Powerful metrics provide multiple clinical assessments from a single blood draw

Obtain relevant clinical data to advance your research.

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What are SomaSignal™ tests?

Clinically meaningful metrics

  • 21 quantitative clinical metrics
  • Relevant to cardiovascular disease, NASH, diabetes, and more
  • Reporting current health state and understanding risk

Derived from just a 55-µL sample

  • Simple and simultaneous sampling for all tests
  • Derived from models based on proteomic signatures
  • Validated against standard clinical measurement

For simple, straightforward clinical trial monitoring

  • Simple blood test enables frequent sampling
  • Does not require specialized physicians/pathologists
  • Simple blood draw is ideal for longitudinal studies

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What tests are available?

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Body fat %

Percent body fat

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Resting energy expenditure

Calories burned at rest

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Lean body mass

Total lean body mass

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Glucose tolerance

Blood glucose levels following sugar intake

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Liver fat

Presence/absence of excess liver fat

SomaSignal_Tests_Icons_body fat_visceral fat

Visceral fat

Fat content around vital organs

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CVD primary

4-year risk of heart attack, stroke, or heart failure

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CVD secondary

4-year risk of heart attack, stroke, or heart failure following an initial event

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Cardiorespiratory fitness

Aerobic fitness level (VO2 max)

Alcohol impact

Predicted weekly alcohol consumption

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NASH: steatosis

Measures NASH-related liver steatosis

SomaSignal_Tests_Icons_body fat_nash inflammation

NASH: inflammation

Measures NASH-related liver inflammation

SomaSignal_Tests_Icons_body fat_nash fibrosis

NASH: Fibrosis

Measures NASH-related Liver Fibrosis

SomaSignal_Tests_Icons_body fat_nash ballooning

NASH: ballooning

Measures NASH-related liver ballooning

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Heart Failure reduced Ejection Fraction: 6 months

Risk of death in 6 months with stable HFrEF

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Heart Failure reduced Ejection Fraction: 12 months

Risk of death in 1 year with stable HFrEF

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Heart Failure preserved Ejection Fraction: 6 months

Risk of death in 6 months with stable HFpEF

SomaSignal_Tests_Icons_body fat_HFpEF - 12

Heart Failure preserved Ejection Fraction: 12 months

Risk of death in 1 year with stable HFpEF

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Kidney prognosis

Risk of worsening Chronic Kidney Disease

Dementia risk

Risk of Dementia diagnosis within 20 years

Fed-fasted

Hours since last meal

How were they developed?

The SomaSignal tests are developed by analyzing thousands of proteins in thousands of patients using the SomaScan Assay. Protein signatures revealed by the SomaScan Assay are compared against standard clinical measurements in order to identify patterns of protein changes that correlate with current health status and future trajectory using machine learning. Each pattern becomes the basis for a specific SomaSignal test. Because each SomaSignal test is generated using a subset of the 7,000 proteins measured by the SomaScan Assay, results for all of the SomaSignal tests can be derived from a single 55-μl blood sample.

Image of all SomaScan Testing Capabilities

See relevant publications in our interactive viewer

Review publications