A multiomic approach to prediction, causation, and prevention of preterm birth and preeclampsia
A multiomic approach to prediction, causation, and prevention of preterm birth and preeclampsia
Recent advances in both genomics, transcriptomics, and proteomics have allowed for the development of novel technologies with greater capabilities for biomarker profiling and discovery. When coupled with high-content data analysis, these multiomic approaches have allowed researchers to generate high-efficiency data to enable new correlations and insights between the genome, transcriptome, and proteome at a molecular level in health and disease. For example, an area of unmet need where multiomics is poised to impact significantly is pregnancy-related complications, such as preterm birth and preeclampsia. A better understanding of the molecular mechanisms of feto-maternal changes during pregnancy could help save lives and improve birthing processes.
Our distinguished presenters — members of the Gaudillière lab at Stanford University — describe how they employed a translational approach that combines single-cell mass cytometry with high-plex proteomic and metabolomic analyses to study the role of the human immune system in the pathobiology of fundamental clinical problems, including pregnancy pathologies. The presenters also explain how they used novel machine-learning methods to train multiomic models and identify biologically relevant predictive biomarkers to develop robust diagnostics rooted in a precise understanding of underlying pathobiological mechanisms.
Ina Stelzer, PhD
Instructor
Stanford University
Julien Hédou, MSc
Data Analyst
Stanford University
Dorien Feyaerts, PhD
Postdoctoral Fellow
Stanford University
A multiomic approach to prediction, causation, and prevention of preterm birth and preeclampsia
A presentation by Ina Stelzer, PhD, Julien Hédou, MSc, and Dorien Feyaerts, PhD
More webinars
WebinarBoutique Webinar : Predicting Pregnancy Complications with High-Plex Proteomics
The interdisciplinary team, comprising 10-15 scientists and clinician-scientists, is dedicated to advancing diagnostics and therapeutics aimed at enhancing maternal and fetal care. Their primary focus lies in the development of interventions for conditions such as ectopic pregnancy and preeclampsia, alongside the creation of diagnostics to prevent stillbirth.
WebinarYoung blood for old brains and the quest to slow brain aging
Aging leads to the degradation of function in nearly all tissues and organs. This process is marked by significant shifts in gene expression and changes in concentrations of all types of biological molecules. Recent technological progress has allowed biologists to measure an unprecedented number of these molecules throughout an organism
WebinarUtilizing proteomic strategies to uncover novel biomarkers and mechanisms in heart failure
Plasma proteomics is a powerful approach for discovering novel protein biomarkers of drug toxicity in various disease contexts. One such biomarker in cardiovascular disease is apolipoprotein M (ApoM), which plays a crucial role in lipid metabolism and transport and is known to have both anti-inflammatory and cardioprotective effects in the body. Studying ApoM using proteomics requires various approaches to understand its expression, modifications, interactions, and functions in the proteome.