Human proteomics: from the operating room to the lab and back

Human proteomics: from the operating room to the lab and back

Optimizing platforms for surgical specimen collection and deep human phenotyping was used to enhance protein biomarker identification using proteomic tools. A series of studies using human eye fluids has helped to diagnose inflammatory retinal disease, select personalized therapies, stage cancer, and point to new therapeutic strategies. These approaches can be broadly applied to human surgical disease.

Learning Objectives

  • Learn workflow for human surgical specimen collection
  • Learn human disease proteomics experimental design
  • Learn future applications of human proteomics to disease diagnosis and treatment

Vinit Mahajan, MD, PhD

Vinit Mahajan, MD, PhD

Vice Chair for Research, Director, Omics Lab, Molecular Surgery Program
Stanford University

Dr. Mahajan is a vitreoretinal surgeon and professor in the Department of Ophthalmology at Stanford University. He is the Vice Chair for Research and directs the Molecular Surgery Program and the NIH-funded Omics Laboratory that uses high-throughput methods in proteomics, genomics, and phenomics to identify molecules involved in eye disease. His research team discovered the first gene to cause non-syndromic uveitis and is now using protein crystallography to design therapeutic inhibitors for calpain-5. Mahajan and his team performed the first CRISPR gene editing therapy for eye disease in human stem cells. Using translational proteomics, Mahajan’s multidisciplinary team is developing new precision health approaches using molecular biomarkers to diagnose retinal disease, select personalized therapies, and decode the anatomic structures of the human eye.

Human proteomics: from the operating room to the lab and back

A presentation by Vinit Mahajan, MD, PhD

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