproductive Disease biology Diagnostics
Proteomic study of hepatocellular carcinoma using a novel modified aptamer-based array (SOMAscan) platform
Qiao, Z et al.
Biochim Biophys Acta 1865(4): 434-443.
Oncology Disease biology Diagnostics Rare
Development of a protein biomarker panel to detect non-small-cell lung cancer in Korea
Jung, YJ et al.
Clin Lung Cancer 18(2): e99-e107.
Oncology Diagnostics
The relationship of circulating proteins in early pregnancy with preterm birth
Lynch, AM et al.
Am J Obstet Gynecol 214(4): 517 e511-518.
Reproductive Disease biology Diagnostics
Identification of definitive serum biomarkers associated with disease activity in primary Sjögren's syndrome
Nishikawa, A et al.
Arthritis Res Ther 18(1): 106.
Immunity Disease biology Diagnostics Target identification
Identification of pathway-specific serum biomarkers of response to glucocorticoid and infliximab treatment in children with inflammatory bowel disease
Heier, CR et al.
Clin Transl Gastroenterol 7(9): e192.
Inflammatory Disease biology Mechanism of action Pediatric
Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice
Lukjanenko, L et al.
Nat Med 22(8): 897-905.
Aging Disease biology Musculoskeletal
Serum pharmacodynamic biomarkers for chronic corticosteroid treatment of children
Hathout, Y et al.
Sci Rep 6: 31727.
Inflammatory Disease biology Diagnostics Pediatric
A cross sectional study of two independent cohorts identifies serum biomarkers for facioscapulohumeral muscular dystrophy (FSHD)
Petek, LM et al.
Neuromuscul Disord 26(7): 405-413.
Musculoskeletal Disease biology Diagnostics
Chemically modified interleukin-6 aptamer inhibits development of collagen-induced arthritis in cynomolgus monkeys
Hirota, M et al.
Nucleic Acid Ther 26(1): 10-19.
Immunity Disease biology Target identification Target validation mechanism of action Binding
Fit for the eye: aptamers in ocular disorders
Drolet, DW et al.
Nucleic Acid Ther 26(3): 127-146.
Ocular Disease biology Diagnostics Target identification Mechanism of action PK/PD
readat: an R package for reading and working with SomaLogic ADAT files
Cotton, RJ et al.
BMC Bioinformatics 17(1): 201.
Respiratory mucosal proteome quantification in human influenza infections
Marion, T et al.
PLoS One 11(4): e0153674.
Infection Disease biology
Six-SOMAmer index relating to immune, protease and angiogenic functions predicts progression in IPF
Ashley, SL et al.
PLoS One 11(8): e0159878.
Respiratory Disease biology Diagnostics Fibrotic
Longitudinal protein changes in blood plasma associated with the rate of cognitive decline in Alzheimer's disease
Sattlecker, M et al.
J Alzheimers Dis 49(4): 1105-1114.
Aging Disease biology Target identification
An evaluation of an aptamer for use as an affinity reagent with MS: PCSK9 as an example protein
Gupta, V et al.
Bioanalysis 8(15): 1557-1564.
SomaScan Binding
Developing clinically relevant biomarkers in inflammatory arthritis: A multiplatform approach for serum candidate protein discovery
McArdle, A et al.
Proteomics Clin Appl 10(6): 691-698.
Immunity Disease biology Diagnostics
The relationship of novel plasma proteins in the early neonatal period with retinopathy of prematurity
Lynch, AM et al.
Invest Ophthalmol Vis Sci 57(11): 5076-5082.
Pediatric Disease biology Diagnostics
Embracing proteins: structural themes in aptamer-protein complexes
Gelinas, AD et al.
Curr Opin Struct Biol 36: 122-132.
SomaScan Structure Binding
Clinical utility of serum biomarkers in Duchenne muscular dystrophy.
Hathout, Y et al.
Clin Proteomics 13: 9.
Rare Review
SELEX: How it happened and where it will go
Gold, L
J Mol Evol 81(5-6): 140-143.
Non-helical DNA triplex forms a unique aptamer scaffold for high affinity recognition of nerve growth factor
Jarvis, TC et al.
Structure 23(7): 1293-1304.
SomaScan Structure Binding
Increased cerebrospinal fluid fibrinogen in major depressive disorder
Hattori, K et al.
Sci Rep 5: 11412.
Neurobiology Disease biology
Plasma protein biomarkers of Alzheimer's disease endophenotypes in asymptomatic older twins: early cognitive decline and regional brain volumes
Kiddle, SJ et al.
Transl Psychiatry 5: e584.
Aging Disease biology Diagnostics Stratification
Large-scale serum protein biomarker discovery in Duchenne muscular dystrophy
Hathout, Y et al.
Proc Natl Acad Sci U S A 112(23): 7153-7158.
Pediatric Disease biology Diagnostics Target identification Musculoskeletal Rare
Practical synthesis of cytidine-5-carboxamide-modified nucleotide reagents
Rohloff, JC et al.
Nucleosides Nucleotides Nucleic Acids 34(3): 180-198.
Influence of 5-N-carboxamide modifications on the thermodynamic stability of oligonucleotides
Wolk, SK et al.
Nucleic Acids Res 43(19): 9107-9122.
SomaScan Binding
Improved preparation of 2 M triethylammonium bicarbonate
Carlson, M et al.
Green Chem Lett Rev 8(3-4): 37-39.
Proteomic methods for biomarker discovery and validation. Are we there yet?
Hathout, Y (2015)
Expert Rev Proteomics 12(4): 329-331.
Circulating proteomic signatures of chronological age
Menni, C et al.
J Gerontol A Biol Sci Med Sci 70(7): 809-816.
Aging Disease biology Diagnostics
A candidate plasma protein classifier to identify Alzheimer's disease.
Zhao, X et al.
J Alzheimers Dis 43(2): 549-563.
Aptamer-based proteomic signature of intensive phase treatment response in pulmonary tuberculosis
Nahid, P et al.
Tuberculosis (Edinb) 94(3): 187-196.
Infection Stratification Diagnostics
Crystal structure of interleukin-6 in complex with a modified nucleic acid ligand
Gelinas, AD et al.
J Biol Chem 289(12): 8720-8734.
SomaScan Structure Binding
Proteomics analysis of cancer exosomes using a novel modified aptamer-based array (SOMAscan™) platform
Webber, J et al.
Mol Cell Proteomics 13(4): 1050-1064.
Oncology Diagnostics Exosomes
DTC-and-me: patient, provider, proteins and regulators.
Steele, FR et al.
J Pers Med 4(1): 79-87.
Beyond antibodies: new affinity reagents to unlock the proteome.
Lollo, B et al.
Proteomics 14(6): 638-644.
SomaScan Binding
Methylation potential associated with diet, genotype, protein, and metabolite levels in the Delta Obesity Vitamin Study
Monteiro, JP et al.
Genes Nutr 9(3): 403.
Metabolic Disease biology Diagnostics
Genetic associations with micronutrient levels identified in immune and gastrointestinal networks
Morine, MJ et al.
Genes Nutr 9(4): 408.
Metabolic Disease biology
Nucleic acid ligands with protein-like side chains: Modified aptamers and their use as diagnostic and therapeutic agents
Rohloff, JC et al.
Mol Ther Nucleic Acids 3:e201.
SomaScan Binding Review Clinical
Specific capture and detection of Staphylococcus aureus with high-affinity modified aptamers to cell surface components
Baumstummler, A et al.
Lett Appl Microbiol 59(4): 422-431.
Infection Diagnostics
Validation of a blood protein signature for non-small cell lung cancer
Mehan, MR et al.
Clin Proteomics 11(1): 32.
Oncology Diagnostics
Systematic selection of modified aptamer pairs for diagnostic sandwich assays
Ochsner, UA et al.
Biotechniques 56(3): 125-128, 130, 132-133.
Cardiovascular Diagnostics Infection SomaScan Binding
Candidate blood proteome markers of Alzheimer's disease onset and progression: a systematic review and replication study
Kiddle, SJ et al.
J Alzheimers Dis 38(3): 515-531.
Aging Disease biology Diagnostics Stratification
Alzheimer's disease biomarker discovery using SOMAscan multiplexed protein technology
Sattlecker, M et al.
Alzheimers Dement 10(6): 724-734.
Aging Disease biology Diagnostics
Detection of Clostridium difficile toxins A, B and binary toxin with slow off-rate modified aptamers
Ochsner, UA et al.
Diagn Microbiol Infect Dis 76(3): 278-285.
Infection Diagnostics Binding
Elucidating novel serum biomarkers associated with pulmonary tuberculosis treatment
De Groote, MA et al.
PLoS One 8(4): e61002.
Infection Disease biology Diagnostics
Interaction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondin
Xie, Y et al.
EMBO Rep 14(12): 1120-1126.
Oncology Disease biology SomaScan
Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy
Loffredo, FS et al.
Cell 153(4): 828-839.
Cardiovascular Disease biology Diagnostics
Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets
Davies, DR et al.
Proc Natl Acad Sci U S A 109(49): 19971-19976.
SomaScan Structure Binding
Aptamers and the RNA world, past and present
Gold, L et al.
Cold Spring Harb Perspect Biol 4(3).
Life's simple measures: unlocking the proteome
Brody, E et al.
J Mol Biol 422(5):595-606.
Protein signature of lung cancer tissues
Mehan, MR et al.
PLoS One 7(4): e35157.
Oncology Disease biology Diagnostics Target identification
Age-dependent changes in the cerebrospinal fluid proteome by slow off-rate modified aptamer array
Baird, GS et al.
Am J Pathol 180(2): 446-456.
Aging Disease biology Diagnostics Neurobiology
Rapid histochemistry using slow off-rate modified aptamers with anionic competition
Gupta, S et al.
Appl Immunohistochem Mol Morphol 19(3): 273-278.
SomaScan Binding
Unlocking biomarker discovery: large scale application of aptamer proteomic technology for early detection of lung cancer
Ostroff, RM et al.
PLoS One 5(12): e15003.
Oncology Disease biology Diagnostics
Aptamer-based multiplexed proteomic technology for biomarker discovery
Gold, L et al.
PLoS One 5(12): e15004.
High-content affinity-based proteomics: unlocking protein biomarker discovery
Brody, EN et al.
Expert Rev Mol Diagn 10(8): 1013-1022.
Expanding the chemistry of DNA for in vitro selection
Vaught, JD et al.
J Am Chem Soc 132(12): 4141-4151.
Proteomics and diagnostics: Let's get specific, again
Zichi, D et al.
Curr Opin Chem Biol 12(1): 78-85.
Interlocking structural motifs mediate molecular discrimination by a theophylline-binding RNA
Zimmermann, GR et al.
Nat Struct Biol 4(8): 644-649.
SomaScan Structure
Let's get specific: the relationship between specificity and affinity
Eaton, BE et al.
Chem Biol 2(10): 633-638.
SomaScan Binding
High-resolution molecular discrimination by RNA
Jenison, RD et al.
Science 263(5152): 1425-1429.