Somasignal™ tests

Clinical trial monitoring will never be the same

What are SomaSignal Tests?

Clinically meaningful
metrics

  • 20 quantitative clinical metrics
  • Relevant to cardiovascular disease, NASH, diabetes, and more

  • Reporting current health state and understanding risk

DERIVED FROM JUST
55 µl BLOOD

  • Simple and simultaneous sampling for all tests

  • Derived from models based on proteomic signatures

  • Validated against standard clinical measurement

for simple, straightforward
clinical trial monitoring

  • Simple blood test enables frequent sampling

  • Does not require specialized physicians/pathologists

  • Simple blood draw is ideal for longitudinal studies

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See the technology in action

What Tests are available?

Body Fat %

Percent Body Fat

Resting Energy Expenditure

Calories burned at rest

Lean body mass

total lean body mass

Glucose Tolerance

Blood glucose levels following sugar intake

Liver Fat

Presence/absence of excess liver fat

Visceral Fat

Fat content around viral organs

CVD Primary

4 year risk of heart attack, stroke, or heart failure

CVD Secondary

4 year risk of heart attack, stroke, or heart failure following an initial event

Cardiorespiratory Fitness

Aerobic fitness level (Vo2 Max)

Alcohol Impact

Predicted weekly alcohol consumption

NASH: Steatosis

Measures NASH-related liver statosis

NASH: Inflammation

Measures NASH-related liver inflammation

NASH: Fibrosis

Measures NASH-related liver fibrosis

NASH: Ballooning

Measures NASH-related liver ballooning

Heart Failure reduced Ejection Fraction 6 months

Risk of death in 6 months with stable HFrEF

Heart Failure reduced Ejection Fraction 12 months

Risk of death in 1 year with stable HFrEF

Heart Failure preserved Ejection Fraction 6 months

Risk of death in 6 months with stable HFpEF

Heart Failure preserved Ejection Fraction 12 months

Risk of death in 1 year with stable HFpEF

How were they developed?

The SomaSignal tests are developed by analyzing thousands of proteins in thousands of patients using the SomaScan Assay. Protein signatures revealed by the SomaScan Assay are compared against standard clinical measurements in order to identify patterns of protein changes that correlate with current health status and future trajectory using machine learning. Each pattern becomes the basis for a specific SomaSignal test. Because each SomaSignal test is generated using a subset of the 7,000 proteins measured by the SomaScan Assay, results for all of the SomaSignal tests can be derived from a single 55 μl blood sample.

Relevant Publications

Comprehensive Liquid
Health Check

Protein signatures from 17,000 samples were compared with traditional health indicators to generate 13 predictive models.

Read in Nature Medicine

CVD risk
scores

2.8M protein measurements were used to develop risk scores for future heart failure, heart attack, stroke and death

Adverse event
prediction

Identification of proteins that could have predicted adverse reactions in the ILLUMINATE trial

Any or all of the tests can be obtained for a single price alone or in conjunction with the full menu of 7,000 analytes