The SOMAscan® Platform

 

Measuring Biology in Real-Time

SomaLogic scientists have solved the challenges inherent in measuring proteins on a large-scale (~5000 proteins simultaneously) and across a wide dynamic range (micromolar to femtomolar). The SOMAscan platform delivers biological insights that enable biomarker discovery, diagnostics development, and pharmaceutical discovery and development.

The SOMAscan® Assay: An Unprecedented Protein Biomarker Discovery and Development Tool

Protein measurements provide a real-time picture of what is happening in our bodies at any given time. They are the best indicators of when things are normal and when things are starting to going awry.

Understanding the many protein changes that underlie both health and disease requires a new kind of proteomic technology that can measure both broadly (thousands of proteins simultaneously) and deeply (high- and low-abundance proteins). Only the SOMAscan assay provides this expansive view.

In essence, the SOMAscan assay converts a difficult problem (protein measurement) into a straightforward solution (DNA measurement). This surprising trick relies on the distinctive properties of the proprietary protein binding reagents used in the assay.

For more information, please see: Rohloff, JC et al. (2014) “Nucleic acid ligands with protein-like side chains: Modified aptamers and their use as diagnostic and therapeutic agents.” Molecular Therapy Nucleic Acids 3(10):e201.

SOMAscan Assay: A Breakthrough Proteomics Technology

SOMAmer® Reagents: A New Class of Protein-Affinity Molecules

SOMAmer (Slow Off-rate Modified Aptamer) reagents consist of a short single-stranded DNA sequence that incorporates a series of modifications that give the SOMAmer “protein-like” appendages. These chemical modifications in turn allow the SOMAmer to tightly bind its target protein in ways never before possible. The specificity is critical for measuring each protein in highly complex protein mixtures such as blood.

For more information, please see: Rohloff, JC et al. (2014) “Nucleic acid ligands with protein-like side chains: Modified aptamers and their use as diagnostic and therapeutic agents.” Molecular Therapy Nucleic Acids 3(10):e201.

SOMAmer Reagents: Specific And Versatile Protein Affinity Reagents