Using non-hypothesized based approaches for biomarker development

Using non-hypothesized based approaches for biomarker development

Jessica Gill, PhD, RN, FAAN, Bloomberg Distinguished Professor at Johns Hopkins School of Nursing, presents research on a highly multiplexed proteomic technique that used a DNA aptamers assay to target 1,305 proteins in plasma samples from athletes with and without a sports-related concussion (SRC). Researchers identified 338 plasma proteins significantly differed in abundance in concussed athletes compared to non-concussed athletes.

Learning objectives

  • Understand current limits of protein quantification
  • Describe ways to improve biomarker identification and measurement related to brain injuries
  • Determine ways to address current limitations to personalized medicine approaches for brain injuries

Image of Dr Jessica Gill

Jessica Gill, PhD, RN, FAAN

Bloomberg Distinguished Professor
Johns Hopkins School of Nursing

Jessica Gill is a national leader in research on the biological mechanisms of traumatic brain injuries (TBI). She has spent decades investigating differential responses in military personnel, athletes, and other patients that have experienced TBIs and the mechanisms underlying these divergent responses. Specifically, Dr. Gill looks for ways to use biomarkers to identify which patients are at high risk for poor recovery and long-term effects including post-traumatic stress disorder, depression, and post-concussive syndrome, and to develop treatments.

After earning her PhD at JHSON, she went to the National Institutes of Health (NIH) to complete a postdoctoral fellowship at the National Institute of Nursing Research that focused on the biological mechanisms of PTSD and depression. At NIH, she also served as a senior investigator and acting deputy scientific director of the National Institute of Nursing Research and deputy director of the Center for Neuroscience and Regenerative Medicine. Dr. Gill was the first nurse to receive the Lasker Clinical Research Scholar Award, considered the most prestigious research grant given by the NIH. As Bloomberg Distinguished Professor of Trauma Recovery Biomarkers, she will hold primary appointments in the Johns Hopkins School of Nursing and the School of Medicine, Department of Neurology.

Using non-hypothesized based approaches for biomarker development

A presentation by Jessica Gill, PhD, RN, FAAN

Share with colleagues

More webinars

WebinarUsing plasma proteomics to understand Alzheimer’s and other brain diseases

Dr. Walker discusses how he integrates proteomic, genetic, brain imaging and cerebral spinal fluid biomarkers from initially cognitively normal individuals who later develop dementia, in order to discover novel blood-based biomarkers and mechanistically relevant proteins for therapeutic target prioritization.

Learn more

WebinarProteomics for precision neuroscience: the power of protein analysis

This webcast highlights how academic, industry and government researchers are directly measuring protein abundance and function via multiplex proteomics to build more detailed characterizations of the biological systems underlying neurodegenerative diseases.

Learn more

WebinarCorrelation of a Nonalcoholic Steatohepatitis Proteomic Test with Clinical Outcomes

In this webinar, Anne Minnich, PhD, biomarker consultant at Bristol Myers Squibb, presents research on the use of the new SomaSignal(TM) NASH bundle test in a recently completed clinical trial.

Learn more