Clinical use of cardiovascular risk score

Introduction: The American Heart Association has outlined strategic impact goals designed to improve the cardiovascular health of Americans by 20% by the year 2020 including improvements in lifestyle and behavior.

Hypothesis: We assessed the hypothesis that sharing with patients a 7-protein cardiovascular risk score would motivate them to better adhere to cardiovascular risk reduction measures.

Methods: The 7-protein risk score (SomaScan® CVD Secondary Risk Panel, SomaLogic) provides % risk by year for experiencing a cardiovascular event up to 5 years. Patients with stable coronary heart disease received a baseline lifestyle and behavior survey, chart abstraction, and blood draw for the 7-protein risk score. Results were shared with the patient by their physician. One month after receiving the panel results, patients were surveyed on the overall impact of the panel on health, lifestyle, and medication changes.

Results: Among the 198 enrolled patients, 25% had ≥ 20% predicted risk of a cardiovascular event in 5 years. Of the 131 patients with follow-up survey results to date, higher risk patients reported higher rates of desirable lifestyle changes, including healthier diet (Figure 4). Lower risk patients stated they would maintain their lifestyle to remain healthy.

Conclusions: Patients presented with their personal 7-protein cardiovascular risk score were motivated to improve their lifestyle and adherence to medications. The additional motivation from the test results, if sustained long-term, may translate into improved outcomes in patients with coronary heart disease.

Share with colleagues

More posters

PosterDementia risk from middle age

In the US the number of individuals affected by dementia is expected to double by 2040. Thus, tools enabling identification of at-risk individuals earlier in disease progression, or before disease onset, are vital.

Learn more

PosterLung Cancer risk in ever smokers

Development and validation of a blood-based protein-only predictor of 5-year lung cancer risk in ever smokers.

Learn more

PosterUrinary proteome

Urinary proteome and its application to predict cardiovascular risk in patients with stable Coronary Heart Disease.

Learn more

Explore posters in our interactive viewer