SOMAmer Reagents: Specific And Versatile Protein Affinity Reagents

Recorded Webinar

This webinar was originally recorded June 6, 2016 and provided an overview of SOMAmer (Slow Off-rate Modified Aptamers) reagents and their utility as protein affinity reagents in many common life science research applications.

With unique amino-acid like modifications, SOMAmer reagents possess the strong binding affinities and high target specificities of antibodies. Since SOMAmer reagents are manufactured using traditional DNA chemical synthesis, they have the advantage of lot-to-lot consistency and superior thermal stability desired for reproducible and robust assay performance. Attendees will develop an appreciation of the benefits and limitations of the SOMAmer reagents by drawing comparisons to more traditional affinity reagents such as antibodies.

Learning Objectives

  • Selection and characterization of the SOMAmer reagents as protein-binding tools
  • Demonstrated specificity of the SOMAmer reagents for distinguishing between highly related proteins
  • Examples of the SOMAmer Reagent performance in flow cytometry, fluorescent cell microscopy, sandwich ELISA-type assays and other common life science applications that rely on protein affinity reagents
  • Key differences between the SOMAmer reagents, traditional aptamers, and antibodies



Erik Zimmerman, Ph.D.
Senior Scientist at SomaLogic

Erik Zimmerman has been at SomaLogic since September 2014. Prior to joining SomaLogic, Erik was a Senior Scientist at Sutro Biopharma, a biotechnology company focusing on discovery and production of antibody-drug conjugates and bispecific antibodies in a cell-free protein expression system.

Download Slides