Scientific Publications

SomaLogic is committed to rapid publication of our scientific findings in the peer-reviewed literature.

Below is a chronological list of select articles by SomaLogic scientists and their collaborators.

Download an annotated publications list that includes articles from users of SomaLogic’s proteomic technology.

2019


Targeting unique epitopes on highly similar proteins GDF-11 and GDF-8 with modified DNA aptamers (2019) UA Ochsner, L Green, T Rice, E Olivas, N Janjic and E Katilius.
Biochemistry, epub ahead of print (SUBSCRIPTION REQUIRED).

Effects of codon optimization on coagulation factor IX translation and structure: Implications for protein and gene therapies (2019) A Alexaki, GK Hettiarachchi, JC Athey, UK Katneni, V Simhadri, N Hamasaki-Katagiri, P Nanavaty, B Lin, K Takeda, D Freedberg, D Monroe, JR Mcgill, R Peters, JM Kames, DD Holcomb, RC Hunt, ZE Sauna, A Gelinas, N Janjic, M Dicuccio, H Bar, AA Komar and C Kimchi-Sarfaty.
Scientific Reports 9(1): 15449

Discovery and validation of a prognostic proteomic signature for tuberculosis progression: a prospective cohort study (2019) A Penn-Nicholson, T Hraha, EG Thompson, D Sterling, SK Mbandi, KM Wall, M Fisher, S Suliman, S Shankar, WA Hanekom, N Janjic, M Hatherill, SHE Kaufmann, J Sutherland, G Walzl, MA De Groote, U Ochsner, DE Zak, TJ Scriba, ACS and GC6–74 cohort study groups.
PLOS Medicine 16(4):e1002781

Proteomic profiles in advanced age-related macular degeneration using an aptamer-based proteomic technology (2019) AM Lynch, BD Wagner, SJ Weiss, KM Wall, AG Palestine, MT Mathias, FS Siringo, JN Cathcart, JL Patnaik, DW Drolet, N Janjic and N Mandava.
Translational Vision Science & Technology 8(1):14

2018


Modified aptamers enable quantitative sub-10-nm cellular DNA-PAINT imaging (2018) S Strauss, PC Nickels, MT Strauss, VK Sabinina, J Ellenberg, JD Carter, S Gupta, N Janjic and R Jungmann.
Nature Methods 15(9):685-688

Also see accompanying editorial:
Improving probes for super-resolution (2018) RP Moore and WR Legant.
Nature Methods 15(9):659-660 (SUBSCRIPTION REQUIRED)

Genomic atlas of the human plasma proteome (2018) BB Sun, JC Maranville, JE Peters, D Stacey, JR Staley, J Blackshaw, S Burgess, T Jiang, E Paige, P Surendran, C Oliver-Williams, MA Kamat, BP Prins, SK Wilcox, ES Z, A Chi, N Bansal, SL Spain, AM Wood, NW Morrell, JR Bradley, N Janjic, DJ Roberts, WH Ouwehand, JA Todd, N Soranzo, K Suhre, DS Paul, CS Fox, RM Plenge, J Danesh, H Runz and AS Butterworth.
Nature 558(7708):73-79

Sperm cell purification from mock forensic swabs using SOMAmer™ affinity reagents (2018) E Katilius, AB Carmel, H Koss, D O’Connell, BC Smith, GM Sanders and GS LaBerge.
Forensic Science International: Genetics 35:9-13 (SUBSCRIPTION REQUIRED)

The impact of the glomerular filtration rate on the human plasma proteome (2018) A Christensson, JA Ash, RK DeLisle, FW Gaspar, R Ostroff, A Grubb, V Lindström, L Bruum and SA Williams.
Proteomics Clinical Applications 12(3):e1700067 (SUBSCRIPTION REQUIRED)

Improving assessment of drug safety through proteomics: early detection and mechanistic characterization of the unforeseen harmful effects of torcetrapib (2018) SA Williams, AC Murthy, RK DeLisle, C Hyde, A Malarstig, R Ostroff, SJ Weiss, MR Segal and P Ganz. 
Circulation 137(10):999-1010

Also see accompanying editorial:
Harnessing the power of proteomics to assess drug safety and guide clinical trials (2018) MPY Lam and Y Ge.
Circulation 137(10):1011-1014

2017


Sequential inflammatory processes define human progression from M. tuberculosis infection to tuberculosis disease (2017) TJ Scriba, A Penn-Nicholson, S Shankar, T Hraha, EG Thompson, D Sterling, E Nemes, F Darboe, S Suliman, LM Amon, H Mahomed, M Erasmus, W Whatney, JL Johnson, W Boom, M Hatherill, J Valvo, MA De Groote, UA Ochsner, A Aderem, WA Hanekom, DE Zak and other members of the ACS cohort study team.
PLOS Pathogens 13(11):e1006687

Trisomy 21 causes changes in the circulating proteome indicative of chronic autoinflammation (2017) KD Sullivan, D Evans, A Pandey, TH Hraha, KP Smith, N Markham, AL Rachubinski, K Wolter-Warmerdam, F Hickey, JM Espinosa and T Blumenthal.
Scientific Reports 7(1):14818

Pharmacokinetic properties of DNA aptamers with base modifications (2017) S Gupta, DW Drolet, SK WolkSM Waugh, JC Rohloff, JD Carter, WS Mayfield, MR Otis, CR Fowler, T Suzuki, M Hirota, Y Ishikawa, DJ Schneider and N Janjic.
Nucleic Acid Therapeutics 27(6):345-353

Structural basis for IL-1α recognition by a modified DNA aptamer that specifically inhibits IL-1α signaling (2017) X Ren, AD Gelina, I von Carlowitz, N Janjic and AM Pyle. 
Nature Communications 8(1):810

Discovery of a six-marker serum protein signature for the diagnosis of pulmonary tuberculosis (2017) MA De Groote, DG Sterling, T Hraha, T Russell, LS Green, K Wall, S Kraemer, R Ostroff, N Janjic and UA Ochsner. 
Journal of Clinical Microbiology 55(10):3057-3071

Potential of high-affinity, Slow Off-Rate Modified Aptamer (SOMAmer) reagents for Mycobacterium tuberculosis proteins as tools for infection models and diagnostic applications (2017) T Russell, LS Green, T Rice, NA Kruh-Garcia, K Dobos, MA De Groote, T Hraha, DG Sterling, N Janjic and UA Ochsner.
Journal of Clinical Microbiology 55(10):3072-3088

Development of a protein biomarker panel to detect non-small-cell lung cancer in Korea (2017) YJ Jung, E Katilius, RM Ostroff, Y Kim, M Seok, S Lee, S Jang, WS Kim and CM Choi.
Clinical Lung Cancer 18(2): e99-e107 (SUBSCRIPTION REQUIRED)

Selection of DNA aptamers with two modified bases (2017) BN Gawande, JC Rohloff, JD Carter, I von Carlowitz, C Zhang, DJ Schneider and N Janjic.
Proceedings of the National Academy of Sciences 114(11):2898-2903

Connecting genetic risk to disease end points through the human blood plasma proteome (2017) K Suhre, M Arnold, AM Bhagwat, RJ Cotton, R Engelke, J Raffler, H Sarwath, G Thareja, A Wahl, RK DeLisle, L Gold, M Pezer, G Lauc, MA El-Din Selim, DO Mook-Kanamori, EK Al-Dous, YA Mohamoud, J Malek, K Strauch, H Grallert, A Peters, G Kastenmüller, C Gieger and J Graumann.
Nature Communications 8:14357

Highly multiplexed proteomic analysis of quantiferon supernatants to identify biomarkers of latent tuberculosis infection (2017) MA De Groote, M Higgins, T Hraha, K Wall, ML Wilson, DG Sterling, N Janjic, R Reves, UA Ochsner and R Belknap.
Journal of Clinical Microbiology 55:391-402

2016


Development and validation of a protein-based risk score for cardiovascular outcomes among patients with stable coronary heart disease (2016) PJ Ganz, B Heidecker, K Hveem, C Jonasson, S Kato, MR Segal, DG Sterling and SA Williams.
Journal of the American Medical Association 315(23):2532-2541

Also see accompanying editorial:  
Using aptamer-based technology to probe the plasma proteome for cardiovascular Disease prediction (2016) M Sabatine.
Journal of the American Medical Association 315(23):2525-2526 (SUBSCRIPTION REQUIRED). For access to electronic version, please contact us.

Chemically modified interleukin-6 aptamer inhibits development of collagen-induced arthritis in cynomolgus monkeys (2016) M Hirota, I Murakami, Y Ishikawa, T Suzuki, S Sumida, S Ibaragi, H Kasai, N Horai, DW Drolet, S Gupta, N Janjic and DJ Schneider.
Nucleic Acid Therapeutics 26(1):10-19

Embracing proteins: structural themes in aptamer-protein complexes (2016) AD Gelinas, DR Davies and N Janjic.
Current Opinion in Structural Biology 36:122-32

Fit for the eye: aptamers in ocular disorders (2016) DW Drolet, LS Green, L Gold and N Janjic.
Nucleic Acid Therapeutics 26(3):127-146

2015


Influence of 5-N-carboxamide modifications on the thermodynamic stability of oligonucleotides (2015) SK Wolk, RK Shoemaker, WS Mayfield, AL Mestdagh and N Janjic.
Nucleic Acids Research 43(19):9107-9122

Association of growth differentiation factor 11/8, putative anti-ageing factor, with cardiovascular outcomes and overall mortality in humans: analysis of the Heart and Soul and HUNT3 cohorts (2015) KA Olson, AL Beatty, B Heidecker, MC Regan, EN Brody, T Foremen, S Kato, RE Mehler, BS Singer, K Hveem, H Dalen, DG Sterling, RM Lawn, NB Schiller, SA Williams, MA Whooley and P Ganz.
European Heart Journal 36(48):3426-3434

Practical synthesis of cytidine-5-carboxamide-modified nucleotide reagents (2015) JC Rohloff, C Fowler, B Ream, JD Carter, G Wardle and T Fitzwater.
Nucleosides Nucleotides and Nucleic Acids 34(3):180-198

Large-scale serum protein biomarker discovery in Duchenne muscular dystrophy (2015) Y Hathout, E Brody, PR Clemens, L Cripe, RK DeLisle, P Furlong, H Gordish-Dressman, L Hache, E Henricson, EP Hoffman, YM Kobayashi, A Lorts, JK Mah, C McDonald, B Mehler, S Nelson, M Nikrad, B Singer, F Steele, D Sterling, HL Sweeney, S Williams and L Gold.
Proceedings of the National Academy of Sciences USA 112(23):7153-7158

Non-helical DNA triplex forms a unique aptamer scaffold for high affinity recognition of nerve growth factor (2015) TC Jarvis, DR Davies. A Hisaminato, DI Resnicow, S Gupta, SM Waugh, A Nagabukuro, T Wadatsu, H Hishigaki, B Gawande, C Zhang, SK Wolk, WS Mayfield, Y Nakaishi, AB Burgin, LJ Stewart, TE Edwards, AD Gelinas, DJ Schneider and N Janjic.
Structure 23(7):1293-1304

Circulating proteomic signatures of chronological age (2015) C Menni, SJ Kiddle, M Mangino, A Viñuela, M Psatha, C Steves, M Sattlecker, A Buil, S Newhouse, S Nelson, S Williams, N Voyle, H Soininen, I Kloszewska, P Mecocci, M Tsolaki, B Vellas, S Lovestone, TD Spector, R Dobson and AM Valdes.
Journal of Gerontology: Series A, Biological Sciences and Medical Sciences 70(7):809-816

2014


Nucleic acid ligands with protein-like side chains: modified aptamers and their use as diagnostic and therapeutic agents (2014) JC Rohloff, AD Gelinas, TC Jarvis, UA Ochsner, DJ Schneider, L Gold and N Janjic.
Molecular Therapy Nucleic Acids 3(10):e201

Specific capture and detection of Staphylococcus aureus with high-affinity modified aptamers to cell surface components (2014) A Baumstummler, D Lehmann, N Janjic and UA Ochsner.
Letters in Applied Microbiology 59(4):422-431

Aptamer-based proteomic signature of intensive phase treatment response in pulmonary tuberculosis (2014) P Nahid, E Bliven-Sizemore, LG Jarlsberg, MA De Groote, JL Johnson, G Muzanyi, M Engle, M Weiner, N Janjic, DG Sterling and UA Ochsner.
Tuberculosis 94(3):187-196

Validation of a blood protein signature for non-small cell lung cancer (2014) M Mehan, SA Williams, JM Siegfried, WL Bigbee, JL Weissfeld, DO Wilson, HI Pass, WN Rom, T Muley, M Meister, W Franklin, YE Miller, EN Brody and RM Ostroff.
Clinical Proteomics 11(1):32

Alzheimer’s disease biomarker discovery using SOMAscan multiplexed protein technology (2014) M Sattlecker, SJ Kiddle, S Newhouse, P Proitsi, S Nelson, S Williams, C Johnston, R Killick, A Simmons, E Westman, A Hodges, H Soininen, I Kloszewska, P Mecocci, M Tsolaki, B Vellas, S Lovestone, AddNeuroMed Consortium and RJ Dobson.
Alzheimer’s & Dementia 10(6):724-734

Systematic selection of modified aptamer pairs for diagnostic sandwich assays (2014) UA Ochsner, LS Green, L Gold and N Janjic.
Biotechniques 56(3):125-133

Proteomics analysis of cancer exosomes using a novel modified aptamer-based array (SOMAscan™) platform (2014) J Webber, TC Stone, E Katilius, BC Smith, B Gordon, MD Mason, Z Tabi, IA Brewis and A Clayton.
Molecular & Cellular Proteomics 13(4):1050-1064

DTC-and-me: patient, provider, proteins and regulators (2014) F Steele and L Gold.
Journal of Personalized Medicine 4(1):79-87

Beyond antibodies: new affinity reagents to unlock the proteome (2014) B Lollo, F Steele and L Gold.
Proteomics 14:638-644

Crystal structure of interleukin-6 in complex with a modified nucleic acid ligand (2014) AD Gelinas, DR Davies, TE Edwards, JC Rohloff, JD Carter, C Zhang, S Gupta, Y Ishikawa, M Hirota, Y Nakaishi, TC Jarvis and N Janjic.
Journal of Biological Chemistry 289(12):8720-8734

Chemically-modified DNA aptamers bind interleukin-6 with high affinity and inhibit signaling by blocking its interaction with interleukin-6 receptor (2014) S Gupta, M Hirota, SM Waugh, I Murakami, T Suzuki, M Muraguchi, M Shibamori, Y Ishikawa, TC Jarvis, JD Carter, C Zhang, B Gawande, M Vrkljan, N Janjic and DJ Schneider.
Journal of Biological Chemistry 289(12):8706-8719

2013


Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy (2013) FS Loffredo, ML Steinhauser, SM Jay, J Gannon, JR Pancoast, P Yalamanchi, M Sinha, C Dall’Osso, D Khong, JL Shadrach, CM Miller, BS Singer, A Stewart, N Psychogios, RE Gerszten, AJ Hartigan, MJ Kim, T Serwold, AJ Wagers and RT Lee.
Cell 153(4):829-839

Measurement of cetuximab and panitumumab-unbound serum EGFR extracellular domain using an assay based on Slow Off-Rate Modified Aptamer (SOMAmer) reagents (2013) NJ Park, X Wang, A Diaz, DM Goos-Root, C Bock, JD Vaught, W Sun and CM Strom.
PLOS ONE 8(8):e71703

Elucidating novel serum biomarkers associated with pulmonary tuberculosis treatment (2013) MA De Groote, P Nahid, L Jarlsberg, JL Johnson, M Weiner, G Muzanyi, N Janjic, DG Sterling and UA Ochsner.
PLOS ONE 8(4):e61002

Interaction with both ZNRF3 and LGR4 is required for the signaling activity of R-spondin (2013) Y Xie, R Zamponi, O Charlat, M Ramones, S Swalley, X Jiang, D Rivera, W Tschatz, B Lu, L Quinn, C Dimitri, J Parker, D Jeffery, SK Wilcox, M Watrobka, P LeMotte, B Granda, JA Porter, VE Myer, A Loew and F Cong.
EMBO Reports 14(12):1120-1126

Taking measure of personalized medicine: the proteome (2013) F Steele and L Gold.
Personalized Medicine 10(2):177-182 (SUBSCRIPTION REQUIRED) For reprint, please contact us.

Candidate blood proteome markers of Alzheimer’s disease onset and progression: a systematic review and replication study (2013) SJ Kiddle, M Sattlecker, P Proitsi, A Simmons, E Westman, C Bazenet, SK Nelson, S Williams, A Hodges, C Johnston, H Soininen, I Kloszewska, P Mecocci, M Tsolaki, B Vellas, S Newhouse, S Lovestone and RJ Dobson.
Journal of Alzheimers Disease 38(3):515-531

Detection of Clostridium difficile toxins A, B, and binary toxin with slow off-rate modified aptamers (2013) UA Ochsner, E Katilius and N Janjic.
Diagnostic Microbiology and Infectious Disease 76(3):278-285 (SUBSCRIPTION REQUIRED)

2012


Early detection of malignant pleural mesothelioma in asbestos-exposed individuals with a noninvasive proteomics-based surveillance tool (2012) RM Ostroff, MR Mehan, A Stewart, D Ayers, EN Brody, SA Williams, S Levin, B Black, M Harbut, M Carbone, C Goparaju and HI Pass.
PLOS ONE 7(10):e46091

Life’s simple measures: unlocking the proteome (2012) E Brody, L Gold, M Mehan, R Ostroff, J Rohloff, J Walker and D Zichi.
Journal of Molecular Biology 422(5):595-606 (SUBSCRIPTION REQUIRED)

Slow Off-Rate Modified Aptamer arrays for biomarker discovery and diagnostic applications (2012) JJ Walker, EN Brody and L Gold.
In Microarrays in Diagnostics and Biomarker Development.” (Ed: B Jordan) Springer, ISBN 978-3-642-28202-7 (SUBSCRIPTION REQUIRED)

Protein signature of lung cancer tissues (2012) MR Mehan, D Ayers, D Thirstup, W Xiong, RM Ostroff, EN Brody, JJ Walker, L Gold, TC Jarvis, N Janjic, GS Baird and SK Wilcox.
PLOS ONE 7(4):e35157

Age-dependent changes in the cerebrospinal fluid proteome by Slow Off-Rate Modified Aptamer array (2012) GS Baird, SK Nelson, TR Keeney, A Stewart, S Williams, ER Peskind and TJ Montine.
American Journal of Pathology 180(2):446-456

Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets (2012) DR Davies, AD Gelinas, C Zhang, JC Rohloff, JD Carter, D O’Connell, SM Waugh, SK Wolk, WS Mayfield, AB Burgin, TE Edwards, LJ Stewart, L Gold, N Janjic and TC Jarvis.
Proceedings of the National Academy of Sciences USA 109(49):19971-19976

2011


From SOMAmer-based biomarker discovery to diagnostic and clinical applications: a SOMAmer-based, streamlined multiplex proteomic assay (2011) S Kraemer, JD Vaught, C Bock, L Gold, E Katilius, TR Keeney, N Kim, NA Saccamano, SK Wilcox, D Zichi and GM Sanders.
PLOS ONE 6(10):e26332

Making the cut: untangling clinical protein biomarker discovery and validation (2011) L Gold, S Williams, N Janjic, N Saccomano and F Steele.
Biomarkers in Medicine 5(2):189-191

Rapid histochemistry using Slow Off-rate Modified Aptamers with anionic competition. (2011) S Gupta, D Thirstrup, TC Jarvis, DJ Schneider, SK Wilcox, J Carter, C Zhang, A Gelinas, A Weiss, N Janjic and GS Baird.
Applied Immunohistochemistry & Molecular Morphology 19(3):273-8 (SUBSCRIPTION REQUIRED)

2010


High-Content Affinity-Based Proteomics: Unlocking Protein Biomarker Discovery (2010) EN Brody, L Gold, RM Lawn, JJ Walker and D Zichi.
Expert Review of Molecular Diagnostics 10(8):1013-1022

Aptamers and the RNA world, past and present (2010) L Gold, N Janjic, T Jarvis, DD Schneider, JJ Walker, SK Wilcox and D Zichi.
Cold Spring Harbor Perspectives in Biology 4(3):a003582

Unlocking biomarker discovery: large scale application of aptamer proteomic technology for early detection of lung cancer (2010) RM Ostroff, WL Bigbee, W Franklin, L Gold, M Mehan, YE Miller, HI Pass, WN Rom, JM Siegfried, A Stewart, JJ Walker, JL Weissfeld, SA Williams, D Zichi and EN Brody.
PLOS ONE 5(12):e15003

Expanding the chemistry of DNA for in vitro selection (2010) JD Vaught, C Bock, J Carter, T Fitzwater, M Otis, D Schneider, J Rolando, S Waugh, SK Wilcox and B Eaton.
Journal of the American Chemical Society 132(12):4141–4151 (SUBSCRIPTION REQUIRED)

The stability of the circulating human proteome to variations in sample collection and handling procedures measured with an aptamer-based proteomics array. (2010) R Ostroff, T Foreman, TR Keeney, S Stratford, JJ Walker and D Zichi.
Journal of Proteomics 73(3):649-66 (SUBSCRIPTION REQUIRED)

Aptamer-based multiplexed proteomic technology for biomarker discovery (2010) L Gold, D Ayers, J Bertino, C Bock, A Bock, EN Brody, J Carter, AB Dalby, BE Eaton, T Fitzwater, D Flather, A Forbes, T Foreman, C Fowler, B Gawande, M Goss, M Gunn, S Gupta, D Halladay, J Heil, J Heilig, B Hicke, G Husar, N Janjic, T Jarvis, S Jennings, E Katilius, TR Keeney, N Kim, TH Koch, S Kraemer, L Kroiss, N Le, W Lindsey, B Lollo, W Mayfield, M Mehan, R Mehler, M Nelson, SK Nelson, D Nieuwlandt, M Nikrad, U Ochsner, RM Ostroff, M Otis, T Parker, S Pietrasiewicz, DI Resnicow, J Rohloff, G Sanders, S Sattin, D. Schneider, B Singer, M Stanton, A Sterkel, A Stewart, S Stratford, JD Vaught, M Vrkljan, JJ Walker, M Watrobka, S Waugh, A Weiss, SK Wilcox, A Wolfson, SK Wolk, C Zhang and D Zichi.
PLOS ONE 5(12):e15004

2008-1990


Proteomics and diagnostics: let’s get specific, again (2008) D Zichi, B Eaton, B Singer and L Gold.
Current Opinion in Chemical Biology 12(1):78–85. (SUBSCRIPTION REQUIRED).

Aptamers: the new frontier in drug development? (2007) B Carlson.
Biotechnology Healthcare 4(2):31-36. 

Aptamers as therapeutic and diagnostic agents (2000) EN Brody and L Gold.
Reviews in Molecular Biotechnology 74(1):5-13. (SUBSCRIPTION REQUIRED).

High affinity ligands from in vitro selection: complex targets. (1998) KN Morris, KB Jensen, CM Julin, M Weil and L Gold.
Proceedings of the National Academy of Sciences USA 95(6):2902-2907.

Let’s get specific: The relationship between specificity and affinity (1995) BE Eaton, L Gold and DA Zichi.
Chemistry & Biology 2(10):633-638.

Systematic evolution of ligands by exponential enrichment: RNA Ligands to bacteriophage T4 DNA polymerase (1990) C Tuerk and L Gold.
Science 249(4968):505-510. (SUBSCRIPTION REQUIRED).