A multiomic approach to prediction, causation, and prevention of preterm birth and preeclampsia
A multiomic approach to prediction, causation, and prevention of preterm birth and preeclampsia
Recent advances in both genomics, transcriptomics, and proteomics have allowed for the development of novel technologies with greater capabilities for biomarker profiling and discovery. When coupled with high-content data analysis, these multiomic approaches have allowed researchers to generate high-efficiency data to enable new correlations and insights between the genome, transcriptome, and proteome at a molecular level in health and disease. For example, an area of unmet need where multiomics is poised to impact significantly is pregnancy-related complications, such as preterm birth and preeclampsia. A better understanding of the molecular mechanisms of feto-maternal changes during pregnancy could help save lives and improve birthing processes.
Our distinguished presenters — members of the Gaudillière lab at Stanford University — describe how they employed a translational approach that combines single-cell mass cytometry with high-plex proteomic and metabolomic analyses to study the role of the human immune system in the pathobiology of fundamental clinical problems, including pregnancy pathologies. The presenters also explain how they used novel machine-learning methods to train multiomic models and identify biologically relevant predictive biomarkers to develop robust diagnostics rooted in a precise understanding of underlying pathobiological mechanisms.
Ina Stelzer, PhD
Instructor
Stanford University
Julien Hédou, MSc
Data Analyst
Stanford University
Dorien Feyaerts, PhD
Postdoctoral Fellow
Stanford University
A multiomic approach to prediction, causation, and prevention of preterm birth and preeclampsia
A presentation by Ina Stelzer, PhD, Julien Hédou, MSc, and Dorien Feyaerts, PhD
More webinars
WebinarPathways to Digital Health: AI and Omics in Rheumatoid Arthritis
Explore how groundbreaking proteomic research is transforming our understanding of rheumatoid arthritis (RA). In this on-demand webinar, Allan Stensballe, PhD, shares new insights into the molecular landscape of RA-affected synovial tissue, revealing how autoantibodies and protein signatures may hold the key to more precise personalized therapies.
WebinarUsing Antibody Profiling to Identify Novel Diagnostic Biomarkers
Current cancer screening methods often lead to false positives, false negatives and invasive biopsies that lack prognostic insights. Emerging research suggests that cancer-specific IgM and IgG antibodies – produced by B cells upon recognizing malignant cells – could serve as stable, easily measurable blood biomarkers for detecting and monitoring high-incidence cancers like melanoma and breast, prostate, bowel, lung and pancreatic cancer. This approach has the potential to improve early diagnosis, reduce uncertainty and enhance treatment planning.
WebinarLinking the plasma proteome to echocardiographic parameters in patients with chronic heart failure
Recent advancements in proteomic profiling have unlocked new possibilities for understanding the complex mechanisms that drive heart failure. Measuring thousands of proteins simultaneously makes it possible to capture a comprehensive overview of the patient's health state and investigate underlying disease progression at a subclinical level.