Human proteomics: From the operating room to the lab and back
Human proteomics: From the operating room to the lab and back
Optimizing platforms for surgical specimen collection and deep human phenotyping was used to enhance protein biomarker identification using proteomic tools. A series of studies using human eye fluids has helped to diagnose inflammatory retinal disease, select personalized therapies, stage cancer, and point to new therapeutic strategies. These approaches can be broadly applied to human surgical disease.
Learning Objectives
- Learn workflow for human surgical specimen collection
- Learn human disease proteomics experimental design
- Learn future applications of human proteomics to disease diagnosis and treatment
Vinit Mahajan, MD, PhD
Vice Chair for Research, Director, Omics Lab, Molecular Surgery Program
Stanford University
Dr. Mahajan is a vitreoretinal surgeon and professor in the Department of Ophthalmology at Stanford University. He is the Vice Chair for Research and directs the Molecular Surgery Program and the NIH-funded Omics Laboratory that uses high-throughput methods in proteomics, genomics, and phenomics to identify molecules involved in eye disease. His research team discovered the first gene to cause non-syndromic uveitis and is now using protein crystallography to design therapeutic inhibitors for calpain-5. Mahajan and his team performed the first CRISPR gene editing therapy for eye disease in human stem cells. Using translational proteomics, Mahajan’s multidisciplinary team is developing new precision health approaches using molecular biomarkers to diagnose retinal disease, select personalized therapies, and decode the anatomic structures of the human eye.
Human proteomics: from the operating room to the lab and back
A presentation by Vinit Mahajan, MD, PhD
More webinars
WebinarDetecting growing tumors through changes in the plasma proteome
In this GEN webinar, Nebojsa Janjic, PhD, will discuss the need for a reliable blood-based screening method capable of detecting cancers earlier. During the webinar, he will highlight results from a study involving researchers from SomaLogic and the University of Colorado School of Medicine that used a test capable of measuring 5000 proteins simultaneously.
WebinarIdentifying Biomarkers for IBD Diagnosis and Management
In this webinar, you’ll hear how proteomics technology can enhance the identification of biomarkers for the accurate diagnosis of Crohn’s disease and ulcerative colitis, as well as the identification of biomarkers that predict response to TNF inhibitors and other biologics in patients with IBD.
WebinarBoutique Webinar : Predicting Pregnancy Complications with High-Plex Proteomics
The interdisciplinary team, comprising 10-15 scientists and clinician-scientists, is dedicated to advancing diagnostics and therapeutics aimed at enhancing maternal and fetal care. Their primary focus lies in the development of interventions for conditions such as ectopic pregnancy and preeclampsia, alongside the creation of diagnostics to prevent stillbirth.