Streamline and strengthen your genomic research
Learn how to uncover disease mechanisms and develop more effective therapeutic strategies at ASHG
Join us at the American Society of Human Genetics 2024 Annual Meeting from November 5–9 in Denver, CO. Visit Booth 145 to hear how SomaScan® technology can provide the most comprehensive approach to understanding health and disease. The SomaScan Assay’s high-plex proteomic analysis can be combined with genomic approaches to enable a more complete understanding of biological systems, disease origins and effective treatments and identify relevant new drug and therapy targets.
Ask us about our newest updates
- Expand your research capabilities: The SomaScan 11K Assay can now be run with human cerebrospinal fluid, cell and tissue samples, meaning researchers can detect and quantify low-abundance proteins accurately, critical for identifying potential biomarkers and therapeutic targets. Learn more
- Ensure precision and trust your data: A new independent head-to-head comparison of precision demonstrates that the SomaScan Assay effectively scales protein measurements when other technologies cannot, while Nature has published corrected results from a study comparing two high-throughput proteomic platforms. Learn more
Speaking events
INDUSTRY EDUCATION SESSION
Proteomics for Precision Healthcare
This industry education session will explore the application of different omic technologies that are now feasible at population scale. Julia Carrasco-Zanini-Sanchez, PhD, Postdoctoral Research Assistant in Computational Genomics and Multi-omics at Queen Mary University of London, will present examples of how the integration of different omics layers can help advance precision medicine across diverse populations.
Wednesday, November 6 | 12:00–1:00 pm | Room 104/106
CO-LAB SESSION
From Genomic Predisposition to Diagnosis and Treatment Efficacy via Proteomics
In this co-lab session, Steffen Oeser, PhD, Technical Support Manager at Standard BioTools, will discuss how proteomics allows for the interrogation of how genetic predisposition influences disease progression and ultimately individual response when treatments become available. Attend to learn about how the SomaScan Assay and other product offerings enable the detection of previously unidentified biomarkers for drug discovery, preclinical and clinical drug development and clinical research across a wide range of diseases and conditions.
Thursday, November 7 | 12:00–12:30 pm | Theater 2
POSTER SESSION
Is There Anything in the Swamp? A Credibility Assessment of Biologic Signals From Non-Secreted Low-Abundance Proteins Measured in Human Plasma
The expansion of proteomic multiplexing now includes the measurement of non-secreted low-abundance proteins. Because the mechanism for the presence of these proteins in plasma is unclear, the biological significance of this fraction of the proteome has been questioned. This poster presents methods to evaluate this question by seeking to determine if proteogenomic associations are present in the non-secreted, low-abundance fraction of the proteome and if this fraction contains other biologically relevant information.
Friday, November 8 | 2:30–4:30 pm | Exhibit & Poster Hall/Upper Level
POSTER SESSION
pQTL Discovery Using the SomaScan High-Plex Proteomics Platform in the COPDGene Study
Protein quantitative trait loci (pQTLs) link genetic variation to proteomic variation, facilitating the discovery of mechanisms underlying genetic disease risks. This poster outlines a pQTL study based on the SomaScan Assay and examines whether genomic and proteomic data can provide a complementary and more comprehensive biological representation than either type of data alone.
Friday, November 8 | 2:30–4:30 pm | Exhibit & Poster Hall/Upper Level
More Poster Sessions and Presentations
| Type | Title | Authors |
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Poster
Friday, November 8 |
1112F – Classification of Continental Ancestry in the Million Veteran Program from High-Throughput Proteomics Data | C. Yandava, P. Schreiner, D. Panyard, P. Devineni, B. Gorman, P. Tsao, S. Pyarajan |
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Poster
Friday, November 8 |
6016F – Comparative, Cross-Population Analysis of the Genetic Regulation of Plasma Proteins in the Million Veteran Program | D. Panyard, C. Yandava, P. Schreiner, D. Dochtermann, B. Gorman, M. Snyder, S. Pyarajan, P. Tsao |
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Poster
Thursday, November 7 |
4047T – Discovery of Core Genes for Type 1 Diabetes via Genome-Wide Aggregation of Trans-Effects Using Proteomics Studies | X. Zhou, A. Iakovliev, S. McGurnaghan, P. McKeigue, A. Spiliopoulou, H. Colhoun |
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Presentation
Thursday, November 7 |
Large-Scale Proteomic and Genomic Analysis Identify Plasma Proteins Influencing Human Brain Structure and Alzheimer’s Disease Risk | C-Y. Chen, C. Ayubcha, B. Sun, T. Ge |
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Poster
Wednesday, November 6 |
1165W – Plasma Protein Signature as Easily Accessible Biomarkers to Predict Future MCI to Dementia Conversion | J. Xi, Y. Zhang, B. Smets, S. Miller, Z. Saad, C. Whelan, S. Li |
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Presentation
Friday, November 8 |
Prioritization of Effector Genes Within Body Mass Index Loci Yields Molecular Insight into the Biology of Body Weight Regulation | V. Diez-Obrero, J. D. Arias, X. Yin, R. A. J. Smit, E. Marouli, E. P. Wilson, A. E. Justice, K. L. Young, M. Graff, M. Guindo-Martinez, Y. V. Sun, P. Deloukas, K. E. North, K. L. Mohlke |
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Poster
Friday, November 8 |
1102F – 39 Unique Proteins Have Differential Responses Associated With Ancestry During Severe COVID-19 Infection | T. Zheng, Y. Ilboudo, T. Lu, G. Butler-Laporte, T. Nakanishi, D. Morrison, D. Adra, B. Richards |
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Presentation
Wednesday, November 6 |
An Atlas of Protein Quantitative Trait Loci in Olink and SomaScan Platforms Uncover Genetic Insights Into Gastroenterological and Hepatological Diseases | C. Khunsriraksakul, H. Markus, S. Chen, L. Wang, D. Chen, L. Carrel, B. Jiang, D. J. Liu |
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Poster
Friday, November 8 |
1117F – Cross-Ancestry Comparison of Aptamer and Antibody Proteomics Measures | J. Nicholas, D. H. Katz, U. A. Tahir, C. L. Debban, F. Aguet, R. P. Bowler, J. Chen, C. B. Clish, J. Coresh, E. Cornell, R. Deo, P. Durda, X. Guo, C. Johnson, L. A. Lange, J. C. Mychaleckyj, P. Ruan, R. P. Tracy, A. C. Wood, B. Yu, M. R. Rooney, A. Manichaikul, R. Dubin, K. L. Mohlke, S. S. Rich, J. Rotter, P. Ganz, R. E. Gerszten, K. D. Taylor, L. M. Raffield |
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Presentation
Friday, November 8 |
Longitudinal Proteomic Aging Index Construction Using Functional Principal Component Analysis in the Framingham Heart Study Offspring Cohort | H. J. Proteau, J. Hebert-Losier, C. I. Christensen, D. J. Liu, H. Markus |
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Poster
Thursday, November 7 |
1151T – Maternal and Fetal Genetic Associations Between the Circulating Proteome and Preeclampsia | J. Hu, C. Cao, B. Ferolito, K. Gravel-Pucillo, M. Maher, J. Valliere, A. Pereira, J-P. Casas, R. Saxena, K. Gray |
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Presentation
Thursday, November 7 |
Multi-Ancestry Proteome-Wide Mendelian Randomization Offers a Comprehensive Protein-Disease Atlas and Potential Therapeutic Targets | C-Y. Su, A. Van Der Graaf, W. Zhang, S. Selber-Hnatiw, T-Y. Yang, Y. Chen, K. Liang, G. Butler-Laporte, F. Matsuda, B. Richards, V. Mooser, J. Flannick, S. Zhou, T. Lu, S. Yoshiji |
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Poster
Thursday, November 7 |
6067T – Multi-Study pQTL Analysis of Circulating Aptamer-Based Proteomics in Multi-Ancestry TOPMed Cohorts | C. Debban, U. Tahir, K. A. Pratte, J. Brody, M. Lee, C. Guo, A. Hill, J. Nicholas, D. Katz, B. Yu, J. Wilson, J. G. Wilson, H. Lin, K. Kechris, S. Gharib, S. Rich, K. Taylor, J. Rotter, P. Ganz, R. F. Dubin, R. Deo, D. Meyers, B. Psaty, M. Cho, S. London, R. Gerszten, L. Raffield, R. Bowler, A. Manichaikul |
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Presentation
Thursday, November 7 |
The Integration of Genomic and Proteomic Profiling Data in TOPMed to Identify Protein-Protein Pathway Partners in Human Plasma | A. Eisman |
User group meeting
Join us at this special symposium one day before ASHG 2024 to learn about the latest advancements in high-throughput, high-plex proteomics enabled by the SomaScan Assay.
Pre-ASHG Proteomics Day Symposium
Monday, November 4 | 8:00 am–6:00 pm
Embassy Suites, Denver Downtown,
Cripple Creek 1 Meeting Room
1420 Stout Street, Denver, CO 80202