Evaluation of precision and correlation for the latest proteomic platforms
Comparative Analysis of Large-Scale Proteomic Platforms: Precision, Strengths, and Limitations
The field of proteomics is rapidly advancing, enabling precise measurement of thousands of proteins, particularly those in higher abundance. This webcast will explore significant differences in precision within and across the latest large-scale proteomic platforms and their intercorrelations, based on blind duplicate split assays of the leading modified aptamer-based 11K and antibody proximity ligation-based 5K platforms. Each platform exhibits distinct strengths and limitations, requiring careful consideration prior to implementation in individual studies.
Aptamer-based technology expands the coverage of human plasma proteomic profiling while maintaining precision. However, adding new antibodies on the latest antibody-based platform often results in values below the limit of detection (LOD) in human plasma. These findings contribute a timely update to the comparative analyses of these prominent assays, highlighting their implications for proteomic research.
Josef Coresh, M.D., Ph.D
Professor of Epidemiology, Medicine and Biostatistics
Dr. Joe Coresh is the George W. Comstock Professor of Epidemiology, Biostatistics and Medicine at The Johns Hopkins University Bloomberg School of Public Health*, where he leads the ARIC study – a cohort of 16,000 participants followed since 1987 – and co-leads the CKD Prognosis Consortium (CKD-PC), which includes over 80 cohorts and >10 million participants from 40+ countries.
Dr. Coresh’s research portfolio is diverse following the blood vessels from the heart to the kidney and the brain with grants of over $5M/year focused on big data and molecular studies. An international expert in kidney and cardiovascular disease epidemiology, Dr. Coresh has co-authored over 800 research articles cited over 100,000 times, was vice-chair of the 2002 NKF guideline whose definition of kidney disease is now used globally, and co-published the equations used for estimating kidney function globally.
Each year since 2014 Dr. Coresh has been recognized as being among the top 1% of researchers in Clinical Medicine globally (by article citations). Among other awards, he received the top scientific and patient impact awards of the United States National Kidney Foundation (NKF Eknoyan and Hume awards) and American Society of Nephrology (ASN Scribner award).
Evaluation of precision and correlation for the latest proteomic platforms
A presentation by Josef Coresh, M.D., Ph.D
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